BackgroundBreast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors.MethodsA cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at (...) least1 year after diagnosis. After one-to-one matching for age, sex, and baseline comorbidities, breast cancer patients who received and did not receive CHM treatment were enrolled. The incidence rate and hazard ratio citation for depression between the two groups was estimated at the end of 2012. A Cox proportional hazard model was constructed to examine the impact of the CHM use on the risk of depression.ResultsDuring the study period, the incidence rate of depression was significantly lower in the treated cohort than in the untreated cohort [8.57 compared with 11.01 per 1,000 person-years citation], and the adjusted HR remained significant at 0.74 in a Cox proportional hazards regression model. The corresponding risk further decreasing to 43% among those using CHM for more than 1 year.ConclusionFinding from this investigation indicated that the lower risk of depression observed in breast cancer patients treated with CHM, suggesting that CHM treatment should be considered for disease management toward breast cancer. Yet, the optimal administered dose should be determined in further clinical trials. (shrink)

Explaining how stereotypes and norms influence role-identities during reflected appraisal processes, we develop a theory about diverse groups of minority men—the “minority masculinity stress theory”—and apply it to Asian American men. We conceptually integrate hegemonic masculinity, stereotypes, and mental health to examine how Asian American men experience masculinity and how their experiences are uniquely stressful. We analyze elicited text from an open-ended questionnaire to explain two experiences of masculinity-related stress: trying to live up to the masculine ideal and enacting work-related (...) role-identities. Regarding the former, we discuss four illustrations—toughness, body image, restrictive emotionality, and heterosexuality—and two involving the latter—achiever and provider. We found that Asian American men receive stereotypical reflected appraisals that contradict potentially positive self-concepts and emphasize achievement beyond typical standards of hegemonic masculinity. Moreover, Asian American men’s role-identities contradict hegemonic masculinity, resulting in reflected appraisals that predispose them toward stress. (shrink)

The mechanistic significance of a kinetic isotope effect on a cytochrome P‐450catalyzed reaction depends, fundamentally, on the nature of the interaction of the substrate with the active site of the enzyme as well as on the nature of the chemistry of the reaction catalyzed. Consequently, kinetic isotope effects can be used to extract information on the topology of the enzyme and the mechanism of substrate oxidation. Kinetic isotope effect studies are sometimes accompanied by ‘metabolic switching’ or a change in metabolic (...) pathway, catalyzed either by the same enzyme or by a different enzyme. For the specific case where ‘metabolic switching’ gives rise to a change in regional specificity for the cytochrome P‐450 catalyzed metabolism of a compound, this change can be explained in terms of the topological constraints on substrate binding imposed by the active site of the enzyme. (shrink)

Nanotechnology shows great promise in a variety of applications with attractive economic and societal benefits. However, societal issues associated with nanotechnology are still a concern to the general public. While numerous technological advancements in nanotechnology have been achieved over the past decade, research into the broader societal issues of nanotechnology is still in its early phases. Based on the data from the Web of Science database, we applied the main path analysis, cluster analysis and text mining tools to explore the (...) main research fronts and hierarchical structure of these societal issues. We found that the research studies fell into four categories: "General Toxicity and EHS (Environment, Health and Safety)," "Medicine and Cytotoxicity," "Assessment and Regulation," and "Environment and Ecotoxicity." These research studies have disclosed much information about the potential effect of nanotechnology on public health and the environment. Relatively speaking, the studies on the assessment, regulation, preventive solutions, and environmental protection are just emerging. This finding indicates that an abundance of effort should be conducted on these emerging themes to maximize the benefits of nanotechnology while minimizing its potential harm. The implications for various parties in this domain are also presented. (shrink)

Over the past decades, anti-cancer treatments have evolved rapidly from cytotoxic chemotherapies to targeted therapies including oral targeted medications and injectable immunooncology and cell therapies. New anti-cancer medications come to markets at increasingly high prices, and health insurance coverage is crucial for patient access to these therapies. State laws are intended to facilitate insurance coverage of anti-cancer therapies.Using Massachusetts as a case study, we identified five current cancer coverage state laws and interviewed experts on their perceptions of the relevance of (...) the laws and how well they meet the current needs of cancer care given rapid changes in therapies. Interviewees emphasized that cancer therapies, as compared to many other therapeutic areas, are unique because insurance legislation targets their coverage. They identified the oral chemotherapy parity law as contributing to increasing treatment costs in commercial insurance. For commercial insurers, coverage mandates combined with the realities of new cancer medications — including high prices and often limited evidence of efficacy at approval — compound a difficult situation. Respondents recommended policy approaches to address this challenging coverage environment, including the implementation of closed formularies, the use of cost-effectiveness studies to guide coverage decisions, and the application of value-based pricing concepts. Given the evolution of cancer therapeutics, it may be time to evaluate the benefits and challenges of cancer coverage mandates. (shrink)

En este texto abordo una de las propuestas ontológicas, epistémicas y metodológicas que sintetiza mejor el trabajo de las epistemologías feministas sobre cómo conceptualizar las nociones de género y sexo, así como su relación en el ámbito biológico. Describo los alcances y limitaciones de esta propuesta y muestro que la propia noción de sexo implica un sesgo androcéntrico desde el que se legitima la dicotomía endógeno/exógeno, un reduccionismo funcional, la idea de coherencia interna y la reducción de nuestra complejidad biológica (...) a los rasgos vinculados con la reproducción respecto a las diferencias biológicas en general y, como mostraré, en el ámbito biomédico en particular al caracterizar las prevalencias y el desarrollo de enfermedades. En contraste, propongo la idea de epigenealogía para una reconceptualización histórica de nuestra materialidad biológica capaz de profundizar en cómo nuestra plasticidad a través de los procesos epigenéticos danza sincrónicamente con nuestra experiencia social, contingente y situada. (shrink)

“Hay un amplio cielo azul. Debajo estoy yo, parada en una esquina del jardín. Mucha gente conoce a mis padres, y la mayoría me conoce a mí; algunos conocen el jardín y hay quienes inclusive caminaron hasta este rincón. Pero yo, entre todas las personas que hay bajo el cielo, soy la única que conoce a este pequeño retoño de manzana. Por eso puedo decir sin insolencia que en realidad me pertenece, porque cuando estoy lejos no le queda más remedio (...) que existir en mis pensamientos. Pienso: ¿Qué es lo qué pienso?”. (shrink)

Lu Ciccia realizó investigaciones en el Departamento de Fisiología del Sistema Nervioso de la Universidad de Buenos Aires, para luego doctorarse en Estudios de Género por la misma universidad. Actualmente, por las derivas de la vida, es académica del Centro de Investigaciones y Estudios de Género de la UNAM. Refiero a la trayectoria de la autora para mostrar hasta qué punto su libro más reciente, La invención de los sexos, es una exposición integral y provocadora de los años de investigación (...) aquí descritos. Este volumen es original en nuestra lengua porque desarrolla una forma de trabajo en la cual los estudios feministas incorporan críticamente en sus registros las formas de investigación de las ciencias experimentales. (shrink)

A través de un largo excurso por la historia de España, el autor se propone descubrir la particularidad de la Ilustración en el país ibérico para desmontar la tesis según la cual, aquende los Pirineos, no hubo propiamente un Siglo de las Luces, y por lo tanto, tampoco una auténtica filosofía moderna. Presenta en un segundo momento la figura intelectual del padre Benito Feijoo como ejemplo paradigmático de lo que fue la Ilustración española y su diferencia con el Enlightement inglés, (...) las Lumières francesas y la Aufklärung alemana. Se desarrolla la idea según la cual el siglo XVIII sentó las bases de una revolución cultural de carácter supranacional que se materializó en la Constitución de Cádiz de 1812, luego abortada por la Restauración absolutista de Fernando VII. (shrink)

The study of Joseon 朝鮮 Neo-Confucianism has recently given some attention to an inclination toward the Learning of the Mind-Heart, and Yi Gan 李柬 is at the center of this research. He was an outstanding disciple of Gwon Sang-ha 權尙夏 and a successor to the philosophical spirit of the Yulgok 栗谷 School; he is renowned for initiating the Horak 湖洛 Debate through his controversies with Han Won-jin 韓元震. In “A Thesis on the Not-Yet-Aroused State,” Yi asserted that the mind-heart is (...) purely good, basing his argument on the doctrine that “li 理 and qi 氣 are actualized as the same entity, and the mind-heart and nature are united as one.” Han Won-jin criticized this assertion as belonging to the Lu-Wang 陸王 School of Neo-Confucianism, and in fact, Yi Gan’s arguments were, in some aspects, consistent with Wang Yangming’s 王陽明 philosophy of the mind-heart. Indisputably, however, Yi Gan was an ardent follower of Zhu Xi’s 朱熹 philosophy. In this case, Yi Gan’s inclination toward the Learning of the Mind-Heart may perhaps be viewed in the tradition of the Learning of the Way, which emphasized self-cultivation and practice, a distinct feature of Joseon Neo-Confucianism. (shrink)

As an important view in the epistemology of perception, dogmatism proposes that for any experience, if it has a distinctive kind of phenomenal character, then it thereby provides us with immediate justification for beliefs about the external world. This paper rejects dogmatism by looking into the epistemology of imagining. In particular, this paper first appeals to some empirical studies on perceptual experiences and imaginings to show that it is possible for imaginings to have the distinctive phenomenal character dogmatists have in (...) mind. Then this paper argues that some of these imaginings fail to provide us with immediate justification for beliefs about the external world at least partly due to their inappropriate etiology. Such imaginings constitute counterexamples to dogmatism. (shrink)

According to phenomenal conservatism or dogmatism, perceptual experiences can give us immediate justification for beliefs about the external world in virtue of having a distinctive kind of phenomenal character—namely phenomenal force. I present three cases to show that phenomenal force is neither pervasive among nor exclusive to perceptual experiences. The plausibility of such cases calls out for explanation. I argue that contrary to a long-held assumption, phenomenal force is a separate, non-perceptual state generated by some metacognitive mechanisms that monitor one’s (...) first-order mental processes and states. This new account advances our understanding of the nature of phenomenal force. (shrink)

Does phenomenal force, the distinctive phenomenology attributed to perceptual experience, really form an integral part of the latter? If not, what implications does it have for perceptual justification? In this paper, I first argue for a metacognitive account, according to which phenomenal force constitutes a separate, metacognitive state. This account opens up a previously unexplored path for challenging phenomenal conservatism or dogmatism, which has been a prominent theory of perceptual justification over the past two decades. Moreover, I investigate several alternative (...) possibilities in which phenomenal force might still be deemed as significant, but ultimately demonstrate that its epistemic role remains marginal at best. (shrink)

Qu’advient-il quand, à la pointe extrême du continent eurasien, la méditation de l’un des plus grands penseurs français franchit les océans pour être accueillie, critiquée sans concession aussi bien que reprise ? Faut-il s’attendre au récit d’un malentendu quand Henri Bergson se trouve relu par son contemporain Nishida Kitarô, né deux années après que son pays se soit ouvert à l’Occident ? Ce dernier va-t-il, depuis le Japon, risquer avec la pensée française ce que firent jadis les européens Leibniz et (...) Malebranche avec la chinoise, ou Schopenhauer avec l’indienne ? Y a-t-il là pure appropriation, et selon quelles spécificités notionnelles et méthodologiques ? Cette rencontre ne laisse-t-elle pas présager, au contraire, un échange véritable quoique encore fragile qui, s’il emprunte presque tout son vocabulaire et ses concepts à l’Europe, en tire un esprit subtil et nouveau ? Les trois études rassemblées dans cet ouvrage se proposent d’envisager ce débat, né il y a près d’un siècle de nous, et la contribution qu’il pourrait apporter à une réflexion sur l’idée de philosophie comparée. (shrink)

Análisis historiográfico del relato de las vicisitudes del alfaquí T.a-lu-t, elaborado por Ibn al-Qu-t.iyya y reproducido por numerosas fuentes andalusíes y orientales. De dicho análisis se desprende que la supuesta versión amplia de la crónica de Ibn al-Qu-t.iyya nunca existió y que la coincidencia entre varias obras en presentar una versión extensa del relato es debida a su común dependencia de un subarquetipo que amplificó retóricamente el texto original de Ibn al- Qu-t.iyya.

ABSTRACT Cognitive penetrability refers to the possibility that perceptual experiences are influenced by our beliefs, expectations, emotions, or other personal-level mental states. In this paper, I focus on the epistemological implication of cognitive penetration, and examine how, exactly, aetiologies matter to the justificatory power of perceptual experiences. I examine a prominent theory, according to which some cognitively penetrated perceptual experiences are like conclusions of bad inferences. Whereas one version of this theory is psychologically implausible, the other version has sceptical consequences. (...) In the second half of the paper, I suggest an alternative theory, drawing on recent empirical research on imagining-perception interaction and the epistemology of imagining. (shrink)

Lun Xun's collected anti-Confucianist writings.

In this collection of essays, art historian and critic Sven Lütticken focuses on aesthetic practice in a rapidly expanding cultural sphere. He analyzes its transformation by the capitalist cultural revolution, whose reshaping of art's autonomy has wrought a field of afters and posts. In a present moment teeming with erosions - where even history and the human are called into question - 'Cultural revolution: aesthetic practice after autonomy' reconsiders these changing values, for relegating such notions safely to the past betrays (...) their possibilities for potential today. Lütticken discusses practices that range from Black Mask to Subversive Aktion, from Krautonomy to Occupy, from the Wet Dream Film Festival in the early 1970s to Jonas Staal's recently established New World Academy. Within these pages Scarlett Johansson meets Paul Chan, Walid Raad, and Hito Steyerl, and Dr. Zira from Planet of the Apes mingles with the likes of Paul Lafargue and Alexandre Kojève. (shrink)

Pre‐marital sex for a woman is regarded as wrong in my country. As a result, it is socially forbidden for a woman to engage in this act. In order to present a woman as a virgin on her marriage day, she is subjected to pressure, and put under control both by her family and societal norms. However, a man is free and never made to suffer any of the above. A woman found to be a virgin on her first night (...) of marriage is seen as a normal person while one suspected to have lost her virginity is made to undergo a series of medical examinations to bring clarity to her situation. (shrink)

本书主要内容是试图在完全遵从经典作家本意基础上,通过深入挖掘,创新,发展唯物史观中的原理,力图找到一种对广大人民群众而言最喜闻乐见而又最能贯彻经典作家本来意图的理论诠释,同时对长期附加在马克思主义原理 上的种种似是而非的错误观念进行拨乱反正,正本清源.并在此基础上对老百姓最为关心的社会领域中的各种社会现象,社会问题加以合情合理解释.重点是运用创新发展了的唯物史观理论对中西方在各个社会领域中的价值观加 以对比分析,揭示其中的产生根源,使广大读者特别是广大青年学生正确理解中西方的种种差异,深入理解中西方文化产生的自然环境,人文背景,社会根源以及各自的优缺点,正确对待老祖宗留给我们的文化遗产,杜绝各种历 史虚无主义思潮的干扰,避免陷入种种厚西薄中的错误观念.