The mitochondrion is known as the “powerhouse” of eukaryotic cells since it is the main site of adenosine 5′‐triphosphate (ATP) production. Using a temperature‐sensitive fluorescent probe, it has recently been suggested that the stray free energy, not captured into ATP, is potentially sufficient to sustain mitochondrial temperatures higher than the cellular environment, possibly reaching up to 50 °C. By 50 °C, some DNA and mitochondrial proteins may reach their melting temperatures; how then do these biomolecules maintain their structure and function? (...) Further, the production of reactive oxygen species (ROS) accelerates with temperature, implying higher oxidative stresses in the mitochondrion than generally appreciated. Herein, it is proposed that mitochondrial heat shock proteins (particularly Hsp70), in addition to their roles in protein transport and folding, protect mitochondrial proteins and DNA from thermal and ROS damage. Other thermoprotectant mechanisms are also discussed. (shrink)

The molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity (...) to remodel in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate. (shrink)

Architectural style is a medium for the promotion of cultural identities and cohesion. South Asian Association for Regional Cooperation nations provide a prism through which all forms of vernacular architecture can be viewed. This study is presented through the lens of the soul of the eye coupled with the power of technological probing. This synthesis affords a most appealing and lyrical exploration of the course of the development of cities within the SAARC nations. It showcases research results combining the above (...) stated synergy—starting from some of SAARC’s sophisticated historic cultures, cultures that ebbed and flowed along its shores and valleys. This paper shall touch upon unique cultural roots stretching back to the Dravidian civilization that flourished over 3500 years ago and also look at the grouping of houses within the Indus Valley Civilization in Lothal and the Sarasvati Valley Civilization in Kalibangan. The sensitivity underlying SAARC architecture and its traditions are seen in many communal settlements, profoundly so in the Indian subcontinent and in Sri Lanka. The paper shall showcase two specific, but nevertheless, distinct styles of communal functioning within unique architectural strongholds in the ancient Ratnagiri University in Odisha, India, and also touch upon a unique blend of styles of landscape architecture in Sri Lanka. The overarching emphasis of this study is that throughout SAARC’s history, architecture has been creatively adopted to the need of its users and the characteristics of its climate and location. It has always fulfilled the needs and nourished the spirit of its people, promoting cultural cohesion even today. In this context, it is interesting to explore traditional techniques of vernacular architecture in houses in Andhra, Tamil Nadu and Kerala. The common thread linking mass housing in Lothal, Kalibangan, Anuradhapura and Ratnagiri about 2 millennia ago, with present day housing patterns, is in the application of sustainable building practices using intelligent building forms, fabric and orientation. This paper explores this commonality from a modern perspective using CFD. As the SAARC countries still struggle to get a fuller understanding of their unique ecology and the complexity of their diverse cultures, revisiting the architectural legacy of their indigenous societies might prove insightful. The need for this revisit becomes even more relevant in the wake of the Paris Agreement and more recently the Kigali Agreement. The discourse on providing indoor thermal comfort to the SAARC people cannot be decoupled from the climate change story—heating, ventilation and cooling consume a large amount of energy and have a deep underlying link with the targets set at Paris and Kigali. The onus will be on a large number of stakeholders to meet these targets—engineers, architects, manufacturers, policy-makers, researchers and consumers. This paper aims at reminding the stakeholders of the richness and the usefulness of their vernacular architecture in upholding the ideal of sustainability. (shrink)

John MacFarlane explores how we might make sense of the idea that truth is relative. He provides new, satisfying accounts of parts of our thought and talk that have resisted traditional methods of analysis, including what we mean when we talk about what is tasty, what we know, what will happen, what might be the case, and what we ought to do.

Modal knowledge accounts that are based on standards possible-worlds semantics face well-known problems when it comes to knowledge of necessities. Beliefs in necessities are trivially sensitive and safe and, therefore, trivially constitute knowledge according to these accounts. In this paper, I will first argue that existing solutions to this necessity problem, which accept standard possible-worlds semantics, are unsatisfactory. In order to solve the necessity problem, I will utilize an unorthodox account of counterfactuals, as proposed by Nolan, on which we also (...) consider impossible worlds. Nolan’s account for counterpossibles delivers the intuitively correct result for sensitivity i.e. S’s belief is sensitive in intuitive cases of knowledge of necessities and insensitive in intuitive cases of knowledge failure. However, we acquire the same plausible result for safety only if we reject his strangeness of impossibility condition and accept the modal closeness of impossible worlds. In this case, the necessity problem can be analogously solved for sensitivity and safety. For some, such non-moderate accounts might come at too high a cost. In this respect, sensitivity is better off than safety when it comes to knowing necessities. (shrink)

This paper surveys attempts in the recent literature to offer a modal condition on knowledge as a way of resolving the problem of scepticism. In particular, safety-based and sensitivity-based theories of knowledge are considered in detail, along with the anti-sceptical prospects of an explicitly anti-luck epistemology.

The paper addresses a problem for the unification of quantum physics with the new Aristotelianism: the identification of the members of the category of substance. I outline briefly the role that substance plays in Aristotelian metaphysics, leading to the postulating of the Tiling Constraint. I then turn to the question of which entities in quantum physics can qualify as Aristotelian substances. I offer an answer: the theory of thermal substances, and I construct a fivefold case for thermal substances, (...) based on the irreversibility of time, the definition of thermodynamic concepts, spontaneous symmetry breaking, phase transitions, and chemical form. (shrink)

Touch is standardly taken to be a proximal sense, principally constituted by capacities to detect proximal pressure and thermal stimulation, and contrasted with the distal senses of vision and audition. It has, however, recently been argued that the scope of touch extends beyond proximal perception; touch can connect us to distal objects. Hence touch generally should be thought of as a connection sense. In this paper, I argue that whereas pressure perception is a connection sense, thermal perception is (...) not. Thermal perception is a proximal sense distinct from touch. One significant consequence of this is that it motivates an alternative explanation of how we detect the thermal properties of the things we touch and what they are. (shrink)

In 1916, Einstein rederived the blackbody radiation law of Planck that originated the idea of quantized energy one hundred years ago. For this purpose, Einstein introduced the concept of transition probability, which had a profound influence on the development of quantum theory. In this article, we adopt Einstein's assumptions with two exceptions and seek the statistical condition for the thermal equilibrium of matter without referring to the inner details of either statistical thermodynamics or quantum theory. It is shown that (...) the conditions of thermodynamic equilibrium of electromagnetic radiation and the energy balance of thermal radiation by the matter, between any of its two energy-states, not only result in Planck's radiation law and the Bohr frequency condition, but they remarkably yield the law of the statistical thermal equilibrium of matter: the Maxwell–Boltzmann distribution. Since the transition probabilities of the modern quantum theory of radiation coincide with their definition in Einstein's theory of blackbody radiation, the presented deduction of the Maxwell–Boltzmann distribution is equally valid within the bounds of modern quantum theory. Consequently, within the framework of the fundamental assumptions, the Maxwell–Boltzmann distribution of energy-states is not only a sufficient, but a necessary condition for thermal equilibrium between the matter and radiation. (shrink)

Machine ethics is the field that strives to develop ‘artificial moral agents’ (AMAs), artificial systems that can autonomously make moral decisions. Some authors have questioned the feasibility of machine ethics, by questioning whether artificial systems can possess moral competence, or the capacity to reach morally right decisions in various situations. This paper explores this question by drawing on the work of several moral philosophers (McDowell, Wiggins, Hampshire, and Nussbaum) who have characterised moral competence in a manner inspired by Aristotle. Although (...) disparate in many ways, these philosophers all emphasise what may be called ‘moral sensitivity’ as a precondition for moral competence. Moral sensitivity is the uncodified, practical skill to recognise, in a range of situations, which features of the situations are morally relevant, and how they are relevant. This paper argues that the main types of AMAs currently proposed are incapable of full moral sensitivity. First, top-down AMAs that proceed from fixed rule-sets are too rigid to respond appropriately to the wide range of qualitatively unique factors that moral sensitivity gives access to. Second, bottom-up AMAs that learn moral behaviour from examples are at risk of generalising from these examples in undesirable ways, as they lack embedding in what Wittgenstein calls a ‘form of life’, which allows humans to appropriately learn from moral examples. The paper concludes that AMAs are unlikely to possess full moral competence, but closes by suggesting that they may still be feasible in restricted domains of public morality, where moral sensitivity plays a smaller role. (shrink)

Classical Confucian philosopher Mengzi 孟子 offers resources that can help shed light on the metaphysical status of moral qualities and answer the question of how we come to perceive them. I argue that Mengzi puts forward an account of virtue as sensitivity similar to that offered by John McDowell. Both thinkers endorse a particular kind of motivationally internalist naturalistic moral realism, and both explain virtue as analogous to perception of secondary qualities. I offer an original contribution to existing literature (...) by further arguing that Mengzi’s view includes an understanding of moral perception as including perception of uniquely human roles and the moral obligations they generate. This essay thus offers a novel textual interpretation of the _Mengzi_. Based on this interpretation, it then puts forth the argument that Mengzi’s version of virtue as sensitivity allows the Confucian thinker to avoid criticisms of McDowell’s “Sensitivity Account” of virtue. In particular, I argue that Mengzi’s account of sensitivity—as one that includes sensitivity to human roles and relationships—is better able to explain variation in perceived moral qualities both over time and across cultures. This is because Mengzi’s view recognizes that what is called for morally shifts with the agent’s social roles. Thus, a Mengzian-influenced Sensitivity Account of virtue can better account for differences in moral judgment by emphasizing that moral facts are a feature of human relationships, which likewise vary between cultures and individuals and change over time. (shrink)

Protein α-helices provide an ordered biological environment that is conducive to soliton-assisted energy transport. The nonlinear interaction between amide I excitons and phonon deformations induced in the hydrogen-bonded lattice of peptide groups leads to self-trapping of the amide I energy, thereby creating a localized quasiparticle (soliton) that persists at zero temperature. The presence of thermal noise, however, could destabilize the protein soliton and dissipate its energy within a finite lifetime. In this work, we have computationally solved the system of (...) stochastic differential equations that govern the quantum dynamics of protein solitons at physiological temperature, T=310 K, for either a single isolated α-helix spine of hydrogen bonded peptide groups or the full protein α-helix comprised of three parallel α-helix spines. The simulated stochastic dynamics revealed that although the thermal noise is detrimental for the single isolated α-helix spine, the cooperative action of three amide I exciton quanta in the full protein α-helix ensures soliton lifetime of over 30 ps, during which the amide I energy could be transported along the entire extent of an 18-nm-long α-helix. Thus, macromolecular protein complexes, which are built up of protein α-helices could harness soliton-assisted energy transport at physiological temperature. Because the hydrolysis of a single adenosine triphosphate molecule is able to initiate three amide I exciton quanta, it is feasible that multiquantal protein solitons subserve a variety of specialized physiological functions in living systems. (shrink)

The two parameters of leaf dimension namely, length and width, show inverse correlation with the third parameter, the thickness. A thermal diffusion model is proposed which explains the inverse relationship between these and envisages that while leaf length and width are directly influenced by the microclimate the thickness is affected by the microclimate through endoclimate and energy balance in the leaves. The significance of the model is discussed in the light of its importance in assessing the survival range of (...) plant species along the altitudinal gradient. (shrink)

A new theory about the origins of consciousness that finds learning to be the driving force in the evolutionary transition to basic consciousness. What marked the evolutionary transition from organisms that lacked consciousness to those with consciousness—to minimal subjective experiencing, or, as Aristotle described it, “the sensitive soul”? In this book, Simona Ginsburg and Eva Jablonka propose a new theory about the origin of consciousness that finds learning to be the driving force in the transition to basic consciousness. Using a (...) methodology similar to that used by scientists when they identified the transition from non-life to life, Ginsburg and Jablonka suggest a set of criteria, identify a marker for the transition to minimal consciousness, and explore the far-reaching biological, psychological, and philosophical implications. After presenting the historical, neurobiological, and philosophical foundations of their analysis, Ginsburg and Jablonka propose that the evolutionary marker of basic or minimal consciousness is a complex form of associative learning, which they term unlimited associative learning (UAL). UAL enables an organism to ascribe motivational value to a novel, compound, non-reflex-inducing stimulus or action, and use it as the basis for future learning. Associative learning, Ginsburg and Jablonka argue, drove the Cambrian explosion and its massive diversification of organisms. Finally, Ginsburg and Jablonka propose symbolic language as a similar type of marker for the evolutionary transition to human rationality—to Aristotle's “rational soul.”. (shrink)

In the Essay Concerning Human Understanding, Locke insists that all knowledge consists in perception of the agreement or disagreement of ideas. However, he also insists that knowledge extends to outer reality, claiming that perception yields ‘sensitive knowledge’ of the existence of outer objects. Some scholars have argued that Locke did not really mean to restrict knowledge to perceptions of relations within the realm of ideas; others have argued that sensitive knowledge is not strictly speaking a form of knowledge for Locke. (...) This chapter argues that Locke’s conception of sensitive knowledge is in fact compatible with his official definition of knowledge, and discusses his treatment of the problem of skepticism, both in the Essay and in the correspondence with Stillingfleet. (shrink)

Albania is part of the emerging economies of the Western Balkan region. Polis University is one of the pioneering institutions in the field of architecture, built environment, and city sciences that represents innovative methodologies and concepts for educational and scientific purposes. Nowadays, many constructions in Albania involve a wide range of different materials. The building envelope is one of the main elements that provide protection from the outside environment but also the required thermal comfort for the inhabitants. The necessary (...) balance must be archived between energy efficiency and the durability of buildings. This paper will focus on the thermal performance and materials composition of two different types of masonry walls, a constituent part of Polis University's main building. The study will be based on an experiment using specific instruments to diagnose these typologies of wall composition. The results are further analyzed and compared. Specific instruments such as the thermal camera (Testo 882), U-value(Testo 435-2), and “Silverline Digital Moisture Meter” (from POLIS Energy lab) are engaged. The collected data are further interpreted through graphs, tables, and diagrams for both cases. It is observed that ventilated facades perform much better than standard facades, therefore their usage is strongly recommended. (shrink)

Literature shows that psychological phenomena, including values, personality, and behaviors, are geographically clustered. The effects of temperature on interpersonal and intergroup aggression have been studied by many social psychologists. To date the interactions between temperature and other geographical factors have not been addressed. This study is aiming to examine the effects of thermal demands and the moderating effects of natural geographical factors on aggressive behavior at national level. Data for 156 societies was obtained from publicly available databases. Consistent with (...) the life-history theory, results of this study showed that aggressive behavior has a positive relationship with heat demands, and a negative relationship with cold demands. Aggressive behavior is also positively correlated with sunlight and altitude, and negatively correlated with coastline vicinity. Forest, coastline vicinity, and rainfall moderated the effect of thermal demands on aggressive behavior. In societies with more forests, with more rainfall, and closer to coastline, the negative effects of cold demands on aggressive behavior are stronger. (shrink)

According to the sensitivity account of knowledge, S knows that p only if S's belief in p is sensitive in the sense that S would not believe that p if p were false. It is widely accepted that the sensitivity condition should be relativized to belief-formation methods to avoid putative counterexamples. A remaining issue for the account is how belief-formation methods should be individuated. In this paper, I argue that while a coarse-grained individuation is still susceptible to counterexamples, (...) a fine-grained individuation makes the target belief trivially insensitive. Therefore, there is no principled way of individuating belief-formation methods that helps the sensitivity account to accommodate different cases. (shrink)

This chapter proposed a novel design methodology called Value-Sensitive Design and its potential application to the field of artificial intelligence research and design. It discusses the imperatives in adopting a design philosophy that embeds values into the design of artificial agents at the early stages of AI development. Because of the high risk stakes in the unmitigated design of artificial agents, this chapter proposes that even though VSD may turn out to be a less-than-optimal design methodology, it currently provides a (...) framework that has the potential to embed stakeholder values and incorporate current design methods. The reader should begin to take away the importance of a proactive design approach to intelligent agents. (shrink)

This paper endeavors to establish foundations for the interaction between hyperintensional semantics and two-dimensional indexing. I examine the significance of the semantics, by developing three, novel interpretations of the framework. The first interpretation provides a characterization of the distinction between fundamental and derivative truths. The second interpretation demonstrates how the elements of decision theory are definable within the semantics, and provides a novel account of the interaction between probability measures and hyperintensional grounds. The third interpretation concerns the contents of the (...) types of intentional action, and the semantics is shown to resolve a puzzle concerning the role of intention in action. Topic-sensitive two-dimensional truthmaker semantics can be interpreted epistemically and metasemantically. (shrink)

The orthodox view about sensitivity and induction has it that beliefs formed via induction are insensitive. Since inductive knowledge is highly plausible, this problem is usually regarded as a reductio argument against sensitivity accounts of knowledge. Some adherents of sensitivity defend sensitivity against this objection, for example by considering backtracking interpretations of counterfactuals. All these extant views about sensitivity and induction have to be revised, since the problem of sensitivity and induction is a different (...) one. Regardless of whether we allow backtracking interpretations of counterfactuals, some instances of induction yield insensitive beliefs whereas others yield sensitive ones. These results are too heterogenous for providing a plausible sensitivity-account of inductive knowledge. Induction remains a serious problem for sensitivity accounts of knowledge. (shrink)

Descartes set for himself the ambitious program of accounting for the functions of the Aristotelian vegetative and sensitive souls without invoking souls or the faculties or powers of souls in his explanations. He rejects the notion that the soul is hylomorphically present in the organs of the body so as to carry out vital and sensory functions. Rather, the body’s organs operate in a purely mechanical fashion. That is what is involved in “mechanizing” these phenomena. The role of the soul (...) is restricted to properly mental functions: to the conscious aspects of sensations and other mental operations; to intellectual acts; and to acts of volition. In effect, soul becomes mind. In order to understand the extent of Descartes’ ambition, this chapter first considers more fully the functions attributed to the soul or to the vital faculties in the Aristotelian and Galenic traditions, and especially the functions of the sensitive soul or power. It draws attention to the cognitive aspects of these functions, beyond the mere operation of the external senses. Then it turns to Descartes’ mechanistic explanations for these cognitive functions. Finally, it situates Descartes’ new mechanistic psychology within the larger context of his novel anthropology, or theory of the human being. (shrink)

Background Teamwork in emergency medical services is a very important factor in efforts to improve patient safety. The potential differences of staff gender on communication, patient safety, and teamwork were omitted. The aim of this study is to evaluate these inadequately examined areas. Methods A descriptive and anonymous study was conducted with an online questionnaire targeting emergency physicians and paramedics. The participants were asked about teamwork, communication, patient safety and handling of errors. Results Seven hundred fourteen prehospital professionals from all (...) over Germany participated. A total of 65.7% of the women harmed a patient (men 72.9%), and 52.6% were ashamed when mistakes were made (men 31.7%). 19.0% of the female participants considered their communication skills to be very good, compared to 81% of the men. More women than men did not want to appear incompetent (28.4%, 15.5%) and therefore did not speak openly about mistakes. Both genders saw the character of their colleagues as a reason for poor team communication (women 89.4%, men 84.9.%). Under high stress, communication decreased (women 35.9%, men 31.0%) and expression became inaccurate (women 18.7%, men 20.1%). Conclusions Team communication problems and teamwork in rescue services are independent of gender. Women seem to have more difficulty with open communication about mistakes because they seem to be subject to higher expectations. Work organization should be adapted to women’s needs to enable more effective error management. We conclude that it is necessary to promote a positive error and communication culture to increase patient safety. (shrink)

We consider an isolated, macroscopic quantum system. Let H be a microcanonical “energy shell,” i.e., a subspace of the system’s Hilbert space spanned by the (finitely) many energy eigenstates with energies between E and E + δE. The thermal equilibrium macro-state at energy E corresponds to a subspace Heq of H such that dim Heq/ dim H is close to 1. We say that a system with state vector ψ H is in thermal equilibrium if ψ is “close” (...) to Heq. We show that for “typical” Hamiltonians with given eigenvalues, all initial state vectors ψ0 evolve in such a way that ψt is in thermal equilibrium for most times t. This result is closely related to von Neumann’s quantum ergodic theorem of 1929. (shrink)

Sensitivity has sometimes been thought to be a highly epistemologically significant property, serving as a proxy for a kind of responsiveness to the facts that ensure that the truth of our beliefs isn’t just a lucky coincidence. But it's an imperfect proxy: there are various well-known cases in which sensitivity-based anti-luck conditions return the wrong verdicts. And as a result of these failures, contemporary theorists often dismiss such conditions out of hand. I show here, though, that a (...) class='Hi'>sensitivity-based understanding of epistemic luck can be developed that respects what was attractive about sensitivity-based approaches in the first place but that's immune to these failures. (shrink)