The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

In his 1934 book Art as Experience John Dewey explores the relationship between human experience and art. His theory builds on the conception of experience inspired by Darwinian biology as the dyna...

Although some cognitive studies provided reasons that children with low socioeconomic status (SES) showed poor mathematical achievements, there was no explicit evidence to directly explain the root of lagged performance in children with low SES. Therefore, the present study explored the differences in neural correlates in the process of symbolic magnitude comparison between children with different SES by the event-related potentials (ERP). A total of 16 second graders from low SES families and 16 from middle/high SES families participated in this (...) study. According to the results of anterior N1 (early attention) and P2 (extraction of numerical meaning) over frontal region, the differences among children with different SES were manifested as differences in general neural activities in terms of attention and top-down cognitive control. In the late stage of cognitive processing, there was no significant difference in the average amplitude of the LPC between the children with different SES, indicating that low SES did not influence the information encoding and memory updating of numerical representation responsible by the parietal lobe. The educational implications of this study were mentioned in the discussion. (shrink)

Scholarly interest in employees’ voluntary pro-environmental behavior has begun to emerge. While this research is beginning to shed light on the predictors of workplace pro-environmental behavior, our understanding of the psychological mechanisms linking the various antecedents to employees’ environmentally responsible behavior and the circumstances under which any such effects are enhanced and/or attenuated is incomplete. The current study seeks to fill this gap by examining: the effects of perceived corporate social responsibility on employees’ voluntary pro-environment behavior; an underlying mechanism that (...) links CSR perceptions to these behaviors; and a boundary condition to these relationships. Data from 183 supervisor-subordinate dyads employed in large- and medium-sized casinos and hotels in Guangdong China and Macau revealed that employees’ corporate social responsibility perceptions indirectly affect their engagement in voluntary pro-environmental behavior through organizational identification, and these effects are stronger for employees high in empathy. (shrink)

This study examines values and value types as well as scores in levels of moral reasoning for␣students enrolled in a business program. These two factors are measured using the Schwartz Personal Values␣Questionnaire and the Defining Issues Test 2. No statistically significant differences in levels of moral␣reasoning, rankings of values, and value types could be attributed to gender. However, eight significant correlations between value types and levels of moral reasoning provide evidence that a systematic relationship exists. The relationships are not only (...) internally consistent but also consistent with the model of values based on motivational goals (Schwartz S. H. and K. Boenke: 2004, Journal of Research in Personality , 38 230–255). (shrink)

Receptor tyrosine kinases and integrins are activated by growth factors and extracellular matrix, respectively. Their activation leads to signal transduction cascades that control many aspects of cell phenotype, including progression through the G1 phase of the cell cycle. However, the signalling cassettes driven by growth factors and matrix do not work independently of each other. Integrin triggering is essential to facilitate kinase‐ and GTPase‐mediated signals and thereby drive efficient transfer of information through the growth factor–cyclin axis. A recent study indicates (...) that an additional type of player has a key role in adhesion‐regulated control of cell cycle, namely ubiquitin ligase.(1) BioEssays 24:17–21, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

A multiphase study tested a proposed mediated moderation model for the joint effects of ethical pressure and power distance orientation on accountants’ ethical judgments of earnings management. Results based on a sample of 354 accountants from China indicated that the relationship between ethical pressure and ethical judgments of earnings management is contingent on the accountants’ power distance orientation. That is, the relationship between ethical pressure and ethical judgments of earnings management was stronger for accountants with a high power distance orientation. (...) The results also demonstrated that ethical beliefs in support of the company serve as a mediator for the interaction effect of ethical pressure and power distance orientation on the outcome. These results are discussed in terms of viewing earnings management as a form of unethical pro-organizational behavior which can be effectively investigated within the framework of the person-situation interactionist model. (shrink)

Scientific integrity is defined as the condition that occurs when individuals adhere to accepted standards, professional values, and practices of the relevant scientific community. This study aims to investigate the influential factors on the scientific integrity in scholarly publishing of researchers in Thailand. The questionnaire was delivered to a sample size of 398 top researchers who had high citations and h-index recorded in the Scopus database during the past 5 years, 316 responses were returned. The findings confirm that there are (...) five factors that affect scientific integrity in scholarly publishing: university/faculty requirements/policies, university support, aspects of publishing, publisher aspects, and researcher-related factors. It is evident that establishing a process and criteria for authorship agreement and verification, as well as dedicating offices or units within the university to address research integrity concerns and provide support to researchers, exhibit the highest factor loading values. The findings ensure that scientific integrity stands out as a top priority for researchers linked with prominent research universities in Thailand. To tackle this challenge, it is recommended for the universities to prioritize initiatives aimed at enhancing researchers’ ethical awareness and nurturing scientific integrity. (shrink)

This paper examines the impact of Chinese business managers’ moral philosophies on the perception of corrupt payments such as bribery, kickbacks and gift giving. Business managers from Mainland China were selected as target respondents. As hypothesized the survey results generally indicate that moral relativism is a significant predictor of Chinese business managers’ favorable perception of bribery and kickbacks. In examining the attitude toward gift giving, the survey showed that an individual’s attitude toward gift giving was neither affected by their moral (...) relativism nor by their moral idealism, which implies that gift giving is widely accepted as legal practice in business in Chinese cultural society. (shrink)

The economical/environmental scheduling problem of the ship integrated energy system has high computational complexity, which includes more than one optimization objective, various types of constraints, and frequently fluctuated load demand. Therefore, the intelligent scheduling strategies cannot be applied to the ship energy management system online, which has limited computing power and storage space. Aiming at realizing green computing on SEMS, in this paper a typical SIES-EESP optimization model is built, considering the form of decision vectors, the economical/environmental optimization objectives, and (...) various types of real-world constraints of the SIES. Based on the complexity of SIES-EESPs, a two-stage offline-to-online multiobjective optimization strategy for SIES-EESP is proposed, which transfers part of the energy dispatch online computing task to the offline high-performance computer systems. The specific constraints handling methods are designed to reduce both continuous and discrete constraints violations of SIES-EESPs. Then, an establishment method of energy scheduling scheme-base is proposed. By using the big data offline, the economical/environmental scheduling solutions of a typical year can be obtained and stored with more computing resources and operation time on land. Thereafter, a short-term multiobjective offline-to-online optimization approach by SEMS is considered, with the application of multiobjective evolutionary algorithm and typical schemes corresponding to the actual SIES-EESPs. Simulation results show that the proposed strategy can obtain enough feasible Pareto solutions in a shorter time and get well-distributed Pareto sets with better convergence performance, which can well adapt to the features of real-world SIES-EESPs and save plenty of operation time and storage space for the SEMS. (shrink)

An account of how the mathematical sciences turn the mind away from becoming and towards being. There are four main conclusions. 1. The study of numbers, when treated independently of the other sciences, uses a particular conception of the nature of numbers to detach the mind from the influence of perceptible objects. 2. The study of ratios and proportions, explicitly the core of Plato's harmonics, is fundamental also to plane and solid geometry and astronomy. 3. Ratios and proportion form the (...) basis for the synoptic vision of all the mathematical sciences. This vision is an essential preparation for dialectic because it makes mathematicians become aware of the limitations of the mathematics they have been engaged in but it also shows them how they can begin to overcome those limitations. 4. The main purpose of the study of numbers, treated finally in relation to the other sciences, is to calculate ratios. (shrink)

The teaching management department carries all the work related to teaching in the whole school. A scientific, efficient, and complete teaching management system cannot only help the teaching management department improve work efficiency and quality but also greatly reduce many problems caused by manual labour risk. This paper designs and implements a teaching management system based on an improved association rule algorithm. First, aiming at the low efficiency of the Apriori algorithm for mining association rules, an association rule model based (...) on interest is proposed. Second, use the MapReduce calculation model to partition the transaction database, then use the improved Apriori optimization algorithm for mining, and finally merge the mining results to obtain frequent itemsets. Through experiments, the optimized algorithm has greatly improved selection mining and computing time than traditional algorithms. (shrink)

In this paper, we examine the information content of insider transactions in China and analyze how ownership structures shape market reaction to these transactions. We find that the cumulative abnormal return to insider purchases is a convex function of the percentage of shares owned by the largest shareholder. Further, the CAR to insider purchases is lower when the largest shareholder is government-related, or when the control rights of the largest shareholder exceed its cash flow rights. We also find that the (...) market reaction to insider purchases is more positive for firms audited by Big4 auditors. However, we do not find a significant relationship between an ownership structure and the market reaction to insider sales. Our results are remarkably robust to alternative model specifications, corporate insider identities, and recent corporate news releases on price-sensitive events. Finally, we show that market reaction to insider purchases is larger for firms with less severe expropriations, as captured by the use of other receivables. (shrink)

v. [1]. Ru -- v. [2]. Shi -- v. [3]. Dao.

This edited volume showcases theological reflections on the Hong Kong protests by scholars and activists from different national and cultural background. It discusses the meaning of crucifixion, atonement, the suffering Messiah, justice, the demonic, and the roles of the Church in a time of global unrest and social ferment and protest.

本书以文化交流的一般理论为基本出发点,从中美文化交流的广阔的社会文化背景着眼,通过杜威五四时期的中国之行的典型个案研究,较为准确地深入探讨了杜威学说与中国文化的辩证关系。.

Publications by Chinese researchers in scientific journals have dramatically increased over the past decade; however, academic misconduct also becomes more prevalent in the country. The aim of this prospective study was to understand the perceptions of Chinese biomedical researchers towards academic misconduct and the trend from 2010 to 2015. A questionnaire comprising 10 questions was designed and then validated by ten biomedical researchers in China. In the years 2010 and 2015, respectively, the questionnaire was sent as a survey to biomedical (...) researchers at teaching hospitals, universities, and medical institutes in mainland China. Data were analyzed by the Chi squared test, one-way analysis of variance with the Tukey post hoc test, or Spearman’s rank correlation method, where appropriate. The overall response rates in 2010 and 2015 were 4.5% and 5.5%, respectively. Data from 15 participants in 2010 were invalid, and analysis was thus performed for 1263 participants. Among the participants, 54.7% thought that academic misconduct was serious-to-extremely serious, and 71.2% believed that the Chinese authorities paid no or little attention to the academic misconduct. Moreover, 70.2 and 65.2% of participants considered that the punishment for academic misconduct at the authority and institution levels, respectively, was not appropriate or severe enough. Inappropriate authorship and plagiarism were the most common forms of academic misconduct. The most important factor underlying academic misconduct was the academic assessment system, as judged by 50.7% of the participants. Participants estimated that 40.1% of published scientific articles were associated with some form of academic misconduct. Their perceptions towards academic misconduct had not significantly changed over the 5 years. Reform of the academic assessment system should be the fundamental approach to tackling this problem in China. (shrink)

This study examines values and value types as well as scores in levels of moral reasoning for␣students enrolled in a business program. These two factors are measured using the Schwartz Personal Values␣Questionnaire and the Defining Issues Test 2. No statistically significant differences in levels of moral␣reasoning, rankings of values, and value types could be attributed to gender. However, eight significant correlations between value types and levels of moral reasoning provide evidence that a systematic relationship exists. The relationships are not only (...) internally consistent but also consistent with the model of values based on motivational goals (Schwartz S. H. and K. Boenke: 2004, Journal of Research in Personality, 38 230–255). (shrink)

Background: The work engagement of police officers pertains to social stability and security, as well as to the orderly operation of the political-economic environment. Although there are many studies on work engagement at present, few studies focus on the influencing factors of police officers’ work engagement. According to the job demands-resources model and the conservation of resources theory, organizational job resources (e.g., perceived organizational support) and personal resources (e.g., regulatory emotional self-efficacy) are important factors influencing work engagement. We assume a (...) moderated mediation model in which job satisfaction plays a mediating role in the relationship between perceived organizational support and work engagement, regulatory emotional self-efficacy moderates not only the relationship between perceived organizational support and job satisfaction but also the relationship between job satisfaction and work engagement. Objective and Method: This study explores the drivers of work engagement through perceived organizational support and regulatory emotional self-efficacy among Chinese police officers using a convenient sampling method to administer a questionnaire to 744 Chinese police officers. A mediated model is proposed to investigate the mediating role of job satisfaction and the regulating role of regulatory emotional self-efficacy. Results: Job satisfaction mediated a positive relationship between organizational support and work engagement, and the perceived organizational support-job satisfaction and the job satisfaction-work engagement relationships were positively moderated by regulatory emotional self-efficacy, such that these relationships were stronger at higher levels of regulatory emotional self-efficacy. These findings, have a practical significance for Chinese police officers’ work engagement advancement. (shrink)

Although prior research has demonstrated that switching schools poses a risk for academic and behavioral functioning among adolescents, relatively little is known about their emotional adjustment, or how it affects emotional well-being. Moreover, the cumulative effects of multiple risk and protective factors on their emotional well-being are even less covered in the existing literature. Guided by a risk and resilience ecological framework, the current study compared emotional well-being, operationalized as positive affect and negative affect, between adolescents who had switched schools (...) and their non-switch counterparts, and examined the direct and interactive effects of teacher autonomy support and two facets of grit (i.e., perseverance and consistency) on emotional well-being in both groups. A propensity score matching analysis was used to balance the two groups in terms of sociodemographic characteristics (i.e., age, gender, and socioeconomic status). A total of 371 adolescents who had switched schools and 742 non-switch counterparts aged from 13 to 18 years were involved in this study. Results indicated that adolescents who had switched schools reported higher levels of negative affect than their non-switch counterparts. Moreover, for adolescents who had switched schools, those who possessed higher levels of perseverance had a significantly negative association between teacher autonomy support and negative affect; however, the corresponding association was independent of perseverance for their non-switch counterparts. The current findings indicate that switching schools is a disadvantage for adolescents’ emotional states. However, teacher autonomy support and perseverance can protect adolescents who switch schools as critical stress-buffering factors against these negative feelings. (shrink)

The article discusses the challenge of Indecent Theology to Latin American liberation theology and feminist theology in unmasking their implicit support for the binary, heterosexual norms of society. Althaus-Reid argues that theology is a sexual act, and provides rich metaphors and language for a vibrant sexual political theology. Her work undresses conventional Christian symbols by queering the intersection of theology, sexuality, and politics.

In this article, the author shares her reflection on the evolution of Ada María Isasi-Díaz’s work, and Mujerista Theology, through the story of Isasi-Díaz own life story. Her complex story, filled with struggle, illustrates the embeddedness of Mujerista Theology in the social fabric and lives of Hispanas and Latinas. The article explores the difficulty of an intellectual seeking to release the voices of grassroots women, even in her own community, and also the cross-cultural possibilities of understanding the language and theology (...) of one cultural group from within another, specifically, the author’s own Chinese context. (shrink)

This study adopted a positive psychology perspective to investigate positive emotion and foreign language enjoyment among Chinese as a second language learners in an emergency remote teaching context amid the COVID-19 pandemic. A set of 90 preparatory Chinese language students was assessed for their level of foreign language enjoyment using the Foreign Language Enjoyment Scale. Participles' scores on self-perceived language achievement and actual test scores were adopted as the measurement of their Chinese language proficiency. The results revealed that: CSL learners (...) experienced high level of FL enjoyment in an online learning context, no significant correlation was found between FLE and leaners' actual language achievement nor between FLE and their self-perceived achievement, female learners showed higher FLE than male learners and gender was found to have a significant effect on FLE-Private, participants' geological location, i.e., whether in China or at home countries, significantly influenced their FLE, participants' regional group was not a significant predictor of FLE, and teacher-related variables and learner self-perceptions of achievement were strong predictors of FLE among CSL learners. The findings highlight the importance of teacher's role in an online learning environment and suggest that FLE may not boost performance in the short term for language beginners but is still conducive in the long run. Implications for both teachers and learners, and suggestions for future researches are provided. (shrink)

Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.

Following Smaldino's definition, we claim that language is also an emergent group-level trait, and propose two facets to verify this statement, both of which also provide a general framework to address the future work about group-level traits.

This study decodes consumers' preference levels using a convolutional neural network in neuromarketing. The classification accuracy in neuromarketing is a critical factor in evaluating the intentions of the consumers. Functional near-infrared spectroscopy is utilized as a neuroimaging modality to measure the cerebral hemodynamic responses. In this study, a specific decoding structure, called CNN-based fNIRS-data analysis, was designed to achieve a high classification accuracy. Compared to other methods, the automated characteristics, constant training of the dataset, and learning efficiency of the proposed (...) method are the main advantages. The experimental procedure required eight healthy participants to view commercial advertisement videos of different durations. The cerebral hemodynamic responses of the participants were measured. To compare the preference classification performances, CNN was utilized to extract the most common features, including the mean, peak, variance, kurtosis, and skewness. Considering three video durations, the average classification accuracies of 15, 30, and 60 s videos were 84.3, 87.9, and 86.4%, respectively. Among them, the classification accuracy of 87.9% for 30 s videos was the highest. The average classification accuracies of three preferences in females and males were 86.2 and 86.3%, respectively, showing no difference in each group. By comparing the classification performances in three different combinations between two groups, male participants were observed to have targeted preferences for commercial advertising, and the classification performance 88.4% between “like” vs. “dislike” out of three categories was the highest. Finally, pairwise classification performance are shown as follows: For female, 86.1%, 87.4%, 85.2%, and for male 85.7, 88.4, 85.1%, respectively. (shrink)

Given that care duties are central to the definition of motherhood across contexts, an extended separation from the woman’s family due to migration presents a major threat to her social identity as a mother and wife. Drawing on West and Zimmerman’s notion of “doing gender” and ethnographic research on Vietnamese low-waged contract workers in Taiwan, I provide vital insights into the discursive processes and everyday practices that underlie migrant women’s negotiations of motherhood and femininity. Specifically, I examine the various ways (...) migrant women perform and negotiate meanings of hy sinh and chịu đựng that are core values of Vietnamese womanhood. Combating the stigma of bad motherhood and failed femininity, I emphasize, is not just about reasserting one’s sense of gendered self but also about reassuring her access to the future support and care of the family. The study emphasizes intentionality and pragmatism in women’s social doings of gender and highlights moral dilemmas in gender politics. (shrink)

1 Background for the Uninitiated RICHMOND CAMPBELL Paradoxes are intrinsically fascinating. They are also distinctively ...

A few days ago, the 1994 film festival sponsored by Human Rights Watch occurred. One of the movies shown was Moving the Mountain, directed by a famous movie director from Britain and produced by an American studio. The film was about a young man from mainland China named Li Lu.

The imprisonment of journalists accused of revealing state secrets has in the past two years become a newsworthy story both in China and abroad. In order to understand this whole business, one has to understand the nature of "secrets" in China and what it means to be accused of leaking them. One must also ask whether it is really possible for journalists in China to have access to secrets and to reveal any secrets. And if they do, then what is (...) the exact nature of their crime? (shrink)