Results for 'hypoxia-ischemia'

32 found
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  1.  39
    The Window of Opportunity: Decision Theory and the Timing of Prognostic Tests for Newborn Infants.Dominic Wilkinson - 2009 - Bioethics 23 (9):503-514.
    In many forms of severe acute brain injury there is an early phase when prognosis is uncertain, followed later by physiological recovery and the possibility of more certain predictions of future impairment. There may be a window of opportunity for withdrawal of life support early, but if decisions are delayed there is the risk that the patient will survive with severe impairment. In this paper I focus on the example of neonatal encephalopathy and the question of the timing of prognostic (...)
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  2.  4
    The Temporal Stage Fallacy: A Novel Statistical Fallacy in the Medical Literature. [REVIEW]David Shier & J. Lee Tilson - 2005 - Medicine, Health Care and Philosophy 9 (2):243-247.
    Celebrated for disproving the traditional view that lack of oxygen at birth (perinatal asphyxia) contributes significantly to cerebral palsy, a 1986 New England Journal of Medicine article by Karin Nelson and Jonas Ellenberg engineered a new consensus in the medical community: that lack of oxygen at birth rarely causes cerebral palsy. We demonstrate that the article's central argument relies on straightforwardly fallacious statistical reasoning, and we discuss significant implications -- e.g. how carefully fetuses are monitored during labor and delivery, expert (...)
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  3.  29
    Effect of Myocardial Infarction and Ischemia on Induction of Cardiac Reentries and Ventricular Fibrillation.Alain L. Bardou, Pierre M. Auger, Soumeya Achour, Philippe Dumee, Pierre J. Birkui & Marie-Claude Govaere - 1995 - Acta Biotheoretica 43 (4):363-372.
    The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...)
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  4.  2
    Ashcroft M. Hypoxia—Inducible Factor—la Nd Oncogenie Signalling.Julia I. Bárdos & Margaret Ashcroft - 2004 - Bioessays 26 (3):262-269.
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  5.  22
    On 25 February 1990, Terri Schiavo, 26 Years of Age, Collapsed in the Hall of Her Apartment and Experienced Severe Hypoxia for Several Minutes. She Had Not Executed a Living Will or a Durable Power of Attorney. Four Months After Her. [REVIEW]Joshua E. Perry, Larry R. Churchill & Howard S. Kirshner - forthcoming - Bioethics.
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  6.  4
    Hypoxia-Inducible Factor-1 and Oncogenic Signalling.Julia I. Bárdos & Margaret Ashcroft - 2004 - Bioessays 26 (3):262-269.
  7.  14
    Going Malignant: The Hypoxia‐Cancer Connection in the Prostate.P. W. Hochachka, J. L. Rupert, L. Goldenberg, M. Gleave & P. Kozlowski - 2002 - Bioessays 24 (8):749-757.
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  8.  10
    Causes and Consequences of Hypoxia and Acidity in Tumour Microenvironments.J. R. Griffiths - 2001 - Bioessays 23 (3):295-296.
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  9.  3
    Hypoxia Worsens Affective Responses and Feeling of Fatigue During Prolonged Bed Rest.Nektarios A. M. Stavrou, Tadej Debevec, Ola Eiken & Igor B. Mekjavic - 2018 - Frontiers in Psychology 9.
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  10.  8
    Fine Tuning the HIF‐1 'Global' O2 Sensor for Hypobaric Hypoxia in Andean High‐Altitude Natives.Peter W. Hochachka & Jim L. Rupert - 2003 - Bioessays 25 (5):515-519.
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  11.  7
    Forebrain Ischemia Produces Hippocampal Damage and a Persistent Working Memory Deficit in Rats.Paul J. Colombo, Hasker P. Davis, Neil Simolke, Frank Markley & Bruce T. Volpe - 1988 - Bulletin of the Psychonomic Society 26 (4):375-377.
  12.  5
    Behavioral Stress and Myocardial Ischemia: An Example of Conditional Response Modification.George E. Billman - 1986 - Behavioral and Brain Sciences 9 (2):295-296.
  13.  4
    Silent Myocardial Ischemia and Infarction by Peter F. Cohn, And: Silent Myocardial Ischemia Ed. By W. Rutishauser and H. Roskamm. [REVIEW]Ted Feldman - 1987 - Perspectives in Biology and Medicine 30 (4):608-610.
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  14.  1
    Hypoxia and the Pulmonary Vasculature.I. Bradley Gordon & Louis N. Katz - 1962 - Perspectives in Biology and Medicine 5 (3):275-292.
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  15. Self-Transcendence Correlates with Brain Function Impairment.Bernardo Kastrup - 2017 - Journal of Cognition and Neuroethics 4 (3):33-42.
    A broad pattern of correlations between mechanisms of brain function impairment and self-transcendence is shown. The pattern includes such mechanisms as cerebral hypoxia, physiological stress, transcranial magnetic stimulation, trance-induced physiological effects, the action of psychoactive substances and even physical trauma to the brain. In all these cases, subjects report self-transcending experiences o en described as ‘mystical’ and ‘awareness-expanding,’ as well as self-transcending skills o en described as ‘savant.’ The idea that these correlations could be rather trivially accounted for on the (...)
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  16.  10
    Solving Donor Organ Shortage with Insights From Freeze Tolerance in Nature.Bryan E. Luu & Kenneth B. Storey - 2018 - Bioessays 40 (10):1800092.
    The North American wood frog, Rana sylvatica, endures seasonal whole‐body freezing during the winter and thawing during the spring without sustaining any apparent damage from ice or oxidative stress. Strategies from these frogs may solve the shortage of human donor organs, which is a multidisciplinary problem that can be alleviated by eliminating geographical boundaries. Rana sylvatica deploys an array of molecular and physiological responses, such as glucose production and microRNA regulation, to help it survive the cold. These strategies have been (...)
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  17.  24
    Central Inhibitory Dysfunctions: Mechanisms and Clinical Implications.Z. Wiesenfeld-Hallin, H. Aldskogius, G. Grant, J.-X. Hao, T. Hökfelt & X.-J. Xu - 1997 - Behavioral and Brain Sciences 20 (3):420-425.
    Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury to the spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response to innocuous stimuli. In its short-lasting phase the allodynia can be relieved with the [gamma]-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses the hyperexcitability of dorsal horn interneurons to mechanical stimuli. Furthermore, there is a reduction in GABA immunoreactivity in the dorsal horn of allodynic rats. Clinical neuropathic (...)
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  18.  13
    Oxygen Therapy in Hospitalized Patients: The Impact of Local Guidelines.Fazal A. Kbar & Ian Allen Campbell - 2006 - Journal of Evaluation in Clinical Practice 12 (1):31-36.
  19.  21
    Lack of Hemispheric Dominance for Consciousness in Acute Ischaemic Stroke.B. Cucchiara, S. E. Kasner, D. A. Wolk, P. D. Lyden, V. A. Knappertz, T. Ashwood, T. Odergren & A. Nordlund - 2003 - Journal of Neurology, Neurosurgery and Psychiatry 74 (7):889-892.
  20.  4
    A Brake for B Cell Proliferation.Julia Jellusova & Robert C. Rickert - 2017 - Bioessays 39 (11):1700079.
    B cell activation is accompanied by metabolic adaptations to meet the increased energetic demands of proliferation. The metabolic composition of the microenvironment is known to change during a germinal center response, in inflamed tissue and to vary significantly between different organs. To sustain cellular homeostasis B cells need to be able to dynamically adapt to changes in their environment. An inability to take up and process available nutrients can result in impaired B cell growth and a diminished humoral immune response. (...)
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  21.  6
    Ethics Briefing.Martin Davies, Ruth Campbell, Sophie Brannan, Veronica English, Rebecca Mussell & Julian C. Sheather - 2018 - Journal of Medical Ethics 44 (10):725-726.
    The Supreme Court has ruled in the case of Y that there is no requirement to seek the approval of the Court of Protection in decisions to withdraw clinically assisted nutrition and hydration from patients in a prolonged disorder of consciousness.1 Mr Y was 52-year-old man who suffered a cardiac arrest after a myocardial infarction as a result of coronary artery disease. It was not possible to resuscitate him for well over 10 min, resulting in severe cerebral hypoxia which caused (...)
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  22.  98
    Mechanism of Development of Pre-Eclampsia Linking Breathing Disorders to Endothelial Dysfunction.Jerath Ravinder, Vernon A. Barnes & Hossam E. Fadel - 2009 - Medical Hypotheses 73:163-166.
    High blood pressure is an important component of pre-eclampsia. The underlying mechanism of development of hypertension in pre-eclampsia is complicated and still remains obscure. Several theories have been advanced including endothelial dysfunction, uteroplacental insufficiency leading to generalized vasoconstriction, increased cardiac output, and sympathetic hyperactivity. Increased blood flow and pressure are thought to lead to capillary dilatation, which damages end-organ sites, leading to hypertension, proteinuria and edema. Additional theories have been put forward based on epidemiological research, implicating immunological and genetic factors. (...)
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  23.  9
    Coordination of Timers and Sensors in Cell Signaling.Junbin Qian, Lendert Gelens & Mathieu Bollen - 2019 - Bioessays 41 (3):1800217.
    Timers and sensors are common devices that make our daily life safer, more convenient, and more efficient. In a cellular context, they arguably play an even more crucial role as they ensure the survival of cells in the presence of various extrinsic and intrinsic stresses. Biological timers and sensors generate distinct signaling profiles, enabling them to produce different types of cellular responses. Recent data suggest that they can work together to guarantee correct timing and responsiveness. By exploring examples of cellular (...)
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  24.  13
    Dynamic Simulation of Mitochondrial Respiration and Oxidative Phosphorylation: Comparison with Experimental Results.François Guillaud & Patrick Hannaert - 2008 - Acta Biotheoretica 56 (1-2):157-172.
    Hypoxia hampers ATP production and threatens cell survival. Since cellular energetics tightly controls cell responses and fate, ATP levels and dynamics are of utmost importance. An integrated mathematical model of ATP synthesis by the mitochondrial oxidative phosphorylation/electron transfer chain system has been recently published :e36, 2005). This model was validated under static conditions. To evaluate its performance under dynamical situations, we implemented and simulated it . Inner membrane potential and [NADH] were used as indicators of mitochondrial function. Root mean squared (...)
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  25.  56
    Cost Analysis of the Utilization of New Vascular Grafts.Raphael Adar & Nava Pliskin - 1980 - Theoretical Medicine and Bioethics 1 (2):213-223.
    A cost analysis of the utilization of new expensive vascular grafts is performed, applying the methodology of decision analysis to the theoretical case of a sixty year old male patient undergoing femoropopliteal grafting for limb threatening ischemia. The problem is presented graphically as a decision tree, uncertainties are quantified in terms of probabilities and end outcomes are evaluated in monetary terms. This informations is then utilized to calculate cost values associated with alternative actions.Based on initial cumulative patency figures of the (...)
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  26.  22
    Incidence of Dispersion of Refractoriness and Cellular Coupling Resistance on Cardiac Reentries and Ventricular Fibrillation.A. L. Bardou, R. G. Seigneuric, J.-L. Chassé & P. M. Auger - 1999 - Acta Biotheoretica 47 (3-4):199-207.
    We used computer simulations to study the possible role of the dispersion of cellular coupling, refractoriness or both, in the mechanisms underlying cardiac arrhythmias. Local ischemia was first assumed to induce cell to cell dispersion of the coupling resistance (Case 1), refractory period (Case 2), or both of them (Case 3). Our numerical experiments based on the van Capelle and Durrer model showed that vortices could not be induced by cell to cell variations. With cellular properties dispersed in a patchy (...)
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  27.  42
    Sympathetic Nervous System and Pain: A Clinical Reappraisal.Helmut Blumberg, Ulrike Hoffmann, Mohsen Mohadjer & Rudolf Scheremet - 1997 - Behavioral and Brain Sciences 20 (3):426-434.
    The target article discusses various aspects of the relationship between the sympathetic system and pain. To this end, the patients under study are divided into three groups. In the first group, called (RSD), the syndrome can be characterized by a triad of autonomic, motor, and sensory symptoms, which occur in a distally generalized distribution. The pain is typically felt deeply and diffusely, has an orthostatic component, and is suppressed by the ischemia test. Under those circumstances, the pain is likely to (...)
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  28.  21
    In Silico Study of the Influence of Intensity and Duration of Blood Flow Reduction on Cell Death Through Necrosis or Apoptosis During Acute Ischemic Stroke.Jean-Pierre Boissel - 2010 - Acta Biotheoretica 58 (2-3):171-190.
    Ischemic stroke involves numerous and complex pathophysiological mechanisms including blood flow reduction, ionic exchanges, spreading depressions and cell death through necrosis or apoptosis. We used a mathematical model based on these phenomena to study the influences of intensity and duration of ischemia on the final size of the infarcted area. This model relies on a set of ordinary and partial differential equations. After a sensibility study, the model was used to carry out in silico experiments in various ischemic conditions. The (...)
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  29.  27
    Ideas in Theoretical Biology Origin of Cancerous Cells From Tumours.Deng K. Niu & Jia-Kuan Chen - 1998 - Acta Biotheoretica 46 (4):379-381.
    With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.
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  30.  6
    The Influence of Antenatal and Maternal Factors on Stillbirths and Neonatal Deaths in New South Wales, Australia.M. Mohsin, A. E. Bauman & B. Jalaludin - 2006 - Journal of Biosocial Science 38 (5):643-657.
    This study identified the influences of maternal socio-demographic and antenatal factors on stillbirths and neonatal deaths in New South Wales, Australia. Bivariate and multivariate analyses were used to explore the association of selected antenatal and maternal characteristics with stillbirths and neonatal deaths. The findings of this study showed that stillbirths and neonatal deaths significantly varied by infant sex, maternal age, Aboriginality, maternal country of birth, socioeconomic status, parity, maternal smoking behaviour during pregnancy, maternal diabetes mellitus, maternal hypertension, antenatal care, plurality (...)
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  31.  6
    Building a Rational Foundation for Neural Transplantation.Hasker P. Davis & Bruce T. Volpe - 1995 - Behavioral and Brain Sciences 18 (1):55-56.
    The neural transplantation research described by Sinden and colleagues provides part of the rationale for the clinical application of neural transplantation. The authors are asked to clarify their view of the role of the cholinergic system in cognition, to address extrahippocampal damage caused by transient forebrain ischemia, and to consider the effects of delayed neural degeneration in their structure-function analysis.
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  32.  4
    A Brief History of Theories Concerning the Mammalian Urine Concentrating Mechanism.S. Thomas - 2001 - Acta Biotheoretica 49 (4):327-340.
    The mechanism by which the mammalian kidney creates the osmotic gradient necessary for urine concentration remains an open question. We present a brief survey of the give-and-take between theory and experiment on this question over the last half century. We start with the introduction of the countercurrent multiplier paradigm in 1951. We finish with a description of a recent suggestion that the explanation for the enigmatic inner medullary osmotic gradient may reside in the very metabolism of the inner medullary cells, (...)
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