The placebo drug reactions from controlled trials were studied for the first time systematically for efficacy and the safety in drug data pooled from randomized, placebo-controlled, multicentre studies. Results: The efficacy of placebo on clinical symptoms and outcome varied between the therapeutic indications. However, no placebo effects on laboratory values, as e.g. blood glucose or Hb1c in diabetics, were noted. The frequency and type of placebo-induced adverse reactions also varied between indication groups. The placebo side effect profile was largely similar (...) to the side effect profile of the active treatment. The mechanisms of placebo effects are manyfold and varied (e.g. endorphin release, conditioning), much lacks explanation. Conclusion: Since the prescription of non-evidence based medicines (= pseudoplacebos) may clearly also result in serious adverse effects, such practice may not only be non-beneficial but may even be harmful. In clinical research, the judicious use of placebo remains essential to establish the efficacy and safety, safeguarding that patients receiving placebo will not be subject to harm and are fully informed. (shrink)

The placebo drug reactions from controlled trials were studied for the first time systematically for efficacy and the safety in drug data pooled from randomized, placebo-controlled, multicentre studies. Results: The efficacy of placebo on clinical symptoms and outcome varied between the therapeutic indications. However, no placebo effects on laboratory values, as e.g. blood glucose or Hb1c in diabetics, were noted. The frequency and type of placebo-induced adverse reactions also varied between indication groups. The placebo side effect profile was largely similar (...) to the side effect profile of the active treatment. The mechanisms of placebo effects are manyfold and varied (e.g. endorphin release, conditioning), much lacks explanation. Conclusion: Since the prescription of non-evidence based medicines (= pseudoplacebos) may clearly also result in serious adverse effects, such practice may not only be non-beneficial but may even be harmful. In clinical research, the judicious use of placebo remains essential to establish the efficacy and safety, safeguarding that patients receiving placebo will not be subject to harm and are fully informed. (shrink)

Jean-Paul Sartre was one of the most influential thinkers of the twentieth century. Regarded as the father of existentialist philosophy, he was also a political critic, moralist, playwright, novelist, and author of biographies and short stories. Thomas R. Flynn provides the first book-length account of Sartre as a philosopher of the imaginary, mapping the intellectual development of his ideas throughout his life, and building a narrative that is not only philosophical but also attentive to the political and literary dimensions (...) of his work. Exploring Sartre's existentialism, politics, ethics, and ontology, this book illuminates the defining ideas of Sartre's oeuvre: the literary and the philosophical, the imaginary and the conceptual, his descriptive phenomenology and his phenomenological concept of intentionality, and his conjunction of ethics and politics with an 'egoless' consciousness. It will appeal to all who are interested in Sartre's philosophy and its relation to his life. (shrink)

The concept of an ecological niche (econiche) has been used in a variety of ways, some of which are incompatible with a relational or functional interpretation of the term. This essay seeks to standardize usage by limiting the concept to functional relations between organisms and their surroundings, and to revise the concept to include epistemic relations. For most organisms, epistemics are a vital aspect of their functional relationships to their surroundings and, hence, a major determinant of their econiche. Rejecting the (...) traditional dualism of organism and environment, an econiche is defined as the reciprocal (dual) of a functionally specified class of organisms (FSTU). From this perspective, an econiche necessarily implies a certain type of organism, and a class of functionally similar organisms implies a special econiche.The econiche concept is also discussed in relation to other ecological terms that reflect the distributional patterns of organisms, such as habitat, and the concept of an empty niche is criticized. (shrink)

This article examines some of the main tenets of competition theory in light of the theory of evolution and the concept of an ecological niche. The principle of competitive exclusion and the related assumption that communities exist at competitive equilibrium - fundamental parts of many competition theories and models - may be violated if non-equilibrium conditions exist in natural communities or are incorporated into competition models. Furthermore, these two basic tenets of competition theory are not compatible with the theory of (...) evolution. Variation in ecologically significant environmental factors and non-equilibrium in population numbers should occur in most natural communities, and such changes have important effects on community relations, niche overlap, and the evolution of ecosystems. Ecologists should view competition as a process occurring within a complexdynamic system, and should be wary of theoretical positions built upon simple laboratory experiments or simplistic mathematical models.In considering the relationship between niche overlap and competition, niche overlap should not be taken as a sufficient condition for competition; many factors may prevent or diminish competition between populations with similar resource utilization patterns. The typically opposing forces of intraspecific and interspecific competition need to be simultaneously considered, for it is the balance between them that in large part determines niche boundaries. (shrink)

In this important book, Thomas R. Flynn reinterprets and evaluates Sartre's social and political philosophy, arguing that the existential ethics of Sartre's ...

Codes of ethics exist in many, if not the majority, of all large U.S. companies today. But how the impact of these written codes affect managerial attitudes and behavior is still not clearly documented or explained. This study takes a step in that direction by proposing that attention should shift from the codes themselves as the sources of ethical behavior to the persons whose behavior is the focus of these codes. In particular, this study investigates the role of code familiarity (...) as a factor impacting the influence of an ethics code on manager behavior. Data collected from 286 executives from companies in the direct selling industry are used to test hypotheses (1) that the perceived usefulness of ethics codes is positively related to the degree of familiarity with the code, and (2) that ethical climate as assessed by managers is positively related to the code''s perceived usefulness. Both hypotheses are supported, and their implications and further research directions are discussed. (shrink)

Sartre and Foucault were two of the most prominent and at times mutually antagonistic philosophical figures of the twentieth century. And nowhere are the antithetical natures of their existentialist and poststructuralist philosophies more apparent than in their disparate approaches to historical understanding. A history, thought Foucault, should be a kind of map, a comparative charting of structural transformations and displacements. But for Sartre, authentic historical understanding demanded a much more personal and committed narrative, a kind of interpretive diary of moral (...) choices and risks compelled by critical necessity and an exacting reality. Sartre's history, a rational history of individual lives and their intrinsic social worlds, was in essence immersed in biography. In Volume One of this authoritative two-volume work, Thomas R. Flynn conducts a pivotal and comprehensive reconstruction of Sartrean historical theory, and provocatively anticipates the Foucauldian counterpoint to come in Volume Two. (shrink)

Sartre and Foucault were two of the most prominent and at times mutually antagonistic philosophical figures of the twentieth century. And nowhere are the antithetical natures of their existentialist and poststructuralist philosophies more apparent than in their disparate approaches to historical understanding. In Volume One of this authoritative two-volume study, Thomas R. Flynn conducted a pivotal and comprehensive reconstruction of Sartrean historical theory. This long-awaited second volume offers a comprehensive and critical reading of the Foucauldian counterpoint. A history, theorized (...) Foucault, should be a kind of map, a comprehensive charting of structural transformations and displacements over time. Contrary to other Foucault scholars, Flynn proposes an "axial" rather than a developmental reading of Foucault's work. This allows aspects of Foucault's famous triad of knowledge, power, and the subject to emerge in each of his major works. Flynn maps existentialist categories across Foucault's "quadrilateral," the model that Foucault proposes as defining modernist conceptions of knowledge. At stake is the degree to which Sartre's thought is fully captured by this mapping, whether he was, as Foucault claimed, "a man of the nineteenth century trying to think in the twentieth.". (shrink)

After presenting the major objections raised against standard formulations of the H-D method of theory testing, I identify what seems to be an important element of truth underlying the method. I then draw upon this element in an effort to develop a plausible formulation of the H-D method which avoids the various objections.

The authors' attempt to explore the ability of animals to monitor how certain they are of their choice behavior, necessarily fails both in their effort to include “higher” mammals (such as monkeys and dolphins) in the class of metacognitive organisms (humans) and in their conclusion that “lower” organisms are not capable of similar behavior.

The authors make a distinction between instrumental copying behavior in which there is a clear reward for the copying behavior and social copying (traditions) in which the rewards for copying are less clear. However, I see no reason to distinguish between the two. We are social animals, for whom copying traditions have important rewards, those of affiliation.

The Making of Western Indology: Henry Thomas Colebrooke and the East India Company. By Rosane Rocher and Ludo Rocher. Royal Asiatic Society Books. London: Routledge, 2012. Pp. xv + 238, 5 plates. $145.

Covering the entire trajectory of his religious life, this book identifies and analyzes the foundations of political and social order in the philosophy of Pope Benedict XVI. Thomas R. Rourke explains Benedict's belief in the value of the Christian tradition's contribution to a contemporary politics of reason.

In this thought provoking work Thomas DeGregori presents the uncommon premise that technology is a human endeavour and a positive force that defines our humanity. Examining a number of revolutionary technological advances in this century, especially those in the agricultural areas, the author debunks common conventional wisdom that would dictate otherwise. For instance, the use of chemicals, including DDT and other pesticides, id often maligned as damaging the environment and the quality of life. Dr DeGregori counters this argument with (...) documentation that demonstrates how use of these chemicals has actually increased life span. Agriculture and Modern Technology will prompt readers to re-examine current popular belief in technology. (shrink)

Abstract Advances in technology now make it possible to monitor the activity of the human brain in action, however crudely. As this emerging science continues to offer correlations between neural activity and mental functions, mind and brain may eventually prove to be one. If so, such a full comprehension of the electrochemical bases of mind may render current concepts of ethics, law, and even free will irrelevant. Content Type Journal Article Category Original Paper Pages 1-5 DOI 10.1007/s11948-012-9351-1 Authors Thomas (...) R. Scott, San Diego State University, San Diego, California, USA Journal Science and Engineering Ethics Online ISSN 1471-5546 Print ISSN 1353-3452. (shrink)

This distinctive and contemporary departure from hackneyed discussions of political theory introduces readers to a contemporary personalism rooted in the work of Bartolome de Las Casas and emerging again in the contributions of Dorothy Day, Peter Maurin as well as the liberation theology of Gustavo Guiterrez and Jon Sobrino. Thomas R. Rourke and Rosita A. Chazarreta Rourke introduce readers to new sources of personalism by investigating and revising the intellectual history of this theory and its development.

Thomas R. Flynn - Dark Feelings, Grim Thoughts: Experience and Reflection in Camus and Sartre - Journal of the History of Philosophy 46:1 Journal of the History of Philosophy 46.1 179-180 Muse Search Journals This Journal Contents Reviewed by Thomas R. Flynn Emory University Robert C. Solomon. Dark Feelings, Grim Thoughts: Experience and Reflection in Camus and Sartre. Oxford-New York: Oxford University Press, 2006. Pp. ii + 241. Cloth, $35.00. This study in existentialist thought is a collection of (...) essays, some previously published, in defense of the thesis that existentialist thought, at least in these works, is the articulation of our pre-reflective experience that yields an immediacy and a richness often sacrificed when one turns to abstract reflection—as Solomon believes Sartre does in Being and Nothingness in.. (shrink)

This study explored the relationship between teachers' self-reported affect toward teaching, teaching self-concept, and responsibility assumed for student achievement. Participants were 182 elementary and secondary school teachers from a large metropolitan school system. Multivariate regression analyses were performed in which teacher gender, affect toward teaching, and teaching self-concept were regressed upon selfresponsibility scores for both positive and negative classroom events. The results showed significant differences with respect to the sex of the teacher, a strong positive association with affect toward teaching (...) scores, and a strong negative association with teaching self-concept scores. Difference in the models for responsibility for positive versus negative events are discussed, together with tentative observations about these trends in the perceptions of teachers. (shrink)

I defend three claims regarding Foucault’s historical a priori and the intelligibility of history that counter commonly received accounts of Husserl’s approach to the same. First, Foucault is not a transcendental thinker in the Kantian sense of the term. His use of the HP is contingent, postdictive, regional and hypothetical. Second, the three “axes” of the dyads knowledge/truth, power/government, and subjectivation/ethics along with Foucault’s “history of the present” enclose a space called “experience” Erfahrung as nonreflective and “freed from inner life.” (...) At this point, “experience” and “multiplicity” coalesce to confirm Foucault’s anti-phenomenological bias and nominalist commitment. Finally, the relations of transformation and displacement that define archaeological change support a “fittingness” between the epistemes in question. Neither necessitating nor aleatory, their relation could be called “aesthetic” in a broad sense. I conclude by listing ways Husserl’s approach to historical intelligibility is the inverse of Foucault’s. (shrink)

Dialectic and narrative reflect the respective inclinations of philosophy and literature as disciplines that fix one another in a Sartrean gaze, admixing envy with suspicion.

The political notoriety and literary fame of Jean‐Paul Sartre (1905–80) (he was awarded but refused the Nobel Prize for Literature in 1962) have tended to eclipse his philosophical accomplishments, at least in the eyes of the public at large. This is unfortunate, since Sartre's philosophical writings are original and insightful, especially in those areas where the philosophy of being (ontology), philosophical psychology, and ethics overlap – the very space in which the literary imagination operates. In fact, there is probably no (...) philosopher of the twentieth century who so personified the creative tension between philosophy and literature as did Jean‐Paul Sartre. His enthusiasm for phenomenology as a method for philosophizing about concrete experience was doubtless born of that tension. After discussing Sartre's work as a phenomenologist, I shall analyze his thought in the areas of ontology, psychology, and ethics, as well as related fields of philosophical inquiry, concluding with several observations about the contemporary relevance of his philosophy. (shrink)

Across Europe, national leaders and ordinary citizens alike face the problems and opportunities raised by increasing economic and political interdependence. Interdependence between nations creates new dilemmas in every sphere of activity. In The Netherlands: Negotiating Sovereignty in an Interdependent World, Thomas Rochon offers a comparative focus and a strong conceptualization of small-state issues applied to present the Netherlands experience.Although all countries face issues of sovereignty and adjustment to international forces, the Dutch have addressed these issues more explicitly and over (...) a longer span of time. How have the Dutch gone about the transformation from global power to small state? What lessons have they learned along the way that might be applied elsewhere in Europe, not to mention the United States? Rochon addresses these issues and provides background information on the people, culture, government, and economy of the country. In the final chapter, he summarizes the Dutch experience and explains that what unites the Netherlands with other industrial nations is how the country copes with change. (shrink)

Food sharing may be used for mate attraction, sexual access, or mate retention in humans, as in many other species. Adult humans tend to perceive more intimacy in a couple if feeding is observed, but the increased perceived intimacy may be due to resource provisioning rather than feeding per se. To address this issue, 210 university students (66 male) watched five short videos, each showing a different mixed-sex pair of adults dining together and including feeding or simple provisioning or no (...) food sharing. A survey concerning attraction and intimacy in the dyad was completed after each video. Both provisioning and feeding produced higher ratings of “Involvement,” with feeding producing the highest ratings. Similarly, the perceived attraction of each actor to the other was lowest when no food sharing was shown and highest when feeding was displayed. These findings are consistent with a view of feeding as a courtship display in humans. (shrink)

On Monday, May 4th, 1970, members of the Ohio National Guard fired 61 rounds of bullets into the Kent State University students protesting about the invasion of Cambodia. This work develops the ideas of the first symposium on American democracy established to commemorate the tragedy.