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Vadim Keyser
California State University, Fresno
  1.  30
    Robust Biomarkers: Methodologically Tracking Causal Processes in Alzheimer’s Measurement.Vadim Keyser & Louis Sarry - 2020 - In Barbara Osimani & Adam La Caze (eds.), Uncertainty in Pharmacology. pp. 289-318.
    In biomedical measurement, biomarkers are used to achieve reliable prediction of, and useful causal information about patient outcomes while minimizing complexity of measurement, resources, and invasiveness. A biomarker is an assayable metric that discloses the status of a biological process of interest, be it normative, pathophysiological, or in response to intervention. The greatest utility from biomarkers comes from their ability to help clinicians (and researchers) make and evaluate clinical decisions. In this paper we discuss a specific methodological use of clinical (...)
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  2.  20
    Experimental Effects and Causal Representations.Vadim Keyser - 2017 - Synthese:1-32.
    In experimental settings, scientists often “make” new things, in which case the aim is to intervene in order to produce experimental objects and processes—characterized as ‘effects’. In this discussion, I illuminate an important performative function in measurement and experimentation in general: intervention-based experimental production (IEP). I argue that even though the goal of IEP is the production of new effects, it can be informative for causal details in scientific representations. Specifically, IEP can be informative about causal relations in: regularities under (...)
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  3.  26
    The Varieties and Dynamics of Moral Repugnance: Prediction Markets and Betting on Matters of Life and Death.Dan Weijers & Vadim Keyser - 2016 - Humanities and Technology Review 35:91-129.
    In this paper, prediction markets that encourage traders to bet on matters of life and death are used to explore the varieties and dynamics of moral repugnance. We define moral repugnance as morally charged feelings of revulsion that correspond (correctly, incorrectly, and indeterminately) to moral reasons and contexts. Rich variations of moral repugnance and their dynamic qualities are presented by investigating the contextual frames in which they arise. These contextual frames constitute interacting conditions composed of information about states of affairs, (...)
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  4.  8
    Methodology at the Intersection Between Intervention and Representation.Vadim Keyser - unknown
    I show that in complex methodological contexts, representational and intervention-based roles require re-conceptualization. I analyze the relations between representation and intervention by focusing on the role of intervention in mediating representations. To do this, first I show how applied scientific practice challenges the simple distinction between representational and intervention-based roles of experiment/measurement. Then I discuss the complex interaction between representation and intervention applied to methodology in biomarker measurement.
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  5. Engaging Science, Artistically.Vadim Keyser - 2017 - Analytic Teaching and Philosophical Praxis 38 (1):47-61.
    In this discussion I show that philosophy of science concepts, especially where examples and thought experiments are limiting, can be enriched with artistic examples. I argue that artistic examples show abstract components and relations that can then be used to engage with philosophical concepts. First, I discuss a useful representational model for thinking about the process of science as analogous to the process of art. I set up philosophy of science as not only open, but also closely connected to art (...)
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  6.  4
    Effects and Artifacts: Robustness Analysis and the Production Process.Vadim Keyser - unknown
    Scientists often use multiple independent methods of identification to distinguish reliable results from those produced in error. This process is referred to as ‘robustness analysis’. I argue that even though robustness analysis is useful for differentiating natural phenomena from artifacts, it fails to differentiate experimentally produced effects from artifacts. I argue that to bypass this problem, we can re-frame the role of robustness analysis to focus on cross-comparison between methods of production. Focusing on the production relation provides information about how (...)
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  7. Artifacts and Artefacts: A Methodological Classification of Context-Specific Regularities.Vadim Keyser - 2019 - In History and Philosophy of Technoscience: Perspectives on Classification in Synthetic Sciences: Unnatural Kinds. London, UK: pp. 63-77.
    Traditionally, in the literature on robustness analysis objects are classified as genuine phenomena (natural objects, events, and processes) or artifacts (results produced in error). But much of biological measurement requires the manipulation of local experimental conditions in order to produce new effects. These types of intervention-based regularities are neither natural objects nor artifacts; characterizing them as either fails adequately to address key ontological properties as well as their role in scientific practice. It is argued that a new classification, based on (...)
     
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