Fecal microbiota transplantation is reportedly the most effective therapy for relapsing Clostridium Difficile infection and a potential therapeutic option for many diseases. It also poses important ethical concerns. This study is an attempt to assess clinicians’ perception and attitudes towards ethical and social challenges raised by fecal microbiota transplantation. A questionnaire was developed which consisted of 20 items: four items covered general aspects, nine were about ethical aspects such as informed consent and privacy issues, four concerned social and regulatory issues, (...) and three were about an FMT bank. This was distributed to participants at the Second China gastroenterology and FMT conference in May 2015. Basic descriptive statistical analyses and simple comparative statistical tests were performed. Nearly three quarters of the 100 respondents were gastro-enterologist physicians. 89% of all respondents believed FMT is a promising treatment modality for some diseases and 88% of whom chose clinical efficacy as the primary reason for recommending FMT. High expectation from patients and pressure on clinicians was reported as the most frequent reasons for not recommending FMT. The clinicians who had less familiarity with FMT reported significantly more worry related to the dignity and psychological impact of FMT compared to those who have high familiarity with FMT.More than half of the respondents were concerned about the commercialization of FMT, although almost one in five respondents did not see this as a problem. We found most respondents have positive attitudes towards FMT but low awareness of published evidence. Informed consent for vulnerable patients, privacy and protection of donors were perceived as the most challenging ethical aspects of FMT. This study identified areas of limited knowledge and ways of addressing ethical issues and indicates the need to devise the education and training for clinicians on FMT. (shrink)

In this paper, we focus on a class of singular fractional differential equation, which arises from many complex processes such as the phenomenon and diffusion interaction of the ecological-economic-social complex system. By means of the iterative technique, the uniqueness and nonexistence results of positive solutions are established under the condition concerning the spectral radius of the relevant linear operator. In addition, the iterative scheme that converges to the unique solution is constructed without request of any monotonicity, and the convergence analysis (...) and error estimate of unique solution are obtained. The numerical example and simulation are also given to demonstrate the application of the main results and the effectiveness of iterative process. (shrink)

The frequent data convergecasting from the sensor nodes to the gateways may cause imbalanced energy consumption in the Wireless Highway Addressable Remote Transducer networks, yielding a short network lifetime and frequent failures in the data acquisition. Existing solutions always tend to tradeoff between the hardware cost, routing complexity, and energy consumption, making the sensor nodes suffer from expensive hardware investment, overloaded network computation, or imbalanced energy consumption. In this paper, an Adaptive Freeshape Clustering protocol is developed for saving and balancing (...) the energy consumption in the WirelessHART networks. In AFC, the Region of Interest is first divided into several fan-shaped clusters. The sensor nodes in each fan-shaped cluster compete for the positions of Cell Node, and the nodes that have succeeded in the competition adjust the radius of their coverages to cover the fan-shaped clusters adaptively with the minimum overlapped areas. In this way, each fan-shaped cluster can be subdivided into several freeshape zones regarding each CN’s coverage, and the CN in each cluster takes charge of convergecasting the data to the CH. The simulations show that AFC can prolong the network lifetime by 37% compared with other related schemes, e.g., HEED, FLOODING, and DIRECT, whereas it can reduce the degree of energy imbalance by 1.29%. (shrink)

We have refined entropy theory to explore the meaning of the increasing sequence data on nucleic acids and proteins more conveniently. The concept of selection constraint was not introduced, only the analyzed sequences themselves were considered. The refined theory serves as a basis for deriving a method to analyze non-coding regions (NCRs) as well as coding regions. Positions with maximal entropy might play the most important role in genome functions as opposed to positions with minimal entropy. This method was tested (...) in the well-characterized coding regions of 12 strains of Classical Swine Fever Virus (CSFV) and non-coding regions of 20 strains of CSFV. It is suitable to analyze nucleic acid sequences of a complete genome and to detect sensitive positions for mutagenesis. As such, the method serves to formulate the basis for elucidating the functional mechanism. (shrink)

Based on ideology-infused psychological contract theory and cognitive evaluation theory, this study investigated the curvilinear relationship between ethical leadership and employee creativity. A curvilinear mediation model was proposed to explain the impact of ethical leadership on creativity, using employee intrinsic motivation as the mediator. Applying a two wave sampling design that consist 258 employees and their leaders, we found that employee creativity improved as ethical leadership increased from low to moderate levels. However, the employee creativity improvement was attenuated when ethical (...) leadership increased from moderate to high levels. Furthermore, the study also revealed that employee intrinsic motivation partially mediated this curvilinear relationship. The theoretical and managerial implications are discussed. (shrink)

To overcome the weakness of generic neural networks ensemble for prediction intervals construction, a novel Map-Reduce framework-based distributed NN ensemble consisting of several local Gaussian granular NN is proposed in this study. Each local network is weighted according to its contribution to the ensemble model. The weighted coefficient is estimated by evaluating the performance of the constructed PIs from each local network. A new evaluation principle is reported with the consideration of the predicting indices. To estimate the modelling uncertainty and (...) the data noise simultaneously, the Gaussian granular is introduced to the numeric NNs. The constructed PIs can then be calculated by the variance of output distribution of each local NN, i.e., the summation of the model uncertainty variance and the data noise variance. To verify the effectiveness of the proposed model, a series of prediction experiments, including two classical time series with additive noise and two industrial time series, are carried out here. The results indicate that the proposed distributed GGNNs ensemble exhibits a good performance for PIs construction. (shrink)

The present study is a cross-sectional survey that investigates ethical practices among Chinese psychotherapists from the perspective of a large representative sample of Chinese clients (N?=?1,100). In reports from clients, we found that psychotherapists did poorly in providing informed consent and had other ethical difficulties in the therapeutic setting and with dual relationships. We conclude that Chinese culture, especially Confucianism, had significant impact on the attitudes toward the psychotherapists' ethical practices, which complicated ethical dilemmas. It is important for cross-cultural psychotherapists (...) to become sensitive to the influences of traditional Chinese culture when counseling Chinese clients. (shrink)