In the past decade, there has been an increase in genomic research and biobanking activities in Africa. Research initiatives such as the Human Heredity and Health in Africa Consortium are contributing to the development of scientific capacity and infrastructure to support these studies on the continent. Despite this growth, genomic research and biobanking have raised important ethical challenges for key research stakeholders, including members of research ethics committees. One of these is the limited ethical and regulatory frameworks to guide the (...) review and conduct of genomic studies, particularly in Africa. This paper is a reflection on a series of consultative activities with research ethics committees in Africa which informed the development of an ethics and governance framework for best practices in genomic research and biobanking in Africa. The paper highlights the engagement process and the lessoned learned. (shrink)

BackgroundThe global interest in developing therapies for Ebola infection management and its prevention is laudable. However the plan to conduct an emergency immunization program specifically for healthcare workers using experimental vaccines raises some ethical concerns. This paper shares perspectives on these concerns and suggests how some of them may best be addressed.DiscussionThe recruitment of healthcare workers for Ebola vaccine research has challenges. It could result in coercion of initially dissenting healthcare workers to assist in the management of EVD infected persons (...) due to mistaken beliefs that the vaccine offers protection. It could also affect equity and justice. For example, where people who are not skilled health care professionals but who provide care to patients infected with Ebola are not prioritized for vaccination. The possibility of study participants contracting Ebola infection despite the use of experimental vaccine, and the standard of care they would receive, needs to be addressed clearly, transparently and formalized as part of the ethics review process. Future access to study products in view of current status of the TRIPS agreement needs to be addressed. Finally, broad stakeholder engagement at local, regional and international levels needs to be promoted using available communication channels to engage local, regional and international support. These same concerns are applicable for current and future epidemics.SummarySuccessful Ebola vaccine development research requires concerted efforts at public dialogue to address misconceptions, equity and justice in participant selection, and honest discussions about risks, benefits and future access. Public dialogue about Ebola vaccine research plans is crucial and should be conducted by trusted locals and negotiated between communities, researchers and ethics committees in research study sites. (shrink)

The introduction of genomics and biobanking methodologies to the African research context has also introduced novel ways of doing science, based on values of sharing and reuse of data and samples. This shift raises ethical challenges that need to be considered when research is reviewed by ethics committees, relating for instance to broad consent, the feedback of individual genetic findings, and regulation of secondary sample access and use. Yet existing ethics guidelines and regulations in Africa do not successfully regulate research (...) based on sharing, causing confusion about what is allowed, where and when. In order to understand better the ethics regulatory landscape around genomic research and biobanking, we conducted a comprehensive analysis of existing ethics guidelines, policies and other similar sources. We sourced 30 ethics regulatory documents from 22 African countries. We used software that assists with qualitative data analysis to conduct a thematic analysis of these documents. Surprisingly considering how contentious broad consent is in Africa, we found that most countries allow the use of this consent model, with its use banned in only three of the countries we investigated. In a likely response to fears about exploitation, the export of samples outside of the continent is strictly regulated, sometimes in conjunction with regulations around international collaboration. We also found that whilst an essential and critical component of ensuring ethical best practice in genomics research relates to the governance framework that accompanies sample and data sharing, this was most sparingly covered in the guidelines. There is a need for ethics guidelines in African countries to be adapted to the changing science policy landscape, which increasingly supports principles of openness, storage, sharing and secondary use. Current guidelines are not pertinent to the ethical challenges that such a new orientation raises, and therefore fail to provide accurate guidance to ethics committees and researchers. (shrink)

Community engagement has been recognised as an important aspect of the ethical conduct of biomedical research, especially when research is focused on ethnically or culturally distinct populations. While this is a generally accepted tenet of biomedical research, it is unclear what components are necessary for effective community engagement, particularly in the context of genomic research in Africa.

COVID‐19, caused by a novel coronavirus named SARS‐CoV‐2, was identified in December 2019, in Wuhan, China. It was first confirmed in sub‐Saharan Africa in Nigeria on 27 February 2020 and has since spread quickly to all sub‐Saharan African countries, causing more than 111,309 confirmed cases and 2,498 deaths as of 03 June 2020. The lessons learned during the recent Ebola virus disease (EVD) outbreaks in some sub‐Saharan African countries were expected to shape and influence the region’s responses to COVID‐19 pandemic. (...) However, some of the challenges associated with the management of the EVD outbreaks persist and create obstacles for the effective management of the COVID‐19 pandemic. This article describes the commonalities between the EVD epidemics and COVID‐19 pandemic, with a view to draw on lessons learned to effectively tackle the ongoing pandemic. Key successes, failures and lessons learned from previous EVD outbreaks are discussed. Recommendations on how these lessons can be translated to strengthen the COVID‐19 response in sub‐Saharan Africa are provided. (shrink)

Community engagement in research, including public health related research, is acknowledged as an ethical imperative. While medical care and public health action take priority over research during infectious disease outbreaks, research is still required in order to learn from epidemic responses. The World Health Organisation developed a guide for community engagement during infectious disease epidemics called the Good Participatory Practice for Trials of Emerging (and Re‐emerging) Pathogens that are Likely to Cause Severe Outbreaks in the Near Future and for which (...) Few or No Medical Counter‐Measures Exist (GPP‐EP). This paper identified priorities for community engagement for research conducted during infectious disease outbreaks drawing on discussions held with a purposive sample of bioethicists, social scientists, researchers, policy makers and laypersons who work with ethics committees in West Africa. These perspectives were considered in the light of the GPP‐EP, which adds further depth and dimension to discussions on community engagement frameworks. It concludes that there is no presumptive justification for the exclusion of communities in the design, implementation and monitoring of clinical trials conducted during an infectious disease outbreak. Engagement that facilitates collaboration rather than partnership between researchers and the community during epidemics is acceptable. (shrink)

Gettier presented the now famous Gettier problem as a challenge to epistemology. The methods Gettier used to construct his challenge, however, utilized certain principles of formal logic that are actually inappropriate for the natural language discourse of the Gettier cases. In that challenge to epistemology, Gettier also makes truth claims that would be considered controversial in analytic philosophy of language. The Gettier challenge has escaped scrutiny in these other relevant academic disciplines, however, because of its façade as an epistemological analysis. (...) This article examines Gettier's methods with the analytical tools of logic and analytic philosophy of language. (shrink)

In this article, I use Edmund Gettier’s Ten Coins hypothetical scenario to illustrate some reasoning errors in the use of definite descriptions. The Gettier problem, central as it is to modern epistemology, is first and foremost an argument, which Gettier (Analysis 23(6):121–123, 1963) constructs to prove a contrary conclusion to a widely held view in epistemology. Whereas the epistemological claims in the case have been extensively analysed conceptually, the strategies and tools from other philosophical disciplines such as analytic philosophy of (...) language, logic and argumentation that Gettier deploys in the case have scarcely received any attention. This work abstracts from the epistemological content and examines Gettier’s handling of the definite description involved, and how that affects the cogency of his argument. (shrink)

The theoretical heuristic of assuming distinct alleles (or genotypes) for alternative phenotypes is the foundation of the paradigm of evolutionary explanation we call the Modern Synthesis. In modeling the evolution of sociality, the heuristic has been to set altruism and selfishness as alternative phenotypes under distinct genotypes, which has been dubbed the “phenotypic gambit.” The prevalence of the altruistic genotype that is of lower evolutionary fitness relative to the alternative genotype for non-altruistic behavior in populations is the basis of the (...) “paradox of altruism.” I show in this article that the assumption of contrasting genotypes for altruism and selfishness in our “phenotypic gambit” is inconsistent with the empirical data when viewed in the light of today’s post-Mendelian understanding of gene expression. I demonstrate that however nuanced and sophisticated the models may have become today, they are still rooted in that fundamentally problematic assumption. I then offer a genetic conception of altruism that best fits the field data. (shrink)

al-Tabarsī is one of the glossators in the Shī‘ah gloss tradition in the second middle period or first sagacity period. al-Tabarsī who had a wide knowledge in the various knowledge branches was mentioned as a glossator, narrator of Mohammad’s all sayings, deeds and approvals and scribe. One of compilations that al-Tabarsī wrote it in the field of gloss is Macmau-l-bayān fī tafsīri-l-Qur’ān. The glossator who widely included the recitations in this work used some evidence related to their averment while he (...) was reporting the recitations, and he made the recitations’ justification in the framework. The averment is a science which determines the correct recitations as distinguishing the correct one of recitation’s differences from the deficient one, and which founds an aspect of the correct category with all the other transferred and linguistic arguments of recitation in the predilection besides the imputation, the formal Qur’ān. Al-Tabarsī first mentioned the recitations under the subtitle of recitation related to the verses in each sura and then transferred the argument of recitations with the term of argument. So the glossator applied to give evidence on them with the linguistic and transferred arguments in each of the parts that the recitations were nearly mentioned. He mentioned the imputation, the Qur’ān lettering, verse, hadith, companion and natural people’s readings. He used Arabic poetry, Arabic idiom, dialect, grammar and syntax rules for the linguistic arguments. In this study, the evidences which were used in the recitations’ averment are reviewed in the sample of al-Tabarsī’s gloss in the name of Majmau-l-bayān. Summary: Full name of al-Tabarsī who was one of the leading scholar of Shī‘a is Fadl b. Hasan b Fadl al-Tabarsī. He was born in Thabaristan. According to some narration he was born in village named Tafrish which is between Kashan and Isfahan. He was called al-Tabarsī by reference to his hometown Thabaristan, according to another opinion he was called al-Tabarsī which comes from his birth place known as Tafrish located between Kashan and Isfahan. Tafrish was translated into Arabic as Tabars. Also, the commentator was known with nicknames such as Amīnü’l-islām, Amīnü’d-dīn and Umdatü’l-Mufassīrīn. He was called Sebzevarī due to the place where he died and named Maşhadī and Ṭūsī because of the place where he was buried. Although he is proficient in many fields, he has been described in the sources as commentator, muhaddīth and faqīh. Mufassīr has written many works in Islamic sciences. one of his works written in the field of commentary is Mujmau-l-bayān fī tafsīri-l-Qurʾān. Mufassīr stated that he wrote this commentary by taking advantage of Ṭūsī 's (d. 460/1067) al-Tibyān by saying “It is a guide from which I benefited from Tibiān light, and I write the subjects on the basis of his method”. The author started to write this work with the encouragement of some of his friends after he had aged quite a bit and his hair turned white. and he saw a gap in this area. He spent a lot of effort to fill that gap. This commentary, written during the first dirayet of the Shī‘a exegesis, is more moderate than the previous periods of Shī‘a commentators. The most basic indicator of this is the definitive rejection of the falsification of the Qurʾān in this period. The second important indicator is that insults and degrading expressions about the first three of the hulafā-i rashid and some of the companions are not accepted. The third important indicator is that most of the verses have been interpreted in a manner that corresponds to the views of the Ahl al-Sunnah school in linguistic analyses and proved by appealing to Arabic poems and sayings. al-Tabarsī mentioned recitation almost in all verses as a subtopic. He performed this in the surah by using subtopics. Then he has used “hujjatuhu” (its evidence) expression to narrate the evident of qirāʾāt. By doing so, commentator grounded qirāʾāts by using their evidences utilizing linguistic and narrative evidences in nearly every mentioned qirāʾāts. İhtijaj is a science that determines the authentic readings by distinguishing authentic readings from the weak ones, and that grounds the reading in the choice of an angle, which is mentioned in the authentic category, with isnād, Mushaf script and all other narrative and linguistic evidences. There are two types of ihtijaj which are ihtijaj bi-l-qirāʾāt ve ihtijaj li-l-qirāʾāt. İhtijaj li-l-qirāʾāt uses the linguistic evidences such as isnād, Mushaf line, Arabic language, consumables-nahiv pedestals, polish differences and the narrative evidences such as verses, hadith, qirāʾāt, Arabic words and poetry in determination and preference of a reading aspect. ihtijaj bi-l-qirāʾāt is the use of kıraa as evidence for any matter of science. al-Tabarsī has also mentioned detection proofs which reveal the authentic ways of qirāʾāt like isnād and rasm al-mushaf. Isnād is attribution to whom take the qirāʾāt from previous persons. This proportion reaches up to the Prophet. The persons in the chain of isnād constitute this chain. al-Tabarsī has given in preface the names of the recitors and narrators, which are famous in the cities, based on the fact that an authentic attribute is the basic element in the determination of the qirāʾāh. Thus he passed on the chains of isnād that reached up to the Prophet. Another thing that al-Tabarsī used in the determination proof of qirāʾāh is rasm al-mushaf. The commentator has used the spelling of al-mushaf scripture as evidence by saying “written in al-mushaf like this”. al-Tabarsī, also mentioned preferable evidences about ways of qirāʾā’s proof. Preferred proofs, are evidence to make choosing between qirāʾāh whose authenticity is defined by means of determination proofs. These evidences are divided into two parts which are determination proofs-based and special. Special evidence has not relation with the determination proofs. It contains evidence categories used to prefer one of the two authentic qirāʾāh as special. These categories are divided into four parts: linguistic, transplant, mental and private. al-Tabarsī has evidenced with verses of narrative proofs in the preferred evidence category. The commentator has mentioned about this method for qirāʾā evidence extensively. He has grounded qirāʾāh by using verses. al-Tabarsī also has evidenced these matters by using words of the Prophet from narrative proofs in the preferred evidence category. In this method commentator has evidenced from hadith after mentioning qirāʾāh ways. al-Tabarsī evidences from narrative proofs with qirāʾāh preferred evidence category. In this context, the commentator mentioned recitation of companion and followers by saying his qirāʾāh after reporting qirāʾāh. Moreover, the commentator has sometimes mentioned recitations which is related with reading seven of the recitation and reading ten of the recitation sciences qurra recitation and sometimes mentioned recitations which are known as shadhdh. Then, he has examined these recitations with the qirāʾāh of companions and followers. al-Tabarsī has benefited from narrative evidences, Arabic poetry and phrase in the preferred evidence category extensively. Another evidence used for examination of qirāʾāh is linguistic evidences. Qirāʾāh are related with Arabic language because it has connection with Qur’ānic wording which revelated in Arabic. al-Tabarsī has benefited from some things such as Arabic grammar rules and dialectic differences extensively. The commentator has benefited from Arabic grammar by emphasizing the meaning of the words with the literary features. He has explained grammar statement related with qirāʾāh aspects. He has also explained linguistic rules which are about aspects. (shrink)