Abstract
Synthetic biology is a research field that has grown rapidly and attracted considerable attention. Most prominently, it has been labelled the ‘engineering of biology’. While other attempts to label the field have been also pursued, the program of engineering can be considered the core of the field’s disciplinary program, of its identity. This article addresses the success of the ‘engineering program’ in synthetic biology and argues that its success can partly be explained by distinct practices of persuasion that aim at persuading scientific, but also non-scientific audiences. The article explores two different modes of persuasion:, building tools as heuristic models and posing visionary claims. Objects such as the toggle switch or the synthetic oscillator in synthetic biology can more adequately be described as heuristic models of engineering instead of simply as prototypes of ‘tools’. Posing visionary claims can be also understood as a persuasion practice, since the claims are used to construct the societal relevance of the field. Drawing upon Michel Callon’s ‘sociology of translation’, I argue that both practices of persuasion aim at ‘enrolling’ entities into the disciplinary identity. The article is based on the textual analysis of rhetorical practices in three synthetic biology review articles which are considered seminal for the history of the field.
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Notes
Although such visionary practices can be attributed to only a few approaches in the field, these are especially important for the legitimization of the field.
In some accounts that aim at proposing the disciplinary program of synthetic biology one refers to a ‘prehistory of synthetic biology’ [2; 8]. Such a claim of continuity can often be found in scientific fields in early phases of their formation [54, 55]. This ‘prehistory’ is identified with the first occurrence of the term synthetic biology in the early 20th century [56: 50]. Most of these usages date even back to the time before 1920 [57: 230]. At that time, Jacques Loeb and Stephane Leduc aimed at establishing a ‘technical biology’ with the ultimate goal of constructing synthetic organisms [58, 59]. Biological organisms in this respect were thought of as ‚chemical machines’ [59]. The thoughts of Leduc and Loeb, however, were mostly refuted by their peers at that time [see 57]. Nevertheless, this small episode is exploited to speak of a ‘renaissance of synthetic biology’ in the very recent development of the field [60].
The ‘persuasiveness’ of objects should not be considered a strategic and intentional action of synthetic biologists but rather the outcome of a techno-scientific practice. I am grateful to reviewer comments for this clarification.
Very recently, a new approach at the boundaries between conceptual history and STS has emerged that focuses on the epistemic quality and performativity of such heuristic models [68, 69]. Drawing on examples of different scientific fields, Benoit Godin argues that such models have many more functions than just translating research questions into propositions that provide a model of reality. On the contrary, heuristic models can be understood as a means of persuasion that relate their phenomenality to a specific semantic repertoire.
See methods section for further details.
These are particularly strong, for instance, in introductions and conclusions of review articles. (Swales 1990; Swales 1989). By the time this paper was being drafted, the article by Gardner et al. (2000) had been cited more than 1,750 times (Source: Web of Knowledge), 1,692 citations being listed in the Web of Science Core collection (provided by Thomson Reuters). According to the Web of Knowledge User Interface, 283 of these citations stem from articles with the document type ‘Review Article’. (Date:10/12/2015).
These are complemented by attempts to baptize the field. Notions of control have influenced considerations as to how this new approach can be legitimately named. The first scientific actors therefore labeled these efforts as ‘intentional biology’ in order to demonstrate that nature can be transformed into a resource by constructionist approaches.
The Article has been cited 283 times according to Web of Science. See footnote 5 for details.
One very recent example is an article entitled: ‘Designer cell signal processing circuits for biotechnology ‘(Bradley et al. 2015) In its abstract it says: ‘Great progress has been made in expanding the categories of characterized biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally program increasingly complex behaviours into living cells. Here I present a current overview of the components and strategies that exist for designer cell signal processing and decision making, discuss how these have been implemented in prototype systems for therapeutic, environmental, and industrial biotechnological applications, and examine emerging challenges in this promising field.’ Consequently, the article shows how the term ‘characterization’ becomes legitimately introduced in synthetic biology through the exemplification of the toggle switch and the oscillator to which the article refers.
Michel Callon labeled such a mechanism the ‘obligatory passage point’ in his ‘sociology of translation’ [16].
The main goal of this step is not to describe all publications but to identify the review documents for a detailed analysis. The criterion for the identification of the review articles should be their influence on the scientific community. I chose ‘times cited’ (as offered by web of Science) as the main criterion for selection. Although it is often contested in the bibliometric community, citations are still the main indicator for that attribute. Furthermore, citations are also the main focus of attention for scientific publications in extra scientific audiences.
It is known from studies of scientific popularization and public understanding of science that citations also influence media coverage and will consequently also reach other, non-scientific audiences [see, for instance 80]. That may be an explanation for why visionary claims can be often found in review articles in synthetic biology which are usually much more often cited than other forms of scientific texts [81, 82]. In synthetic biology, review papers make up an untypically huge part of the publications in the field [44].
In a similar vein, Elena Simakova interpreted the engagement of researchers in interviews as the settings about future stories in nanotechnology as a means of ‘making nano matter’ [39].
Results of the study are not presented here, but the methods section provides an overview of the general approach.
According to Perelman and Olbrechts-Tyteca, this refers to the ‘choice of presentation’ which is one element by which the persuasiveness of the discourse might be improved. They argue that the presentation of the arguments, their style and interpretation needs to relate to the audience’s preferences [88]. Of course, again, such an effect on the audience cannot directly be studied in textual analysis alone but needs to be complemented by analyses of how the audience reacts to the presentations of claims [76: 868].
The results suggest that audiences are more willing to accept normative evaluations from narratives than from logical or scientific arguments [91: 13616].
Temporality is an important aspect of building future expectations. Cynthia Selin in her study on the emergence of the nanotechnology discourse holds that the temporal distance is only implicitly incorporated in visionary claims: ‘The recourse to time built into an expectation can be short or longer term, yet is rarely made explicit’ [31: 211].
Examples of these ‘grand narratives’ are typically legitimating narrations such as ‘the natural state’ treaty in the 17th century.
The label ‘synthetic biology’ emerged as a term to conquer that niche of disciplinary transformation. Campos explored how the term ‘synthetic biology developed among biologists and biotechnologists to establish a transformation of biology. Initially, the new program was supposed to be labeled ‘intentional biology’, a concept which was put forward particularly by Drew Endy and Robert Carlson [61]. As biologists refused to accept that all previous biological research might be labeled ‘unintentional, the term’ ‘ synthetic biology’ was introduced. Hence, the initial aim to underline the engineering effort is less obvious.
Bensaude-Vincent has uncovered that besides ‘putting engineering into biology’, ‘chemical biology’ was another disciplinary project by way of which synthetic biology was supposed to be be oriented to follow the model of Synthetic Organic Chemistry [95]. Benner and Sismour are the main scientific actors that pushed forward these ideas, but others followed them by relating synthetic biology to its envisioned disciplinary ancestors [21].
Similarly, Law and Williams interpret the opening paragraphs of the DIVEMA group article as a tool to bind to the program: ‚The aim is to mobilize those with an interest in chemotherapy. An array of claims and hypotheses about Divema and its compounds is so designed as to be attractive to those concerned with the chemical treatment of cancer [41: 540].
This might contradict Cynthia Selin’s observations regarding the strategies for acquiring legitimacy in nanotechnology [2]. Selin claimed a two-headed strategy of visionary communication: Scientists use the distant future and its promises to gain funding and legitimacy with politicians, but continue to reject the vision when seeking legitimacy within their own communities of practice (…) [2: 213].
The term ‘persuasion tale’ was used in order to refer to the ‘tale of emergence’ of synthetic biology, a term employed by Molyneux-Hodgson and Meyer [28].
In an interview with a leading scholar in the field, the interviewee complained about this writing practice in synthetic biology. ‘Even in the first PhD papers’, he admitted, (…)’you will find these sentences about what synthetic biology aims at and how it seeks to contribute to certain problems. If you think of cancer research, you will soon find how strange that is: No one would expect you to begin an article by ‘cancer research aims’ or ‘cancer research contributes to” [113].
This does even more apply to ‘Converging Technologies’ [115] as another concept that has been introduced to the science policy interface with the attempt to follow the footsteps of nanotechnology. Whereas many technological developments can be related to the concept (1202008), no dedicated epistemic practice has been established.
Simakova explored various sites where such societal relevance can be addressed, most of them not oriented only towards scientific but other societal audiences such as instance technology transfer offices or educational programs.
According to Calvert and Fujimura [117: 160], the search for a binding disciplinary program in the realm of other sciences can be interpreted as a means to achieve greater epistemic credibility.
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Acknowledgments
This work has been funded by the German Research Foundation in the context of the project “Reviews als Legitimationsressource neuer Forschungsfelder. Die Rolle von wissenschaftlichen Reviews als strategischem Medium im Legitimationsprozess zwischen Wissenschaft und Gesellschaft am Beispiel der Synthetischen Biologie“ which is part of a priority program on “Science and the Public” (SPP 1409). I am grateful to Stephan Gauch and Martin Reinhart for helpful recommendations. Furthermore, I am indebted to communications with participants of the European Summer School on Technology Assessment which took place in Berlin, 14–19th September 2014.
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Blümel, C. Enrolling the Toggle Switch: Visionary Claims and the Capability of Modeling Objects in the Disciplinary Formation of Synthetic Biology. Nanoethics 10, 269–287 (2016). https://doi.org/10.1007/s11569-016-0276-z
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DOI: https://doi.org/10.1007/s11569-016-0276-z