Research in the organizational sciences has tended to portray prosocial behavior as an unqualified positive outcome that should be encouraged in organizations. However, only recently, have researchers begun to acknowledge prosocial behaviors that help maintain an organization’s positive image in ways that violate ethical norms. Recent scandals, including Volkswagen’s emissions scandal and Penn State’s child sex abuse scandal, point to the need for research on the individual factors and situational conditions that shape the emergence of these unethical pro-organizational (...) behaviors. Drawing on trait activation theory, we argue that the “dark” trait of Machiavellianism should make individuals more willing to engage in UPB. Further, we argue that this willingness will be augmented when Machiavellians hold bottom-line-mentality climate perceptions, or the perception that ethical standards matter less than organizational performance. Using data from 170 U.S. employees, results suggested that Machiavellians are more willing to engage in UPB, but that BLMCPs may not affect their motivation to engage in UPB. We discuss the study’s theoretical and practical implications, as well as avenues for research. (shrink)

We develop a cultural evolutionary theory of the origins of prosocial religions and apply it to resolve two puzzles in human psychology and cultural history: the rise of large-scale cooperation among strangers and, simultaneously, the spread of prosocial religions in the last 10–12 millennia. We argue that these two developments were importantly linked and mutually energizing. We explain how a package of culturally evolved religious beliefs and practices characterized by increasingly potent, moralizing, supernatural agents, credible displays of faith, (...) and other psychologically active elements conducive to social solidarity promoted high fertility rates and large-scale cooperation with co-religionists, often contributing to success in intergroup competition and conflict. In turn, prosocial religious beliefs and practices spread and aggregated as these successful groups expanded, or were copied by less successful groups. This synthesis is grounded in the idea that although religious beliefs and practices originally arose as nonadaptive by-products of innate cognitive functions, particular cultural variants were then selected for their prosocial effects in a long-term, cultural evolutionary process. This framework reconciles key aspects of the adaptationist and by-product approaches to the origins of religion, explains a variety of empirical observations that have not received adequate attention, and generates novel predictions. Converging lines of evidence drawn from diverse disciplines provide empirical support while at the same time encouraging new research directions and opening up new questions for exploration and debate. (shrink)

Research in the organizational sciences has tended to portray prosocial behavior as an unqualified positive outcome that should be encouraged in organizations. However, only recently, have researchers begun to acknowledge prosocial behaviors that help maintain an organization’s positive image in ways that violate ethical norms. Recent scandals, including Volkswagen’s emissions scandal and Penn State’s child sex abuse scandal, point to the need for research on the individual factors and situational conditions that shape the emergence of these unethical pro-organizational (...) behaviors. Drawing on trait activation theory, we argue that the “dark” trait of Machiavellianism should make individuals more willing to engage in UPB. Further, we argue that this willingness will be augmented when Machiavellians hold bottom-line-mentality climate perceptions, or the perception that ethical standards matter less than organizational performance. Using data from 170 U.S. employees, results suggested that Machiavellians are more willing to engage in UPB, but that BLMCPs may not affect their motivation to engage in UPB. We discuss the study’s theoretical and practical implications, as well as avenues for research. (shrink)

Ninety-five freshmen each recruited three peers to play a "group bidding game," an N-person prisoner’s dilemma in which anyone could win movie tickets depending on their scores in the game. Prior to playing, all participants completed a measure of prosocial value orientation. Replicating and extending earlier findings (Sheldon and McGregor 2000), our results show that prosocial participants were at a disadvantage within groups. Despite this vulnerability, prosocial participants did no worse overall than asocial participants because a counteracting (...) group-level advantage arose for prosocials, who tended to be concentrated in groups. Implications of this assortative process for the egoism/altruism debate, and for hierarchical selection theory, are discussed. (shrink)

This study examined the relationship between person–organization (PO) fit on prosocial identity (prosocial PO fit) and various employee outcomes. The results of polynomial regression analysis based on a sample of 589 hospital employees, which included medical doctors, nurses, and staff, indicate joint effects of personal and organizational prosocial identity on the development of a sense of organizational identification and on the engagement in prosocial behaviors toward colleagues, organizations, and patients. Specifically, prosocial PO fit had a (...) curvilinear relationship with organizational identification, such that organizational identification increased as organizational prosocial characteristics increased toward personal prosocial identity and then decreased when the organizational prosocial characteristics exceeded the personal prosocial identity. In addition, organizational identification and prosocial behaviors increased as both personal and organizational prosocial identity increased from low to high. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the (...) dynamics of prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

Anger has traditionally been associated with aggression and antagonistic behavior. A series of studies revealed that experiences of third-party anger can also lead to prosocial behavior. More specifically, three studies, hypothetical scenarios as well as a behavioral study, revealed that third-party anger can promote compensation of the victim. The results also showed a preference for such prosocial behaviors over antagonistic behaviors. We conclude that behaviors stemming from anger, whether antagonistic or prosocial, are reactions to inequity, albeit determined (...) by the constraints of the situation. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the (...) dynamics of prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

We investigate how changes to the payoffs of cooperative behavior affect the evolutionary dynamics. Paradoxically, the larger the benefits of cooperation, the less likely it is to evolve. This holds true even in cases where cooperation is strictly dominant. Increasing the benefits from prosocial behavior has two effects: first, in some circumstances it promotes the evolution of spite; and second, it can decrease the strength of selection leading to nearly neutral evolution of strategies. In light of these results we (...) must reevaluate standard philosophical perspectives on the evolution of cooperation and morality. (shrink)

Examining the costs and motivations of warfare is key to conundrums concerning the relevance of this troubling phenomenon to the evolution of social attachment and cooperation, particularly during adolescence and young adulthood—the developmental time period during which many participants are first recruited for warfare. The study focuses on Samburu, a pastoralist society of approximately 200,000 people occupying northern Kenya’s semi-arid and arid lands, asking what role the emotionally sensitized, peer-driven adolescent life stage may have played in the cultural and genetic (...) coevolution of coalitional lethal aggression. Research in small-scale societies provides unparalleled opportunities for sharply defined variables, particularly in age generation societies in which all young men are initiated into “warriorhood.” Proposing an epigenetic and component behavior approach, we examine whether raiding activities such as number of raids, killing, and sparing enemy lives associate with DNA methylation in two candidate genes: MAOA, linked to mood and arousal, and NR3C1, linked to stress and immune response. We report statistically significant associations between the epigenetic variables and the combat variables of overall raiding activity and reportedly showing mercy to enemies. In contrast, epigenetic variables did not associate with post-traumatic stress disorder symptom scores, and the only combat variable associated with PTSD was losing one’s own livestock in a raid. These findings raise important questions concerning the mechanisms driving warfare’s paradoxical mix of violent and altruistic behaviors. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the (...) dynamics of prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

Humans rely heavily on their prosocial relationships. We propose that the experience and display of prosocial emotions evolved to regulate such relationships through inhibiting individual selfishness in service of others. Two emotions in particular serve to meet two central requirements for upholding prosociality: gratitude motivates maintenance of ongoing prosocial interactions, and guilt motivates repair of ruptured prosocial interactions. We further propose, and review developmental evidence, that nascent forms of these two emotions serve their respective functions from (...) early in ontogeny. The remarkably early emergence of these prosocial emotions allows even very young children to participate in and benefit from prosociality. We discuss the implications of and challenges to this conclusion and identify pressing future directions for this work. (shrink)

Current perspectives on attractiveness-related prosocial biases emphasize the contribution of evolutionarily shaped mating drives. Here, we extend these concepts by highlighting the pivotal role of the hypothalamic peptide oxytocin in augmenting the salience and rewarding value of social stimuli, including the partner's face, thereby fostering social bonding in general and the stability of monogamous pair bonds and offspring care in particular.

This study examined the hypothesis that religiosity would be differentially related to six types of adolescent prosocial behaviour, and that these relations would be mediated by the prosocial value of kindness. Self?report data were collected from 142 high school students (63 per cent female; 91 per cent White; M age?=?16.8, S?=?.80). Religiosity was a significant positive predictor of kindness, as well as compliant, anonymous and altruistic prosocial behaviour, but not public, dire and emotional prosocial behaviour. Associations (...) between religiosity and both compliant and altruistic prosocial behaviours were mediated by kindness. Direct and indirect paths were found between religiosity and anonymous prosocial behaviour. Thus, partial support was found for the mediational hypothesis. Discussion focused on the utility of distinguishing among different types of prosocial behaviours and on the role of religion and values in promoting moral education. (shrink)

Do basic human values facilitate prosocial behaviour on a global scale? This study, for the first time, analyzes the effect of values on prosocial behaviour in the context of public support for foreign development assistance. Support for foreign development assistance is a prosocial act intended to benefit the less fortunate in developing nations. Despite a plethora of evidence showing the effect of personal values on prosocial behaviour, the literature has neglected the value origins of support for (...) development assistance. I argue that personal values play a crucial role in shaping individuals’ support for foreign development assistance. Using data from nationally representative samples covering 11 Organisation for Economic Cooperation and Development countries, I show that self-transcendence and openness to change values, as defined by Schwartz’ theory of values, are reliable predictors of support for foreign development assistance. By linking human values to foreign development aid, this study expands the purview of values research to the domain of global governance and opens up new avenues of interdisciplinary inquiry that apply theories of values to different dimensions of world affairs. (shrink)

Bering argues that belief in posthumous intentional agency may confer added fitness via the inhibition of opportunistic behavior. This is true only if these agents are interested parties in our moral choices, a feature which does not result from Bering's imaginative constraint hypothesis and extends to supernatural agents other than dead people's souls. A by-product model might handle this better.

We argue that the counterfactual representations of popular culture, like their religious cognates, are shaped by cognitive constraints that become visible when considered in aggregate. In particular, we argue that comic-book literature embodies core intuitions about sociality and its maintenance that are activated by the cognitive problem of living in large groups. This leads to four predictions: comic-book enforcers should be punitively prosocial, be quasi-omniscient, exhibit kin-signalling proxies and be minimally counterintuitive. We gauge these predictions against a large sample (...) of 19,877 characters that were derived from 72,611 comics using data scraping techniques. Our results corroborate the view that cognitive constraints exercise a selective effect on the transmission of popular culture. (shrink)

Anger is often primarily portrayed as a negative emotion that motivates antagonistic, aggressive, punitive, or hostile behavior. We propose that this portrayal is too one-sided. A review of the literature on behavioral consequences of anger reveals evidence for the positive and even prosocial behavioral consequences of this emotion. We outline a more inclusive view of anger and its role in upholding cooperative and moral behavior, and suggest a possible role of equity concerns. We also suggest new predictions and lines (...) of research derived from our perspective. (shrink)

Ethical leadership encompasses the personal conduct of the leader and the leader’s expectations that followers behave ethically. Building on social learning and social exchange theory, we propose that ethical leadership interacts with coworker ethicality to predict personnel’s ethical intentions and organizational citizenship behavior. Using data collected from a large organizational sample, we use moderated regression analysis to test the main and interactive effects of ethical leadership and coworker ethicality on ethical intentions and OCB as it relates to conscientiousness, civic virtue, (...) and altruism. Study 1 examines how ethical leadership and coworker ethicality interact to predict ethical intentions using a sample of 1,551 military personnel. Study 2 extends the results of Study 1 by examining how ethical leadership and coworker ethicality interact to predict OCB using a combined sample of 3,363 military and civilian personnel. Consistent with social learning theory, we found positive relationships between ethical leadership and coworker ethicality with ethical outcomes. Consistent with social exchange theory, we found that perceptions of ethical leadership strengthened the relationship between coworker ethicality and ethical intentions and OCB, highlighting the importance of leaders in shaping the behavior of organizational members. (shrink)

Empathy facilitates everyday social interactions and has often been linked in the literature to prosocial behavior. Robust evidence has been found for a positive relationship between experiencing empathy and behaving prosocially. However, empathy, and the empathy–prosocial behavior relationship in particular, has been studied mostly in combination with negative emotions. Less research has been conducted on empathy for positive emotions, and the link between positive empathy and displayed prosocial behavior has not been intensively investigated so far. The purpose (...) of the present article is thus twofold: first, we review and summarize research evidence on empathy for positive emotions, and second, we propose that people’s motivation to maintain an experienced positive affect is a viable mechanism linking positive empathy and prosocial behavior. (shrink)

Existing economic models of prosociality have been rather silent in terms of proximate psychological mechanisms. We nevertheless identify the psychologically most informed accounts and offer a critical discussion of their hypotheses for the proximate psychological explanations. Based on convergent evidence from several fields of research, we argue that there nevertheless is a more plausible alternative proximate account available: the social motivation hypothesis. The hypothesis represents a more basic explanation of the appeal of prosocial behavior, which is in terms of (...) anticipated social rewards. We also argue in favor of our own social motivation hypothesis over Robert Sugden’s fellow-feeling account (due originally to Adam Smith). We suggest that social motivation not only stands as a proximate account in its own right but also provides a plausible scaffold for other more sophisticated motivations (e.g., fellow-feelings). We conclude by discussing some possible implications of the social motivation hypothesis on existing modeling practice. (shrink)

Understanding religion requires explaining why supernatural beliefs, devotions, and rituals are both universal and variable across cultures, and why religion is so often associated with both large-scale cooperation and enduring group conflict. Emerging lines of research suggest that these oppositions result from the convergence of three processes. First, the interaction of certain reliably developing cognitive processes, such as our ability to infer the presence of intentional agents, favors—as an evolutionary by-product—the spread of certain kinds of counterintuitive concepts. Second, participation in (...) rituals and devotions involving costly displays exploits various aspects of our evolved psychology to deepen people's commitment to both supernatural agents and religious communities. Third, competition among societies and organizations with different faith-based beliefs and practices has increasingly connected religion with both within-group prosociality and between-group enmity. This connection has strengthened dramatically in recent millennia, as part of the evolution of complex societies, and is important to understanding cooperation and conflict in today's world. (shrink)

Abstract This paper will attempt to organize and critically review recent research relevant to classroom approaches for fostering prosocial behaviour in early childhood. Seven applicable approaches for the classroom (positive reinforcement, discipline, modelling, verbal instruction and exhortation, cooperative experiences, role?playing, and emotional self?reflection) are conceptualized as falling within four categories of learning: learning through behavioural consequences, learning by observation, learning through verbal prescription and learning through personal experience. The review uncovers an overall inadequate research base for definitive conclusions, but (...) finds some support for the effectiveness of certain approaches to prosocial education with this very young population. Suggestions for future research are offered. (shrink)

There is evidence from the empirical sciences that >happiness= B understood in the social scientists= sense of >positive affect=B leads to prosocial behaviour: the happiest amongst us are more likely to help others. There is also scientific evidence of a genetic component to positive affect: genetic differences can account for some of the observed variances in positive affect. Let us think of >happy-people-pills= as pharmacological agents, modeled on those with a genetic predisposition for high levels of positive affect, which (...) will promote positive moods and emotions in >normally= happy persons. It is argued that if we want to increase prosocial behaviour then we should (other things being equal) promote the use of happy-people-pills. Since we should increase prosocial behaviour, we should (other things being equal) promote the use of happy-people-pills. In a short paper like this, I cannot possibly show that everything else is equal. However, I hope to establish at least a prima facie case for policy that permits the creation and distribution of happy-people-pills. (shrink)

Prosocial compensation is a corporate social responsibility practice that involves donating money to a charitable cause on behalf of customers as a means to compensate them for their loss after a service failure. In order to determine the effectiveness of PC, we carried out three experiments while also comparing its effectiveness within private and public settings. Experiment 1 focused on the signaling effects of communicating the promise to offer PC to potential customers in the event of service failure. Results (...) show that, in both private and public settings, PC has positive effects on corporate image, credibility, and word-of-mouth intent. More significantly, PC improved one’s CSR image, whereas more tangible compensation, such as a gift voucher, did not. Experiments 2A and 2B focused on the effects of offering PC after a service failure on perceptions of justice. Results show that PC contributes to perceived distributive justice, procedural justice, and post-recovery satisfaction in both private and public settings. Our study showed that PC could be a relevant new CSR practice for organizations wanting to enhance theirs CSR image while contributing to fulfilling their ethical and philanthropic CSR responsibilities. We discuss the implications of our findings and offer several avenues for follow-up research on this initial study on PC. (shrink)

We report on a study of the religious correlates of generalized trust. Our critical frame leads us to explore novel questions about how nonreligion may encourage social trust. We find that those who believe the bible to be a book of fables are more trusting than those with other beliefs about the text, and that nontheists report a greater willingness to trust. We discuss the implications of our findings for future research about religious belief and generalized trust.

Following important work by Pizarro, Uhlmann and Salovey (2003) on moral judgments of uncontrolled/impulsive versus controlled/ deliberate action, we focus on the related issue of the moral evaluation of emotion-motivated versus principle-driven behavior. We examine: (a) the potential lesser blameworthiness of antisocial acts perceived as driven by emotion as opposed to principle; (b) how factors governing the moral evaluation of antisocial acts might extend to the evaluation of prosocial acts; and (c) how overriding a moral emotion in favor of (...) a moral principle affects moral attributions. (shrink)

In her work, Doris Bischof-Köhler describes how empathically motivated prosocial behavior emerges during the second year of life. From a cross-cultural perspective we argue that this developmental pathway is prototypical for autonomy-oriented sociocultural contexts. Bischof-Köhler’s theory should be complemented by a theory of situational helping behavior based on shared intentional relations to provide an alternative developmental pathway for understanding toddlers’ prosocial behavior. Because this developmental pathway does not presuppose an understanding of self and others as autonomous intentional agents, (...) it may be more typical for relatedness-oriented sociocultural contexts. (shrink)

Ethical growth and prosocial development are increasingly salient learning outcomes in higher education. Previous research has shown that the traditional college years facilitate moral development, especially with respect to moral reasoning. This research examined the impact of college experiences on students’ sense of active responsibility for others—prosocial orientation—via a longitudinal, multi-institutional design through the Spirituality and Higher Education project at University of California, Los Angeles. Data from over 14,000 undergraduates show that key college experiences predict growth on (...) class='Hi'>prosocial outcomes. Especially salient predictors include active forms of learning, engagement with diversity and other means by which students encounter multiple perspectives. Implications for higher education are discussed. (shrink)

Although the political and consumer consciousness has turned increasingly green, many firms continue to resist the adoption of environment-friendly technological innovations—even in the face of higher costs, negative health effects, and stricter government oversight. This article examines how business owners weigh the trade-offs associated with environment-friendly innovations by examining the role of prosocial motivation in their decision-making process. We use primary data to overcome a common restriction in studying environmental innovations—the scarcity of relevant data—to analyze how business owners’ expectations, (...) perceptions, and motivations affect innovation in organizational processes and, consequently, the level of environmental friendliness of their products or services. We found that prosocial motivation had a significant negative impact on innovation adoption and that it is expressed differently under high and low levels of customer compatibility—possibly because business owners have a larger number of competing social objectives and priorities. Our results further showed that the innovation’s ability to satisfy downstream customer demands has the greatest impact on environment-friendly innovation adoption decisions by business owners. This study enhances our understanding of how business owners make innovation decisions based on competing business, environmental and social objectives and provides a foundation for future research in this area. (shrink)

Pulling from theories of social exchange, deonance, and fairness heuristics, this study focuses on the relationship between overall justice climate and both the prosocial and deviant behaviors of groups. Specifically, it considers two contextual boundary conditions on this effect—corporate social responsibility and group moral identity. Results from a laboratory experiment are presented, which show a significant effect for overall justice climate and a two-way interaction between overall justice climate and CSR on group-level prosocial and deviant behaviors, and a (...) marginally significant interaction of group moral identity with overall justice climate on group deviance. The implications of contextual influences on workplace ethics and justice are discussed. (shrink)

The study was designed to examine 8-12-year-olds' peer assessments of prosocial behaviour and their relationship to self-assessments, teacher-assessments and peer acceptance. Although prosocial behaviour has been studied for many years, it has been narrowly operationalised and research has tended to lack ecological validity. To rectify these weaknesses, child-generated normative prosocial behaviours were used to generate peer nomination items for the purpose of rating children's performance of prosocial behaviour in peer interactions. Children also filled out self-ratings of (...) social behaviour and peer sociometric nominations. Teachers assessed children's social behaviour, rating the same child-generated prosocial behaviours. Popular children were rated as significantly more prosocial than all other sociometric groups and rejected children were rated as significantly less prosocial than all other groups. The highest correlation was found between teacher and peer reports of prosocial behaviour. Self-ratings and peer-ratings of prosocial behaviour were significantly related, as were self-ratings and teacherratings of prosocial behaviour. Implications of research findings are discussed. (shrink)

Mentioning products or brands on Facebook enables individuals to display an ideal self to others through a form of virtual conspicuous consumption. Drawing on conspicuous donation behaviour literature, we investigate ‘conspicuous virtue signalling’, as conspicuous consumption on Facebook. CVS occurs when an individual mentions a charity on their Facebook profile. We investigate need for uniqueness and attention to social comparison information as antecedents of two types of CVS–self-oriented and other-oriented. We also explore the relationship between CVS and self-esteem, and offline (...) prosocial and unethical behaviour intentions. Data from two studies, a college survey and an adult survey via MTurk, were analysed using structural equation modelling. Results indicate that NFU predicts both forms of CVS, while ATSCI influences both forms of CVS for adults and other-oriented CVS for students. Self-esteem is enhanced by self-oriented CVS. Self-oriented CVS predicts donation intention whereas other-oriented CVS significantly reduces donation intention for both samples. Furthermore, a significant relationship between CVS and purchase intention of counterfeit luxury goods is revealed. Findings provide insights into conspicuous virtue signalling and the relationship between CVS on Facebook and offline behavioural intentions. (shrink)

Disease-specific stem cell therapies, created from induced pluripotent stem cell lines containing the genetic defects responsible for a particular disease, have the potential to revolutionize the treatment of refractory chronic diseases. Given their capacity to differentiate into any human cell type, these cell lines might be reprogrammed to correct a disease-causing genetic defect in any tissue or organ, in addition to offering a more clinically realistic model for testing new drugs and studying disease mechanisms. Clinical translation of these therapies provides (...) an opportunity to design a more systematic, accessible and patient-influenced model for the delivery of medically innovative treatments to chronically ill patients. (shrink)