Results for 'clinical research'

1000+ found
Order:
  1. Clinical research: Should patients pay to play?Ezekiel J. Emanuel, Steven Joffe, Christine Grady, David Wendler & Govind Persad - 2015 - Science Translational Medicine 7 (298):298ps16.
    We argue that charging people to participate in research is likely to undermine the fundamental ethical bases of clinical research, especially the principles of social value, scientific validity, and fair subject selection.
    Direct download  
     
    Export citation  
     
    Bookmark   3 citations  
  2.  70
    Developing Clinical Research Relationship: Views from Within.Olga Zvonareva & Lloyd Akrong - 2015 - Developing World Bioethics 15 (3):257-266.
    The nature of the relationship between clinical investigator and research participant continues to be contested. The related discussions have largely focused on the doctor-researcher dichotomy thought to permeate the work of a clinical investigator with research participants, whom in turn occupy two corresponding roles: patient and subject. This paper contributes to current debates on the topic by providing a voice to research participants, whose perspectives have been largely invisible. It draws on 42 in-depth interviews conducted (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  3. Clinical Research Consultation: A Casebook.Marion Danis (ed.) - 2012 - Oxford University Press.
    Starting research -- Enrolling research participants -- Protecting research participants -- Conducting research with vulnerable populations -- Balancing clinical research and clinical care -- Navigating interpersonal difficulties -- Ending research.
    Direct download  
     
    Export citation  
     
    Bookmark   1 citation  
  4.  51
    Clinical research projects at a German medical faculty: follow-up from ethical approval to publication and citation by others.A. Blumle, G. Antes, M. Schumacher, H. Just & E. von Elm - 2008 - Journal of Medical Ethics 34 (9):e20-e20.
    Background: Only data of published study results are available to the scientific community for further use such as informing future research and synthesis of available evidence. If study results are reported selectively, reporting bias and distortion of summarised estimates of effect or harm of treatments can occur. The publication and citation of results of clinical research conducted in Germany was studied.Methods: The protocols of clinical research projects submitted to the research ethics committee of the (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   5 citations  
  5. Clinical Research Involving Pregnant Women.Françoise Baylis & Angela Ballantyne (eds.) - 2016 - Cham: Imprint: Springer.
    This book discusses 'how' to respectfully and responsibly include pregnant women in clinical research. In sharp contrast, the existing literature predominantly focuses on the reasons 'why' the inclusion of pregnant women in clinical research is necessary - viz., to develop effective treatments for women during pregnancy, to promote fetal safety, to reduce harm to women and fetuses from suboptimal care, and to allow access to the benefits of research participation. This book supports the shift to (...)
    No categories
     
    Export citation  
     
    Bookmark  
  6.  20
    Monitoring Clinical Research: An Obligation Unfulfilled.Charles Weijer, Stanley Shapiro, Abraham Fuks, Kathleen Cranley Glass & Myriam Skrutkowska - unknown
    The revelation that data obtained for the US-based National Surgical Adjuvant Breast and Bowel Project (NSABP) from subjects enrolled at Hôpital Saint-Luc in Montreal was falsified has eroded public trust in research. Institutions can educate researchers and help prevent unethical research practices by establishing procedures to monitor research involving human subjects. Research monitoring encompasses four categories of activity: annual reviews of continuing research, monitoring of informed consent, monitoring of adherence to approved protocols and monitoring of (...)
    Direct download  
     
    Export citation  
     
    Bookmark   8 citations  
  7.  10
    The Clinical Research. A first approach.Tatiana Marañon Cardonne & León Robaina - 2015 - Humanidades Médicas 15 (1):163-184.
    La investigación clínica es la actividad encaminada a conocer el resultado de una intervención o un producto para el diagnóstico o la terapéutica en los seres humanos. El ensayo clínico es el principal exponente de la investigación clínica y toda evaluación experimental de una sustancia o medicamento en seres humanos. En Cuba, existe un desarrollo importante de la biotecnología y de los centros de investigación que necesitan de ensayos clínicos según estándares nacionales e internacionales. En el presente trabajo se exponen (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  8.  39
    Rethinking the Ethics of Clinical Research: Widening the Lens.Alan Wertheimer - 2010 - Oxford University Press.
    Introduction -- Facing up to paternalism in research ethics -- Preface to a theory of consent transactions in research : beyond valid consent -- Should we worry about money? -- Exploitation in clinical research -- The interaction principle.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   33 citations  
  9.  34
    Clinical research with economically disadvantaged populations.C. C. Denny & C. Grady - 2007 - Journal of Medical Ethics 33 (7):382-385.
    Concerns about exploiting the poor or economically disadvantaged in clinical research are widespread in the bioethics community. For some, any research that involves economically disadvantaged individuals is de facto ethically problematic. The economically disadvantaged are thought of as “venerable” to exploitation, impaired decision making, or both, thus requiring either special protections or complete exclusion from research. A closer examination of the worries about vulnerabilities among the economically disadvantaged reveals that some of these worries are empirically or (...)
    Direct download (8 more)  
     
    Export citation  
     
    Bookmark   18 citations  
  10. The Oxford Textbook of Clinical Research Ethics.Ezekiel J. Emanuel (ed.) - 2008 - Oxford University Press.
    Comprehensive in scope and research, this book will be a crucial resource for researchers in the medical sciences, as well as teachers and students alike.
    Direct download  
     
    Export citation  
     
    Bookmark   27 citations  
  11.  78
    Ethics and Regulation of Clinical Research.Robert J. Levine - 1986 - Urban & Schwarzenberg.
    In this book, Dr. Robert J. Levine reviews federal regulations, ethical analysis, and case studies in an attempt to answer these questions.
    Direct download  
     
    Export citation  
     
    Bookmark   113 citations  
  12. Clinical Research on the Subject with Dementia.Nina M. Mirarchi - 2005 - Penn Bioethics Journal 1 (1).
     
    Export citation  
     
    Bookmark  
  13. Clinical research in plastic surgery.B. Coghlan - forthcoming - Bulletin of Medical Ethics.
     
    Export citation  
     
    Bookmark  
  14.  10
    Clinical research: up from 'clinical epidemiology'.Olli S. Miettinen, Lucas M. Bachmann & Johann Steurer - 2009 - Journal of Evaluation in Clinical Practice 15 (6):1208-1213.
    Clinical research must be understood to be the foundation of scientific medicine of the clinical type. But the essence of scientific clinical medicine remains a matter of profound confusion, even in clinical academia, and so does the essence of clinical research. The confusion now revolves, principally, around ‘clinical epidemiology’. We address clinical research in the meaning of quintessentially ‘applied’ clinical research, which we take to be the foundation of (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  15. Clinical research and the physician–patient relationship: the dual roles of physician and researcher.Nancy Mp King & Larry R. Churchill - 2008 - In Peter A. Singer & A. M. Viens (eds.), The Cambridge Textbook of Bioethics. Cambridge University Press.
     
    Export citation  
     
    Bookmark   1 citation  
  16.  8
    Clinical research should not be permitted to escape the ethical orbit of clinical care.David Steinberg - 2002 - American Journal of Bioethics 2 (2):27 – 28.
    (2002). Clinical Research Should Not Be Permitted to Escape the Ethical Orbit of Clinical Care. The American Journal of Bioethics: Vol. 2, No. 2, pp. 27-28.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  17.  6
    For clinical research: a formula for improved prognosis.K. A. Gruber - 1988 - Perspectives in Biology and Medicine 31 (4):612.
  18. Consent in Clinical Research.Collin O'Neill - 2018 - In Andreas Müller & Peter Schaber (eds.), The Routledge Handbook of the Ethics of Consent. New York, USA: Routledge. pp. 297-310.
    This article addresses two areas of continuing controversy about consent in clinical research: the question of when consent to low risk research is necessary, and the question of when consent to research is valid. The article identifies a number of considerations relevant to determining whether consent is necessary, chief of which is whether the study would involve subjects in ways that would (otherwise) infringe their rights. When consent is necessary, there is a further question of under (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  19.  21
    Conducting clinical research in polish conditions.Marek Labon - 2006 - Science and Engineering Ethics 12 (1):185-188.
    This paper comments on Polish legal guarantees for diseased persons with reference to the hazards that accompany experimental treatment. While acknowledging that participation in a clinical research program provides patients with additional opportunities for advanced treatment, the paper also points out that systems for monitoring patients participating in experimental treatment require improvement.
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  20.  81
    Contextualizing clinical research: The epistemological role of clinical equipoise.James A. Anderson - 2009 - Theoretical Medicine and Bioethics 30 (4):269-288.
    Since its introduction in 1987, Benjamin Freedman’s principle of clinical equipoise has enjoyed widespread uptake in bioethics discourse. Recent years, however, have witnessed a growing consensus that the principle is fundamentally flawed. One of the most vocal critics has undoubtedly been Franklin Miller. In a 2008 paper, Steven Joffe and Miller build on this critical work, offering a new conception of clinical research ethics based on science, taking what they call a “scientific orientation” toward the ethics of (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  21.  20
    Clinical Research in Context: Reexamining the Distinction between Research and Practice.J. A. Anderson - 2010 - Journal of Medicine and Philosophy 35 (1):46-63.
    At least since the seminal work of the (US) National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in the 1970s, a fundamental distinction between research and practice has underwritten both conceptual work in research ethics and regulations governing research involving human subjects. Notwithstanding its undoubted historical importance, I believe the distinction is problematic because it misrepresents clinical inquiry. In this essay, I aim to clarify the character of clinical inquiry (...)
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  22.  9
    Is Clinical Research and Ethics a Zero-sum Game?Charles Weijer - unknown
    Direct download  
     
    Export citation  
     
    Bookmark  
  23.  3
    Clinical research involving children.R. E. Kauffman - 2000 - Bioethics Forum 16 (4):45.
    Direct download  
     
    Export citation  
     
    Bookmark  
  24.  4
    Clinical Research: Auditory Stimulation in the Disorders of Consciousness.Jiajie Zhu, Yifan Yan, Wei Zhou, Yajun Lin, Zheying Shen, Xuanting Mou, Yan Ren, Xiaohua Hu & Haibo Di - 2019 - Frontiers in Human Neuroscience 13.
  25.  28
    Can Clinical Research Be Both Ethical and Scientific? A Commentary inspired by Rosser and Marquis.Helen Bequaert Holmes - 1989 - Hypatia 4 (2):156-168.
    Problems with clinical research that create conflicts between doctors' therapeutic and research obligations may be fueled by a rigid view of science as determiner of truth, a heavy reliance on statistics, and certain features of randomized clinical trials. I suggest some creative, feminist approaches to such research and explore ways to provide choice for patients and to use values in directing both therapy and science - to enhance the effectiveness of each.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  26.  9
    Clinical Research Subject Selection during Public Health Disasters: Reconceptualizing Fairness in a Global Ethical Context.Ikeolu O. Afolabi, Stephen O. Sodeke & Michael O. S. Afolabi - 2020 - American Journal of Bioethics 20 (2):38-41.
    Volume 20, Issue 2, February 2020, Page 38-41.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  27.  16
    Reasonable Risks In Clinical Research: A Critique and a Proposal for the Integrative Approach.Alex John London - unknown
    Before participants can be enrolled in a clinical trial, an institutional review board must determine that the risks that the research poses to participants are ‘reasonable.’ This paper examines the two dominant frameworks for assessing research risks and argues that each approach suffers from significant shortcomings. It then considers what issues must be addressed in order to construct a framework for risk assessment that is grounded in a compelling normative foundation and might provide more operationally precise guidance (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   17 citations  
  28. Clinical research law in Jordan: An ethical analysis.Ibrahim Ramahi & Henry Silverman - 2009 - Developing World Bioethics 9 (1):26-33.
  29.  30
    The Clinical Research of Nanomedicine: A New Ethical Challenge?Urban Wiesing & Jens Clausen - 2014 - NanoEthics 8 (1):19-28.
    Nanomedicine promises unprecedented innovations for diagnosis and therapy as well as for predicting and preventing diseases. On the other hand it raises fears linked to new and unknown characteristics of nanoscale materials. Both, promises and fears, are closely linked to the realm of uncertainty. To a large extent it is currently not known which expectations could become reality and which suspected adverse events might come true. Medicine is quite familiar with decision-making under uncertainty. Rules and regulations for clinical (...) have been developed to reduce possible harm for research participants without abandoning necessary investigations. Here we examine whether clinical research trials of nanomedicine need new regulations and conclude that the established rules should suffice. (shrink)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  30.  46
    Clinical research methods for the new millennium.Bruce G. Charlton Md - 1999 - Journal of Evaluation in Clinical Practice 5 (2):251-263.
  31.  28
    Innovative Practice, Clinical Research, and the Ethical Advancement of Medicine.Jake Earl - 2019 - American Journal of Bioethics 19 (6):7-18.
    Innovative practice occurs when a clinician provides something new, untested, or nonstandard to a patient in the course of clinical care, rather than as part of a research study. Commentators have noted that patients engaged in innovative practice are at significant risk of suffering harm, exploitation, or autonomy violations. By creating a pathway for harmful or nonbeneficial interventions to spread within medical practice without being subjected to rigorous scientific evaluation, innovative practice poses similar risks to the wider community (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   18 citations  
  32. International Clinical Research and Justice in the Belmont Report.Joseph Millum - 2020 - Perspectives in Biology and Medicine 63 (2):374-388.
    The Belmont Report was written by a US Commission charged by the US Congress to advise on research supported by the US government. Its focus was understandably domestic. In the 40 years since its publication, clinical research has become increasingly international. Many clinical trials have sites in multiple countries, and many of the host countries are relatively impoverished. Such research raises some distinctive ethical issues. This paper outlines some of the key ethical challenges that have (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  33.  32
    Clinical research without consent in adults in the emergency setting: a review of patient and public views. [REVIEW]Jan Lecouturier, Helen Rodgers, Gary A. Ford, Tim Rapley, Lynne Stobbart, Stephen J. Louw & Madeleine J. Murtagh - 2008 - BMC Medical Ethics 9 (1):9.
    In emergency research, obtaining informed consent can be problematic. Research to develop and improve treatments for patients admitted to hospital with life-threatening and debilitating conditions is much needed yet the issue of research without consent (RWC) raises concerns about unethical practices and the loss of individual autonomy. Consistent with the policy and practice turn towards greater patient and public involvement in health care decisions, in the US, Canada and EU, guidelines and legislation implemented to protect patients and (...)
    Direct download (11 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  34.  81
    Exploitation in clinical research.Alan Wertheimer - 2008 - In Ezekiel J. Emanuel (ed.), The Oxford Textbook of Clinical Research Ethics. Oxford University Press. pp. 201--10.
    Direct download  
     
    Export citation  
     
    Bookmark   18 citations  
  35.  66
    Reframing Consent for Clinical Research: A Function-Based Approach.Scott Y. H. Kim, David Wendler, Kevin P. Weinfurt, Robert Silbergleit, Rebecca D. Pentz, Franklin G. Miller, Bernard Lo, Steven Joffe, Christine Grady, Sara F. Goldkind, Nir Eyal & Neal W. Dickert - 2017 - American Journal of Bioethics 17 (12):3-11.
    Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions. The first (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   50 citations  
  36.  4
    Ethics status of clinical research and trials in developing countries.Yuanyuan Liu - 2015 - Eubios Journal of Asian and International Bioethics 25 (4):124-127.
    With the development of economic globalization, more and more clinical research and trials shift from developed countries to developing countries. The globalization of clinical trials also brings some ethical and scientific concerns. This paper discussed some ethical problems of clinical trials in the developing countries including 1) "golden rice" event in China; 2) Informed consent in clinical trials in developing countries; 3) Ethical consciousness in clinical research and trials in developing countries. The essay (...)
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  37.  18
    Clinical Research Involving Pregnant Women ed. by Françoise Baylis and Angela Ballantyne. [REVIEW]Elizabeth Victor - 2019 - International Journal of Feminist Approaches to Bioethics 12 (1):175-179.
    As a feminist bioethicist, I have frequently wondered why the exclusion of pregnant women has been the default position for most clinical research and how social values have influenced this decision. Relatedly, I wonder what responsible research involving pregnant women would look like. As a theorist who conducts research on the concept of vulnerability, I have often wanted to know why there has been so little research into the harmful effects of the routine exclusion of (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  38.  14
    Clinical Research in Times of Pandemics.S. -A. Chong, B. J. Capps, M. Subramaniam, T. C. Voo & A. V. Campbell - 2010 - Public Health Ethics 3 (1):35-38.
    During a pandemic, where there is widespread human infection, various and varying measures are taken that are targeted at public health objectives. During the early stages of a pandemic, these objectives may focus on containing the disease and minimizing its spread, but they may switch to mitigation as the emergent infectious disease takes hold in a population. There has been considerable debate and elucidation of the ethical principles and framework for the various responses including the need to fast track (...) and vaccine development. However, the measures imposed during a pandemic would have unintended and untoward effect on ongoing clinical research. For example, precautionary measures, such as social distancing, may hamper ongoing clinical research, because recruitment and participation of patients and healthy volunteers is a potential source of virus spread. In this paper, we argue that a framework is needed to ensure the continuity of such research. Such a framework that considers the pertinent issues would need the ‘buy in’ of the key stakeholders (policy makers, funding agencies, institutional authorities, researchers and subjects) to ensure that the issues that are ethically relevant to pandemic planning would not be neglected or overlooked. (shrink)
    Direct download (8 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  39.  15
    Clinical research ethics in Irish healthcare: Diversity, dynamism and medicalization.S. L. Condell & C. Begley - 2012 - Nursing Ethics 19 (6):810-818.
    Gaining ethical clearance to conduct a study is an important aspect of all research involving humans but can be time-consuming and daunting for novice researchers. This article stems from a larger ethnographic study that examined research capacity building in Irish nursing and midwifery. Data were collected over a 28-month time frame from a purposive sample of 16 nurse or midwife research fellows who were funded to undertake full-time PhDs. Gaining ethical clearance for their studies was reported as (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  40.  28
    Linking international clinical research with stateless populations to justice in global health.Bridget Pratt, Deborah Zion, Khin M. Lwin, Phaik Y. Cheah, Francois Nosten & Bebe Loff - 2014 - BMC Medical Ethics 15 (1):49.
    In response to calls to expand the scope of research ethics to address justice in global health, recent scholarship has sought to clarify how external research actors from high-income countries might discharge their obligation to reduce health disparities between and within countries. An ethical framework—‘research for health justice’—was derived from a theory of justice (the health capability paradigm) and specifies how international clinical research might contribute to improved health and research capacity in host communities. (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  41.  9
    Financial conflicts and clinical research.Karin Meyers - 2009 - IRB: Ethics & Human Research 31 (4):17.
    “Financial Conflicts and Clinical Research’”: a letter from Karin Meyers about “Community Hospital Oversight of Clinical Investigators’ Financial Relationships ”.
    Direct download  
     
    Export citation  
     
    Bookmark  
  42.  10
    Clinical Research before Informed Consent.Franklin G. Miller - 2014 - Kennedy Institute of Ethics Journal 24 (2):141-157.
    The results of the first randomized controlled trial of a medical treatment were reported in 1947. The antibiotic streptomycin was demonstrated to be dramatically superior to bed rest alone in treating tuberculosis. Looking back on this trial in 1990, A. B. Hill, the distinguished medical statistician who played a prominent role in the use of randomization in this study, made a telling statement about the moral climate of clinical research at the time: "Of course, there were no ethical (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  43.  2
    Perspectives regarding privacy in clinical research among research professionals from the Arab region: an exploratory qualitative study.Latifa Adarmouch, Marwan Felaefel, Robert Wachbroit & Henry Silverman - 2020 - BMC Medical Ethics 21 (1):1-16.
    Background Protecting the privacy of research participants is widely recognized as one of the standard ethical requirements for clinical research. It is unknown, however, how research professionals regard concepts of privacy as well as the situations in the research setting that require privacy protections. The aim of this study was to explore the views of research professionals from Arab countries regarding concepts and scope of privacy that occur in clinical research. Methods We (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  44.  89
    Hard paternalism, fairness and clinical research: why not?Sarah J. L. Edwards & James Wilson - 2012 - Bioethics 26 (2):68 - 75.
    Jansen and Wall suggest a new way of defending hard paternalism in clinical research. They argue that non-therapeutic research exposing people to more than minimal risk should be banned on egalitarian grounds: in preventing poor decision-makers from making bad decisions, we will promote equality of welfare. We argue that their proposal is flawed for four reasons.First, the idea of poor decision-makers is much more problematic than Jansen and Wall allow. Second, pace Jansen and Wall, it may be (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  45.  17
    Clinical Research Is a Team Sport.Ross E. McKinney - 2019 - American Journal of Bioethics 19 (4):22-23.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  46. Critical thinking in clinical research: applied theory and practice using case studies.Felipe Fregni & Ben M. W. Illigens (eds.) - 2018 - New York, NY: Oxford University Press.
  47.  91
    Ethics in Clinical Research.Jane Barrett - 2006 - Icr.
    Chapter One: Introduction “The ethical basis of all [medical] research is that information gained from one patient's experience should, where feasible, ...
    Direct download  
     
    Export citation  
     
    Bookmark  
  48.  24
    Therapeutic Obligation in Clinical Research.Charles Weijer & Paul B. Miller - unknown
    Direct download  
     
    Export citation  
     
    Bookmark   8 citations  
  49.  39
    Avoiding Exploitation in Clinical Research.Solomon R. Benatar - 2000 - Cambridge Quarterly of Healthcare Ethics 9 (4):562-565.
    Clinical research has become a burgeoning activity in recent years, largely stimulated by the pharmaceutical industry's interest in new drugs with high marketing profiles. Several other forces fuel this thrust: the increasing dependence of academic medical institutions on research funding from industry; the need for large, efficient multicenter trials to obtain reliable and statistically significant results in the shortest possible time for drug registration purposes; and access to research subjects in countries. The intense interest in HIV/AIDS (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   19 citations  
  50. Justice in international clinical research.Bridget Pratt & Beatrice Loff - unknown
1 — 50 / 1000