Here we review concepts related to an ensemble description of G-protein-coupled receptors. The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor, a prototypical class A GPCR. 19F Nuclear Magnetic Resonance studies show that apo A2AR is characterized by a broad ensemble of conformers, spanning inactive to active states, and resembling states defined earlier for rhodopsin. In keeping with (...) ideas associated with a conformational selection mechanism, addition of agonist serves to allosterically restrict the overall degrees of freedom at the G protein binding interface and bias both states and functional dynamics to facilitate G protein binding and subsequent activation. While the ligand does not necessarily “induce” activation, it does bias sampling of states, increase the cooperativity of the activation process and thus, the lifetimes of functional activation intermediates, while restricting conformational dynamics to that needed for activation. GPCRs represent a ubiquitous class of transmembrane receptors, responsible for cell signaling and cell homeostasis. Their activation gives rise to conformational changes that allow the receptor to engage downstream partners. Activation can be thought of in terms of a free energy landscape associated with distinct conformers, responsible for the process. Here, the action of ligands is seen to alter this landscape by enabling transitions between key intermediates. (shrink)

本书运用逻辑学原理重新审视《易经》的本质,通过对《易经》作者的思维形式和思维逻辑的分析把握,揭示《易经》所反映的思想内容。.

Current work in language models (LMs) helps us speed up or even skip thinking by accelerating and automating cognitive work. But can LMs help us with critical thinking -- thinking in deeper, more reflective ways which challenge assumptions, clarify ideas, and engineer new concepts? We treat philosophy as a case study in critical thinking, and interview 21 professional philosophers about how they engage in critical thinking and on their experiences with LMs. We find that philosophers do not find LMs to (...) be useful because they lack a sense of selfhood (memory, beliefs, consistency) and initiative (curiosity, proactivity). We propose the selfhood-initiative model for critical thinking tools to characterize this gap. Using the model, we formulate three roles LMs could play as critical thinking tools: the Interlocutor, the Monitor, and the Respondent. We hope that our work inspires LM researchers to further develop LMs as critical thinking tools and philosophers and other 'critical thinkers' to imagine intellectually substantive uses of LMs. (shrink)

As the final work by Ye Xiushan, one of the most famous philosophers and scholars of philosophy in China, this two-volume set scrutinizes the historical development of both Chinese and Western philosophy, aiming to explore the convergence between the two philosophical traditions. Combining historical examination and argumentation based on philosophical problematics, the author discusses the key figures and schools of thought from both traditions. Far from being a cursory comparison between different philosophical concepts and categories, the author discusses the logical (...) paths and conceptual approaches of the two traditions on the same philosophical issues, thus giving insights into conceptual categories commonly used in both Chinese and Western philosophies. The two volumes illuminate the different core spirits and dilemmas of Western philosophy and Chinese philosophy, encouraging a constructive dialogue between the two and a new transformation of Chinese philosophy in itself. The title will appeal to scholars, students, and general readers interested in philosophical history, comparative philosophy, Chinese philosophy, and Western philosophy ranging over Greek philosophy, German classic philosophy, and contemporary continental philosophy. (shrink)

Drawing on social exchange theory and benevolent leadership literature, we show how the largesse associated with benevolent leadership can cause subordinates to feel obliged to undertake illegitimate tasks assignments that go beyond their job duties. The hypotheses are tested in a scenario experimental study and a multisource, time-lagged field survey. Both studies indicate that benevolent leadership evokes indebtedness in subordinates (called felt obligation), which is then indirectly related to their willingness to undertake illegitimate tasks. The second study shows that subordinates (...) who try to avoid actions that damage relationships (called disintegration avoidance) and those who feel job insecurity are most willing to perform illegitimate assignments. Practical implications for curbing workplace exploitation are discussed. (shrink)

Collected works of Dge-lugs-pa scholar predominantly on doctrines, commentary on Vasubandhu's Abhidharmakośa, study on Abhisamayālaṅkāra of Pañcaviṃśatisāhasrikā Prajñāparāmitā, Buddhist logic, philosophy, rituals, etc.

Selected works of author's on critical analysis on different concepts of Buddhist doctrines and philosophy.

本书æ ̄国内第一部对公元前721-前221年的华夏体系500年进行理论总结的研究成æž."华夏主义"分析了华夏体系500年间影响大国兴衰的主要理论和思想,并从理论范式的角度总结出老子范式,孔子范式,商子范式 ,管子范式四大范式,它们分别在齐国,楚国,吴国,越国,魏国.

In this article, we examine the empirical association between firm value and CSR engagement for firms in sinful industries, such as tobacco, gambling, and alcohol, as well as industries involved with emerging environmental, social, or ethical issues, i.e., weapon, oil, cement, and biotech. We develop and test three hypotheses, the window-dressing hypothesis, the value-enhancement hypothesis, and the value-irrelevance hypothesis. Using an extesive US sample from 1995 to 2009, we find that CSR engagement of firms in controversial industries positively affects firm (...) value after controlling for various firm characteristics. To address the potential endogeneity problem, we further estimate a system of equations and change regression and continue to find a positive relation between CSR engagement and firm value. Our findings support the value-enhancement hypothesis and are consistent with the premise that the top management of US firms in controversial industries, in general, considers social responsibility important even though their products are harmful to human being, society, or environment. (shrink)

本书是国家社会科学基金课题《唐末五代十国儒学研究》的研究成果，该课题以唐末五代十国时期的儒学为研究对象，把儒学范式的转变作为研究的中心问题，着重探讨了在唐宋社会变革的背景下，唐末五代十国时期儒学的范式 转变。本书通过考察唐末五代十国时期儒学核心概念、基本范畴的演进，寻绎出其在历史语境中“惟精惟微”的变化，提出如下观点：唐末五代十国儒学，是“唐宋变革”在学术形态上的重要表现，也是对这一时期社会巨变的思 想回应。唐末五代十国儒学是一种新范式的儒学，显示出由汉唐儒学向宋代儒学嬗变的过渡特点。.

經濟倫理的對話 財富思想的對話 支配類型的對話 理念類型的對話 決策倫理的對話 《儒家與韋伯的五個對話》為跨越政治、經濟、宗教與方法學等領域的思想史學術創作。葉仁昌教授累積了將近三十年的思考與體會，很大膽並充滿創意地，對儒家與韋伯（Max Weber）開展了五個批判性的對話。包括了清教徒與東亞的經濟倫理、欠缺無限利潤心的儒家財富思想、道德型正當性的支配類型、義利之辨的四種理念類型，以及何不曰利的決策倫理省思。藉此，不只重構了韋伯若干論述 的框架，也爲儒家提供了新視角下的不同詮釋。 韋伯是一位經典的大師，葉仁昌教授卻不只具體地指出韋伯對儒家的理解盲點，還應用韋伯的方法學來新論儒家，更試圖補足韋伯對儒家在研究上的遺漏，完成韋伯未竟的探索，甚至重構韋伯有關支配類型的框架。當然，在這樣 的過程中，儒家也因為新的視角而得到了不同詮釋。.

We empirically examine the impact of corporate social responsibility (CSR) on CEO compensation using a large sample of the US firms from 1996 to 2010. We develop and test two hypotheses, the overinvestment hypothesis based on agency theory and the conflict–resolution hypothesis based on stakeholder theory. We find that the lag of CSR adversely affects both total compensation and cash compensation, after controlling for various firm and board characteristics. Our estimates show that an interquartile increase in CSR is followed by (...) a 4.35% (2.78%) decrease in total (cash) compensation. We also find an inverse association between lagged employee relations and CEO compensation. Our results are robust to the correction for endogeneity using instrumental variable approach. Taken together, our results support the conflict–resolution hypothesis, but not the CSR overinvestment argument. (shrink)

Study on Tibetan Buddhist logic; includes some poems and essays.

Ben shu zhi zai yong zhe xue yan jiu de fang shi zheng ti lun shu fo xue ti xi. wei le shi pu tong da zhong neng chu kui wan zheng de fo jiao xi tong, zuo zhe fen bie cong fo jiao de ge di yu pai bie,zhe xue si xiang guan dian,si miao jian zhu yi ji fo jing shu ji lun zhu deng fang mian jin xing liao xiang jin de xu shu ji tao lun. shu (...) zhong chu le dui fo jiao wen hua zhi shi de zheng li yu chuan hang, hai hui jie he you zuo zhe zai de zhe xue ji Zhongguo wen hua ling yu zhong di yan jiu cheng guo. ben shu zun zhong zong jiao ben shen, zai xie zuo shou fa shang shi fen yan jin, fo jing ji xue zhe guan dian jie zhi yi yin yong xing shi lie chu, bing bu zuo ping lun ; dui zhuan men de shu yu hui dai you jiao zhu,jian suo shen zhi shi fan wen yuan wen de shuo ming, ke du xing qiang bing yi yu cha yue. (shrink)

On elementary Buddhist logic and dialectical studies.

Explanatory notes on the philosophical positions (sidhānta) of Vaibhāṣika, Sautrāntika, Yogācāra, and Mādhyamika schools of Buddhism with Hinduism.

Buddhist dialectic reasoning and debates for beginner.

Commentary on Yon tan rin po cheʼi mdzod text of ʼJigs-med-gliṅ-pa Raṅ-byuṅ-rdo-rje, 1729 or 30-1798, dealing on Rdzogs-chen doctrine of Rñiṅ-ma-pa sect.