The insulin/insulin‐like growth factor‐1 (IGF‐1) signaling (IIS) pathway is a pivotal genetic program regulating cell growth, tissue development, metabolic physiology, and longevity of multicellular organisms. IIS integrates a fine‐tuned cascade of signaling events induced by insulin/IGF‐1, which is precisely controlled by post‐translational modifications. The ubiquitin/proteasome‐system (UPS) influences the functionality of IIS through inducible ubiquitylation pathways that regulate internalization of the insulin/IGF‐1 receptor, the stability of downstream insulin/IGF‐1 signaling targets, and activity of nuclear receptors for control of gene expression. An age‐related (...) decline in UPS activity is often associated with an impairment of IIS, contributing to pathologies such as cancer, diabetes, cardiovascular, and neurodegenerative disorders. Recent findings identified a key role of diverse ubiquitin modifications in insulin signaling decisions, which governs dynamic adaption upon environmental and physiological changes. In this review, we discuss the mutual crosstalk between ubiquitin and insulin signaling pathways in the context of cellular and organismal homeostasis. (shrink)

The author argues that there is no such thing as a unique and general taxonomy of non-at-issue contents. Accordingly, we ought to shun large categories such as “conventional implicature”, “F-implicature”, “CI”, “Class B” or the like. As an alternative, we may, first, describe the “semantic profile” of linguistic devices as accurately as possible. Second, we may explicitly tailor our categories to particular theoretical purposes.

This paper presents the outlines of a phenomenological theory of foundational or non-inferential knowledge according to which the facts or states of affairs towards which our beliefs are intentionally directed can sometimes serve as reasons or evidence for what we believe. This occurs in acts of fulfillment, in which an object or state of affairs is given as it is thought to be. Hopp further argues that the sorts of empirical facts that can serve as reasons for noninferentially justified beliefs (...) are not confined to facts about one’s own occurrent mental states, but include facts about the physical world as well. In the course of defending the view against objections, Hopp argues that we should be internalists about the reasons in virtue of which what we believe is justified but externalists about the factors in virtue of which our states of believing have the status of being justified. He also argues against the claim that mental states, such as perceptual experiences, constitute our evidence for empirical beliefs. (shrink)

„Rechtsgefühl“ kann das individuelle Gerechtigkeitsempfinden, das Judiz der Richterin im Entscheidungsfindungsprozess, das emotionale Aufbäumen der unterlegenen Partei nach der Entscheidung, eine kollektive Rechtsüberzeugung bezeichnen. Verweise auf das „Rechtsgefühl“ werden oft genutzt, um Rechtssysteme oder einzelne Rechtsakte von innen oder von außen zu legitimieren oder zu delegitimieren. Als sozialer Kompass und normative Rechtfertigung versagt „Rechtsgefühl“ dagegen, wenn es mit zahlreichen gegenläufigen Rechtsgefühlen konkurriert. Dieser Frage nach dem Stellenwert divergierender Rechts- und Gerechtigkeitsempfindungen gehen die in diesem Band versammelten Beiträge aus praktischer, theoretischer (...) und historischer Perspektive nach. Mit Beiträgen von Prof. Dr. Gabriele Britz, Prof. Dr. Jeanne Gaakeer, Prof. Dr. Thorsten Keiser, Prof. Dr. Sylvia Kesper-Biermann, Prof. Dr. Frans-Willem Korsten, Prof. Dr. Greta Olson und Prof. Dr. Franz Reimer. (shrink)

Die Frage nach dem Menschen ist heute – im Zeitalter der zunehmenden Verschmelzung von Mensch und Technik, der Genom-Editierung und der fortgeschrittenen Naturalisierung des Menschenbildes – aktueller denn je. Der Autor präsentiert hier erstmals eine systematische und prägnante Darstellung der Idee einer neuen Anthropologie, welche die mundanen, transzendentalen und transphänomenalen Aspekte des Menschseins gleichermaßen berücksichtigt und die Reduktion des Menschen auf seinen biologischen Körper zurückweist. Diese ‚Fundamentalanthropologie‘ genannte Disziplin versteht sich als philosophische Grundlagendisziplin und als Herzstück der Philosophie als allgemeiner (...) Anthropologie. Außerdem werden in diesem Band zentrale und aktuelle philosophische Themen wie Selbstbewusstsein, Identität des Ich, das Wesen des menschlichen Geistes sowie die Zukunft des Menschen erstmals zum Gegenstand fundamentalanthropologischer Analysen gemacht. (shrink)

In the course of history, the doctrine of just war has proven to be susceptible to political misuse. Furthermore, it features a number of conceptual deficiencies. In the leading perspective of ‘just peace’, peace ethics primarily emphasises the task of violence prevention, for which the realisation and protection of human rights gain central importance. Even the traditional term ‘common good’ can be reformulated in this context. The concept of ‘just peace’ critically confronts the discussion on the legitimacy of pre-emptive wars. (...) With regard to ‘humanitarian interventions’, it calls for a sophisticated catalogue of criteria that helps to define the presuppositions under which such interventions can be deemed legitimate. (shrink)

In vision research metacontrast masking is a widely used technique to reduce the visibility of a stimulus. Typically, studies attempt to reveal general principles that apply to a large majority of participants and tend to omit possible individual differences. The neural plasticity of the visual system, however, entails the potential capability for individual differences in the way observers perform perceptual tasks. We report a case of perceptual learning in a metacontrast masking task that leads to the enhancement of two types (...) of adult human observers despite identical learning conditions. In a priming task both types of observers exhibited the same priming effects, which were insensitive to learning. Findings suggest that visual processing of target stimuli in the metacontrast masking task is based on neural levels with sufficient plasticity to enable the development of two types of observers, which do not contribute to processing of target stimuli in the priming task. (shrink)

To analyze the role of automatic processes in the fulfilment of delayed intentions, we extended a typical prospective memory setting with a context signal to indicate whether the intended action is to be carried out or not. Building on dual-process models of cognition, we hypothesized that automatic and controlled processes are in opposition when the action is to be suppressed, because automatic processes trigger the associated response whereas controlled processes exert inhibition. Experiment 1 demonstrates the occurrence of false prospective memory (...) responses to cues with the “suppress” signal. Experiment 2 shows that the rate of false prospective memory responses is sensitive to a manipulation that strengthens the role of automatic processes in prospective memory. The findings support the use of false prospective memory responses for the study of automatic processes in the execution of delayed intentions. (shrink)

The problem of finding sufficient doxastic conditions for backward induction in games of perfect information is analyzed in a syntactic framework with subjunctive conditionals. This allows to describe the structure of the game by a logical formula and consequently to treat beliefs about this structure in the same way as beliefs about rationality. A backward induction and a non-Nash equilibrium result based on higher level belief in rationality and the structure of the game are derived.

In metacontrast masking target visibility is modulated by the time until a masking stimulus appears. The effect of this temporal delay differs across participants in such a way that individual human observers’ performance shows distinguishable types of masking functions which remain largely unchanged for months. Here we examined whether individual differences in masking functions depend on different response criteria in addition to differences in discrimination sensitivity. To this end we reanalyzed previously published data and conducted a new experiment for further (...) data analyses. Our analyses demonstrate that a distinction of masking functions based on the type of masking stimulus is superior to a distinction based on the target–mask congruency. Individually different masking functions are based on individual differences in discrimination sensitivities and in response criteria. Results suggest that individual differences in metacontrast masking result from individually different criterion contents. (shrink)

The idea that Eastern and Western societies should do everything together because they're exactly the same and their interests are identical is not, as some would have it, a sign of evolutionary maturity or scientific insight, but a desperate form of political manipulation, new Western imperialism, and, yes, wishful thinking. Surely our cultural differences and identities make the world more colorful." Thorsten Pattberg's East-West Dichotomy discusses the philosophical concept that two diametrically opposed hemispheres exist - East and West. As (...) the Peking University scholar demonstrates with numerous examples, their cultures and way of thinking differ radically; one could say they are 180 degrees apart. Pattberg's underlying argument is that because of the dichotomy Westerners, who are mostly rugged individualists, are more analytic and deductive in their thinking, while Easterners, who are more focused on the collective, favor a more intuitive, inductive, "holistic" approach to life. Moreover, he explores the origin and the future of the dichotomy, and shows how it has shaped the West's and the East's different attitudes towards nature, philosophy (both epistemology and ethics), as well as gender and society. Pattberg also shows his willingness to take on any potential critic of his theory in his chapter "Problems with the Dichotomy." This book is a valuable resource for those eager to gain a better understanding of the "Western" and "Eastern" psyches and of how they both harmonize and clash. (shrink)

A syntactic formalism for the modeling of belief revision in perfect information games is presented that allows to define the rationality of a player's choice of moves relative to the beliefs he holds as his respective decision nodes have been reached. In this setting, true common belief in the structure of the game and rationality held before the start of the game does not imply that backward induction will be played. To derive backward induction, a “forward belief” condition is formulated (...) in terms of revised rather than initial beliefs. Alternative notions of rationality as well as the use of knowledge instead of belief are also studied within this framework. Footnotes1 I would like to thank Wlodek Rabinowicz and three anonymous referees for very helpful comments. (shrink)

This article challenges the view that sociological explanation is based on methodological individualism and suggests using relational concepts for constructing explanations of social phenomena. It develops a relational concept of social mechanisms based on sociological systems theory and illustrates its explanatory power by drawing on research on changes in educational organizations in Germany.

In diesem Aufsatz soll der Takt als ein moral- und tugendrelevantes Phänomen bestimmt werden. Ausgehend von einer kontrastierenden Abgrenzung gegenüber anderen Umgangsformen, wendet er sich wichtigen Theoriestücken zu, die sich explizit mit dem Takt befassen, um an ihnen entscheidende problematische Aspekte aufzuzeigen und zu korrigieren. Anschließend erfolgt die handlungstheoretische Erklärung als einer Form des Perspektivenwechsels. Diese erlaubt es zugleich, auch die moralische Dimension des Takts und seinen Status als Tugend zu fokussieren, die zwar nicht nur, aber vor allem in einer (...) multidimensional charakterisierbaren demokratischen Gesellschaft ihren relevanten Ort hat. (shrink)

ABSTRACTDepression is marked by rigid thinking and the inability to generate different and more positive views on the self. The current study conceptualises this a perspective-taking deficit, which is defined as a deficit in the ability to overcome one’s egocentrism. Previous research has demonstrated that individuals with depression are impaired in Theory of Mind reasoning and empathy – two social cognitions that involve cognitive and affective perspective-taking. Here, it was investigated whether these deficits generalise to visuo-spatial perspective-taking. To test this, (...) a convenience sample completed a test-battery including measures of cognitive and visuo-spatial perspective-taking and closely matched cognitive and visuo-spatial control tasks. The results showed that individuals exhibiting high levels of depressive symptoms were specifically impaired on both perspective-taking tasks but performed equally well on the cont... (shrink)

In this issue of Consciousness and Cognition, Bachmann comments on our study , which revealed two groups of observers with qualitative individual differences in metacontrast masking that are enhanced by perceptual learning. We are pleased that our study receives this attention and even more about Bachmann’s extremely positive comments. In this invited reply we argue that observers seem to be similar only at the beginning of the experiment but they have no choice as to which group to join. Findings strongly (...) recommend to look at the data of individual subjects. (shrink)

In den letzten drei Dekaden ist es zu einer Renaissance des Republikanismus gekommen. Ein spezifisch republikanisches Freiheitsverstandnis und die Debatte um entpolitisierende Wirkungen komplexer liberaler Demokratien haben sich dabei als in hohem Masse anschlussfahig an eine Vielzahl gegenwartiger Diskurse - von Global Governance bis hin zu Postdemokratie - erwiesen. Das Verstandnis von Republikanismus als einer modernen politischen Theorie wurde so weiter gestarkt und republikanische Ansatze gelten wieder als der zentrale Gegenspieler eines liberalen Staats- und Politikverstandnisses. Der Sammelband greift diese Renaissance (...) auf und bietet einen fur den deutschen Sprachraum bis dato fehlenden Uberblick uber Entwicklungstendenzen und Debatten im modernen republikanischen Denken. Er liefert eine Systematisierung von Ansatzen und Stromungen und erortert die Leistungsfahigkeit republikanischer Theorie gerade mit Blick auf Gegenwartsfragen. Mit Beitragen von: Richard Bellamy, Dorothea Gadeke, Philip Holzing, Sebastian Huhnholz, Marcus Llanque, Horst Mewes, Andreas Oldenbourg, Emanuel Richter, Daniel Schulz, Winfried Thaa, Thorsten Thiel, Christian Volk, Florian Weber und Sabrina Zucca-Soest. (shrink)

In the so-called “international credit market crisis,” which started in the second half of 2007 in the US subprime mortgage market, financial derivatives, most notably credit default swaps (CDS), have been publically blamed for having caused, or at least aggravated, the economic and monetary debacle. However, sound economic [...].

In this paper, I develop a syntactic framework for the analysis ofstrategic form games that is based on a straightforward combination ofstandard systems of doxastic, probabilistic and conditionalpropositional logic. In particular, for the probabilistic part I makeuse of the axiomatization provided in Fagin and Halpern (1994). The use ofconditionals allows to represent a strategic form game by a logicalformula in a very natural way. Also expected utility maximization can benaturally captured. I use this framework to prove a version of a (...) resulton Nash equilibrium conjectures first presented in Aumann and Brandenburger (1995). (shrink)

Ausgehend von einer Gegenüberstellung der erkenntnistheoretischen Grundpositionen des Empirismus und der Transzendentalphilosophie (Apriorismus) will der Autor am Beispiel der Probleme «Begriffsbildung» und «Kausalität» zeigen, wie sich klassische philosophische Kontroversen (Hume-Kant) unter Zuhilfenahme erkenntnistheoretisch relevanter biologisch-psychologischer Forschungsergebnisse (J. Piaget, K. Lorenz) lösen lassen.

Many scholars claim that Frege's theory of colouring is committed to a radical form of subjectivism or emotivism. Some other scholars claim that Frege's concept of colouring is a precursor to Grice's notion of conventional implicature. I argue that both of these claims are mistaken. Finally, I propose a taxonomy of Fregean colourings: for Frege, there are purely aesthetic colourings, communicative colourings or hints, non-communicative colourings.

Drawing on central research questions of memory studies, this article outlines various topics and divergent concepts about the relationship between the history of science and the public perception of scientists and scholars. The focus is on the different recurring trends and transformation processes, to which this culture of remembrance is subject and the various roles of historians in this context. The article also serves as an introduction to this special issue and its contributions, which use exemplary studies from the history (...) of medicine and pedagogy to shed light on the continual negotiation process of cultures of remembrance resulting from changing historical frames of reference, particularly in dealing with the legacy of National Socialism. (shrink)

This paper offers a detailed reconstruction of Frege’s theory of side-thoughts and its relation to other parts of his pragmatics, most notably to the notion of colouring, to the notion of presupposition, and to his implicit notion of multi-propositionality. I also highlight some important differences between the subsemantic categories employed by Frege and those used in contemporary pragmatics.