The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy‐related proteins. Activation of Atg1 followed by recruitment of both Atg9 vesicles and the PI3K complex I to the PAS (phagophore assembly site) are particularly crucial steps in its formation. Ypt1, a small Rab GTPase in yeast cells, also plays an essential role in the formation of the autophagy initiation complex through multiple regulatory (...) pathways. In this review, our primary focus is to discuss how signaling molecules initiate the assembly of the autophagy initiation complex, and highlight the significant roles of Ypt1 in this process. We end by addressing issues that need future clarification. (shrink)

In the analysis of Shaanxi Red Tourism Development status and existing problems, based on the proposed development of red tourism strategic positioning, strategic objectives and strategic measures, through the implementation of the "1312 Project", that is to cultivate a red tourism capital, northern Shaanxi, Guanzhong , 3 large red tourism sector in southern Shaanxi, and 12 fine line, as the red following the Warriors travel to create a new ace after the Shaanxi tourism products. Based on the analysis of the (...) current situation of Shaanxi red-tourism development, strategic positioning, goals and corresponding measures of developing Shaanxi red-tourism are put forward. Through implementing the project of 1312, which stands for one red-tourism center, three red -tourism regions and twelve red-tourism routes, the red-tourism products of Shaanxi would become new trump tourism products. (shrink)

This study explored the relationship among the emotional labor, psychological capital, and mental health of preschool teachers. A questionnaire survey was conducted on 411 preschool teachers in China. The results revealed the following: One emotional labor strategy had a significant negative effect on mental health, whereas two emotional labor strategies had significant positive effects. The psychological capital of preschool teachers had a complete mediation on the relationship between expression of naturally felt emotions and mental health and between the deep acting (...) and mental health. (shrink)

Philosophers are now wary of conflating the “fittingness” or accuracy of an emotion with any form of moral assessment of that emotion. Justin D’Arms and Daniel Jacobson, who originally cautioned against this “conflation”, also warned philosophers not to infer that an emotion is inaccurate from the fact that feeling it would be morally inappropriate, or that it is accurate from the fact that feeling it would be morally appropriate. Such inferences, they argue, risk committing “the moralistic fallacy”, a mistake they (...) claim is widespread throughout the work of contemporary and historical moral philosophers. I argue that many basic and familiar forms of moral assessment of the emotions are not subject to these arguments. I illustrate this by reconsidering the idea that to assess an emotion as “fitting” is to assess it as what a virtuous person would feel. After showing how assessments akin to this “virtue-theoretical” notion of fit may be prevalent even outside of the Aristotelian tradition, I suggest some more charitable and philosophically productive interpretations of the philosophical views of the emotions that D’Arms and Jacobson criticize, and argue that we cannot coherently theorize about the fittingness conditions of the emotions in a morally neutral way. (shrink)

兩甲子前，中國戰敗於日本，儒家士大夫遂尋求全面制度變革，行之數千年的堯舜周孔治理之道被棄如敝屣。此後百年，雖有仁人志士守護道統，復興儒學，唯多局限於精神、道德、文化領域，以為儒家未曾塑造、維護良好秩序 ，更不可能行於當世。 本書作者卻力排眾議，為當前中國之制度變革提出「儒家憲政」方案。作者認為，一國憲政當扎根於自身文明，儒家在中國文明中具有特殊地位，這决定了中國憲政必為儒家憲政。 本書上卷「義理」，參考中國數千年的治理實踐，疏解儒家經典，闡明常在常新的中國治理之道；下卷「更化」，探討當下中國通往儒家憲政之路。作者並不準備提出整全的憲制方案，反而保持充分開放的心態。作者認為，唯有 歸宗道統，中國之政治秩序才可趨於良善、穩定，但「人能弘道」，當世君子不能不因時而立制，為此不能不廣泛參照西方的法度。 故「儒家憲政」既不同於自由民主憲政或社會主義憲政，亦有別於「儒教憲政」。作者以為，前者無視中國文明傳統、憑空立憲，而失之於「不及」；後者「生乎今之世，反古之道」，而失之於「過」。儒家憲政中道而行，或可 供有志於治國平天下的賢明君子採擇一二。.

TikTok has one of the most advanced algorithm systems and is the most addictive as compared to other social media platforms. While research on social media addiction is abundant, we know much less about how the TikTok information system environment affects users’ internal states of enjoyment, concentration, and time distortion, which in turn influences their addiction behavior. To fill this gap, this study collects responses from 659 adolescents in China aged between 10 and 19 years old, and the data is (...) then analyzed using Partial Least Square. We find that the system quality has a stronger influence than information quality in determining adolescents’ experience with TikTok and that the flow experience has significant direct and indirect effects on TikTok addiction behavior. Notably, this study finds that TikTok addiction is determined by users’ mental concentration on the medium and its content. Several theoretical insights from the stimulus–organism–response model and the flow theory are used to explain the findings. (shrink)

Les questions d’éthique reviennent aujourd’hui avec force dans les sciences sociales en général et en sociologie en particulier. Cet article met en évidence les écueils que doivent éviter les comités d’éthique de la recherche universitaire dans le domaine des sciences sociales. L’auteur soutient que les écueils en question ne peuvent aisément être évités que par le dialogue entre les principaux acteurs concernés. En dernière analyse, dit l’auteur, le rôle des comités d’éthique de la recherche universitaire doit être d’assurer l’éducation à (...) l’éthique à travers un débat démocratique au sein de la communauté universitaire. (shrink)

Ces textes sont ceux d'un artiste engagé dans la société et d'un critique affirmé. Ils abordent des thématiques fondamentales: le rapport de l'artiste avec son sujet de travail, la lecture explicative de textes littéraires et le dialogue avec les auteurs, le questionnement sur les fondements des manifestations culturelles en société. Mais ils évoquent aussi des aspects plus régionaux, avec un entretien sur un rite de société, l'explication de quelques fondamentaux de la musique en Afrique, un historique des arts visuels en (...) Côte d'Ivoire et au Togo. Ils ne pouvaient se clore que par l'analyse des corrélations entre fonds et formes, pour trouver et déterminer des évidences plastiques. (shrink)

戴震（1723—1777），字东原，休宁隆阜（今安徽黄山屯溪）人，清代著名思想家。全书考察了戴震心理学思想的历史背景及其来源，探讨了戴震心理学思想的基本观点，阐述了戴震的认知心理、人格心理、教育心理以 及品德心理等方面的基本思想和历史影响。戴震的心理学思想植根于中国历史与文化，具有理论的基础性、思想的民族性和时代的传承性，对中国心理学研究具有重要意义和启示。本书是目前国内第一本对戴震心理学思想全面系 统研究的学术著作。.

In [16], Peterzil and Steinhorn proved that if a group G definable in an o-minimal structure is not definably compact, then G contains a definable torsion-free subgroup of dimension 1. We prove here a p-adic analogue of the Peterzil–Steinhorn theorem, in the special case of abelian groups. Let G be an abelian group definable in a p-adically closed field M. If G is not definably compact then there is a definable subgroup H of dimension 1 which is not definably compact. (...) In a future paper we will generalize this to non-abelian G. (shrink)

As with certain other self-reflexive emotions, such as guilt and shame, our understanding of self-hatred may be aided by views of the mind which posit an internalized other whose perspective on oneself embodies and focuses a set of concerns and values, and whose perspective one is in some sense vulnerable to. To feel guilt for some transgression is not solely to feel the anger that one would feel toward another’s trespasses, now directed back onto oneself as an object of that (...) anger; it is at the same time to react to that anger – perhaps, for example, to accept it as deserved, or to welcome the lashing of one’s bad conscience. To feel shame before oneself is not just to see oneself in some compromising way, it is to feel compromised by one’s own gaze. Likewise, the person who hates herself does not feel the hatred that she might have for another, simply taking herself as object of that attitude. She is not merely the seat of an internalized hostile voice and perspective that she may, for example, react to with indifference. She does not only tell herself that she is “worthless” but, will typically feel herself so in response. And her suffering may not just result from pain she is inclined to inflict, but suffering that, in some sense, she is inclined to suffer. But how is this so? How, in self-hatred, does one become not only subject to, but vulnerable and even receptive to one’s own hostility? (shrink)

Buddhist teachings and practices can be viewed as a journey of soteriological transformation, where language, as a tool for the analysis of views, occupies a place of special significance and importance. This article examines how the concept of non-duality, from the Madhyamaka perspective, has served as a powerful rhetorical device with the explicit aim of fostering soteriological transformation. Among the various expressions representative of the Madhyamaka perspective, two are particularly explored in this article for their facilitation of soteriological transformation: the (...) expression of ‘neither a dharma nor a not-dharma’ and the teaching that ‘one should let go even of dharmas, still more so not-dharmas’ . I argue that the Madhyamaka expression of ‘neither A nor not-A’ is hardly ever just about conforming to any linguistic conventions. It is about gaining liberation from linguistic conventions and unexamined remarks. (shrink)

Richard Rorty's philosophy has two basic commitments: one to postmodernism and the other to liberalism. However, these commitments generate tension. As a postmodernist, he sharply criticizes the Enlightenment; as a liberal, he forcefully defends it. His postmodernist liberalism actually explains liberalism using irrationalism. /// 罗蒂哲学有两个基本承诺，一个是对后现代主义的承诺，一个是对自由主义 的承诺。但是这两种承诺之间存在着紧张关系: 作为后现代主义者，罗蒂对启蒙提 出了强烈的批评; 作为自由主义者，他又在极力地维护启蒙。罗蒂的后现代自由主 义实质上是以非理性主义来解释自由主义。.

This article aims to summarize the current ethical issues in the field of clinical and counseling psychology and the process of developing professional ethical standards in China. First, through a review of the history of counseling and psychotherapy in China, general background information is provided. Important ethical issues are then discussed based on the results from several empirical studies. Finally, the process of developing the new edition of the Chinese Psychological Society Code of Ethics for Clinical and Counseling Psychology, the (...) main contents as well as the considerations taken into account in the development of this code are presented. (shrink)

Objectives: Athlete burnout is a crucial concern affecting the development and athletic performance of young weightlifters. To reduce or relieve the prevalence of athlete burnout, this study examined the relationship across social support, sports motivation, mental toughness, and athlete burnout in weightlifters.Methods: A total of 315 weightlifters aged 17–28 years old from Sichuan, Chongqing, and Shanxi in China participated in this survey. The Perceived Available Support in Sport Questionnaire, Sports Motivation Questionnaire, Sports Mental Toughness Questionnaire, and Athlete Burnout Questionnaire were (...) used in this study. SPSS Statistics 19.0, AMOS 21.0, and PROCESS 3.0 macro were used to analyze the collected data.Results: The results indicated that weightlifters’ social support could negatively significantly affect athlete burnout [beta = −0.398; 95% confidence interval : −0.3699, −0.2184; P < 0.05) via mental toughness and sports motivation. The mediation analysis revealed that they had partial mediating effect, including three paths: First, social support had a direct effect on athlete burnout ; second, sport mental toughness had a mediating effect on athlete burnout ; and finally, sports motivation had a mediating effect on athlete burnout.Conclusion: The findings revealed that social support could inhibit or prevent athlete burnout via mental toughness and sports motivation; thus, to decrease or relieve the prevalence of burnout in weightlifters, it is an important solution to enhance their social support. (shrink)

本书定位于后现代知识论研究,以科学知识作为主要考察对象,通过系统梳理知识权力研究的若干思想资源,重点探讨知识的权力属性及知识,权力二者之间的密切关联,力图从马克思主义哲学的高度揭示当代知识生产的现状及 内在本质,促动人们反思通过知识获得自由与解放的可能性,正当性及紧迫性.

This book comprises 30 chapters representing certain new trends in reconcenptualizing Confucian ideas, ideals, values and ways of thinking by scholars from China and abroad. While divergent in approaches, these chapters are converged on conceptualizing and reconceptualizing Confucianism into something philosophically meaningful and valuable to the people of the 21st century. They are grouped into three parts, and each is dedicated to one of the three major themes this book attempts to address. Part one is mainly on scholarly reviews of (...) Confucian doctrines by which new interpretations will be drawn out. Part two is an assembled attempt to reexamine Confucian concepts, in which critiques of traditional views lead to new perspectives for perennial questions. Part three is focused on reinterpreting Confucian virtues and values, in the hope that a new sense of being moral can be gained through old normative forms. (shrink)

This article argues that current data for the safety and efficacy of fecal microbiota transplants as a treatment for any indication, including recurrent Clostridioides difficile infection, is low-quality. It develops a governance proposal that encourages production of high-quality evidence by incentivizing well-designed RCTs of stool and stoolderived microbial products. The proposal would require that FDA change its current enforcement approach, but it would not require any change in statutes or regulations.

In his article "Marxism and Revisionism," Lenin pointed out that Marxist theory "had to fight at every step in its journey of life." The history of the development of Marxism is one of the struggle against streams of various socialist ideas. Marxism developed in the struggle. In the 1840s Germany was on the eve of a bourgeois democratic revolution. In order to mobilize the proletariat and the broad masses of the people to participate in the impending democratic revolution, the bourgeoisie (...) had first of all to bring the theory of revolution into the workers' movement, combine the theory of revolution with the workers' movement, and found a proletarian revolutionary party on the basis of this combination. However, at that time, not only in France and Britain but also in Germany there were various socialist schools and ideas and "genuine socialism" was one of the influential socialist schools. Up to 1864 the "genuine socialists" vigorously disseminated their philistine viewpoint in the Union of Justice Advocates and hindered the founding of a proletarian revolutionary party. In order to arm the proletariat with the theory of revolution, win over the Union of Justice Advocates to their side, and turn the union into a real proletarian revolutionary party which would be armed with scientific socialism, Marx and Engels put up a firm struggle against various socialist schools which were hostile to scientific socialism, particularly against "genuine socialism," which had great influence in the Union of Justice Advocates, and theoretically smashed the "genuine socialist" school. In this struggle, Marx and Engels exposed the real class nature of the philistine theory, thoroughly refuted its erroneous viewpoints, particularly the "genuine socialist" flapdoodle about "love," smashed this school, and eliminated this school's evil effects on the workers' movement. Today it is still highly pertinent for us to study the writings and letters of Marx and Engels during the struggle. (shrink)