We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.3 (2003) 407 [Access article in PDF] Reply By Margaret J. Osler and Richard A. Watson In his comments on our historiographical Notes in the October 2002 issue of JHP, A. P. Martinich misrepresents our position by erroneously claiming that we presume a sharp dichotomy between the analytic history of philosophy and the historical history of philosophy. Neither of us accepts such a (...) premise. Once that misreading is eliminated there are few disagreements between each of us and Martinich.We agree that any meaningful history of philosophy must be both philosophically sophisticated and historically grounded. History without philosophy would be nothing but chronicle; history of philosophy without historical context would describe a series of moves, but explain nothing. A desideratum of both history and philosophy is careful reading, exposition, and analysis of texts.... (shrink)

This article gives new information about the social, cultural, and political beliefs of Thomas Wilson, the first Secretary and Treasurer of the Yorkshire Geological and Polytechnic Society founded in 1837. Wilson's private correspondence was not available to J. W. Davis, who wrote the standard history of the Society to celebrate its jubilee. Davis's history underestimates the part played by Wilson and overestimates the importance of Thomas William Embleton, whose private papers were placed at Davis's disposal. It is shown that Wilson, (...) and not Embleton, was the driving force in forming and consolidating the Society, especially with respect to its early difficulties in defining even its title and aims. (shrink)