Good agricultural practices certification schemes have been promoted to enhance agricultural sustainability. This study seeks to explain the adoption of GAP certification schemes through an analysis of the role of personal values in guiding such choice. It is a departure from approaches taken in previous studies in the area. Through the laddering interview technique of means-end chain analysis, a hierarchical value map was systematically schematized to illustrate the relationship between adoption of GAP, outcomes, and personal values driving the choice. The (...) personal values identified in this study cluster under the headings of “better life”, “religious responsibility”, “healthy life”, and “responsible farmer”. Amongst these, the main evidence pointed to the desire to have “better life” through the enhanced financial position that is perceived to arise as a consequence of GAP adoption as being of primary importance. These findings suggest that, while profit is not the sole end driver of adoptive behavior, GAP certification schemes have to be seen as lucrative and to enhance the goals of achieving core personal values. Other empirical information in this study also has significant policy implications. It is a key finding of this paper that effective promotions of GAP should be tailored and targeted at specific segments of the farmer population. (shrink)

According to Hobbes, individuals care about their relative standing in a way that shapes their social interactions. To model this aspect of Hobbesian psychology, this paper supposes that agents have social preferences, that is, preferences about their comparative resource holdings. Introducing uncertainty regarding the social preferences of others unleashes a process of trust-unravelling, ultimately leading to Hobbes’s ‘state of war’. This Trust-unravelling Model incorporates important features of Hobbes’s argument that past models ignore.

The secretory pathway delivers proteins synthesized at the rough endoplasmic reticulum (RER) to various subcellular locations via the Golgi apparatus. Currently, efforts are focused on understanding the molecular machineries driving individual processes at the RER and Golgi that package, modify and transport proteins. However, studies are routinely performed using non‐dividing cells. This obscures the critical issue of how the secretory pathway is affected by cell division. Indeed, several studies have indicated that protein trafficking is down‐regulated during mitosis. Moreover, the RER (...) and Golgi apparatus exhibit gross reorganization in mitosis. Here I provide a relatively neglected perspective of how the mitotic cyclin‐dependent kinase (CDK1) could regulate various stages of the secretory pathway. I highlight several aspects of the mitotic control of protein trafficking that remain unresolved and suggest that further studies on how the mitotic CDK1 influences the secretory pathway are necessary to obtain a deeper understanding of protein transport. (shrink)

This paper presents an adaptive fuzzy sliding-mode controller for multiple Euler–Lagrange systems communicated with directed topology. Based on the graph theory and Lyapunov–Krasovskii functions, a delay-dependent sufficient condition for the existence of sliding surfaces is given in terms of linear matrix inequalities. The asymptotic stability is analyzed by using the Lyapunov method in the presence of unknown parametric dynamics, actuator faults, and time-varying delays. The usage of adaptive techniques is to adapt the unknown parameters so that the objective of globally (...) asymptotic stability is achieved. Finally, simulation results are provided to illustrate the effectiveness of the proposed control scheme. (shrink)

Scholars have generally underestimated the level of Roman involvement in Africa in the period between the annexation of Carthage in 146 b.c. and Caesar's victory at Thapsus in 46 b.c., and the land in Africa which the Romans annexed has been conventionally called public land (ager publicus). This paper analyses the surviving text of the African provisions of the epigraphic lex agraria of 111 b.c. and notes that the term ager publicus is not attested in the provincial section of the (...) law. The land in Africa appears simply as ager in Africa and the term ager publicus is confined exclusively to Italy in the law of 111. However, Cicero's references to Rullus’ agrarian proposal in 64/3 b.c. in the De lege agraria suggest that the term ager publicus was used to qualify land existing outside Italy in Rullus’ proposal. This paper argues that the concept of ager publicus as opposed to private land developed in Africa between 111 and 63 b.c., and that this was linked to privatization of ager in Africa in this period. The results of this study suggest a high degree of Roman exploitation of African land prior to the Caesarean and Augustan colonies in the 40s b.c. (shrink)

BackgroundSharing de-identified individual-level health research data is widely promoted and has many potential benefits. However there are also some potential harms, such as misuse of data and breach of participant confidentiality. One way to promote the benefits of sharing while ameliorating its potential harms is through the adoption of a managed access approach where data requests are channeled through a Data Access Committee (DAC), rather than making data openly available without restrictions. A DAC, whether a formal or informal group of (...) individuals, has the responsibility of reviewing and assessing data access requests. Many individual groups, consortiums, institutional and independent DACs have been established but there is currently no widely accepted framework for their organization and function.Main textWe propose that DACs, should have the role of both promotion of data sharing and protection of data subjects, their communities, data producers, their institutions and the scientific enterprise. We suggest that data access should be granted by DACs as long as the data reuse has potential social value and provided there is low risk of foreseeable harms. To promote data sharing and to motivate data producers, DACs should encourage secondary uses that are consistent with the interests of data producers and their own institutions. Given the suggested roles of DACs, there should be transparent, simple and clear application procedures for data access. The approach to review of applications should be proportionate to the potential risks involved. DACs should be established within institutional and legal frameworks with clear lines of accountability, terms of reference and membership. We suggest that DACs should not be modelled after research ethics committees (RECs) because their functions and goals of review are different from those of RECs. DAC reviews should be guided by the principles of public health ethics instead of research ethics.ConclusionsIn this paper we have suggested a framework under which DACs should operate, how they should be organised, and how to constitute them. (shrink)

The use of placebos in randomised controlled trials is a subject of considerable ethical debate. In this paper we present a set of considerations to evaluate the ethics of placebo controlled trials that includes: social value of the study; need for a randomised controlled trial and placebo; standards of care; risks of harm due to administration of placebo and the harm benefit balance; clinical equipoise; and double standards. We illustrate the application of these considerations using a case study of a (...) large ongoing multicentre, placebo-controlled, double-blinded, randomised trial to determine primaquine anti-relapse efficacy in vivax malaria. There is an urgent need for primaquine anti-relapse studies in order to rationalise the management of a potentially fatal disease. An ethical justification for the use of the placebo arm is provided on the grounds that the actual current applied standard of care in most endemic places does not include primaquine. It has also been argued that there is clinical equipoise among the primaquine study arms and that the risk of harms of being in the placebo arm is the risk of having relapse, which is no more than not being included in the trial, and that there are no double standards. Based on our set of considerations, we conclude that a placebo arm is not only justified but imperative in this study. We propose that similar considerations should be prospectively applied to other placebo controlled trials and observational control arms where no treatment is offered. (shrink)

Background The ownership status of individual-level health data affects the manner in which it is used. In this paper we analyze two competing models of the ownership status of the data discussed in the literature recently: private ownership and public ownership. Main body In this paper we describe the limitations of these two models of data ownership with respect to individual-level health data, in particular in terms of ethical principles of justice and autonomy, risk mitigation, as well as technological, economic, (...) and conceptual issues. We argue that undifferentiated application of neither private ownership nor public ownership will allow us to resolve all the problems associated with effective, equitable, and ethical use of data. We suggest that, instead of focusing on data ownership, we should focus on the institutional and procedural aspects of data governance, such as using Data Access Committees (DACs) or equivalent managed access processes, which can balance the elements of these two ownership frameworks. Conclusion Undifferentiated application of the ownership concept (private or public) is not helpful in resolving problems associated with sharing individual-level health data. DACs or equivalent managed access processes should be an integral part of data governance. They can approve or disapprove data access requests after considering the potential benefits and harms to data subjects, their communities, primary researchers, and the wider society. (shrink)

Community engagement (CE) is gaining prominence in global health research. A number of ethical goals–spanning the instrumental, intrinsic, and transformative–have been ascribed to CE in global health research. This paper draws attention to an additional transformative value that CE is not typically linked to but that seems very relevant: solidarity. Both are concerned with building relationships and connecting parties that are distant from one another. This paper first argues that furthering solidarity should be recognized as another ethical goal for CE (...) in global health research. It contends that, over time, CE can build the bases of solidaristic relationships—moral imagination, recognition, understanding, empathy—between researchers and community members. Applying concepts from existing accounts of solidarity, the paper develops preliminary ideas about who should be engaged and how to advance solidarity. The proposed approach is compared to current CE practice in global health research. Finally, the paper briefly considers how solidaristic CE could affect how global health research is performed. (shrink)

This is a study of 288 Korean and 323 Japanese Business executives. The result indicates that, (1) the business executives believe basically in higher level business ethics, but (2) they occasionally have to make unethical business decisions which conflict with their personal values, because of prevailing business practices. (3) However, they think higher ethical standards is useful for long-term profit and for improving workers' attitudes, and the standards can be improved, and (4) to improve ethical standards, model setting by superiors (...) is the most important and clear-cut company policies and code of ethics are essential. (shrink)

Research funders, regulatory agencies, and journals are increasingly expecting that individual-level data from health research will be shared. Broad consent to such sharing is considered appropriate, feasible and acceptable in low- and middle-income settings, but to date limited empirical research has been conducted to inform the design of such processes. We examined stakeholder perspectives about how best to seek broad consent to sharing data from the Mahidol Oxford Tropical Medicine Research Unit, which implemented a data sharing policy and broad consent (...) to data sharing in January 2016. Between February and August 2017 qualitative data were collected at two sites, Bangkok and the Thai-Myanmar border town of Mae Sot. We conducted eighteen semi-structured interviews. We also conducted four focus group discussions with a total of nineteen people. Descriptive and thematic coding informed analysis of aspects of data sharing that are considered most important to inform participants about, and the best ways to explain complex and abstract topics relating to data sharing. The findings demonstrated that clinical trial participants prioritise information about the potential benefits and harms of data sharing. Stakeholders made multiple suggestions for clarifying information provided about data sharing on such topics. There was significant variation amongst stakeholders’ perspectives about how much information should be provided about data sharing, and it was clear that effective information provision should be responsive to the study, the study population, the individual research participant and the research context. Effectively communicating about data sharing with research participants is challenging in practice, highlighting the importance of robust and effective data sharing governance in this context. Broad consent should incorporate effective and efficient explanations of data sharing to promote informed decision-making, without impeding research participants’ understandings of key aspects of the research from which data will be shared. Further work is required to refine both the development of core information about data sharing to be provided to all research participants, and appropriate solutions for context specific-challenges arising when explaining data sharing. (shrink)

Since January 2016, the Mahidol Oxford Tropical Medicine Research Unit has trialled a data-sharing policy where requests to access research datasets are processed through a Data Access Committee. In this paper, we share our experiences establishing data management systems and data-sharing infrastructure including a data-sharing policy, data access committee and related procedures. We identified a number of practical and ethical challenges including requests for datasets collected without specific or broad consent to data sharing and requests from pharmaceutical companies for data (...) to support drug registration applications. We also encountered significant resource constraints which required the development of appropriate human resources and infrastructure. We suggest a research agenda to promote responsible and equitable data sharing while safeguarding the rights and interests of research participants and researchers. (shrink)

Cellular events must be executed in a certain sequence during the cell division in order to maintain genome integrity and hence ensure a cell's survival. In M phase, for instance, chromosome segregation always precedes mitotic exit (characterized by mitotic kinase inactivation via cyclin destruction); this is then followed by cytokinesis. How do cells impose this strict order? Recent findings in budding yeast have suggested a mechanism whereby partitioning of chromosomes into the daughter cell is a prerequisite for the activation of (...) mitotic exit network (MEN). So far, however, a regulatory scheme that would temporally link the initiation of cytokinesis to the execution of mitotic exit has not been determined. We propose that the requirement of MEN components for cytokinesis, their translocation to the mother–daughter neck and triggering of this translocation by inactivation of the mitotic kinase may be the three crucial elements that render initiation of cytokinesis dependent on mitotic exit. BioEssays 24: 659–666, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The current study examined the validity of HEXACO personality traits (at the broad trait-level and narrow facet-level) and Self-Control as predictors of counterproductive academic behavior (CAB; at the overall level and specific dimensional level) among college students. We collected data from 483 undergraduate students in South Korea who completed self-report measures of HEXACO personality traits, Self-Control, CAB. Results showed that Conscientiousness (r = −.23) and Honesty-Humility (r = −.25) were significantly correlated with CAB and that Self-Control provided incremental validity over (...) HEXACO personality traits in predicting CAB. The correlations of Conscientiousness and Self-Control with CAB were consistently negative at the facet-level. However, within each HEXACO trait, there was some variability in the strength (and sometimes, the direction) of the relationships between the facet traits and CAB dimensions. Additionally, hierarchical multiple regression analysis results showed that Self-Control provided incremental validity for predicting CAB beyond prediction provided by the HEXACO personality traits. The results provide further support for personality and Self-Control as meaningful predictors of counterproductive academic behavior in college. (shrink)

This article explores rage in the context of Korean feminist movements. Rage as a corporeal force can be combined with other emotional modalities to achieve consistency, durability, efficiency, and intensity. These modalities are interdependent, and rage, in relation to indignation, becomes a revolutionary affect that changes power dynamics. Women's indignant rage challenges the patriarchal value system and increases women's agency. Korean women deploy the politics of rage to “Escape the Corset” and free themselves from the oppressive devices—patriarchal family structures and (...) traditional notions of femininity and beauty—that oppress women's bodies. The “Escape the Corset” movement, driven by indignant rage, materializes the possibility of resistance and creation that puts an end to the phallic economy of desire and meaning, and it elaborates a new modality of women's life cycle and relation to the world. Unlike indignant rage, a feminist revolutionary tool, rage combined with hatred is a conservative affect that annihilates the possibility of change and maintains the status quo. The politics of rage promotes a deconstruction of the patriarchal system, joining with a subversive and cathartic joy that contains hope for a more just future. (shrink)

Too often Confucian women’s voices and experiences are neglected as insignificant. This paper provides a wide and diverse set of examples of traditional Chinese and Korean women who knew and practiced Confucian ritual. Though representing only a small percentage of traditional women, these examples provide clear evidence and compelling arguments that support the following three conclusions. First, that the Confucian tradition did not deny women’s ability to know and perform rituals; second, that Confucian women read, learned, evaluated, decided, and contributed (...) to re/create the conception and practice of ritual; and third, that this led at least some women and the men around them to recognize and admire not only their moral agency but also their ability to become sages. (shrink)

로크 철학의 주된 내용인 인간 본성 백지설, 원자적 개인관, 반원죄설, 관용론, 교육론은 서로 긴밀하게 연결되어 있다. 순응성 테제(malleability thesis)로 요약할 수 있는 로크의 교육론은 인간 본성 백지설과 인격 동일성 이론에 의해 뒷받침된다. 그 중에서 특히 로크 철학의 상징처럼 되어 버린 인간 본성 백지설은 상당히 왜곡되고 과장되었다는 비판을 받아 왔다. 로크가 조기 교육에서 강조하는 습관은 너무나 강력해서 아이를 습관의 제국(the empire of habit)의 신하가 되게 한다. 아이의 이성 자체가 보호자와 공동체가 요구하는 습관적 사고와 행동의 토대 위에 형성된다. 여기서 다른 사람들의 의견에 (...) 철저하게 의존하는 것이 아이를 자유롭게 한다는 ‘자유의 역설’(Paradox of Liberty)이 성립된다. 자유는 훈련의 산물이고 아이는 보호자에 의해 제시된 공동체의 덕의 모델에 따르기를 선택하는 행위자라는 의미에서만 자유롭다. 로크 교육론의 구축된 자유에 비추어 볼 때 자연적 자유는 어떤 의미를 갖는지 결코 분명하지 않다. (shrink)

BackgroundCommunity engagement is increasingly promoted as a marker of good, ethical practice in the context of international collaborative research in low-income countries. There is, however, no widely agreed definition of community engagement or of approaches adopted. Justifications given for its use also vary. Community engagement is, for example, variously seen to be of value in: the development of more effective and appropriate consent processes; improved understanding of the aims and forms of research; higher recruitment rates; the identification of important ethical (...) issues; the building of better relationships between the community and researchers; the obtaining of community permission to approach potential research participants; and, the provision of better health care. Despite these diverse and potentially competing claims made for the importance of community engagement, there is very little published evidence on effective models of engagement or their evaluation.MethodsIn this paper, drawing upon interviews with the members of a Community Advisory Board on the Thai-Myanmar border, we describe and critically reflect upon an approach to community engagement which was developed in the context of international collaborative research in the border region.Results and conclusionsDrawing on our analysis, we identify a number of considerations relevant to the development of an approach to evaluating community engagement in this complex research setting. The paper also identifies a range of important ways in which the Community Advisory Board is in practice understood by its members to have morally significant roles and responsibilities beyond those usually associated with the successful and appropriate conduct of research. (shrink)

This article investigates the views of Song Siyeol 宋時烈 (1607–1689), a Confucian scholar-official in Joseon Korea, on marriage ritual, with a special focus on the issue of women’s remarriage. Song opposed the legal ban on women’s remarriage that was enforced in his age, despite the danger this invited of being accused of promoting licentious deeds as well as generating suspicion about his loyalty as a subject. He clearly understood women’s remarriage as an ethical and not a legal issue. The ethical (...) principle of his conception of spousal loyalty, or ui 義, however, reveals its gendered aspect through his discussion with a fellow Confucian scholar. Moreover, his private behavior exemplifies the gendered aspects of his view on spousal fidelity. In addition, the unequal application of ui was supported by beliefs about the asymmetrical relation between Heaven and Earth, that were widely held and deployed by Confucians of Joseon Korea. (shrink)

Volume 20, Issue 8, August 2020, Page W14-W16.

Community engagement is increasingly recognized as a critical element of medical research, recommended by ethicists, required by research funders and advocated in ethics guidelines. The benefits of community engagement are often stressed in instrumental terms, particularly with regard to promoting recruitment and retention in studies. Less emphasis has been placed on the value of community engagement with regard to ethical good practice, with goals often implied rather than clearly articulated. This article outlines explicitly how community engagement can contribute to ethical (...) global health research by complementing existing established requirements such as informed consent and independent ethics review. The overarching and interlinked areas are respecting individuals, communities and stakeholders; building trust and social relationships; determining appropriate benefits; minimizing risks, burdens and exploitation; supporting the consent process; understanding vulnerabilities and researcher obligations; gaining permissions, approvals and building legitimacy and achieving recruitment and retention targets. (shrink)

This essay offers an analysis of the writing and practices of Song Siyŏl as a way to explore the philosophical concepts and philosophizing process of Confucian ritual in relation to women. As a symbolic and influential figure in Korean philosophy and politics, his views contributed to shaping the orthodox interpretation of the theory and practice of Neo-Confucian ritual regarding women. By demonstrating and analyzing what kinds of issues were discussed in terms of women in four family rituals, I delineate the (...) ways in which Song Siyŏl positioned women in his ritualist metaphysics and to examine his philosophizing process. (shrink)

This essay introduces two Korean women Confucian philosophers: Im Yun- jidang and Gang Jeongildang who lived in the latter period of the Joseon dynasty. Im Yunjidang was the first Confucian woman to explicitly claim women possessed an equal capacity to become sages as men. Gang Jeong- ildang made it clear that she was inspired by and sought to develop the thought of Im and added her own unique insights and new perspectives. Though they and their writings differ in many ways, (...) these two women philosophers created a lineage of female sages, marking a turning point in the history of Confucian philosophy. This paper aims to provide the his- torical background that shaped their thought and to introduce some of their writings in the hope of inspiring readers to study further the lives and philosophies of these two remarkable women and to take up and extend the insights they have left behind. (shrink)

This paper analyzes two philosophers’ views on chastity as a virtue, comparing Song Siyeol, a Korean neo-Confucian philosopher of the east, and David Hume, a Scottish philosopher. Despite the importance in and impact on women’s lives, chastity has been understated in religio-philosophical fields. The two philosophers’ understandings and arguments differ in significant ways and yet share important common aspects. Analyzing the views of Song and Hume helps us better understand and approach the issue of women’s chastity, not only as a (...) historical phenomenon but also in the contemporary world, more fully and deeply. The analysis will provide an alternative way to re-appropriate the concept of chastity as a virtue. (shrink)

This paper introduces Song Siyeol, known as Master Song (Songja 宋子), who had a great influence on Korean philosophy and politics in late Joseon (18-19th century). Among his Great Compendium, there are substantial body of writings and comments related to women. As his views directly and indirectly contributed to shaping orthodox Korean Neo- Confucian views regarding women, his writings are an invaluable resource for understanding women and gender in the late Joseon period. This paper presents his views on women, focusing (...) on issues related to rituals. By highlighting and analyzing the issues discussed regarding the role of women in four traditional family rituals, I delineate ways in which Song Siyeol positioned women in his ritualist metaphysics and use this analysis to examine his philosophical approach, which reflects his views on, and understanding of, women, gender, and associated philosophical concepts, while making meaningful and practical discoveries that can be embraced and implemented by women and people today. (shrink)

Nipah virus is a priority pathogen that is receiving increasing attention among scientists and in work on epidemic preparedness. Despite this trend, there has been almost no bioethical work examining ethical considerations surrounding the epidemiology, prevention, and treatment of Nipah virus or research that has already begun into animal and human vaccines. In this paper, we advance the case for further work on Nipah virus disease in public health ethics due to the distinct issues it raises concerning communication about the (...) modes of transmission, the burdens of public health surveillance, the recent use of stringent public health measures during epidemics, and social or religious norms intersecting with preventive measures. We also advance the case for further work on Nipah virus disease in research ethics, given ethical issues surrounding potential vaccine trials for a high-fatality disease with sporadic spillover events, the different local contexts where trials may occur, and the potential use of unproven therapeutics during outbreaks. Further bioethics work may help to ensure that research and public health interventions for Nipah virus disease are ethically acceptable and more likely to be effective. (shrink)

Background Achieving meaningful consent can be challenging, particularly in contexts of diminished literacy, yet is a vital part of participant protection in global health research. Method We explored the challenges and potential solutions of achieving meaningful consent through a qualitative study in a predominantly hill tribe ethnic minority population in northern Thailand, a culturally distinctive population with low literacy. Semi-structured interviews were conducted with 37 respondents who had participated in scrub typhus clinical research, their family members, researchers and other key (...) informants. A thematic analysis was conducted. Results Our analysis identified four interrelated themes surrounding participants’ ability to give consent: varying degrees of research understanding, limitations of using informal translators, issues impacting decisions to join research, and voluntariness of consent. Suggestions for achieving more meaningful consent included the use of formal translators and community engagement with research populations. Conclusions Participant’s agency in decision making to join research should be supported, but research information needs to be communicated to potential participants in a way that they can understand. We found that improved understanding about the study and its potential benefits and harms goes beyond literacy or translation and requires attention to social and cultural factors. (shrink)

Some of the important conceptual debates between different approaches to class analysis can be interpreted as reflecting different ways of linking temporality to class structure. In particular, processual concepts of class can be viewed as linking class to the past whereas structural concepts link class to the future. This contrast in the temporality of class concepts in turn is grounded in distinct intuitions about why class is explanatory of social conflict and social change. Processural approaches to class see its explanatory (...) power as deriving from the way meanings and identities are linked to class via a history of experiences; structural approaches, in contrast, emphasize the linkage between class and perceived interests via the objective possibilities facing people in different class locations. This paper tries to integrate these two temporalities by exploring the ways in which trajectories of class experience intersect structures of objective possibility in shaping different dimensions of class consciousness. (shrink)

ABSTRACTThis article describes our experience using art and theatre to engage rural communities in western Cambodia to understand malaria and support malaria control and elimination. The project was a pilot science–arts initiative to supplement existing engagement activities conducted by local authorities. In 2016, the project was conducted in 20 villages, involved 300 community members and was attended by more than 8000 people. Key health messages were to use insecticide-treated bed-nets and repellents, febrile people should attend village malaria workers, and to (...) raise awareness about the risk of forest-acquired malaria. Building on the experience and lessons learnt in the year prior, the 2017 project which was conducted in 15 villages involved 600 community members and attracted more than 12,000 people. In addition to the malaria theme, upon discussion with local health authorities, secondary theme was added to the 2017 project. We learnt the following lessons from our experience in... (shrink)

It has been suggested that community advisory boards can play a role in minimising exploitation in international research. To get a better idea of what this requires and whether it might be achievable, the paper first describes core elements that we suggest must be in place for a CAB to reduce the potential for exploitation. The paper then examines a CAB established by the Shoklo Malaria Research Unit under conditions common in resource-poor settings – namely, where individuals join with a (...) very limited understanding of disease and medical research and where an existing organisational structure is not relied upon to serve as the CAB. Using the Tak Province Border Community Ethics Advisory Board as a case study, we assess the extent to which it might be able to take on a role minimising exploitation were it to decide to do so. We investigate whether, after two years in operation, T-CAB is capable of assessing clinical trials for exploitative features and addressing those found to have them. The findings show that, although T-CAB members have gained knowledge and developed capacities that are foundational for one-day taking on a role to reduce exploitation, their ability to critically evaluate studies for the presence of exploitative elements has not yet been strongly demonstrated. In light of this example, we argue that CABs may not be able to perform such a role for a number of years after initial formation, making it an unsuitable responsibility for many short-term CABs. (shrink)

Bioethicists have long debated the content of sponsors and researchers' obligations of justice in international clinical research. However, there has been little empirical investigation as to whether and how obligations of responsiveness, ancillary care, post-trial benefits and research capacity strengthening are upheld in low- and middle-income country settings. In this paper, the authors argue that research ethics guidelines need to be more informed by international research practice. Practical guidance on how to fulfil these obligations is needed if research groups and (...) other actors are to successfully translate them into practice because doing so is often a complicated, context-specific process. Case study research methods offer one avenue for collecting data to develop this guidance. The authors describe how such methods have been used in relation to the Shoklo Malaria Research Unit's vivax malaria treatment (VHX) trial (NCT01074905). Relying on the VHX trial example, the paper shows how information can be gathered from not only international clinical researchers but also trial participants, community advisory board members and research funder representatives in order to: (1) measure evidence of responsiveness, provision of ancillary care, access to post-trial benefits and research capacity strengthening in international clinical research; and (2) identify the contextual factors and roles and responsibilities that were instrumental in the fulfilment of these ethical obligations. Such empirical work is necessary to inform the articulation of obligations of justice in international research and to develop guidance on how to fulfil them in order to facilitate better adherence to guidelines' requirements. (shrink)

Im is known for arguing, on the basis of core neo-Confucian beliefs concerning a shared human nature, that women are equally capable of mastering the Confucian classics, cultivating themselves, and thereby becoming “female sages.” Throughout her varied writings, she defends this idea, offering highly original, powerful interpretations of a range of philosophical issues and historical cases that bring out neglected aspects of Confucian moral life. In most of her writings, she makes clear that the Confucian moral ideal requires not only (...) acting in certain ways but also with a particular sensitivity and style. Her insights deepen our understanding of the Confucian tradition but also contribute in original and important ways to contemporary moral philosophy. (shrink)

Gang Jeongildang acknowledged that she was inspired by and sought to continue the work of Im Yunjidang. Gang established herself as an original and important philosopher in her own right and as part of what is the first and only example of a tradition of Korean female Confucian philosophers. Her extant writings consist mostly of philosophical poetry and short personal missives to her husband and these present—in both content and style—a rich and profound resource not only for how she struggled (...) to pursue the Confucian ideal of becoming a female sage in the face of the poverty and hardship of her daily life but also for how anyone might take the challenges of everyday life as the primary arena for moral cultivation. Her letters to her husband are especially valuable as an example of how this most basic familial relationship did, can, and should figure more centrally in Confucian reflection on self-cultivation and more generally in our account of the moral life. (shrink)