Two enzymes involved in the synthesis of pyrimidine and purine nucleotides, CTP synthase (CTPS) and IMP dehydrogenase (IMPDH), can assemble into a single or very few large filaments called rods and rings (RR) or cytoophidia. Most recently, asymmetric cytoplasmic distribution of organelles during cell division has been described as a decisive event in hematopoietic stem cell fate. We propose that cytoophidia, which could be considered as membrane‐less organelles, may also be distributed asymmetrically during mammalian cell division as previously described (...) for Schizosaccharomyces pombe. Furthermore, because each type of nucleotide intervenes in distinct processes (e.g., membrane synthesis, glycosylation, and G protein‐signaling), alterations in the rate of synthesis of specific nucleotide types could influence cell differentiation in multiple ways. Therefore, we hypothesize that whether a daughter cell inherits or not CTPS or IMPDH filaments determines its fate and that this asymmetric inheritance, together with the dynamic nature of these structures enables plasticity in a cell population. (shrink)

I argue that Dilworth has not shown the type / token theory of film identity to be non-viable, since there is no reason to think that a single object cannot be a token of two types. Even if we assume a single inheritance view of types, Dilworth's argument runs into other problems. Dilworth does not provide any convincing argument as to why intentions are necessary for identifying film and why production history alone will not suffice for identifying (...) hardly conceivable forgeries. Intention is not necessary for distinguishing between fakes and the real thing, nor is it necessary to differentiate between two artworks with the same token. Moreover, taking the notion of intentions into consideration leads to a splintering problem. I propose that production history, presentation, and non-numerical template identity suffice to identify a film on a multiple inheritance type / token theory. (shrink)

Recent work on inheritance systems can be divided into inclusive conceptions, according to which genetic and non-genetic inheritance are both involved in the development and transmission of nearly all animal behavioral traits, and more demanding conceptions of what it takes for non-genetic resources involved in development to qualify as a distinct inheritance system. It might be thought that, if a more stringent conception is adopted, homologies could not subsist across two distinct inheritance systems. Indeed, it is (...) commonly assumed that homology relations cannot survive a shift between genetic and cultural inheritance systems, and substantial reliance has been placed on that assumption in debates over the phylogenetic origins of hominin behavioral traits, such as male-initiated intergroup aggression. However, in the homology literature it is widely accepted that a trait can be homologous—that is, inherited continuously in two different lineages from a single common ancestor—despite divergence in the mechanisms involved in the trait’s development in the two lineages. In this paper, we argue that even on an extremely stringent understanding of what it takes for developmental resources to form a separate inheritance system, homologies can nonetheless subsist across shifts between distinct inheritance systems. We argue that this result is a merit of this way of characterizing what it is to be an inheritance system, that it has implications for adjudicating between alternative accounts of homology, and that it offers an important cautionary lesson about how to reason with the homology concept, particularly in the context of cultural species. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Inheriting Identity and Practicing TransformationThe Time of Feminist PoliticsShannon HoffA human life unfolds over time. No moment of it can be considered apart from the others, independently of the fact that the human being was and will be, and so no moment is sufficient on its own to tell us of the nature of that identity. Each moment is insufficient as an expression of who we are, as an (...) answer to the question of what we want to be, or as a point at which a full account of our identity could be given. And we live each moment as if afflicted by a dual blindness with regard to the past and future that lend it significance; while exercising pervasive influence in the present, this past and future are relatively inaccessible to our reflective insight. We are always “growing up,” so to speak, from out of a childhood that can never be the purely transparent object of reflection, to an adulthood or “accomplishment” of identity that is always in the mysterious future, unimaginable in the terms of the adolescence in which we find ourselves.My purpose here is to show how this issue resonates in the context of feminist philosophy, feminist critique, and feminist practice—that is, how a consideration of time and its impact on human experience allows us to highlight the accomplishments of various avenues of feminist thought, to elaborate their shortcomings in relation to each other, to perceive the reasons behind the tensions among them, and to understand the way in which they are (and should [End Page 167] be understood as) connected. I will work through the issue of what it means to live in the temporal dimensions of past, present, and future—what it means to inherit an already meaningful world, to be an individual in the present, and to be propelled into an uncertain future—so as to provide a general framework by which to interpret the history of feminist thought. I will explain these different temporal dimensions in terms of the (respective) ideas of cultivation, universality, and transformation, identifying the positive and negative significance of each and also the demand that the tensions among them be negotiated. Finally, I will show that feminist justice is in fact found here, as answerability to all three—to communities of cultivation, to the demands of universality, and to the inconclusiveness and transformability of human identity. While much feminist thinking has been committed to exploring these elements singly, in abstraction from the others, and while such work is important, it is also valuable to explicitly explore the relationships and tensions among these different aspects, to articulate how to act and think in light of this underlying conceptual context, and to do so in a more explicit and self-conscious way.There is, of course, a disadvantage to not exploring these elements on their own terms: namely, that one handles their subtleties roughly. A further and related danger is that involved in trying to draw a broad picture of a tradition with complex and conflicting elements, one that does not count itself as a tradition at times—as a “we,” a feminism, or a feminist thought.1 While I will talk about “feminism” or “feminist thought,” I do not presume that these differences do not exist; my goal is simply to explore what is involved in an elaboration of a critical interpretation of society, when the society one critically interprets is an agent in one’s formation. The description of the dynamics of human becoming, agency, and critique I develop below has the purpose of showing that it is possible to understand differences between feminist positions as complementary, a process that will lead me to underemphasize stringent divisions and charged oppositions and to focus on drawing connections. Let us turn now to a preliminary description of the conceptual framework I seek to construct.Feminism and TimeTo advance feminist purposes is, one might presume, to hope for and work toward a new and transformed reality in the future. It would seem, however, that this reality cannot be clearly envisioned in the present, since that would require the transformation of the very people envisioning it. In... (shrink)

Our first tools, sticks and stones, were very different from ourselves. But many tools now resemble us, in function or form, and they are beginning to have minds. A loose parallel with our own evolution suggests how they may develop in future. Computerless industrial machinery exhibits the behavioral flexibility of single-celled organisms. Today's best computer-controlled robots are like the simpler invertebrates. A thousand-fold increase in computer power in this decade should make possible machines with reptile-like sensory and motor competence. (...) Growing computer power over the next half century will allow robots that learn like mammals, model their world like primates and eventually reason like humans. Depending on your point of view, humanity will then have produced a worthy successor, or transcended inherited limitations and transformed itself into something quite new. No longer limited by the slow pace of human learning and even slower biological evolution, intelligent machinery will conduct its affairs on an ever faster, ever smaller scale, until coarse physical nature has been converted to fine-grained purposeful thought. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Violent Inheritance: Sexuality, Land, and Energy in Making the North American West by E. CramNathan StormerViolent Inheritance: Sexuality, Land, and Energy in Making the North American West. By E. Cram. Oakland: University of California Press, 2022. 292 pp. Cloth $85.00, paper $34.95. ISBN: 0520379470.E. Cram’s Violent Inheritance is an exceptional work that presents a distinctive synthesis of queer, decolonial, and mixed-method scholarship. The goal of (...) the book, Cram states, is to both “reimagine the place of racialized sexualities in contemporary conversations about environment, energy, and systems of violence” and “anchor these questions in contested memories of the North American West” (5). The book does just that, drawing from many contemporary streams of thought in rhetoric as well as the environmental and energy humanities to fashion a new and subtle analytic of infrastructures of feeling, which is supported by a range of conceptual innovations. For readers of this journal, Cram’s choice to ground theory quite literally in the land will be, I suspect, highly rewarding for those with interests crossing a wide range of topics: queer studies, violence, affect, Indigenous thought, sexuality and modernity, memory studies, rhetoric and materialism, ecological thought, ambience, regionalism. The breadth of scholarly dialogues that Cram harmonizes is simply impressive, reflecting the many years and the care they have devoted to this project.The book is composed of five chapters including a conceptual first chapter followed by four separate yet reinforcing studies. These are framed by a tidy introduction that prepares the reader admirably for the synergistic work to follow and a conclusion that stresses the bonds between the chapters without compromising the particularity of each study. In that regard, Violent Inheritance is both a single work guided by several cross-cutting ideas and questions and an anthology of sorts that prompts a series of discrete, rich conversations. The careful writing is evident in every paragraph, often presenting the reader with elegant, thought-provoking formulations [End Page 199] of deep onto-epistemological problems that never feel weighted down by the complexity of dwelling on “onto-epistemic” matters.The introduction sets out the question of the book in engaging fashion. Cram asks, in the first sentence, “What does it mean to route ‘sexuality’ through modernity’s relationship to energy?” They use nineteenth-century eugenic physician John Harvey Kellogg’s Rocky Mountain climatic therapeutics to exemplify how “climate and the environment” became crucial to “the production of theories of sexuality” (3). Cram proposes energy to be “perhaps the dominant relationship between humans and the environment” and points to the ways that “racial and sexual value” have been assigned to a broad range of practices of “revitalization and exhaustion,” such that “racial and sexual vitality converge in extractivism” (3, 5, 4). In this way, the “bodily vitality” of the “normative sexual subject” demands privileged access to land and the energy that can be taken from it, be it affective or petrochemical. The emergence of sexual modernity, Cram thus contends, is inextricably tied to the regime of energy extraction. Through selected cases, Cram follows “nonlinear traces of this regime’s enduring materiality and sedimentation: the ecological, energetic, and affective inheritance that I call ‘land lines’” (6). The term “land lines” refers to how “political and economic actions tether, or forge connections, between domains of sexuality and land use,” and “names the aggregation of layers of cultural sediment or the violent inheritance of any given place.... As method, to trace land lines asks in earnest how places of memory and memorialization mediate these relationships” (6,7, emphasis original). The choice of the North American West follows from Cram having grown up there and the particular land lines that bind them to its violent inheritance, as well as the West’s stature as a colonial reservoir of myth and abundant energy.The separate chapters are saturated with meticulous detail, studied reflection, and constant insight that reward slow reading, making a synoptic view misleading. Nevertheless, chapter 1 travels through the 1893 journal of author Owen Wister (who helped create the myth of the West) to map a rhetoric of reinvigorated, masculinized settler sexuality by way of access to the West and the healing energy... (shrink)

What happens when humans and birds engage each other through a collaboration-as-fantasy mediated by computers? Could such an exercise be modelled in a way that helps us to transcend the techno-ocularcentric fetishes for precision and certainty which demarcate our time? From Edgar Wind’s notion of 'incarnation' – as the place where empirical experience and metaphysical foundation meet in the single cognitive and experiential act – this article bridges the analogue with the digital, navigating nature’s strategies to embody inherited and (...) learned complex behaviours in the design of nests, in what I call data-nests. (shrink)

That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes (...) but also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens. BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 34.3 (2001) 225-244 [Access article in PDF] Sophistic Travel: Inheriting the Simulacrum Through Plato's "The Sophist" John Muckelbauer Was it not Plato himself who pointed out the direction for the reversal of Platonism? ------Gilles Deleuze, The Logic of Sense 1. Developing an itinerary: guides and lineages A single question marks our departure, a question that, while apparently straightforward, has assumed so many shapes and disguises (...) that it would not be unjust to claim it has infected all of Western history. In its current manifestation, however, we will take our cue from Plato in phrasing it thus: What is a Sophist? When Plato first formulated the question in these terms, he well understood that its self-evident simplicity could be deceptive and that its effects might proliferate uncontrollably. As Jacques Derrida comments, "The question of what the Sophists really were is an enormous question" (Olson 17). In Plato's case, attempting to "hunt down" the Sophist led from a disturbing journey through the world of images to an unsettling encounter with the existence of nonbeing.Of course, the issue of Plato's distaste for sophistry is well-covered ground, so well-covered, in fact, that nearly all contemporary rhetorical scholarship that attempts to assert the value of sophistic rhetoric does so by reproducing an antagonism between sophistry and Platonism (see, e.g., Poulokos, Jarratt, Vickers). 1 A particularly interesting example, simply because it is so persistently skeptical of most conventional assumptions about sophistry, is G. B. Kerford's The Sophistic Movement. It is an excellent and careful treatment of sophistry in which he insists on the importance of approaching the Sophists without prior assumptions as to their relationship to the history of thought or politics--something that he shows has been far too prevalent in previous appropriations. Nevertheless, in his treatment of Plato's dialogue the Sophist, he writes, "It is clear that [Plato's] characterizations [End Page 225] in the Sophist constitute an outright condemnation" (5). Given the wealth of readings of different dialogues that express sentiments similar to Kerford's, the antagonistic structure of Platonic-Sophistic relations is apparently quite certain; it is something we know.It is also true that as a result of the many forays across the terrain of this antagonism, we know a great many other things about the relationship between Plato and sophistry. We know, for instance, that Plato was an idealist who abhorred the Sophist's interest in practical discursive wisdom. We know, as well, that Plato was a reactionary aristocrat who resented the Sophists for selling speeches and encouraging democracy. Without question, the many trips across this oppositional territory have been important expeditions for both Philosophy and Rhetoric, providing each discourse with a sense of its own distinct identity. 2 At very least, the mutual suspicion that often characterizes contemporary relations between these two disciplines is symptomatic of our inheritance of this Platonic mantra.It is, of course, quite difficult to avoid repeating this mantra of opposition between Philosophy and Rhetoric. Any attempt to champion one of the terms--even the supposedly underprivileged one, Rhetoric--overtly reproduces this opposition. But so too do most efforts to reduce one term to the other (i.e., claims stating that Philosophy is inevitably rhetorical) insofar as they must begin with the assumption that they know what rhetoric is; in other words, they must begin with what may schematically be characterized as a philosophical relation to rhetoric and to philosophy. Said differently, the two common disciplinary strategies that generate the opposition between rhetoric and philosophy, (1) championing the Sophists over Plato and (2) claiming that Plato is rhetorical, both effectively privilege the very notion of philosophy that they are attempting to discredit, i.e., one that is based on the notion of a preexistent, recognizable, and knowable identity, a fundamental truth.Given the renewed scholarly interest in the Sophists as early rhetoricians, it is curious that very few and very brief rhetorical engagements exist with the Platonic dialogue the Sophist--largely, one suspects, either because everyone already "knows" that it contains yet another... (shrink)

Synaesthesia is a neurodevelopmental condition characterised by anomalous sensory perceptions and associated alterations in cognitive function. This chapter summarises what is known about the familial transmission of synaesthesia and its genetic underpinnings. Early familiality studies showed evidence for a strong genetic predisposition, a highly skewed female: male ratio, and an absence of male-to-male transmission. These patterns supported an early hypothesis of a single-gene X-linked dominant mode of inheritance with male lethality. Subsequent analyses in larger samples indicated that the (...) mode of inheritance was likely to be more complex, with both the strong female skew and absence of male-to-male transmission brought into question. We review in detail the first whole genome linkage scan for auditory-visual synaesthesia and a subsequent family linkage study on coloured sequence synaesthesia. Together these results suggest linkage to five chromosomes but give no support for linkage to the X-chromosome. We discuss candidate genes within these regions and potential implications for the aetiology of synaesthesia. We also discuss the implications of these pioneering genome scans for our understanding of synaesthesia and of how different synaesthetic phenotypes may arise from different genetic predispositions interacting with other genes and with the environment. (shrink)

Developmental systems theory (DST) expands the unit of replication from genes to whole systems of developmental resources, which DST interprets in terms of cycling developmental processes. Expansion seems required by DST's argument against privileging genes in evolutionary and developmental explanations of organic traits. DST and the expanded replicator brook no distinction between biological and cultural evolution. However, by endorsing a single expanded unit of inheritance and leaving the classical molecular notion of gene intact, DST achieves only a nominal (...) reunification of heredity and development. I argue that an alternative conceptualization of inheritance denies the classical opposition of genetics and development while avoiding the singularity inherent in the replicator concept. It also yields a new unit--the reproducer--which genuinely integrates genetic and developmental perspectives. The reproducer concept articulates the non-separability of "genetic" and "developmental" roles in units of heredity, development, and evolution. DST reformulated in terms of reproducers rather than replicators preserves an empirically interesting distinction between cultural and biological evolution. (shrink)

I note with interest the Controversy regarding a baby born free of an inherited predisposition to early onset Alzheimer’s disease through the use of preimplantation genetic diagnosis .1,2 As the medical geneticist for the PGD programme for single gene disorders in Melbourne, Australia, I have seen many couples who have considered PGD for a wide range of genetic conditions. My observation is that many couples look to PGD for “milder” conditions and adult onset conditions for which they are not (...) comfortable to have traditional prenatal diagnosis and termination of pregnancy.An example of this is that in the last 11 years our unit has undertaken 13 prenatal diagnoses for Huntington’s disease from nine couples, whereas in the two years that we have been offering it we have had six requests for PGD for Huntington’s disease and three couples …. (shrink)

This article seeks to identify and analyse the most significant changes regarding parental leave provision in post-communist Romania, as well as the extent to which its legal adjustments that took place after 1990 reveal both old trends inherited from the former political regime as well as new tendencies influenced by EU norms and directives. Consequently, this article has a twofold structure. First, a brief overview of the main concepts and theoretical approaches to parental leave will allow us to proceed to (...) a proper understanding of the epistemological tools underpinning this research object. Second, this article tackles the numerous legislative changes concerning parental leave that occurred after the fall of the communist regime. Although limited to a single category of research sources, this inquiry is indispensable for analysing the extent to which childcare and the gendered division of parental responsibilities have become real political struggles within the post-communist public agenda in Romania. (shrink)

Derrida's Specters of Marx asks whether and how we could inherit Marx today: whether we might find, in a certain spirit of Marx, the critical resources to challenge resurgent liberal ideals, without this challenge assuming a dogmatic or totalitarian form. Derrida's own response to this question involves a curious move: a material transformation of Marx's text, in which Derrida first foreshadows, and then carries out, the excision of a single sentence from the pivotal passage in which Marx christens the (...) commodity fetish. The excision subtly transforms the meaning of Marx's text and, in the process, acts out a vision of inheritance as an active, transformative performance, rather than as a passive transmission of inherited content to its heirs. In this paper, I explore the way in which Derrida foreshadows and then effects this curious elision. I highlight the distinctive understanding of transformative inheritance at the heart of Derrida's text, and also pose the question of why Derrida should effect this particular transformation in the search for a certain deconstructive spirit in Marx's work. (shrink)

The target article excludes ancestral neutrality as a cause for the inheritance of schizophrenia, with an argument relating to selection against a single allele in the Finnish population. However, drift would predominate over selection within subisolates of the Finnish population. Comparisons of subisolates with heterogeneous populations may provide clues to the endophenotypic structure of complex polygenetic heritable mental disorders. (Published Online November 9 2006).

Enlightenment thought and its contemporary followers usually support two contradictory principles simultaneously. The first is universality. Truth is universal because it is truth for all. Claims to universality are made in logic and science, but also in areas that are culturally or politically controversial. Recently, universalism has become a key term to express a fundamental critique of identity politics. For much of European history, Christianity provided such a universal truth. But with the decline of its cultural hegemony and the rise (...) of particular nation-states, conflicting truth claims became weapons in violent conflicts, leading Hobbes to argue that dangerous truth claims must be neutralized by robust political power. In the eighteenth century, rationalism became more optimistic, interpreting universalism as cosmopolitanism based on universal reason and progress through history. The second principle is historicism, which is the self-reflexive look at the historical origins of universal claims and theories. Historicism emerged in the nineteenth century as a response to the application of rationalism to history. It challenged the universal claims of the French Revolution, emphasizing instead the unique value of each historical entity. This revealed a fundamental paradox: when universalism becomes self-reflexive, it recognizes that it has non-universal historical origins, thereby undermining itself. After the devastation of World War II and the Holocaust, the Universal Declaration of Human Rights (1948) represented a significant effort toward a new universalism. It sought to establish human rights as universal principles for the emerging world order. But history repeated itself: Historicism once again weakened confidence in human rights. The enemies of human rights take advantage of this weakness. We therefore have to live with the paradox that universalism is necessary because humanity shares a single world, but that historical self-reflection is also unavoidable. In other words, the Enlightenment principle of universalism must accept historicism as an integral part of itself. (shrink)

Is it possible to know anything about life we have not yet encountered? We know of only one example of life: our own. Given this, many scientists are inclined to doubt that any principles of Earth’s biology will generalize to other worlds in which life might exist. Let’s call this the “N = 1 problem.” By comparison, we expect the principles of geometry, mechanics, and chemistry would generalize. Interestingly, each of these has predictable consequences when applied to biology. The surface-to-volume (...) property of geometry, for example, limits the size of unassisted cells in a given medium. This effect is real, precise, universal, and predictive. Furthermore, there are basic problems all life must solve if it is to persist, such as resistance to radiation, faithful inheritance, and energy regulation. If these universal problems have a limited set of possible solutions, some common outcomes must consistently emerge. In this chapter, I discuss the N = 1 problem, its implications, and my response (Mariscal 2014). I hold that our current knowledge of biology can justify believing certain generalizations as holding for life anywhere. Life on Earth may be our only example of life, but this is only a reason to be cautious in our approach to life in the universe, not a reason to give up altogether. In my account, a candidate biological generalization is assessed by the assumptions it makes. A claim is accepted only if its justification includes principles of evolution, but no contingent facts of life on Earth. (shrink)

Species’ adaptation to their environments occurs via a range of mechanisms of adaptation. These include genetic adaptations as well as non-traditional inheritance mechanisms such as learned behaviors, niche construction, epigenetics, horizontal gene transfer, and alteration of the composition of a host’s associated microbiome. We propose to supplement these with another modality of eco-evolutionary dynamics: cases in which adaptation to the environment occurs via what may be called a “distributed adaptation,” in which the adaptation is not conferred via something carried (...) by an individual of the adapted species (as with genes, behavior, or associated microbes), but by some structural or compositional aspect of the population. Put differently, the adaptively relevant information cannot be reduced to information possessed by a single individual, whether genetic or otherwise. Rather, the adaptively relevant information is distributed, and is found strictly at the population level. While human culture is presumably such a case, as may be cases found in social insects, we want to suggest that there are other cases that belong to this category and to explore its evolutionary implications. In particular, we discuss the factors that affect whether adaptive information is stored in a distributed way, to what degree, and what kinds of adaptive information are most likely to be found in this modality of adaptation. (shrink)

Artificial Intelligence, in press. Abstract: For some time we have been developing, and have had significant practical success with, a time-sensitive, contradiction-tolerant logical reasoning engine called the active logic machine (ALMA). The current paper details a semantics for a general version of the underlying logical formalism, active logic. Central to active logic are special rules controlling the inheritance of beliefs in general (and of beliefs about the current time in particular), very tight controls on what can be derived from (...) direct contradictions (P &￢P), and mechanisms allowing an agent to represent and reason about its own beliefs and past reasoning. Furthermore, inspired by the notion that until an agent notices that a set of beliefs is contradictory, that set seems consistent (and the agent therefore reasons with it as if it were consistent), we introduce an “apperception function” that represents an agent’s limited awareness of its own beliefs, and serves to modify inconsistent belief sets so as to yield consistent sets. Using these ideas, we introduce a new definition of logical consequence in the context of active logic, as well as a new definition of soundness such that, when reasoning with consistent premises, all classically sound rules remain sound in our new sense. However, not everything that is classically sound remains sound in our sense, for by classical definitions, all rules with contradictory premises are vacuously sound, whereas in active logic not everything follows from a contradiction. (shrink)

Dans le titre un peu provocateur de ce livre, les lecteurs reconnaîtront sans peine un clin d’œil fait à la parabole du « fils prodigue » de l’évangile de Luc. D’emblée, l’auteure explique l’intérêt de ce récit biblique : alors que le fils dont il est question, revient à la maison, domaine privilégié des femmes, la parabole ne parle jamais d’elles. L’histoire de Luc ne concerne que des hommes. Pour Élisabeth Parmentier, ce silence est significatif de l’expérience des femmes dans (...) la « maison-É... (shrink)

Since 1990, the multinational public accounting firms have all adopted flexible work arrangement policies. In part, the firms are doing this to fulfill an ethical obligation in creating an appropriate professional environment for their employees. This study examines the effect of participation in a flexible work arrangement program on an individual''s professional success and anticipated turnover as perceived by the participant''s peers and superiors. Subjects from one Big Five accounting firm read a description of a manager and answered a series (...) of questions about the likelihood of the manager''s promotion to partner, voluntary and involuntary turnover, and desirability on a job. Gender and participation in a flexible work arrangement were manipulated in a 2×2 design. The results indicate that participation in a flexible work arrangement evoked significantly more pessimistic predictions on all of the dimensions. Gender did not have an effect on the likelihood ratings. Follow-up questions about the factors that enhance and hinder individuals career success in each work scenario indicated that the perceived ability to "juggle" and the ability to "pull one''s weight" potentially affects evaluations of what it takes to be a successful professional in the financial services environment. Implications for professional and ethics practice and research are also presented. (shrink)

J’ai rencontré Marie-Jeanne Bérère à Lyon en 1994. C’était une petite femme vive, à la parole claire et précise, avec un bel accent bourguignon. Elle avait accepté une interview, à son domicile lyonnais, le 23 mars 1995. Je souhaitais la revoir pour ce numéro de CLIO, Histoire, Femmes et Sociétés sur les Chrétiennes mais elle est décédée dans l’été 2000, à 73 ans, sans avoir eu le temps de rédiger ses mémoires. Son itinéraire de femme engagée dans l’Église catholique est (...) celui d’une chrétienn... (shrink)

Flexible work arrangements (FWAs) are widely offered in public accounting as a tool to retain valued professional staff. Previous research has shown that participants in FWAs are perceived to be less likely to succeed in their careers in public accounting than individuals in public accounting who do not participate in FWAs (Cohen and Single, 2001). Research has also documented an increasing backlash against family–friendly policies in the workplace as placing unfair burdens on individuals without children. Building directly on a (...) previous study in this journal (Cohen and Single, 2001), this study addresses the issue of whether the documented perceptions toward FWA participants are the result of electing to take part in the FWA or the result of bias against employees with children. The research questions are addressed in a 3 × 2 experimental setting in which we manipulate FWA participation, along with family status and gender of a hypothetical manager in a public accounting firm. Our findings indicate that FWA participants are viewed as less likely to advance and as less committed than individuals without children or individuals who had children but who were not taking part in a FWA. Male FWA participants are viewed as less likely to succeed than female FWA participants. This effect appears to arise from a perception that FWA participants are willing to make sacrifices in their careers to accommodate family needs and thus may not be as committed to making the sacrifices perceived as necessary to meet the rigorous demands of the public accounting environment. This raises the ethical question of what could be done to change the culture in public accounting to foster a substantive support system for individuals who want to balance a family and a career. (shrink)

Flexible work arrangements (FWAs) are widely offered in public accounting as a tool to retain valued professional staff. Previous research has shown that participants in FWAs are perceived to be less likely to succeed in their careers in public accounting than individuals in public accounting who do not participate in FWAs (Cohen and Single, 2001). Research has also documented an increasing backlash against family–friendly policies in the workplace as placing unfair burdens on individuals without children. Building directly on a (...) previous study in this journal (Cohen and Single, 2001), this study addresses the issue of whether the documented perceptions toward FWA participants are the result of electing to take part in the FWA or the result of bias against employees with children. The research questions are addressed in a 3 × 2 experimental setting in which we manipulate FWA participation, along with family status and gender of a hypothetical manager in a public accounting firm. Our findings indicate that FWA participants are viewed as less likely to advance and as less committed than individuals without children or individuals who had children but who were not taking part in a FWA. Male FWA participants are viewed as less likely to succeed than female FWA participants. This effect appears to arise from a perception that FWA participants are willing to make sacrifices in their careers to accommodate family needs and thus may not be as committed to making the sacrifices perceived as necessary to meet the rigorous demands of the public accounting environment. This raises the ethical question of what could be done to change the culture in public accounting to foster a substantive support system for individuals who want to balance a family and a career. (shrink)

Description Logics are nowadays widely accepted as formalisms which provide reasoning facilities which allow us to discover inconsistencies in ontologies in an automatic fashion. Where ontologies are developed in modular fashion, they allow changes in one module to propogated through the system of ontologies automatically in a way which helps to maintain consistency and stability. For this feature to be utilized effectively, however, requires that domain ontologies be represented in a normalized form.

This paper serves as an introduction to the special issue on “Reconciling Nature and Nurture in Behavior and Cognition Research” and sets its agenda to resolve the 'interactionist' dichotomy of nature as the genetic, and stable, factors of development, and nurture as the environmental, and plastic influences. In contrast to this received view it promotes the idea that all traits, no matter how developmentally fixed or universal they seem, contingently develop out of a single-cell state through the interaction of (...) a multitude of developmental resources that defies any easy, dichotomous separation. It goes on to analyze the necessary ingredients for such a radical, epigenetic account of development, heredity and evolution: 1. A detailed understanding of the epigenetic nature of the regulatory mechanisms of gene expression; 2. The systematical questioning of preconceptions of 'explanatory' categories of behavior, such as 'innate' or 'programmed'; 3. Especially in psychological research the integration of the concepts of 'development' and 'learning', and a richer classification of the concept of 'environment' in the production of behavior; 4. A fuller understanding of the nature of inheritance that transcends the restriction to the genetic material as the sole hereditary unit, and the study of the process of developmental niche construction; and last 5. Taking serious the role of ecology in development and evolution. I hope that an accomplishment of the above task will then lead to a 'postgenomic' synthesis of nature and nurture that conceptualizes 'nature' as the natural phenotypic outcome 'nurtured' by the natural developmental process leading to it. (shrink)

Life is perpetuated through a single-cell bottleneck between generations in many organisms. Here, I highlight that this cell holds information in two distinct stores: in the linear DNA sequence that is replicated during cell divisions, and in the three-dimensional arrangement of molecules that can change during development but is recreated at the start of each generation. These two interdependent stores of information – one replicating with each cell division and the other cycling with a period of one generation – (...) coevolve while perpetuating an organism. Unlike the genome sequence, the arrangement of molecules, including DNA, RNAs, proteins, sugars, lipids, etc., is not well understood. Because this arrangement and the genome sequence are transmitted together from one generation to the next, analysis of both is necessary to understand evolution and origins of inherited diseases. Recent developments suggest that tools are in place to examine how all the information to build an organism is encoded within a single cell, and how this cell code is reproduced in every generation. Life relies on the information for making organisms that is encoded in single cells and transmitted between generations. These cell codes include interdependent stores of information that replicate and that cycle. Understanding evolution and the origins of inherited diseases requires analysis of cell codes. (shrink)

Contemporary biology has inherited two key assumptions from the Modern Synthesis about the nature of population lineages: sexual reproduction is the exemplar for how individuals in population lineages inherit traits from their parents, and random mating is the exemplar for reproductive interaction. While these assumptions have been extremely fruitful for a number of fields, such as population genetics and phylogenetics, they are increasingly unviable for studying the full diversity and evolution of life. I introduce the “mixture” account of population lineages (...) that escapes these assumptions by dissolving the Modern Synthesis’s sharp line separating reproduction and development and characterizing reproductive integration in population lineages by the ephemerality of isolated subgroups rather than random mating. The mixture account provides a single criterion for reproductive integration that accommodates both sexual and asexual reproduction, unifying their treatment under Kevin de Queiroz’s generalized lineage concept of species. The account also provides a new basis for empirically assessing the effect of random mating as an idealization on the empirical adequacy of population genetic models. (shrink)

To understand lying, we naturally focus on small scale lies involving one speaker, one listener, one assertion. This methodology confers artificial plausibility upon the requirement that liars intend to deceive. For it excludes principal-agent conflicts that emerge from linguistic division of labor. When an employee lies for her boss, she need not inherit his motive to deceive. She displays loyalty even if her lie does not deceive. Focus on a single lie in isolation also blinds us to tactical deceptions (...) such as telling a lie which is intended to be caught to advance another lie. Many of these complexities arise from situations that approximate common knowledge without quite crystallizing into this uniform transparency. (shrink)

This essay is a critical review of two recent collections, Feminism and Foucault: Reflections on Resistance, edited by Irene Diamond and Lee Quinby and Feminism as Critique: On the Politics of Gender, edited by Seyla Benhabib and Drucilla Cornell. While the collections differ in their manner of addressing the critical sources that have inspired them-the former relying upon a single theorist, the latter attempting to move through some of the philosophical history that constitutes our present theoretical terrain-both attempt to (...) think through and thus revisualize some of the categories of difference which we have inherited. Though the best essays from these collections are celebrated for demonstrating how "feminism as critique" can work to move us toward a clearer and more inclusive feminist theory, questions are raised about what the inattention to race in these volumes suggests about our own role in the construction of power and knowledge, and the erasures that help to secure them both. (shrink)

Formalisms such as description logics (DL) are sometimes expected to help terminologies ensure compliance with sound ontological principles. The objective of this paper is to study the degree to which one DL-based biomedical terminology (SNOMED CT) complies with such principles. We defined seven ontological principles (for example: each class must have at least one parent, each class must differ from its parent) and examined the properties of SNOMED CT classes with respect to these principles. Our major results are: 31% of (...) the classes have a single child; 27% have multiple parents; 51% do not exhibit any differentiae between the description of the parent and that of the child. The applications of this study to quality assurance for ontologies are discussed and suggestions are made for dealing with multiple inheritance. (shrink)

This paper evaluates and criticises the developmental systems conception of evolution and develops instead an extension of the gene's eye conception of evolution. We argue (i) Dawkin's attempt to segregate developmental and evolutionary issues about genes is unsatisfactory. On plausible views of development it is arbitrary to single out genes as the units of selection. (ii) The genotype does not carry information about the phenotype in any way that distinguishes the role of the genes in development from that other (...) factors. (iii) There is no simple and general causal criterion which distinguishes the role of genes in development and evolution. (iv) There is, however, an important sense in which genes but not every other developmental factor represent the phenotype. (v) The idea that genes represent features of the phenotype forces us to recognise that genes are not the only, or almost the only, replicators. Many mechanisms of replication are involved in both development and evolution. (vi) A conception of evolutionary history which recognises both genetic and non-genetic replicators, lineages of replicators and interactors has advantages over both the radical rejection of the replicator/interactor distinction and the conservative restriction of replication to genetic replication. (shrink)

It is argued that, in order to account for examples where the indexicals `now' and `here' do not refer to the time and location of the utterance, we do not have to assume (pace Quentin Smith) that they have different characters (reference-fixing rules), governed by a single metarule or metacharacter. The traditional, the fixed character view is defended: `now' and `here' always refer to the time and location of the utterance. It is shown that when their referent does not (...) correspond to the time and/or location of the utterance, `now' and `here' work in an anaphoric way, inheriting their reference from another noun phrase. The latter may be explicit or implicit in the discourse. It is also shown that `now' and `here' can inherit their reference from a presupposed or tacit reference. In that case, they are coreferential with what will be labeled a `tacit initiator'. This anaphoric interpretation has the merit of fitting within the Kaplanian distinction between pure indexicals (`now', `here', `today', etc.) and demonstratives (`this', `that', `she', etc.). (shrink)

Abu Hamid al-Ghazali, a Muslim jurist-theologian and polymath who lived from the mid-eleventh to the early twelfth century in present-day Iran, is a figure equivalent in stature to Maimonides in Judaism and Thomas Aquinas in Christianity. He is best known for his work in philosophy, ethics, law, and mysticism. In an engaged re-reading of the ideas of this preeminent Muslim thinker, Ebrahim Moosa argues that Ghazali's work has lasting relevance today as a model for a critical encounter with the Muslim (...) intellectual tradition in a modern and postmodern context. Moosa employs the theme of the threshold, or dihliz , the space from which Ghazali himself engaged the different currents of thought in his day, and proposes that contemporary Muslims who wish to place their own traditions in conversation with modern traditions consider the same vantage point. Moosa argues that by incorporating elements of Islamic theology, neoplatonic mysticism, and Aristotelian philosophy, Ghazali's work epitomizes the idea that the answers to life's complex realities do not reside in a single culture or intellectual tradition. Ghazali's emphasis on poiesis--creativity, imagination, and freedom of thought--provides a sorely needed model for a cosmopolitan intellectual renewal among Muslims, Moosa argues. Such a creative and critical inheritance, he concludes, ought to be heeded by those who seek to cultivate Muslim intellectual traditions in today's tumultuous world. (shrink)

According to the somatic mutation theory (SMT), cancer begins with a genetic change in a single cell that passes it on to its progeny, thereby generating a clone of malignant cells. It is strongly supported by observations of leukemias that bear specific chromosome translocations, such as Burkitt's lymphoma, in which a translocation activates the c‐myc gene, and chronic myeloid leukemia (CML), in which the Philadelphia chromosome causes production of the BCR‐ABL oncoprotein. Although the SMT has been modified and extended (...) to encompass tumor suppressor genes, epigenetic inheritance, and tumor progression through accumulation of further mutations, perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene.magnified imageDavid Vaux is at the Walter and Eliza Hall Institute and La Trobe Institute for Molecular Science, Melbourne, Australia. (shrink)

Monarchy is a form of government that, roughly, dictates that the right to rule is inherited by birth by a single ruler. But monarchy (absolute or constitutional) breaches fundamental moral principles that undergird representative democracy, such as basic moral equality, dignity and desert. Simply put, the monarchs (and their family) are treated as morally superior to ordinary citizens and as a result ordinary citizens are treated in an unfair and undignified manner. For example, monarchs are respected, enjoy dignity, income, (...) opportunity, public office and exalted social status just because of their inherited office, which is due to the mere historical accident of family lineage. Hence, we have good moral reason to abolish monarchy. Finally, I briefly reply to the pragmatic argument for constitutional monarchy, namely, the argument that monarchy can be allowed to play a largely ceremonial role in the context of democracy because it is beneficial for the function of society. As I argue, societies run by presidential democracies can function equally well and, what is more, no matter what the pragmatic reasons for constitutional monarchy are, we still have stronger moral reasons against it. Therefore, it should be abolished. (shrink)

Darwinian evolutionary theory has two key terms, variations and biological selection, which finally lead to survival of the fittest variant. With the rise of molecular genetics, variations were explained as results of error replications out of the genetic master templates. For more than half a century, it has been accepted that new genetic information is mostly derived from random error-based events. But the error replication narrative has problems explaining the sudden emergence of new species, new phenotypic traits, and genome innovations (...) as a sudden single event. Meanwhile, it is recognized that errors cannot explain the evolution of genetic information, genetic novelty, and complexity. Now, empirical evidence establishes the crucial role of non-random genetic content editors, such as viruses, diversity generating retroelements, and other RNA networks, to produce new genetic information, complex regulatory control, inheritance vectors, genetic identity, immunity, new sequence space, evolution of complex organisms, and evolutionary transitions. (shrink)

Reasons are given for suggesting that individuation of the human embryo does not begin until the primitive streak forms at about the fourteenth day after conception; this view, though contested by many, is held by very many committed Christians of all denominations. In the conceptus or pre-embryo, after the formation of a blastocyst at about four-five days after fertilisation, biopsy of a single cell from the outer layer of cells (which later can form the membranes and placenta) can be (...) used to determine the sex of the conceptus and will ultimately be used to detect the presence of an abnormal gene such as that for Duchenne-type muscular dystrophy, without detriment to development of the basal cell mass from which the embryo forms. The potential benefits in the prevention of inherited disease are profound. (shrink)

It Is My Pleasure To Introduce this discussion of Naoko Saito's American Philosophy in Translation. We have contributions from three experts in American philosophy, all of whom have been in conversation with the author for many years: Jim Garrison, Vincent Colapietro, and Steven Fesmire. Prior to their contributions, I would like to set the scene with some brief remarks to introduce the book and to explain something of its background.Over the past two decades, I have worked closely with Saito on (...) a number of projects, and I have been familiar with her ideas for this book since its inception. In some respects, the book is the product of studies in American philosophy that go back to her time as an undergraduate in Tokyo in the 1980s, ideas that were advanced considerably when she did an MA at Harvard, taking classes with Stanley Cavell and Hilary Putnam, and subsequently when she completed her PhD at Teachers College, with René Arcilla as her advisor and Cavell as a member of her committee. It was against this background that, in 2006, Saito published her first singly authored book, The Gleam of Light: Moral Perfectionism and Education in Dewey and Emerson. As that title indicates, she was already exploring the relation between Dewey and pragmatism, on the one hand, and American transcendentalism, on the other. Her sense back then of some separation between these traditions of thought, and of the nature of the tensions between them, has been refined and, for the most part, strengthened in the years since that earlier publication. No doubt she has been influenced in this by Cavell, who, in one essay, for example, asks: “What's the use of calling Emerson a pragmatist?” In any case, her account of this relationship is extended and altered significantly in American Philosophy in Translation.Through the course of her research, Saito has been conscious of the fact that she is studying American philosophy from a distance—a distance that is geographical, cultural, and linguistic—and she retains a thoughtful humility in relation to this. But she also sees here a possible opening to the perception and release of untapped aspects of these traditions of thought, in ways that might fertilize and extend the ground in which the inheritance of American philosophy has flourished. This is very much the line that she pursues in this book. In the light of this, and as the book's title indicates, there is a particular focus on language and translation. It is important that the latter term is understood not merely as an attractive metaphor for change and transformation: crucial to her developing argument is the experience of translating between languages and the reality of the experience in the lives of so many today, within the academy and without. In the course of this experience, one is sometimes confronted, quite self-consciously, with a word or phrase that resists translation. But sometimes—more often in the life of the accomplished or habituated speaker of the foreign language in question—the experience persists as an undercurrent, subtly opening a world that is other in some respects from the one that comes to light in the mother tongue.By contrast, to the many (especially Anglophone) monolingually minded, the need for translation can appear as an unwanted barrier, something of a nuisance, a problem to be solved. This is by no means a response confined, however, to the uneducated (or the Anglophone or the monolingual). There is also a sophisticated variant of this narrowness of outlook where faith is placed in an artificial or technical language with the power, the fantasy runs, to overcome the vagaries of natural language. Hilary Putnam recalls how Rudolf Carnap, whose stature as a thinker and as a human being he does not doubt, felt strongly that “for all x, planned x is better than unplanned x” and was drawn to the idea of a common world language: Thus the idea of a socialist world in which everyone spoke Esperanto (except scientists, who, for their technical work, would employ notations from symbolic logic) was one which would have delighted him. And I recently had a conversation with a student who remarked quite casually that it would not be a bad idea if there were only one language and one literature: “We would get used to it, and it might help to prevent war.” (Putnam 185)Putnam does not deign to respond to the latter assertion. What is foregrounded in his discussion is that monolingualism is likely to hide the plurality of goods that is realized in different cultures. The importance of that plurality is surely something that the luminaries of American philosophy bring to light. Indeed, Putnam's key point of reference in making these remarks is William James.The undercurrent of translation in the experience of the more accomplished speaker of a foreign language can act then as a sensitization to cultural difference, to different possibilities of thought and being. But in fact, this shifting of thought can apply within any language itself, not just inter- but intra-lingually, opening an insight that is close to the heart of American philosophy. If one can hear the cry of the rooster, then one may be wakened also by Thoreau's turn of expression in the idea of the “father tongue”: through a maturing experience of the language we are brought up with, we come to “a reserved and select expression, too significant to be heard by the ear, which we must be born again in order to speak” (Thoreau 69). This renewed investment in language, this continual return to our words, is what opens them to new thought and gives them interest. It is first an inheritance from the culture we are brought up in, but it dies in our speech and thinking if we do not turn it to something new. To build, we must begin by borrowing an axe, but we can return it sharper than when we borrowed it.If translation is operative in our language as a whole, as Saito's argument shows, this points to the many little rebirths within ourselves and in our interactions with one another. In fact, the point becomes political in that democracy depends upon this renewal of our words. This renewal resists not only the allure of ideology but also the now familiar etiolated rhetoric of “political realism.” Moreover, it points beyond the reliance, within the politics of recognition, on the defining of groups and categories toward a politics of acknowledgment.In this vein, Saito's outsider perspective is in tune with what Richard Bernstein has called the “global resurgence of American pragmatism.” The borderline or outsider perspective can have a powerful effect on thought, in relation to which Saito invites the reader to recall that America's past was itself an outsider-past: it was outside Europe, a relation with which it was bound to struggle, but it was also ready, as Emerson and Thoreau demonstrate, to draw from greater cultural distances, where it found congenial aspects in East Asian thought.Saito stresses the anti-foundationalist character of American philosophy as of critical importance for both philosophy and politics, and again her discussion of language is crucial to this. Dewey's emphasis on communication, with his relatively flat style of prose, is contrasted with the stylistic experiment and invention that she finds in Emerson, Thoreau, and Cavell. She sees the style of these writers, in some contrast to that of Dewey, as having a salutary, destabilizing effect. She wants to destabilize Dewey. It is entirely consonant with her position, furthermore, that she raises doubts about the bland acceptance of a politics of inclusion. Not only can this become a surreptitious form of discipline and control: it can engender the conformism that Emerson worked so hard to prevent.The book finishes on a more aesthetic note, taking up lines of thought in Dewey's aesthetics but turning this toward the more extravagant elision, in Thoreau, of the functional and the beautiful. The thematization of the aesthetic in this way is, she tries to show, crucial to our (political) world. (shrink)

The 1940s and 1950s were marked by intense debates over the origin of drug resistance in microbes. Bacteriologists had traditionally invoked the notions of ‘training’ and ‘adaptation’ to account for the ability of microbes to acquire new traits. As the field of bacterial genetics emerged, however, its participants rejected ‘Lamarckian’ views of microbial heredity, and offered statistical evidence that drug resistance resulted from the selection of random resistant mutants. Antibiotic resistance became a key issue among those disputing physiological vs. genetic (...) explanations of variation in bacteria. Postwar developments connected with the Lysenko affair gave this debate a new political valence.Proponents of the neo-Darwinian synthesis weighed in with support for the genetic theory. However, certain features of drug resistance seemed inexplicable by mutation and selection, particularly the phenomenon of ‘multiple resistance’—the emergence of resistance in a single strain against several unrelated antibiotics. In the late 1950s, Tsutomu Watanabe and his collaborators solved this puzzle by determining that resistance could be conferred by cytoplasmic resistance factors rather than chromosomal mutation. These R factors could carry resistance to many antibiotics and seemed able to promote their own dissemination in bacterial populations. In the end, the vindication of the genetic view of drug resistance was accompanied by a recasting of the ‘gene’ to include extrachromosomal hereditary units carried on viruses and plasmids. (shrink)

In their 1987 Nature publication, “Mitochondrial DNA and Human Evolution,” Rebecca Cann, Mark Stoneking, and Allan C. Wilson gave a new reconstruction of human evolution on the basis of differences in mitochondrial DNA among contemporary human populations. This phylogeny included an African common ancestor for all human mitochondrial DNA (mtDNA) lineages, and Cann et al.’s reconstruction became known as the “Out of Africa” hypothesis. Since mtDNA is inherited exclusively through the maternal line, the common ancestor who was first branded African (...) Eve later became known as Mitochondrial Eve (mtEve, for short). -/- In this paper, I show that mtEve was not a single, successful, or purely scientific discovery. Instead, she was produced many times and in many ways, each of which informed the next. Importantly, though Wilson and colleagues heralded mitochondrial DNA as a source of certainty, objectivity, and consensus for evolutionary inference, their productions of Mitochondrial Eve depended as much on popular assumptions about the certainty of maternal inheritance as they did on new molecular and computational tools. This recognition lets us reevaluate the complex consequences of these productions, which, like mtEve herself, could not be confined to a purely social, material, or scientific dimension. (shrink)

Parts of the genome of a single individual can have conflicting interests, depending on which parent they were inherited from. One mechanism by which these conflicts are expressed in some taxa, including mammals, is genomic imprinting, which modulates the level of expression of some genes depending on their parent of origin. Imprinted gene expression is known to affect body size, brain size, and the relative development of various tissues in mammals. A high fraction of imprinted gene expression occurs in (...) the brain. Biologists including Hamilton, Trivers and Haig have proposed that this may explain some intrapersonal conflict in humans. This speculation amounts to an inference from conflict within the genome to conflict within the brain or mind. This is a provocative proposal, which deserves serious attention. In this paper I assess aspects of Haig’s version of the proposal. I argue, first, that the notion that intragenomic conflict predicts personal inconsistency should be rejected. Second, while it is unlikely that it credibly predicts sub-personal agents representing conflicting genetic interests, it is plausible that it predicts that the division of cognitive labour could be exploited to turn sub-systems into proxies for conflicting interests. (shrink)