Philosophers of psychology debate, among other things, which psychological models, if any, are (or provide) mechanistic explanations. This should seem a little strange given that there is rough consensus on the following two claims: 1) a mechanism is an organized collection of entities and activities that produces, underlies, or maintains a phenomenon, and 2) a mechanistic explanation describes, represents, or provides information about the mechanism producing, underlying, or maintaining the phenomenon to be explained (i.e. the explanandum phenomenon) (...) (Bechtel and Abrahamsen 2005; Craver 2007). If there is a rough consensus on what mechanisms are and that mechanistic explanations describe, represent, or provide information about them, then how is there no consensus on which psychological models are (or provide) mechanistic explanations? Surely the psychological models that are mechanistic explanations are the models that describe, represent, or provide information about mechanisms. That is true, of course; the trouble arises when determining what exactly that involves. Philosophical disagreement over which psychological models are mechanistic explanations is often disagreement about what it means to describe, represent, or provide information about a mechanism, among other things (Hochstein 2016; Levy 2013). In addition, one's position in this debate depends on a host of other seemingly arcane metaphysical issues, such as the nature of mechanisms, computational and functional properties (Piccinini 2016), and realization (Piccinini and Maley 2014), as well as the relation between models, methodologies, and explanations (Craver 2014; Levy 2013; Zednik 2015). Although I inevitably advocate a position, my primary aim in this chapter is to spell out all these relationships and canvas the positions that have been taken (or could be taken) with respect to mechanistic explanation in psychology, using dynamical systems models and cognitive models (or functional analyses) as examples. (shrink)

This paper critiques the new mechanistic explanatory program on grounds that, even when applied to the kinds of examples that it was originally designed to treat, it does not distinguish correct explanations from those that blunder. First, I offer a systematization of the explanatory account, one according to which explanations are mechanistic models that satisfy three desiderata: they must 1) represent causal relations, 2) describe the proper parts, and 3) depict the system at the right ‘level.’ Second, I (...) argue that even the most developed attempts to fulfill these desiderata fall short by failing to appropriately constrain explanatorily apt mechanistic models. -/- *This paper used to be called "The Emperor's New Mechanisms". (shrink)

In some influential histories of ancient philosophy, teleological explanation and mechanistic explanation are assumed to be directly opposed and mutually exclusive alternatives. I contend that this assumption is deeply flawed, and distorts our understanding both of teleological and mechanistic explanation, and of the history of mechanistic philosophy. To prove this point, I shall provide an overview of the first systematic treatise on mechanics, the short and neglected work Mechanical Problems, written either by Aristotle or (...) by a very early member of his school. I will argue that the work is thoroughly Aristotelian in methodology, and that taking it seriously can deepen our understanding of Aristotle’s discussion of animal and human self-motion in the Physics and On the Movement of Animals. (shrink)

This paper defines and defends a notion of teleological function which is fit to figure in explanations concerning how organic systems, and the items which compose them, are able to perform certain activities, such as surviving and reproducing or pumping blood. According to this notion, a teleological function of an item (such as the heart) is a typical way in which items of that type contribute to some containing system's ability to do some activity. An account of what it is (...) for an item to contribute to a containing system's ability to perform an activity is provided. I argue that the view acquires its normative status in virtue of the fact that it obeys a function-accident distinction and obeys a function-dysfunction distinction; that the view is ahistorical; and, that its ahistoricity provides it with an advantage over one of its main competitors. (shrink)

The idea at the core of the New Mechanical account of explanation can be summarized in the claim that explaining means showing ‘how things work’. This simple motto hints at three basic features of Mechanistic Explanation (ME): ME is an explanation-how, that implies the description of the processes underlying the phenomenon to be explained and of the entities that engage in such processes. These three elements trace a fundamental contrast with the view inherited from Hume and (...) later from strict logical empiricism (see Creath 2017), focused on epistemic and formal features of science and according to which issues concerning the kind of entities and processes that lie within a theory’s domain are extraneous to science and belong instead to ontology or metaphysics. Philosophers belonging to the new mechanical philosophy believe that the received view of scientific explanation (Hempel 2001), pivoting on the notion of law of nature, overshadows this insight. Since its origin in the 17th century, mechanical philosophy aimed to explain natural phenomena by reducing them to mechanisms. Traditional attempts to define the concept of mechanism involved the identification of a limited set of fundamental elements as, for instance, contact action, action at a distance, inertial motion (see e.g. Hesse 2005), and, more recently, transmission of a mark, or of a conserved quantity (see Frisch, this volume). The new mechanical philosophy rejects this austere characterization of mechanisms and mechanistic explanation and aim at providing a novel, philosophically rigorous explication of the concept of mechanism and of its role in scientific explanation and practice. ME has been adopted with profit in philosophy of special sciences (for instance in biomedical sciences, e.g. in the explanation of chemical transmission at synapses ((Machamer, Darden and Craver 2000), MDC henceforth); but also in social sciences, e.g. the three kinds of social mechanisms in Coleman’s analysis of Max Weber’s account of the role of the Protestant ethic in the growth of capitalism (Hedström and Swedberg 1998)), where exceptionless regularities are rarely ever found. In physics, it is generally possible to formulate explanations in law-based form, with the result that the plurality of explanatory forms might be overlooked. This should not come as a surprise, given that physics was the main inspiration for logical empiricists, and, in particular, Newtonian physics was a template for Hempel’s formulation of the covering law model. However, this situation is unfortunate, since, we will argue, knowing how things work is often part of the explanation of physical phenomena. In this chapter, we provide an introduction to the basic features of ME, with specific focus on its application to physics (section 1). The main part of the chapter is devoted to the defence of two theses: on the one hand, some domains of physics are not compatible with mechanistic reasoning and explanation (section 2); on the other hand, a comprehensive account of explanation in physics can’t dispense with ME (section 3). (shrink)

Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids (...) certain objections to Salmon's account of causal-mechanical explanation. I conclude by discussing how mechanistic explanations can provide understanding by unification. (shrink)

In a recent book and an article, Carl Craver construes the relations between different levels of a mechanism, which he also refers to as constitutive relations, in terms of mutual manipulability (MM). Interpreted metaphysically, MM implies that inter-level relations are symmetrical. MM thus violates one of the main desiderata of scientific explanation, namely explanatory asymmetry. Parts of Craver’s writings suggest a metaphysical interpretation of MM, and Craver explicitly commits to constitutive relationships being symmetrical. The paper furthermore explores the option (...) of interpreting MM epistemologically, as a means for individuating mechanisms. It is argued that MM then is redundant. MM should therefore better be abandoned. (shrink)

Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids (...) certain objections to Salmon's account of causal-mechanical explanation. I conclude by discussing how mechanistic explanations can provide understanding by unification. (shrink)

Pseudo‐mechanistic explanations in psychology and cognitive neuroscienceThis paper focuses on the level of systems/cognitive neuroscience. It argues that the great majority of explanations in psychology and cognitive neuroscience is “pseudo‐mechanistic.” On the basis of various case studies, Hommel argues that cognitive neuroscience should move beyond what he calls an “Aristotelian phase” to become a mature “Galilean” science seeking to discover actual mechanisms of cognitive phenomena.

Craver claims that mechanistic explanation is ontic, while Bechtel claims that it is epistemic. While this distinction between ontic and epistemic explanation originates with Salmon, the ideas have changed in the modern debate on mechanistic explanation, where the frame of the debate is changing. I will explore what Bechtel and Craver’s claims mean, and argue that good mechanistic explanations must satisfy both ontic and epistemic normative constraints on what is a good explanation. I (...) will argue for ontic constraints by drawing on Craver’s work in Sect. 2.1, and argue for epistemic constraints by drawing on Bechtel’s work in Sect. 2.2. Along the way, I will argue that Bechtel and Craver actually agree with this claim. I argue that we should not take either kind of constraints to be fundamental, in Sect. 3, and close in Sect. 4 by considering what remains at stake in making a distinction between ontic and epistemic constraints on mechanistic explanation. I suggest that we should not concentrate on either kind of constraint, to the neglect of the other, arguing for the importance of seeing the relationship as one of integration. (shrink)

Philosophers of science typically associate the causal‐mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon’s account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex‐systems approach avoids (...) certain objections to Salmon’s account of causal‐mechanical explanation. I conclude by discussing how mechanistic explanations can provide understanding by unification. (shrink)

The philosophy of mechanisms has developed rapidly during the last 30 years. As mechanisms-based explanations are often seen as an alternative to nomological, law-based explanations, MBEs could be relevant in IS. We begin by offering a short history of mechanistic philosophy and set out to clarify the contemporary landscape. We then suggest that mechanistic models provide an alternative to variance and process models in IS. Finally, we highlight how MBEs typically contain deliberate misrepresentations. Although MBEs have recently been (...) advocated as critical realist accounts in IS, idealizations seem to violate some fundamental tenets of CR and research method principles for CR. Idealizations in MBEs, therefore, may risk being regarded as flawed in IS. If it turns out that CR cannot account for idealizations, naturalism can, and it does so without extra-philosophical baggage. (shrink)

The ontic conception of scientific explanation has been constructed and motivated on the basis of a putative lexical ambiguity in the term explanation. I raise a puzzle for this ambiguity claim, and then give a deflationary solution under which all ontically-rendered talk of explanation is merely elliptical; what it is elliptical for is a view of scientific explanation that altogether avoids the ontic conception. This result has revisionary consequences for New Mechanists and other philosophers of science, (...) many of whom have assimilated their conception of explanation to the ontic conception. (shrink)

In this paper I apply the mechanistic account of explanation to engineering science. I discuss two ways in which this extension offers further development of the mechanistic view. First, functional individuation of mechanisms in engineering science proceeds by means of two distinct sub types of role function, behavior function and effect function, rather than role function simpliciter. Second, it offers refined assessment of the explanatory power of mechanistic explanations. It is argued that in the context of (...) malfunction explanations of technical systems, two key desiderata for mechanistic explanations, ‘completeness and specificity’ and ‘abstraction’, pull in opposite directions. I elaborate a novel explanatory desideratum to accommodate this explanatory context, dubbed ‘local specificity and global abstraction’, and further argue that it also holds for mechanistic explanations of malfunctions in the biological domain. The overall result is empirically-informed understanding of mechanistic explanation in engineering science, thus contributing to the ongoing project of understanding mechanistic explanation in novel or relatively unexplored domains. I illustrate these claims in terms of reverse engineering and malfunction explanations in engineering science. (shrink)

We provide an account of mechanistic representation and explanation that has several advantages over previous proposals. In our view, explaining mechanistically is not simply giving an explanation of a mechanism. Rather, an explanation is mechanistic because of particular relations that hold between a mechanical representation, or model, and the target of explanation. Under this interpretation, mechanistic explanation is possible even when the explanatory target is not a mechanism. We argue that taking this (...) view is not only coherent and plausible, it gives a more sophisticated view of the relationship between mechanical models and their targets. This allows us to address some ambiguities within the mechanist framework, and delivers a more intuitive way to interpret scientists' use of the term "mechanism". (shrink)

Both in biology and psychology there has been a tendency on the part of many investigators to focus solely on the mature organism and ignore development. There are many reasons for this, but an important one is that the explanatory framework often invoked in the life sciences for understanding a given phenomenon, according to which explanation consists in identifying the mechanism that produces that phenomenon, both makes it possible to side-step the development issue and to provide inadequate resources for (...) actually explaining development. When biologists and psychologists do take up the question of development, they find themselves confronted with two polarizing positions of nativism and empiricism. However, the mechanistic framework, insofar as it emphasizes organization and recognizes the potential for self-organization, does in fact provide the resources for an account of development which avoids the nativism-empiricism dichotomy. (shrink)

Two widely accepted assumptions within cognitive science are that (1) the goal is to understand the mechanisms responsible for cognitive performances and (2) computational modeling is a major tool for understanding these mechanisms. The particular approaches to computational modeling adopted in cognitive science, moreover, have significantly affected the way in which cognitive mechanisms are understood. Unable to employ some of the more common methods for conducting research on mechanisms, cognitive scientists’ guiding ideas about mechanism have developed in conjunction with their (...) styles of modeling. In particular, mental operations often are conceptualized as comparable to the processes employed in classical symbolic AI or neural network models. These models, in turn, have been interpreted by some as themselves intelligent systems since they employ the same type of operations as does the mind. For this paper, what is significant about these approaches to modeling is that they are constructed specifically to account for behavior and are evaluated by how well they do so—not by independent evidence that they describe actual operations in mental mechanisms. (shrink)

In this article we analyze the methodological commitments of a radical embodied cognition approach to social interaction and social cognition, specifically with respect to the explanatory framework it adopts. According to many representatives of REC, such as enactivists and the proponents of dynamical and ecological psychology, sociality is to be explained by focusing on the social unit rather than the individuals that comprise it and establishing the regularities that hold on this level rather than modeling the sub-personal mechanisms that could (...) be said to underlie social phenomena. We point out that, despite explicit commitment, such a view implies an implicit rejection of the mechanistic explanation framework widely adopted in traditional cognitive science, which, in our view, hinders comparability between REC and these approaches. We further argue that such a position is unnecessary and that enactive mechanistic explanation of sociality is both possible and desirable. We examine three distinct objections from REC against mechanistic explanation, which we dub the decomposability, causality and extended cognition worries. In each case we show that these complaints can be alleviated by either appreciation of the full scope of the mechanistic account or adjustments on both mechanistic and REC sides of the debate. (shrink)

It is argued that once biological systems reach a certain level of complexity, mechanistic explanations provide an inadequate account of many relevant phenomena. In this article, I evaluate such claims with respect to a representative programme in systems biological research: the study of regulatory networks within single-celled organisms. I argue that these networks are amenable to mechanistic philosophy without need to appeal to some alternate form of explanation. In particular, I claim that we can understand the mathematical (...) modelling techniques of systems biologists as part of a broader practice of constructing and evaluating mechanism schemas. This argument is elaborated by considering the case of bacterial chemotactic networks, where some research has been interpreted as explaining phenomena by means of abstract design principles. (shrink)

This volume offers a broad, philosophical discussion on mechanical explanations. Coverage ranges from historical approaches and general questions to physics and higher-level sciences . The contributors also consider the topics of complexity, emergence, and reduction. Mechanistic explanations detail how certain properties of a whole stem from the causal activities of its parts. This kind of explanation is in particular employed in explanatory models of the behavior of complex systems. Often used in biology and neuroscience, mechanistic explanation (...) models have been often overlooked in the philosophy of physics. The authors correct this surprising neglect. They trace these models back to their origins in physics. The papers present a comprehensive historical, methodological, and problem-oriented investigation. The contributors also investigate the conditions for using models of mechanistic explanations in physics. The last papers make the bridge from physics to economics, the theory of complex systems and computer science . This book will appeal to graduate students and researchers with an interest in the philosophy of science, scientific explanation, complex systems, models of explanation in physics higher level sciences, and causal mechanisms in science. (shrink)

Recently, Piccinini and Craver have stated three theses concerning the relations between functional analysis and mechanistic explanation in cognitive sciences: No Distinctness: functional analysis and mechanistic explanation are explanations of the same kind; Integration: functional analysis is a kind of mechanistic explanation; and Subordination: functional analyses are unsatisfactory sketches of mechanisms. In this paper, I argue, first, that functional analysis and mechanistic explanations are sub-kinds of explanation by scientific (idealized) models. From that (...) point of view, we must take into account the tradeoff between the representational/explanatory goals of generality and precision that govern the practice of model-building. In some modeling scenarios, it is rational to maximize explanatory generality at the expense of mechanistic precision. This tradeoff allows me to put forward a problem for the mechanist position. If mechanistic modeling endorses generality as a valuable goal, then Subordination should be rejected. If mechanists reject generality as a goal, then Integration is false. I suggest that mechanists should accept that functional analysis can offer acceptable explanations of cognitive phenomena. (shrink)

Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development (...) of mechanistic models, identifying five constraints which guide the articulation of models in molecular systems biology. These constraints are not independent of one another, with the result that modeling becomes an iterative process. We illustrate the use of these constraints in the modeling of the mechanism for bistability in the lac operon. (shrink)

Resurgent interest in both mechanistic and counterfactual theories of explanation has led to a fair amount of discussion regarding the relative merits of these two approaches. James Woodward is currently the pre-eminent counterfactual theorist, and he criticizes the mechanists on the following grounds: Unless mechanists about explanation invoke counterfactuals, they cannot make sense of claims about causal interactions between mechanism parts or of causal explanations put forward absent knowledge of productive mechanisms. He claims that these shortfalls can (...) be offset if mechanists will just borrow key tenets of his counterfactual theory of causal claims. What mechanists must bear in mind, however, is that by pursuing this course they risk both the assimilation of the mechanistic theories of explanation into Woodward’s own favored counterfactual theory, and they risk the marginalization of mechanistic explanations to a proper subset of all explanations. An outcome more favorable to mechanists might be had by pursuing an actualist-mechanist theory of the contents of causal claims. While it may not seem obvious at first blush that such an approach is workable, even in principle, recent empirical research into causal perception, causal belief, and mechanical reasoning provides some grounds for optimism. (shrink)

Biological processes are often explained by identifying the underlying mechanisms that generate a phenomenon of interest. I characterize a basic account of mechanistic explanation and then present three challenges to this account, illustrated with examples from molecular biology. The basic mechanistic account is insufficient for explaining nonsequential and nonlinear dynamic processes, is insufficient for explaining the inherently stochastic nature of many biological mechanisms, and fails to give a proper framework for analyzing organization. I suggest that biological processes (...) are best approached as a multidimensional gradient—with some processes being paradigmatic cases of mechanisms and some being marginal cases. (shrink)

Mechanistic accounts of explanation have recently found popularity within philosophy of science. Presently, we introduce the idea of an extended mechanistic explanation, which makes explicit room for the role of environment in explanation. After delineating Craver and Bechtel’s account, we argue this suggestion is not sufficiently robust when we take seriously the mechanistic environment and modeling practices involved in studying contemporary complex biological systems. Our goal is to extend the already profitable mechanistic picture (...) by pointing out the importance of the mechanistic environment. It is our belief that extended mechanistic explanations, or mechanisms that take into consideration the temporal sequencing of the interplay between the mechanism and the environment, allow for mechanistic explanations regarding a broader group of scientific phenomena. (shrink)

Although there is a consensus among philosophers of mathematics and mathematicians that mathematical explanations exist, only a few authors have proposed accounts of explanation in mathematics. These accounts fit into the unificationist or top-down approach to explanation. We argue that these models can be complemented by a bottom-up approach to explanation in mathematics. We introduce the mechanistic model of explanation in science and discuss the possibility of using this model in mathematics, arguing that using it (...) does not presuppose a Platonist view of mathematics and allows one to gain insight into why a theorem is true by answering what-if-things-had-been-different questions. (shrink)

The philosophical conception of mechanistic explanation is grounded on a limited number of canonical examples. These examples provide an overly narrow view of contemporary scientific practice, because they do not reflect the extent to which the heuristic strategies and descriptive practices that contribute to mechanistic explanation have evolved beyond the well-known methods of decomposition, localization, and pictorial representation. Recent examples from evolutionary robotics and network approaches to biology and neuroscience demonstrate the increasingly important role played by (...) computer simulations and mathematical representations in the epistemic practices of mechanism discovery and mechanism description. These examples also indicate that the scope of mechanistic explanation must be re-examined: With new and increasingly powerful methods of discovery and description comes the possibility of describing mechanisms far more complex than traditionally assumed. (shrink)

We address the question of whether and to what extent explanatory and modelling strategies in systems biology are mechanistic. After showing how dynamic mathematical models are actually required for mechanistic explanations of complex systems, we caution readers against expecting all systems biology to be about mechanistic explanations. Instead, the aim may be to generate topological explanations that are not standardly mechanistic, or to arrive at design principles that explain system organization and behaviour in general, but not (...) specific mechanisms. These abstraction strategies serve various aims, including prediction and control, that are central to understanding the epistemic diversity of systems biology. (shrink)

Jon Elster worries about the explanatory power of the social sciences. His main concern is that they have so few well-established laws. Elster develops an interesting substitute: a special kind of mechanism designed to fill the explanatory gap between laws and mere description. However, his mechanisms suffer from a characteristic problem that I will explore in this article. As our causal knowledge of a specific problem grows we might come to know too much to make use of an Elsterian mechanism (...) but still lack a law. We might then find ourselves in the paradoxical position of knowing more relevant causal truths about the phenomenon we are interested in than we did before, but being able to explain less. If this possibility is realized in social science settings, as I argue it might well be, Elster?s mechanistic account is threatened. Moreover, even if the possibility is rarely realized in that way, it raises, simply as a possibility, a conceptual problem with Elster?s mechanistic framework. (shrink)

The past two decades have witnessed an increase in interest in social mechanisms and mechanistic explanations of social macro-phenomena. This paper addresses the question of what the components of social mechanisms in mechanistic explanations of social macro-phenomena must be. Analytical sociology’s initial position and the main new proposals by analytical sociologists are discussed. It is argued that all of them are faced with outstanding difficulties. Subsequently, a minimal requirement regarding the components of social mechanisms is introduced. It is (...) held that a component of a social mechanism in a mechanistic explanation of a social macro-phenomenon must not have the explanandum phenomenon as a part of it. (shrink)

_Abstract_: Nudges have proven to be effective tools for steering citizens toward desirable behaviors and make valuable additions to any policy-maker’s toolbox. Disappointingly, however, there are no mechanistic explanations for how nudges work, leaving policy-makers unable to explain what happens when they are implemented. This paper identifies some neglected ethical implications of the resulting citizens lack of awareness of such mechanisms. We first examine mechanistic explanations in relation to citizens’ understanding on how they work. Then, we look at (...) mechanistic explanations in light of the suggestion advanced by some ethicists that nudges be considered ethically acceptable in modern liberal democracies provided the explicit transparency of the nudges employed. _Keywords_: Nudge; Ethics of Nudging; Mechanistic Evidence; In-principle Transparency; Explicit Transparency _Spiegazioni meccanicistiche e l’etica dei _nudges _Riassunto_: I _nudge_ si sono rivelati strumenti di _policy_ efficaci nello "spingere gentilmente" i cittadini verso comportamenti considerati desiderabili. Per questa ragione i nudge sono considerati validi strumenti della cassetta degli attrezzi di un _policymaker_. Tuttavia, è in qualche modo deludente la mancanza di spiegazioni meccanicistiche dei nudge, dalla quale risulta l'incapacità dei _policymaker_ di spiegare quello che succede quando i nudge vengono effettivamente implementati. Questo articolo identifica alcune implicazioni etiche finora trascurate connesse alla inconsapevolezza da parte dei cittadini circa i meccanismi che governano i _nudge_. Da una parte, le nostre considerazioni metteranno in relazione le spiegazioni meccanicistiche con la comprensione dei _nudge_ da parte dei cittadini. Dall'altra parte, metteremo in relazione le spiegazioni meccanicistiche con il concetto di trasparenza esplicita, ossia la richiesta avanzata da alcuni eticisti al fine di considerare i _nudge_ eticamente accettabili nelle moderne democrazie liberali. _Parole chiave_: Nudge; Etica dei nudge; Spiegazioni meccanicistiche; Trasparenza implicita; Trasparenza esplicita. (shrink)

This paper discusses the important paper by Paul Thagard on the pathway version of mechanistic explanation that is currently used in chemical explanation. The author claims that this method of explanation has a respectable pedigree and can be traced back to the Chemical Revolution in the arguments used by the Lavoisier School in their theoretical duels with Richard Kirwan, the proponent of a revised phlogistonian theory. Kirwan believed that complex chemical reactions could be explained by recourse (...) to affinity tables that catalogued the attraction that various simple bodies possessed towards each other. To explain was in effect to make a delayed prediction, it is not enough just to show how a phenomenon fits into the discernible patterns of the world. Lavoisier, Fourcroy and their colleagues used pathway reasoning, although disguising this fact by suggesting that affinities varied when subjected to n-body situations. (shrink)

Despite widespread recognition that psychiatry would be better served by a classificatory system based on etiology rather than mere description, it goes without saying that much of the necessary work is yet to be done. In this chapter I take up the increasingly important question of how mechanistic explanation fits into the larger effort to build a scientifically sound etiological and nosological framework. I sketch a rough picture of what mechanistic explanation should look like in the (...) context of psychiatric research, with a focus on several potential challenges posed by the special features of many psychiatric conditions. These include the role of social and environmental factors, the relatively transient nature of symptoms, the presumably complex organization of underlying systems, and the likelihood that many disorders are the product of nonstandard development. I suggest that these explanatory challenges can be met with a sufficiently broad notion of mechanism, one that allows for something less than the flawless execution of internal operations, appeals to the influence of contextual factors, and attends to organizational relations both within the mechanism itself and across the wider cognitive system. (shrink)

Piccinini and Craver (Synthese 183:283–311, 2011) argue for the surprising view that psychological explanation, properly understood, is a species of mechanistic explanation. This contrasts with the ‘received view’ (due, primarily, to Cummins and Fodor) which maintains a sharp distinction between psychological explanation and mechanistic explanation. The former is typically construed as functional analysis, the analysis of some psychological capacity into an organized series of subcapacities without specifying any of the structural features that underlie the (...) explanandum capacity. The latter idea, of course, sees explanation as a matter of describing structures that maintain (or produce) the explanandum capacity. In this paper, I defend the received view by criticizing Piccinini and Craver’s argument for the claim that psychological explanation is not distinct from mechanistic explanation, and by showing how psychological explanations can possess explanatory force even when nothing is known about the underlying neurological details. I conclude with a few brief criticisms about the enterprise of mechanistic explanation in general. (shrink)

This paper discusses a class of mechanistic explanations employed in engineering science where the activities and organization of nonstandard entities are cited as core factors responsible for failures. Given the use of mechanistic language by engineers and the manifestly mechanistic structure of these explanations, I consider several interpretations of these explanations within the new mechanical framework. I argue that these interpretations fail to solve several philosophical problems and propose an account of fictional mechanism explanations instead. According to (...) this account, fictional mechanism explanations provide descriptions of fictional mechanisms that enable the tracking of counterfactual dependencies of the physical system they model by capturing system constraints. Engineers use these models to learn about and understand properties of materials, to build computational simulations of their behaviour, and to design new materials. (shrink)

The topic of mechanistic explanation in neuroscience has been a subject of recent discussion. There is a lot of interest in understanding what these explanations involve. Furthermore, there is disagreement about whether neurological mechanisms themselves should be viewed as reductionist in nature. In this paper I will explain how these two issues are related. I will, first, describe how mechanisms support a form of antireductionism. This is because the mechanisms that exist should be seen as involving part-whole relations, (...) where the behavior of a whole is more than the sum of its parts. After this, I will consider mechanistic explanations and how they can be understood. While some people think the explanations concern existing entities in the world, I will argue that we can understand the explanations by viewing them in terms of arguments. Despite the fact that it is possible to understand mechanistic explanations in this manner, the antireductionist point remains. (shrink)

An important strategy in the discovery of biological mechanisms involves the piecing together of experimental results from interventions. However, if mechanisms are investigated by means of ideal interventions, as defined by James Woodward and others, then the kind of information revealed is insufficient to discriminate between modular and non-modular causal contributions. Ideal interventions suffice for constructing webs of causal dependencies that can be used to make some predictions about experimental outcomes, but tell us little about how causally relevant factors are (...) organized together and how they interact with each other in order to produce a phenomenon. I argue that lab research relies on more elaborated types of interventions targeting in a controlled fashion multiple variables at the same time in order to probe the temporal organization of causally-relevant factors along distinct causal pathways and to test for non-modular interaction effects, thus providing crucial spatial-temporal constraints guiding the formulation of more detailed mechanistic explanations. (shrink)

This paper explores the question of whether all or most explanations in biology are, or ideally should be, ‘mechanistic’. I begin by providing an account of mechanistic explanation, making use of the interventionist ideas about causation I have developed elsewhere. This account emphasizes the way in which mechanistic explanations, at least in the biological sciences, integrate difference‐making and spatio‐temporal information, and exhibit what I call fine‐tunedness of organization. I also emphasize the role played by modularity conditions (...) in mechanistic explanation. I will then argue, in agreement with John Dupré, that, given this account, it is plausible that many biological systems require explanations that are relatively non‐mechanical or depart from expectations one associates with the behaviour of machines. (shrink)

Many explanations in molecular biology, neuroscience, and other fields of experimental biology describe mechanisms underlying phenomena of interest. These mechanistic explanations account for higher-level phenomena in terms of causally active parts and their spatiotemporal organization. What makes such a mechanistic description explanatory? The best-developed answer, Craver's causal-mechanical account, has several weaknesses. It does not fully explicate the target of explanation, interlevel relation, or interactive nonmodular character of many biological mechanisms as we understand them. An alternative account of (...) MEx, emphasizing interdependence among a mechanism's components, remedies these difficulties. (shrink)

In this essay I propose that what design principles in systems biology and systems neuroscience do is to present abstract characterizations of mechanisms, and thereby facilitate mechanistic explanation. To show this, one design principle in systems neuroscience, i.e., the multilayer perceptron, is examined. However, Braillard (2010) contends that design principles provide a sort of non-mechanistic explanation due to two related reasons: they are very general and describe non-causal dependence relationships. In response to this, I argue that, (...) on the one hand, all mechanisms are more or less general (or abstract), and on the other, many (if not all) design principles are causal systems. (shrink)

The paper discusses methodological guidelines for evaluating mechanistic explanations. According to current accounts, a satisfactory mechanistic explanation should include all of the relevant features of the mechanism, its component entities and activities, and their properties and organization, as well as exhibit productive continuity. It is not specified, however, how this kind of mechanistic completeness can be demonstrated. I argue that parameter sufficiency inferences based on mathematical model simulations provide a way of determining whether a mechanism capable (...) of producing the phenomenon of interest can be constructed from mechanistic components organized, acting, and having the properties described in the mechanistic explanation. (shrink)

The problem of fuzzy boundaries when delineating cortical areas is widely known in human brain mapping and its adjacent subdisciplines . Yet, a conceptual framework for understanding indeterminacy in neuroscience is missing, and there has been no discussion in the philosophy of neuroscience whether indeterminacy poses an issue for good neuroscientific explanations. My paper addresses both these issues by applying philosophical theories of vagueness to three levels of neuroscientific research, namely to cytoarchitectonic studies at the neuron level intra-areal neuronalinteraction measured (...) by the BOLD-signal of functional magnetic resonance imaging and inter-areal connectivity between different cortical areas. The rest of the paper explores how this framework can be extended to mechanistic explanations in neuroscience. I discuss a semantic and an ontic interpretation of vagueness in mechanistic explanations and argue how both become scientifically interesting from the perspective of a philosophy of scientific practice. (shrink)

Hodgkin and Huxley’s model of the action potential is an apparent dream case of covering‐law explanation in biology. The model includes laws of physics and chemistry that, coupled with details about antecedent and background conditions, can be used to derive features of the action potential. Hodgkin and Huxley insist that their model is not an explanation. This suggests either that subsuming a phenomenon under physical laws is insufficient to explain it or that Hodgkin and Huxley were wrong. I (...) defend Hodgkin and Huxley against Weber’s heteronomy thesis and argue that explanations are descriptions of mechanisms. †To contact the author, please write to: Department of Philosophy, Philosophy‐Neuroscience‐Psychology Program, Washington University in St. Louis, One Brookings Drive, Wilson Hall, St. Louis, MO 63130; e‐mail: [email protected]. (shrink)