This study aimed to explore the mediating effects of internet gaming disorder, social network use, and generalized pathological internet use on the association between loneliness and depression. A total of 2211 junior high school students completed questionnaires regarding loneliness, internet gaming disorder, social network use, GPIU, and depression. The results of a structural equation model revealed that the path coefficient of loneliness to depression was significantly positive, loneliness could not predict depression through GPIU directly, but loneliness could predict depression through (...) internet gaming disorder to GPIU, loneliness could predict depression through social network use to GPIU, and loneliness could not predict depression through internet gaming disorder to social network use to GPIU. These results provided significant implications for the prevention and reduction of depression in Chinese junior high school students. (shrink)