A pathogenic connection between autoreactive T cells, fungal infection, and carcinogenesis has been demonstrated in studies of human autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy as well as in a mouse model in which kinase-dead Ikkα knock-in mice develop impaired central tolerance, autoreactive T cell–mediated autoimmunity, chronic fungal infection, and esophageal squamous cell carcinoma, which recapitulates APECED. IκB kinase α is one subunit of the IKK complex required for NF-κB activation. IKK/NF-κB is essential for central tolerance establishment by regulating the development of medullary thymic (...) epithelial cells that facilitate the deletion of autoreactive T cells in the thymus. In this review, we extensively discuss the pathogenic roles of inborn errors in the IKK/NF-κB loci in the phenotypically related diseases APECED, immune deficiency syndrome, and severe combined immunodeficiency; differentiate how IKK/NF-κB components, through mTEC, T cells/leukocytes, or epithelial cells, contribute to the pathogenesis of infectious diseases, autoimmunity, and cancer; and highlight the medical significance of IKK/NF-κB in these diseases. IKK/NF-κB regulates the expression of many genes that encode proteins involved in many crucial biological functions, such as immunity, tissue homeostasis, and fungal/bacterial/viral infections. Also, IKKα plays anti-tumor activities in many organs independently of NF-κB pathways. Thus, an inborn error in one of these gene loci can cause severe human diseases through these complicated mechanisms. (shrink)

Responding to recent concerns about the reliability of the published literature in psychology and other disciplines, we formed the X-Phi Replicability Project to estimate the reproducibility of experimental philosophy. Drawing on a representative sample of 40 x-phi studies published between 2003 and 2015, we enlisted 20 research teams across 8 countries to conduct a high-quality replication of each study in order to compare the results to the original published findings. We found that x-phi studies – as represented in our sample (...) – successfully replicated about 70% of the time. We discuss possible reasons for this relatively high replication rate in the field of experimental philosophy and offer suggestions for best research practices going forward. (shrink)

This study examines Chinese undergraduates’ perceptions of plagiarism in English academic writing in relation to their disciplinary background, academic enculturation, and gender. Drawing on data collected from 270 students at two universities in China, it finds clear discipline-based differences in participants’ knowledge of plagiarism and perceptions about its causes; an enculturational effect on perceived acceptability of and condemnatory attitudes toward plagiarism, with senior students being less harsh than their junior counterparts; and complex interactions among disciplinary background, length of study, and (...) gender. Furthermore, it reveals conceptions of legitimate intertextuality differing from those prevalent in Anglo American academia and clearly punitive stances on perceived plagiarism. These results suggest the need to take an educative rather than punitive approach to source use in English academic writing. (shrink)

In order to address the influence of unethical leader behaviors in the form of abusive supervision on subordinates’ retaliatory responses, we meta-analytically examined the impact of abusive supervision on subordinate deviance, inclusive of the role of justice and power distance. Specifically, we investigated the mediating role of supervisory- and organizationally focused justice and the moderating role of power distance as one model explaining why and when abusive supervision is related to subordinate deviance toward supervisors and organizations. With 79 independent sample (...) studies, we found that abusive supervision was more strongly related to supervisory-focused justice, compared to organizationally focused justice perceptions, and both types of justice perceptions were related to target-similar deviance. Finally, our results showed that the negative implications of abusive supervision were stronger in lower power distance cultures compared to higher power distance cultures. (shrink)

ABSTRACT: According to a traditional account, understanding why X occurred is equivalent to knowing that X was caused by Y. This paper defends the account against a major objection, viz., knowing-that is not sufficient for understanding-why, for understanding-why requires a kind of grasp while knowledge-that does not. I discuss two accounts of grasp in recent literature and argue that if either is true, then knowing that X was caused by Y entails at least a rudimentary understanding of why X occurred. (...) If my defense is successful, it would cast doubt on an influential account of the epistemic value of understanding. (shrink)

It is worth noting that Maddy oversimplifies the history of Gettierology, for a lot of epistemologists who work on the Gettier Problem do not engage in analysing the concept of knowledge.

Response strategy is a key for preventing widespread corruption vulnerabilities in the public construction sector. Although several studies have been devoted to this area, the effectiveness of response strategies has seldom been evaluated in China. This study aims to fill this gap by investigating the effectiveness of response strategies for corruption vulnerabilities through a survey in the Chinese public construction sector. Survey data obtained from selected experts involved in the Chinese public construction sector were analyzed by factor analysis and partial (...) least squares-structural equation modeling. Analysis results showed that four response strategies of leadership, rules and regulations, training, and sanctions, only achieved an acceptable level in preventing corruption vulnerabilities in the Chinese public construction sector. This study contributes to knowledge by improving the understanding of the effectiveness of response strategies for corruption vulnerabilities in the public construction sector of developing countries. (shrink)

This paper presents a human-computer interaction model with a three layers learning mechanism in a pervasive environment. We begin with a discussion around a number of important issues related to human-computer interaction followed by a description of the architecture for a multi-agent cooperative design system for pervasive computing environment. We present our proposed three- layer HCI model and introduce the group formation algorithm, which is predicated on a dynamic sharing niche technology. Finally, we explore the cooperative reinforcement learning and fusion (...) algorithms; the paper closes with concluding observations and a summary of the principal work and contributions of this paper. (shrink)

This study examined the relations between properties of attentional networks and Mind Wandering across individuals. For the attentional networks, we measured three components of attention, known as alerting, orienting, and executive control, using the Attention Network Test . To investigate MW, we measured thought probes embedded in the Sustained Attention to Response Task . Moreover, four performance characteristics of the SART were calculated as behavioral indices of MW. Three of them showed significant associations with probed MW. Most research regarding MW (...) focused on its relation to executive functions, while the present study revealed that MW, as indexed by self-reports and RT variability, was negatively correlated with orienting, specifically the exogenous orienting system. Furthermore, there was a positive association between RT variability and executive control. Our results suggest that individuals with higher tendency of MW are less sensitive to irrelevant external stimuli, supporting the decoupling hypothesis of MW. (shrink)

What do Philosophers do? Skepticism and the Practice of Philosophy. By Maddy Penelope.

Appendix 1 was incomplete in the initial online publication. The original article has been corrected.

Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging studies for meta-analysis, or generating new hypotheses. To promote these goals, the ImmPort data repository was created for the broader research community to explore the wide spectrum of clinical and basic research data and associated findings. The ImmPort ecosystem consists of four components–Private Data, Shared Data, Data (...) Analysis, and Resources—for data archiving, dissemination, analyses, and reuse. To date, more than 300 studies have been made freely available through the Shared Data portal (immport.org/immportopen), which allows research data to be repurposed to accelerate the translation of new insights into discoveries. (shrink)

Building on prior research in Confucianism and business, the current study examines the effects of Confucianism on consumer trust of government involvement with products and company brands. Based on three major ideas of Confucianism – meritocracy, loyalty to superior, and separation of responsibilities – it is expected that consumers under the influence of Confucianism would perceive products from government-involved enterprises to have more desirable attributes and show preference for their company brands. Findings from an empirical study in the Chinese automobile (...) market support the hypotheses. The results suggest that small firms doing business in China would especially benefit from some association with the government. These results also provide managerial implications for enterprises in other countries with a Confucian cultural background. (shrink)

There seem to be cases where A believes p, and B believes not-p, but neither makes a mistake. This is known as faultless disagreement. According to the epistemic account, in at least some cases of faultless disagreement either A or B must believe something false, and the disagreement is faultless in the sense that each follows the epistemic norm. Recently, philosophers have raised various objections to this account. In this paper, I propose a new version of the epistemic account and (...) show how it can handle those objections. (shrink)

Objectives: To investigate the current situation of completing the informed consent for do-not-resuscitate (DNR) orders among the competent patients with terminal illness and the ethical dilemmas related to it. Participants: This study enrolled 152 competent patients with terminal cancer, who were involved in the initial consultations for hospice care. Analysis: Comparisons of means, analyses of variance, Student’s t test, χ2 test and multiple logistic regression models. Results: After the consultations, 117 (77.0%) of the 152 patients provided informed consent for hospice (...) care and DNR orders. These included 21 patients (17.9%) who signed the consent by themselves, and 96 (82.1%) whose consent sheet was signed only by family members. The reasons why patients were not involved in the discussions toward the consent (n = 82) included poor physical or psychological condition (44.9%), concerns of the consultant hospice team (37.2%), and the family’s refusal (28.2%). On a multivariate analysis, patients’ awareness of their poor prognosis (odds ratio = 4.07, 95% confidence interval = 2.05 to 8.07) and their understanding of hospice care (2.27, 1.33 to 3.89) were two independent factors (p<0.01) that influenced their participation in the discussions or their personal signature in the informed consent. Conclusion: The family-oriented culture in Asian countries may violate the principles of the Patient Self-Determination Act and the requirements of the Hospice Care Law in Taiwan, which inevitably poses an ethical dilemma. Earlier truth-telling and continuing education of the public by hospice care workers will be helpful in solving such ethical dilemmas. (shrink)

Seeking an alternative metaphysical view to anthropocentrism, which problematically places humans at the center of nature, Brasovan brings together the Neo-Confucian Wang Fuzhi’s account with ecological humanism. He aims to contribute a view of humans and nature that consists of continuous, dynamic and complex systems. Through critically engaging Brasovan’s account, I discuss Wang’s anti-anthropocentric metaphysics, his qi monism, and the spiritual side of his philosophy. I then criticize Brasovan’s project on two accounts: his categorization of Wang’s qi monism as materialism (...) (with provisos) and his lack of discussion of anthropocentric concepts in Wang’s philosophy. Lastly, I draw the reader’s attention to the rich resources presented by Wang, who witnesses and partakes in the interaction amongst the Confucian, Daoist, and Buddhist traditions; I also emphasize the significance and promises brought by Brasovan’s approach of engaging Neo-Confucian thinkers with modern philosophical concerns such as the demand of ecological humanism. (shrink)

Stewart Shapiro has objected to the epistemicist theory of vagueness on grounds that it gives counterintuitive predictions about cases involving conditional obligation. This paper details a response on the epistemicist’s behalf. I first argue that Shapiro’s own presentation of the objection is unsuccessful as an argument against epistemicism. I then reconstruct and offer two alternative arguments inspired by Shapiro’s considerations, and argue that these fail too, given the information-sensitive nature of conditional obligations.

In this paper, I survey some recent literature produced by the established Chinese philosophers who regularly publish in Chinese philosophy journals and work in Mainland China. Specifically, I review the recent research of these philosophers in two areas: Chinese Philosophy and epistemology. In each area, I focus on two topics that have caught the attention of a lot of Chinese philosophers. I argue that the Chinese philosophers’ research on these topics has two prevalent problems: (i) a lot of arguments they (...) make are weak; (ii) they tend not to critically engage with others. I discuss a metaphilosophical objection that weak argumentation and disengagement are not vices of philosophical research. I also try to make sense of (i) and (ii) in terms of some cultural factors. (shrink)

Is corporate social responsibility linked to performance-related instrumentality or real moral concerns? Does CSR create resource advantages? Reasons for and results of CSR remain unclear. We choose a leading retail company in a Confucian, collectivist, and high power distance society and ask whether managers are naturally oriented toward societal actions. We study managerial perceptions regarding the importance and the performance of CSR in relation to other management factors. Drawing on Hunt's ) resource advantage theory, we find that the perceived importance (...) of CSR is only fair vis-à-vis other management factors, but its high performance makes it a core resource for the company. (shrink)