During the early years of the COVID-19 pandemic, preclinical and clinical research were sped up and scaled up in both the public and private sectors and in partnerships between them. This resulted in some extraordinary advances, but it also raised a range of issues regarding the ethics, rigour, and integrity of scientific research, academic publication, and public communication. Many of the failures of scientific rigour and integrity that occurred during the pandemic were exacerbated by the rush to generate, disseminate, and (...) implement research findings, which not only created opportunities for unscrupulous actors but also compromised the methodological, peer review, and advisory processes that would usually identify sub-standard research and prevent compromised clinical or policy-level decisions. While it would be tempting to attribute these failures of science and its translation solely to the “unprecedented” circumstances of the COVID-19 pandemic, the reality is that they preceded the pandemic and will continue to arise once it is over. Existing strategies for promoting scientific rigour and integrity need to be made more rigorous, better integrated into research training and institutional cultures, and made more sophisticated. They might also need to be modified or supplemented with other strategies that are fit for purpose not only in public health emergencies but in any research that is sped-up and scaled up to address urgent unmet medical needs. (shrink)

This book is a study of ancient views about 'moral luck'. It examines the fundamental ethical problem that many of the valued constituents of a well-lived life are vulnerable to factors outside a person's control, and asks how this affects our appraisal of persons and their lives. The Greeks made a profound contribution to these questions, yet neither the problems nor the Greek views of them have received the attention they deserve. This book thus recovers a central dimension of Greek (...) thought and addresses major issues in contemporary ethical theory. One of its most original aspects is its interrelated treatment of both literary and philosophical texts. The Fragility of Goodness has proven to be important reading for philosophers and classicists, and its non-technical style makes it accessible to any educated person interested in the difficult problems it tackles. This new edition features an entirely new preface by Martha Nussbaum. (shrink)

This paper explores the principle that knowledge is fragile, in that whenever S knows that S doesn’t know that S knows that p, S thereby fails to know p. Fragility is motivated by the infelicity of dubious assertions, utterances which assert p while acknowledging higher-order ignorance whether p. Fragility is interestingly weaker than KK, the principle that if S knows p, then S knows that S knows p. Existing theories of knowledge which deny KK by accepting a Margin (...) for Error principle can be conservatively extended with Fragility. (shrink)

Medicine seeks to overcome one of the most fundamental fragilities of being human, the fragility of good health. No matter how robust our current state of health, we are inevitably susceptible to future illness and disease, while current disease serves to remind us of various frailties inherent in the human condition. This article examines the relationship between fragility and uncertainty with regard to health, and argues that there are reasons to accept rather than deny at least some forms (...) of uncertainty. In situations of current ill health, both patients and doctors seek to manage this fragility through diagnoses that explain suffering and provide some certainty about prognosis as well as treatment. However, both diagnosis and prognosis are inevitably uncertain to some degree, leading to questions about how much uncertainty health professionals should disclose, and how to manage when diagnosis is elusive, leaving patients in uncertainty. We argue that patients can benefit when they are able to acknowledge, and appropriately accept, some uncertainty. Healthy people may seek to protect the fragility of their good health by undertaking preventative measures including various tests and screenings. However, these attempts to secure oneself against the onset of biological fragility can cause harm by creating rather than eliminating uncertainty. Finally, we argue that there are good reasons for accepting the fragility of health, along with the associated uncertainties. (shrink)

In _The Fragility of Things_, eminent theorist William E. Connolly focuses on several self-organizing ecologies that help to constitute our world. These interacting geological, biological, and climate systems, some of which harbor creative capacities, are depreciated by that brand of neoliberalism that confines self-organization to economic markets and equates the latter with impersonal rationality. Neoliberal practice thus fails to address the fragilities it exacerbates. Engaging a diverse range of thinkers, from Friedrich Hayek, Michel Foucault, Hesiod, and Immanuel Kant to (...) Voltaire, Terrence Deacon, Friedrich Nietzsche, and Alfred North Whitehead, Connolly brings the sense of fragility alive as he rethinks the idea of freedom. Urging the Left not to abandon the state but to reclaim it, he also explores scales of politics below and beyond the state. The contemporary response to fragility requires a militant pluralist assemblage composed of those sharing affinities of spirituality across differences of creed, class, gender, sexual orientation, and ethnicity. (shrink)

John Rawls's transition from A Theory of Justice to Political Liberalism was driven by his rejection of Theory's account of stability. The key to his later account of stability is the idea of public reason. We see Rawls's account of stability as an attempt to solve a mutual assurance problem. We maintain that Rawls's solution fails because his primary assurance mechanism, in the form of public reason, is fragile. His conception of public reason relies on a condition of consensus that (...) we argue is unrealistic in modern, pluralistic democracies. After rejecting Rawls's conception of public reason, we offer an ‘indirect alternative’ that we believe is much more robust. We cite experimental evidence to back up this claim. (shrink)

In this article thinking on corporate social responsibility is compared with the dominant political theory of the market: theneoclassical theory. The comparison shows that thinking on CSR fundamentally collides with that theory. For example, their respectivenormative views on man are incompatible, as are their respective views on the modus operandi of the market. Given that CSR is desirable it follows that a new political theory of the market is needed. This article suggests some initial steps toward developing that new political (...) theory of the market. For example, it defends the proposition that the neoclassical idea of the market as a harmonic sphere must be replaced by the idea of the market as a fragile system. (shrink)

This book is a study of ancient views about "moral luck." It examines the fundamental ethical problem that many of the valued constituents of a well-lived life are vulnerable to factors outside a person's control, and asks how this affects our appraisal of persons and their lives. The Greeks made a profound contribution to these questions, yet neither the problems nor the Greek views of them have received the attention they deserve. This updated edition contains a new preface.

Are fanatical beliefs rational? This paper examines this question. After outlining two arguments for the rationality of fanatical beliefs, based respectively on what I call the "crippled epistemology" explanation and the "echo chambers" explanation, the paper rejects these arguments by appeal to considerations related to higher-order evidence. Then it explains what defending the rationality of fanatical beliefs actually requires. From this, it derives the practical conclusion that radicalization can be prevented and the growth of fanaticism stalled by preventing the encroachment (...) of "fragile values.". (shrink)

This article explores the role of second-order anger in the formation of resistant feminist space through the work of María Lugones and Sara Ahmed. I argue that this incommunicative form of anger can operate as a bridge between two senses of resistant spatiality in Lugones, connecting the hangout, which is a collective and transgressive space for alternative sense making, and the cocoon, which is a solitary and germinative space of tense internal transformation. By weaving connections with Ahmed’s concept of feminist (...) fragile sheltering, I demonstrate that the insulating character of second-order anger need not be equated with spatial solitude. Rather, given its orientation toward a future becoming away from oppressed subjectivity, germinative cocooning can be understood as constitutive of collective, feminist, and resistant spaces. I conclude, therefore, that feminist spaces ought to shelter second-order angers and embrace fragility as a condition of resistant transformation. (shrink)

This first-ever collection of original essays devoted to philosopher, theologian, and poet Jean-Louis Chrétien’s work, this interdisciplinary collection includes Chrétien’s collaborators, successors, and Anglophone interpreters and explores themes of temporality, prayer, and religious reading.

We prove various theorems about the preservation and destruction of the tree property at ω2. Working in a model of Mitchell [9] where the tree property holds at ω2, we prove that ω2 still has the tree property after ccc forcing of size \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\aleph_1}$$\end{document} or adding an arbitrary number of Cohen reals. We show that there is a relatively mild forcing in this same model which destroys the tree property. Finally we (...) prove from a supercompact cardinal that the tree property at ω2 can be indestructible under ω2-directed closed forcing. (shrink)

Sparked by the recent threats to an open and pluralistic society in both Europe and the United States, The Fragility of Tolerant Pluralism is an exploration of social and political philosophy. Using the early sixteenth century as a lens to view our own struggles with multiple visions of a good society, the book looks at tolerant pluralism in the light of the twin challenges of resurgent nationalisms and Islamist terrorism. The book makes a case not only for social toleration, (...) but for a deep pluralism that both values and celebrates difference. It also suggests that the radical sects in Europe in the early sixteenth-century challenged the political and religious monisms of both Catholic and Protestant territories, hence planting the seeds of tolerant pluralism. The struggles faced in the sixteenth-century both reflect and inform our own pressing concerns today and as such, The Fragility of Tolerant Pluralism draws six lessons for our current situation. (shrink)

Critics have charged that Heidegger's account of authenticity is morally nihilistic, that his fundamental ontology is either egocentric or chauvinistic; and many see Heidegger's turn to Nazism in 1933 as following logically from an indifference, and even hostility, to "otherness" in the premises of his early philosophy. In_ The Fragile "We": Ethical Implications of Heidegger's "Being and Time,"_ Lawrence Vogel presents three interpretations of authentic existence--the existentialist, the historicist, and the cosmopolitan--each of which is a plausible version of the personal (...) ideal depicted in _Being and Time._ He then draws parallels between these interpretations and three moments in the contemporary liberal-communitarian debate over the relationship of the "I" and the "We." His book contributes both to a diagnosis of what there is about _Being and Time_ that invites moral nihilism and to a sense of how fundamental ontology might be recast so that "the other" is accorded an appropriate place in an account of human existence. (shrink)

Recognizing the potential hidden artistic contributions of persons with dementia opens new opportunities for interpretation and potential communication. This visual essay explores the authors’ responses to the fragile objects of art produced by a person with severe dementia and examines what may be learned from them.

Ordinary common knowledge is formally expressed by strong probabilistic common belief. How strong exactly? The question can be answered by drawing from the similar equivalence, recently explored, between plain and probabilistic individual beliefs. I argue that such a move entails that common knowledge displays a double fragility: as a description of a collective state and as a phenomenon, because it can respectively disappear as group size increases, or more worryingly as the epistemic context changes. I argue that despite this (...) latter fragility, the effects of common knowledge on action are robust. Unfortunately, this in turn leads to a third fragility, that of the concept of common knowledge, which threatens to collapse on probabilistic common belief. This also reveals a disanalogy between the individual and the collective cases. I finally pinpoint the subtle difference entailed by the two concepts, expressed in terms of the attitude towards contrary evidence or of the agents’ awareness. As a result, common knowledge can be defended as a concept, which refers to a fragile yet distinct collective attitude. (shrink)

Loss of the Y‐chromosome is a common feature of species with chromosomal sex determination. However, our understanding of why some lineages frequently lose Y‐chromosomes while others do not is limited. The fragile Y hypothesis proposes that in species with chiasmatic meiosis the rate of Y‐chromosome aneuploidy and the size of the recombining region have a negative correlation. The fragile Y hypothesis provides a number of novel insights not possible under traditional models. Specifically, increased rates of Y aneuploidy may impose positive (...) selection for (i) gene movement off the Y; (ii) translocations and fusions which expand the recombining region; and (iii) alternative meiotic segregation mechanisms (achiasmatic or asynaptic). These insights as well as existing evidence for the frequency of Y‐chromosome aneuploidy raise doubt about the prospects for long‐term retention of the human Y‐chromosome despite recent evidence for stable gene content in older non‐recombining regions. (shrink)

Du silex à l'internet l'Homme dans toute sa complexité.

Interfirm collaboration and trust are topics currently exciting research interest. The literature treats trust as a unitary concept, providing little understanding of those processes that create trust, or are employed by parties relying on trust. I suggest that two distinct forms of trust can be observed in economic exchanges: fragile trust and resilient trust. I define these kinds of trust, speculate on processes by which economic actors learn about them, and explore contexts in which they are likely to be relied (...) upon by economic actors. I conclude with a discussion of implications for practice and scholarship. (shrink)

It is customarily assumed that paracomplete and paraconsistent solutions to liar paradoxes require a logical system weaker than classical logic. That is, if a logic is not fragile to liar paradoxes, it must be logically weaker than classical logic. Defenders of classical logic argue that the losses of weakening it outweigh the gains. Advocates of paracomplete and paraconsistent solutions disagree. We articulate the notion of fragility with respect to the liar paradox and show that it can be disentangled from (...) logical strength. Strength and resilience to paradox do not force a trade-off with respect to liars: there can be logics which are not weaker than classical logic and are solid to the liar. (shrink)

Few discussions of the ethics of mitochondrial ‘replacement’ techniques have drawn significant ethical distinctions between the two approaches now legal in the U.K. However, Anthony Wrigley, Stephen Wilkinson and John Appleby have together argued that under some circumstances pronuclear transfer (PNT) may be in better ethical standing than maternal spindle transfer (MST). They base their conclusion on what they allege to be different implications of the techniques with respect to non‐identity considerations, which they ground on a version of origin essentialism. (...) I raise a series of problems for their argument, which have cautionary implications for invocations of origin essentialism that go beyond specialized debates regarding MST and PNT. I argue that (i) origin essentialism is a fragile foundation for non‐identity considerations; (ii) gametic essentialism, which Wrigley et al. believe licenses their claims, is more questionable than origin essentialism; (iii) gametic essentialism does not straightforwardly justify their conclusion; and (iv) their conclusion in fact relies on an especially dubious position that we can call chromosomal origin essentialism. No good reasons have yet been supplied to distinguish PNT from MST on ethical grounds, and one should be wary of basing claims with practical impact on fragile foundations relating to origin essentialism. (shrink)

Laver [L] and others [G-S] have shown how to make the supercompactness or strongness of κ indestructible by a wide class of forcing notions. We show, alternatively, how to make these properties fragile. Specifically, we prove that it is relatively consistent that any forcing which preserves $\kappa^{<\kappa}$ and κ+, but not P(κ), destroys the measurability of κ, even if κ is initially supercompact, strong, or if I1(κ) holds. Obtained as an application of some general lifting theorems, this result is an (...) "inner model" type of theorem proved instead by forcing. (shrink)

Are fragile majorities capable of opening themselves to deep-rooted and new ethnic and cultural pluralism? What role does education play in this process? Based on ten years of comparative research, Fragile Majorities and Education is a nuanced study of ethnic dominance, linguistic integration of immigrants, and diversity in education. Ethnic relations are often depicted in an oversimplified framework where a clear dominant majority exercises power over various minorities. In many societies worldwide, however, this model does not hold true. In some (...) countries, two or more groups possess relatively equal power to control the state and impose their definitions of the nation, as is the case with Flemish speakers and French speakers in Belgium, and with Catholics and Protestants in Northern Ireland. In other instances, such as in Quebec or Catalonia, clearly identifiable majorities are nonetheless minorities at a larger nation-state level, which creates a situation of ambiguous ethnic dominance. Marie McAndrew analyzes and clarifies these complex situations through the lens of education as a means for both maintaining and transforming ethnic boundaries and identities. Deeply insightful and meticulously researched, Fragile Majorities and Education is a groundbreaking contribution to the field of ethnic studies. (shrink)

It is perhaps our noblest cause, and certainly one of our oldest: to end suffering. Think of the Buddha, Chuang Tzu, or Marcus Aurelius: stoically composed figures impervious to the torments of the wider world, living their lives in complete serenity—and teaching us how to do the same. After all, isn’t a life free from suffering the ideal? Isn’t it what so many of us seek? Absolutely not, argues Todd May in this provocative but compassionate book. In a moving examination (...) of life and the trials that beset it, he shows that our fragility, our ability to suffer, is actually one of the most important aspects of our humanity. May starts with a simple but hard truth: suffering is inevitable. At the most basic level, we suffer physically—a sprained ankle or a bad back. But we also suffer insults and indifference. We suffer from overburdened schedules and unforeseen circumstances, from moral dilemmas and emotional heartaches. Even just thinking about our own mortality—the fact that we only live one life—can lead us to tremendous suffering. No wonder philosophies such as Buddhism, Taosim, Stoicism, and even Epicureanism—all of which counsel us to rise above these plights—have had appeal over the centuries. May highlights the tremendous value of these philosophies and the ways they can guide us toward better lives, but he also exposes a major drawback to their tenets: such invulnerability is too emotionally disengaged from the world, leading us to place too great a distance between ourselves and our experience. Rather than seeking absolute immunity, he argues most of us just want to hurt less and learn how to embrace and accept what suffering we do endure in a meaningful way. Offering a guide on how to positively engage suffering, May ultimately lays out a new way of thinking about how we exist in the world, one that reassures us that our suffering, rather than a failure of physical or psychological resilience, is a powerful and essential part of life itself. (shrink)

Journal of Political Philosophy, EarlyView.

Journal of Political Philosophy, EarlyView.

In a recent volume titled Demande (Expectation), containing texts written over a period of more than thirty years, but each devoted to different aspects of the relationship between philosophy and literature, Jean-Luc Nancy offers a suggestive account of their mutual genesis and ongoing dialogue in order to underline the way in which, beyond their apparent dialectical reciprocity, philosophy and literature are each inseparable from the unanswered and unanswerable questions they ask themselves and each other. Both, in other words, are said (...) to belong to the “in-between,” that fragile zone of undecidability that, according to Nancy’s reading of Kant, is a salient characteristic of all supposed self-identity. This article explores some of the implications of Nancy’s formulation as it affects the seemingly intractable question of myth’s interruption. It considers in particular some of the problematic features, deriving, it argues, from the inescapable fragility of thought itself, that may to be found in Nancy’s sometimes tense and contradictory engagement with the work of Maurice Blanchot, the subject of two important essays in Demande, which raises probing questions of Nancy’s own philosophical enterprise. (shrink)

In this paper I argue that while Noë’s actionist approach offers an excellent elaboration of classical approaches to conceptual understanding, it risks underestimating the role of social interactions and relations. Noë’s approach entails a form of body-based individualism according to which understanding is something the mind does all by itself. I propose that we adopt a stronger perspective on the role of sociality and consider the human mind in terms of socially enacted autonomy. On this view, the mind depends constitutively (...) on engaging with and relating to others. As a consequence, conceptual understanding must be seen as a co-achievement. It is a fragile endeavour precisely because it depends not only on the individual but also on the continuous contribution of other subjects. (shrink)

I will argue that deep moral enhancement is relatively prone to unexpected consequences. I first argue that even an apparently straightforward example of moral enhancement such as increasing human co-operation could plausibly lead to unexpected harmful effects. Secondly, I generalise the example and argue that technological intervention on individual moral traits will often lead to paradoxical effects on the group level. Thirdly, I contend that insofar as deep moral enhancement targets higher-order desires, it is prone to be self-reinforcing and irreversible. (...) Fourthly, I argue that the complex causal history of moral traits, with its relatively high frequency of contingencies, indicates their fragility. Finally, I conclude that attempts at deep moral enhancement pose greater risks than other enhancement technologies. For example, one of the major problems that moral enhancement is hoped to address is lack of co-operation between groups. If humanity developed and distributed a drug that dramatically increased co-operation between individuals, we would likely see a paradoxical decrease in co-operation between groups and a self-reinforcing increase in the disposition to engage in further modifications – both of which are potential problems. (shrink)

This article is about the materiality of difference, about race, sex and sexual differences among others. To find out about these differences and their materialities, this article looks not into bodies but rather at how bodies are positioned in spaces and how they are enacted in practice. In the first part of the article, the focus is on the relationality of identities and how they are made and unmade in specific practices. The second part of the article attends to the (...) various histories and practices that are drawn together in one specific body and how they help to enact a particular version of the body. Differences, it is argued, are not given ‘entities’ out there, awaiting dis-covery; rather they are effects that come about in relational practices. This indicates that materiality is not simply a given that can be taken on board, but it is the very configuration through which differences can be articulated. (shrink)

This article analyzes Heidegger’s Paris lecture, “The End of Philosophy and the Task of Thinking,” in an attempt to understand the historical “task” that Heidegger seeks to examine when confronted with the agony of philosophy today. I attempt to valorize the understanding of time and history that Heidegger stages in his reading by demonstrating its entrance to be radical and novel with respect to other moments in Heidegger’s production: history here is not of “destiny”, that is, it does not coincide (...) with the appropriating orientation of man in time already presented in Heidegger’s other texts; rather, it is understood on the basis of the opening to the future that fragilizes and suspends all hope and all historical resolution. History is thought here as the desertification of present times, the completion of metaphysical nihilism, in which there opens at the same time a “perhaps” that, repeated many times throughout the lecture, takes up in all its complexity the problem of the future’s coming, of the extraordinary, of the opening, that is, of what, from the future, exceeds destiny. (shrink)

Abstract David Sobel (2001) objects to Bernard Williams's internalism, the view that an agent has a reason to perform an action only if she has some motive that will be served by performing that action. Sobel is an unusual challenger in that he endorses neo-Humean subjectivism, ?the view that it is the agent's subjective motivational set that makes it the case that an agent does or does not have a reason to φ? (219). Sobel's objection in fact arises from this (...) very commitment. Internalism, he says, is incompatible with the best subjectivist accounts of reasons for action?accounts that suggest that there are what he calls fragile reasons and perhaps also superfragile ones, both of which allegedly provide for counterexamples to internalism. I argue that such reasons do not in fact threaten internalism. I then briefly explore whether internalism is vulnerable to a related charge?that it commits the conditional fallacy. (shrink)

Introduction: Fundamental Ontology as a "Fundamental Ethics" In his "Letter on Humanism" Martin Heidegger claims that the fundamental ontology he works out ...

The theoretical framework adopted in the exact sciences, for constructing and testing deterministic theories on the one hand, and modelling and analysis of observed phenomena on the other, is often implicitly assumed to be that of structural stability. In view of recent developments in nonlinear dynamics, it is argued here that in general it may not be possible to assume strict determinism and structural stability simultaneously; either strict determinism holds, in which case the fragility framework may turn out to (...) be the appropriate framework for the study of certain phenomena in the exact sciences, or ‘structural stability’ is restored at the expense of introducing stochasticity. In this sense a certain degree of indeterminacy may be unavoidable even at the classical level. (shrink)

This book about philosophy of medicine bestows a bottom-up and not a top-down approach. It starts from clinical medicine and epidemiology, analyzing their interrelations with philosophical instruments. The book criticizes the constant search for generalities and the essentialism that too often characterizes this discipline, which results in philosophers of medicine dialoguing with each other without direct contact with medical science. In the light of Ludwig Wittgenstein's philosophy, this book proposes an approach to the philosophy of medicine based on the quorum (...) of language, what Wittgenstein calls family resemblances. In this way the author establishes a philosophy of medicine that is closely related to the medical clinic and to public health and as such avoids armchair philosophy. “Don’t think, but look", wrote Wittgenstein. (shrink)

The possibility of social and technological collapse has been the focus of science fiction tropes for decades, but more recent focus has been on specific sources of existential and global catastrophic risk. Because these scenarios are simple to understand and envision, they receive more attention than risks due to complex interplay of failures, or risks that cannot be clearly specified. In this paper, we discuss the possibility that complexity of a certain type leads to fragility which can function as (...) a source of catastrophic or even existential risk. The paper first reviews a hypothesis by Bostrom about inevitable technological risks, named the vulnerable world hypothesis. This paper next hypothesizes that fragility may not only be a possible risk, but could be inevitable,and would therefore be a subclass or example of Bostrom’s vulnerable worlds. After introducing the titular fragile world hypothesis, the paper details the conditions under which it would be correct, and presents arguments for why the conditions may in fact may apply. Finally, the assumptions and potential mitigations of the new hypothesis are contrasted with those Bostrom suggests. (shrink)