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  1.  42
    Functional Activity of the Novel Alzheimer's Amyloid Beta-Peptide Interacting Domain in the APP and BACE1 Promoter Sequences and Implications in Activating Apoptotic Genes and in Amyloidogenesis.J. A. Bailey, B. Maloney, Y. W. Ge & D. K. Lahiri - 2011 - Gene 488:13-22.
    Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...)
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  2.  27
    Functional Characterization of Three Single-Nucleotide Polymorphisms Present in the Human APOE Promoter Sequence: Differential Effects in Neuronal Cells and on DNA-Protein Interactions.B. Maloney, Y. W. Ge, R. C. Petersen, J. Hardy, J. T. Rogers, J. Perez-Tur & D. K. Lahiri - 2010 - Am J Med Genet B Neuropsychiatr Genet 153:185-201.
    Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...)
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  3.  54
    NF-B Mediates Amyloid Beta Peptide-Stimulated Activity of the Human Apolipoprotein E Gene Promoter in Human Astroglial Cells.Y. Du, X. Chen, X. Wei, K. R. Bales, D. T. Berg, S. M. Paul, M. R. Farlow, B. Maloney, Y. W. Ge & D. K. Lahiri - 2005 - Brain Res Mol Brain Res 136:177-88.
    The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...)
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  4.  12
    PuF, an Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer's Amyloid-Beta Precursor Protein Via a Tissue-Specific Proximal Regulatory Element.D. K. Lahiri, B. Maloney, J. T. Rogers & Y. W. Ge - 2013 - Bmc Genomics 14:68.
    BACKGROUND: Alzheimer's disease is intimately tied to amyloid-beta peptide. Extraneuronal brain plaques consisting primarily of Abeta aggregates are a hallmark of AD. Intraneuronal Abeta subunits are strongly implicated in disease progression. Protein sequence mutations of the Abeta precursor protein account for a small proportion of AD cases, suggesting that regulation of the associated gene may play a more important role in AD etiology. The APP promoter possesses a novel 30 nucleotide sequence, or "proximal regulatory element" , at -76/-47, from the (...)
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    Taking Down the Unindicted Co-Conspirators of Amyloid Beta-Peptide-Mediated Neuronal Death: Shared Gene Regulation of BACE1 and APP Genes Interacting with CREB, Fe65 and YY1 Transcription Factors. [REVIEW]D. K. Lahiri, Y. W. Ge, J. T. Rogers, K. Sambamurti, N. H. Greig & B. Maloney - 2006 - Curr Alzheimer Res 3:475-83.
    Major hallmarks of Alzheimer's disease include brain deposition of the amyloid-beta peptide , which is proteolytically cleaved from a large Abeta precursor protein by beta and gamma- secretases. A transmembrane aspartyl protease, beta-APP cleaving enzyme , has been recognized as the beta-secretase. We review the structure and function of the BACE1 protein, and of 4129 bp of the 5'-flanking region sequence of the BACE1 gene and its interaction with various transcription factors involved in cell signaling. The promoter region and 5'-untranslated (...)
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