Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double‐stranded RNA (dsRNA) base pairs. However, the criteria for recognizing nonself dsRNAs are rather lenient, and hairpin structure of self‐RNAs can also trigger an immune response. Consequently, aberrant activation of RNA sensors has (...) been reported in numerous human diseases. Yet, in most cases, the activating antigens remain unknown. Recent studies have developed sequencing techniques tailored to specifically capture dsRNAs and identified that various noncoding elements in the nuclear and the mitochondrial genome can generate dsRNAs. Here, the identity of endogenous dsRNAs, their recognition by dsRNA sensors, and their implications in the pathogenesis of human diseases ranging from inflammatory to degenerative are presented. (shrink)

Morality seems important, in the sense that there are practical reasons — at least for most of us, most of the time — to be moral. A central theoretical motivation for consequentialism is that it appears clear that there are practical reasons to promote good outcomes, but mysterious why we should care about non-consequentialist moral considerations or how they could be genuine reasons to act. In this paper we argue that this theoretical motivation is mistaken, and that because many arguments (...) for consequentialism rely upon it, the mistake substantially weakens the overall case for consequentialism. We argue that there is indeed a theoretical connection between good states and reasons to act, because good states are those it is fitting to desire and there is a conceptual connection between the fittingness of a motive and reasons to perform the acts it motivates. But while some of our motives are directed at states, others are directed at acts themselves. We contend that just as the fittingness of desires for states generates reasons to promote the good, the fittingness of these act-directed motives generates reasons to do other things. Moreover, we argue that an act’s moral status consists in the fittingness of act-directed feelings of obligation to perform or avoid performing it, so the connection between fitting motives and reasons to act explains reasons to be moral whether or not morality directs us to promote the good. This, we contend, de-mystifies how there could be non-consequentialist reasons that are both moral and practical. (shrink)

This book argues that the meaning of negation, perhaps the most important logical constant, cannot be defined within the framework of the most comprehensive theory of proof-theoretic semantics, as formulated in the influential work of Michael Dummett and Dag Prawitz. Nils Kürbis examines three approaches that have attempted to solve the problem - defining negation in terms of metaphysical incompatibility; treating negation as an undefinable primitive; and defining negation in terms of a speech act of denial - and concludes that (...) they cannot adequately do so. He argues that whereas proof-theoretic semantics usually only appeals to a notion of truth, it also needs to appeal to a notion of falsity, and proposes a system of natural deduction in which both are incorporated. Offering new perspectives on negation, denial and falsity, his book will be important for readers working on logic, metaphysics and the philosophy of language. (shrink)

Truth is one of the most debated topics in philosophy; Wolfgang Kunne presents a comprehensive critical examination of all major theories, from Aristotle to the present day. He argues that it is possible to give a satisfactory 'modest' account of truth without invoking problematic notions like correspondence, fact, or meaning. The clarity of exposition and the wealth of examples will make Conceptions of Truth an invaluable and stimulating guide for advanced students and scholars.

ABSTRACT Early modern alchemy studied both matter and life, much like today's life sciences. What material life is and how it comes about intrigued alchemists. Many found the answer by assuming a vital principle that served as the source and cause of life. Recent literature has presented important cases in which vitalist formulations incorporated corpuscular or mechanical elements that were characteristic of the New Science and other cases in which vitalist thinking influenced important figures of the Scientific Revolution. Not merely (...) speculative, vitalist ideas also motivated chymical practice. The unity of life science and material science that is found in many formulations of Renaissance alchemy disintegrated in Georg Ernst Stahl's version of post-Cartesian vitalism. (shrink)

At the end of section §6 in the Analytic of the Beautiful, Kant defines taste as the “faculty for judging an object or a kind of representation through a satisfaction or dissatisfaction without any interest”. On the face of it, Kant’s definition of taste includes both; positive and negative judgments of taste. Moreover, Kant’s term ‘dissatisfaction’ implies not only that negative judgments of taste are those of the non-beautiful, but also that of the ugly, depending on the presence of an (...) actual displeasure. (shrink)

This paper examines Georg Ernst Stahl's first book, the Zymotechnia Fundamentalis, in the context of contemporary natural philosophy and the author's career. I argue that the Zymotechnia was a mechanical theory of fermentation written consciously against the influential "fermentational program" of Joan Baptista van Helmont and especially Thomas Willis. Stahl's theory of fermentation introduced his first conception of phlogiston, which was in part a corpuscular transformation of the Paracelsian sulphur principle. Meanwhile some assumptions underlying this theory, such as the composition (...) of matter, the absolute passivity of matter and the "passions" of sulphur, reveal the combined scholastic and mechanistic character of Stahl's natural philosophy. In the conclusion I show that Stahl's theory of fermentation undermined the old fermentational program and paved the way for his dualist vitalism. (shrink)

En radicalisant le projet d'une phénoménologie de l'affectivité, en interrogeant l'abîme intérieur de l'éprouver, et en y resaissisant la source de toute création possible, cet ouvrage fait de la question du pâtir le point de départ d'une nouvelle théorie de l'agir.

As the twentieth century draws to a close and the rush to globalization gathers momentum, political and economic considerations are crowding out vital ethical questions about the shape of our future. Now, Hans Kung, one of the world's preeminent Christian theologians, explores these issues in a visionary and cautionary look at the coming global society. How can the new world order of the twenty first century avoid the horrors of the twentieth? Will nations form a real community or continue to (...) aggressively pursue their own interests? Will the Machiavellian approaches of the past prevail over idealism and a more humanitarian politics? What role can religion play in a world increasingly dominated by transnational corporations? Kung tackles these and many other questions with the insight and moral authority that comes from a lifetime's devotion to the search for justice and human dignity. Arguing against both an amoral realpolitik and an immoral resurgence of laissez faire economics, Kung defines a comprehensive ethicfounded on the bedrock of mutual respect and humane treatment of all beingsthat would encompass the ecological, legal, technological, and social patterns that are reshaping civilization. If we are going to have a global economy, a global technology, a global media, Kung argues, we must also have a global ethic to which all nations, and peoples of the most varied backgrounds and beliefs, can commit themselves. "The world," he says, "is not going to be held together by the Internet." For anyone concerned about the world we are creating, A Global Ethic for Global Politics and Economics offers equal measures of informed analysis, compassionate foresight, and wise counsel. (shrink)

Highly intelligent... It is understandable while being scholarly and should be read by anyone seeking an overview of ethical history as it relates to the present. -- Church and Synagogue Library Association.

This book tells about the "History of Zen" in China and Japan. It has altogether 16 chapters. The first eight chapters are about Zen in China and the later eight chapters about Zen in Japan. It is mainly concerned with a detailed account of inheriting lineage and sermons of different Zen schools and sects in China and Japan as well as the specific facts of Chinese monks crossing over to Japan for preaching and Japanese monks coming to China for studying. (...) Chan (Zen) Buddhism first arose in China some fifteen hundred years ago, with Bodhidarma or Daruma being the First Patriarch. It would go on to become the dominant form of Buddhism in China in the late Tang Dynasty, absorbing China's local culture to form a kind of Zen Buddhism with Chinese characteristics. Zen Buddhism has not only exerted considerable influence on Chinese society and culture throughout its history, but has also found its way into Japan and the Democratic People's Republic of Korea. The lineage charts at the end of the book, collected by the author from different corners of the world, represent an invaluable resource. Further, the works and views on Zen of Western scholars introduced in this book are of great reference value for the Zen world. (shrink)

Les uns sont fascinés par la hardiesse et la constance de sa pensée, les autres la rejettent au motif que sa métaphysique est extravagante et son raisonnement obscur. Mais alors, quel profit tirer de la lecture de l'œuvre de Plotin? Mieux que tout autre, Plotin réussit à faire le point sur les doctrines philosophiques qui l'ont précédé, y compris le scepticisme. Et il y parvient avec une perspicacité et une originalité exceptionnelles, tout en restant un strict partisan du platonisme. Interpréter (...) Plotin dans sa confrontation avec ses prédécesseurs, c'est prendre part à un passionnant débat et soumettre à une évaluation les acquis et les limites de chacun. Telle est la démarche à laquelle invite ce livre qui est consacré à la théorie du savoir. Après que le doute sceptique ait ébranlé les théories antérieures, Plotin innove en faisant coïncider savoir objectif et connaissance de soi. Ce geste théorique, ses antécédents et ses conséquences sont au cœur de ce travail de recherche"--P. [4] of cover. (shrink)