In “Missing the Forest for the Trees: Aduhelm, Accelerated Approvals & the Agency,” Dr. Matthew Herder argues that agency capture and politicized discretion drive delays in confirmatory trials of accelerated approval drugs amongst other concerns at US Food and Drug Administration (FDA). In highlighting this important problem and offering nuanced insight into agency workings based in part on interviews with twenty-three unnamed FDA officials and a three-drug case study, Dr. Herder suggests two innovative solutions. However, amidst broader debates balancing agency (...) expertise, data, and delegation, these proposed policy solutions would benefit from more corroborative evidence and consideration of institutional advantages within constitutional limits. (shrink)

Shedding light on a fundamental tension in liberal theory, Liberalism and Empire reaches beyond post-colonial studies to revise our conception of the grand liberal tradition and the conception of experience with which it is associated.

Pure insight, however is in the first instance without any content; it is the sheer disappearance of content; but by its negative attitude towards what it excludes it will make itself real and give itself a content.—Hegel, Phenomenology of Mind.

This paper is about Gandhi's critique of politics, of which his ambivalence towards democracy was a part. I argue that for Gandhi the ground of moral action is fearlessness, while that of political reason is security and self-defense. Gandhi sees the context of moral action in the mundane fabric of everyday life, in places such as the family and the village. For that reason he does not believe that moral action requires being supplemented by the particular kind of unity which (...) politics and the state call for and necessitate. (shrink)

The present study focuses on furthering the theoretical foundations of the field of spirituality and religiosity in the workplace by providing a parsimonious definition, and multi-dimensional model for the construct of spirituality grounded in a pluralistic and historically authentic framework using the Sophia Perennis or Perennial Philosophy. In this process, the study addresses the dilemma of religiosity versus spirituality faced by researchers in this area, 175). It also addresses concerns regarding the potential conflicts related to spirituality and religiosity that could (...) arise in a secular workplace, which emphasizes inclusiveness and equality. A three factor model of spirituality is developed using the grounded theory approach, 3–21) and is corroborated by factor analysis of multiple samples, and participants representing three major world faith traditions. (shrink)

The rapid advancement of algorithmic trading has demonstrated the success of AI automation, as well as gaps in our understanding of the implications of this technology proliferation. We explore ethical issues in the context of autonomous trading agents, both to address problems in this domain and as a case study for regulating autonomous agents more generally. We argue that increasingly competent trading agents will be capable of initiative at wider levels, necessitating clarification of ethical and legal boundaries, and corresponding development (...) of norms and enforcement capability. (shrink)

The enduring appeal of liberalism lies in its commitment to the idea that human beings have a "natural" potential to live as free and equal individuals. The realization of this potential, however, is not a matter of nature, but requires that people be molded by a complex constellation of political and educational institutions. In this eloquent and provocative book, Uday Singh Mehta investigates in the major writings of John Locke the implications of this tension between individuals and the institutions (...) that mold them. The process of molding, he demonstrates, involves an external conformity and an internal self-restraint that severely limit the scope of individuality. Mehta explores the centrality of the human imagination in Locke's thought, focusing on his obsession with the potential dangers of the cognitive realm. Underlying Locke's fears regarding the excesses of the imagination is a political anxiety concerning how to limit their potential effects. In light of Locke's views on education, Mehta concludes that the promise of liberation at the heart of liberalism is vitiated by its constraints on cognitive and political freedom. (shrink)

Terror and its cognates have come to signify the darkest excesses of contemporary and 20th-century political life. These include aggressive claims to purity; murderous manifestations of programmatic and religious self-certainty; paranoid and devastating responses to threats to national security; and more generally, an intensity of instrumental forms of thinking and acting that give to individuals, groups, and states a broad warrant for deploying violence as a means to their purposefulness. Hannah Arendt reflected deeply on the implications of such high-minded and (...) bellicose purposefulness. This chapter focuses on how Arendt also associated terror with something utterly commonplace, whose reach and provenance extended well beyond the 20th century—namely, in the political attempt to address ubiquitous social questions. (shrink)

Decolonization of the European empires in the twentieth century was spurred by the colonized based on two purposes: the desire for independence, and the desire to build a sovereign political identity. The most obvious feature of the first intention was the formation of anti-imperialist movements, organised under the banner ‘they must leave’. The latter was characterized by the establishment of constitutional government, which highlighted the identity of a novice country in a political and unified form and which featured a central (...) source of power. These two purposes share a complex relationship. For power to be sovereign, independence must be gained first. Power cannot be obligated to the wishes of another power or constrained by the laws of another regime. The struggle for independence of European empires did not readily create the conditions for the exercise of a sovereign power. It was elusive at the moment of independence. This chapter discusses some of the implications of these two purposes, with emphasis on the second purpose and the Indian experience. It addresses questions such as: what is the meaning of collective identity to those newly independent countries in the context of politics; what were the pressures on the claims to political identity and unity; how did these pressures encourage a revolutionary mindset in the conceptualization of constitutional provisions and political power; and how does the struggle for political identity relate to the history of nation and its struggle for independence? (shrink)

This research was conducted to study the ethical issues involved in managing change-related issues and assess whether people in organizations perceive them to be ethical. Besides assessing people's perceptions of ethicality, it also explored the reasons people give for judging a situation as ethical or unethical. Research was conducted using scenarios involving ethical dilemmas related to lay offs, skills obsolescence, misinfor mation and preference for younger over older employees. Results show that the respondents were divided over three situations, namely, lay (...) offs, misinformation and preference for younger employees. The issue of skills obsolescence was considered unethical by most. The reasons given for judging a situation were different, implying that the ethical and unethical were not treated as two ends of a continuum. (shrink)

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The (...) animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions. (shrink)

The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)

It is widely accepted that translational research practitioners need to acquire special skills and knowledge that will enable them to anticipate, analyze, and manage a range of ethical issues. While there is a small but growing literature that addresses the ethics of translational research, there is a dearth of scholarship regarding how this might apply to engineers. In this paper we examine engineers as key translators and argue that they are well positioned to ask transformative ethical questions. Asking engineers to (...) both broaden and deepen their consideration of ethics in their work, however, requires a shift in the way ethics is often portrayed and perceived in science and engineering communities. Rather than interpreting ethics as a roadblock to the success of translational research, we suggest that engineers should be encouraged to ask questions about the socio-ethical dimensions of their work. This requires expanding the conceptual framework of engineering beyond its traditional focus on “how” and “what” questions to also include “why” and “who” questions to facilitate the gathering of normative, socially-situated information. Empowering engineers to ask “why” and “who” questions should spur the development of technologies and practices that contribute to improving health outcomes. (shrink)

Reasoning about concurrent programs involves representing the information that concurrent processes manipulate disjoint portions of memory. In sophisticated applications, the division of memory between processes is not static. Through operations, processes can exchange the implied ownership of memory cells. In addition, processes can also share ownership of cells in a controlled fashion as long as they perform operations that do not interfere, e.g., they can concurrently read shared cells. Thus the traditional paradigm of distributed computing based on locations is replaced (...) by a paradigm of concurrent computing which is more tightly based on program structure. Concurrent Separation Logic with Permissions, developed by O’Hearn, Bornat et al., is able to represent sophisticated transfer of ownership and permissions between processes. We demonstrate how these ideas can be used to reason about fine-grained concurrent programs which do not employ explicit synchronization operations to control interference but cooperatively manipulate memory cells so that interference is avoided. Reasoning about such programs is challenging and appropriate logical tools are necessary to carry out the reasoning in a reliable fashion. We argue that Concurrent Separation Logic with Permissions provides such tools. We illustrate the logical techniques by presenting the proof of a concurrent garbage collector originally studied by Dijkstra et al., and extended by Lamport to handle multiple user processes. (shrink)

77 ff. ; RS Deshmukh, Religion in Vedic Literature, p. 331. Jacobi seems to take the extreme view that the conception of immortality of the Soul was unknown ...

The Perils of Invention is based on three Hannah Arendt Center Conferences: "Human Being in an Inhuman Age," "Lying and Politics," and "Truthtelling: Democracy in an Age without Facts." Contributions written for these conferences are placed alongside many new essays that reflect on the ideas they raised. The result is a freshly invigorated investigation into these critical and timely themes. The authors have diverse backgrounds--Arendt scholars, public intellectuals, novelists, journalists, and business people--and include Uday Mehta, Marrianne Constable, Nicholson Baker, (...) George Kateb, Marianne Constable, Linda M.G. Zerilli, Peg Birmingham, Davide Panagia, and many others. (shrink)

To approach the Hindu poetic art -- On Indian music -- Concerning Uday Shankar -- The origin of the theatre of Bharata -- Oriental book reviews -- The hymn of man -- To the liquid -- Knowledge of the self -- Some Sanskrit texts on poetry.