Skip to main content
Log in

Ethische Relevanz und faktische Mängel in der Kommunikation von Spezifika der Organspende nach Kreislaufstillstand

Ethical relevance and factual deficiencies in the communication of specifics of organ donation after circulatory determination of death

  • Originalarbeit
  • Published:
Ethik in der Medizin Aims and scope Submit manuscript

Zusammenfassung

In zahlreichen Ländern nimmt die Zahl von Organspenden nach Kreislaufstillstand (donation after circulatory determination of death, DCDD) zu, obwohl in der Medizinethik verschiedene Aspekte der DCDD kritisch diskutiert werden. In unserer Arbeit identifizieren wir ethisch relevante Aspekte der DCDD basierend auf einer umfassenden Literaturanalyse. Wir fokussieren dabei insbesondere auf zwei Aspekte: vorbereitende Maßnahmen und Irreversibilität des Todeskriteriums. Danach untersuchen wir in einer weltweit durchgeführten Auswertung von Webseiten von Organspende-Organisationen und einer begleitenden Umfrage, inwieweit diese ethisch relevanten Aspekte von DCDD in der Information potenziell spendewilliger Personen eine Rolle spielen. Es zeigt sich, dass in der Mehrheit der Webseiten der Organisationen auf die Thematik DCDD nicht oder kaum eingegangen wird, die befragten Verantwortlichen der Organisationen aber die Wichtigkeit der Aufklärung bei spendewilligen Personen betonen. Wir diskutieren diese Diskrepanz und weisen auf zentrale Punkte hin, über welche spendewillige Personen informiert werden sollen, wenn diese Form der Organspende in ihrem jeweiligen Land praktiziert wird. Zudem plädieren wir dafür, dass das Todeskriterium und die Prozeduren zur Todesfeststellung in der Transplantationsmedizin einheitlich sein sollen, um kritisch diskutierte Aspekte im Kontext der DCDD entschärfen zu können.

Abstract

Introduction

In many countries, the number of organ donations after circulatory determination of death (DCDD) is increasing, although various aspects of DCDD are critically discussed in medical ethics. In our work, we identify ethically relevant aspects of the DCDD—in particular regarding preparatory measures and the irreversibility of the death criterion—and we investigate to what extent persons interested in becoming organ donors are informed about those issues.

Methods

We performed a comprehensive literature review on ethical issues of DCDD. Subsequently, we conducted a worldwide evaluation of organ donation organisations’ websites and an accompanying survey to investigate the extent to which ethically relevant aspects of DCDD play a role in the information of persons interested in becoming organ donors.

Results

We find that a majority of the organisations’ websites do not deal with the subject of DCDD, whereas the responsibles of the organisations surveyed emphasised the importance of education for potential donors.

Conclusion

We point out central issues about which persons willing to become organ donors should be informed if DCDD is practiced in their respective countries. In addition, we advocate that the criteria and the procedures for determining death in the context of transplantation medicine should be uniform in order to defuse some of the critically discussed aspects in the context of DCDD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Notes

  1. Siehe www.irodat.org (letzter Zugriff am 1. Aug. 2018).

Literatur

  • Adhiyaman V, Adhiyaman S, Sundaram R (2007) The Lazarus phenomenon. J R Soc Med 100(12):552–557. https://doi.org/10.1177/0141076807100012013

    Article  PubMed  PubMed Central  Google Scholar 

  • Bastami S, Krones T, Biller-Andorno N (2012) Whose consent matters? Controlled donation after cardiac death and premortem organ-preserving measures. Transplantation 93(10):965–969

    Article  Google Scholar 

  • Beauchamp T, Childress J (2013) Principles of biomedical ethics, 7. Aufl. Oxford University Press, New York

    Google Scholar 

  • Bendorf A, Kelly PJ, Kerridge IH, McCaughan GW, Myerson B, Stewart C, Pussell BA (2013) An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates. PLoS ONE 8(5):e62010

    Article  CAS  Google Scholar 

  • Bernat JL (2006) The whole brain concept of death remains optimum public policy. J Law Med Ethics 34:35–43

    Article  Google Scholar 

  • Bernat JL (2010a) Point: Are donors after circulatory death really dead, and does it matter? Yes and yes. Chest 138(1):13–16

    Article  Google Scholar 

  • Bernat JL (2010b) How the distinction between “irreversible” and “permanent” illuminates circulatory-respiratory death determination. J Med Philos 35(3):242–255

    Article  Google Scholar 

  • Birch SC (2013) The dead donor rule: A defense. J Med Philos 38(4):426–440

    Article  Google Scholar 

  • Black K, Miller K, Beck G, Moser M (2016) What information about donation after circulatory death is available on the Internet for potential donor families? Clin Transplant 30(8):934–939

    Article  Google Scholar 

  • Boucek MM, Mashburn C, Dunn SM, Frizell R, Edwards L, Pietra B, Campbell D, Denver Children’s Pediatric Heart Transplant Team (2008) Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 359(7):709–714

    Article  CAS  Google Scholar 

  • Bracco D, Noiseux N, Hemmerling TM (2007) The thin line between life and death. Intensive Care Med 33(5):751–754

    Article  Google Scholar 

  • Browne A (2010) The ethics of organ donation after cardiocirculatory death: Do the guidelines of the Canadian Council for Donation and Transplantation measure up? Open Med 4(2):e129–33

    PubMed  PubMed Central  Google Scholar 

  • Carcillo JA, Orr R, Bell M, Joffe A, Maffei FA, Sullivan J, Han YY, Thomas J (2010) A call for full public disclosure and moratorium on donation after cardiac death in children. Pediatr Crit Care Med 11(5):641–643

    Article  Google Scholar 

  • Chen YS, Lin JW, Yu HY, Ko WJ, Jerng JS, Chang WT, Chen WJ, Huang SC, Chi NH, Wang CH, Chen LC, Tsai PR, Wang SS, Hwang JJ, Lin FY (2008) Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: An observational study and propensity analysis. Lancet 372(9638):554–561

    Article  Google Scholar 

  • Childress JF (2008) Organ donation after circulatory determination of death: Lessons and unresolved controversies. J Law Med Ethics 36(4):766–771

    Article  Google Scholar 

  • Christen M, Bastami S, Gloor M, Krones T (2015) Resolving some, but not all informed consent issues in DCDD – the Swiss experiences. Am J Bioeth 15(8):29–31. https://doi.org/10.1080/15265161.2015.1045095

    Article  PubMed  Google Scholar 

  • Christensen B, Michel M (2012) Organtransplantation zwischen Integritätsschutz und Drittinteressen. https://jusletter.weblaw.ch/juslissues/2012/649.html (Jusletter 30. Januar 2012: 1–16)

    Google Scholar 

  • Dalle Ave AL, Bernat JL (2016) Using the brain criterion in organ donation after the circulatory determination of death. J Crit Care 33:114–118

    Article  Google Scholar 

  • Dalle Ave AL, Shaw DM (2017) Controlled donation after circulatory determination of death: Ethical issues in withdrawing life-sustaining therapy. J Intensive Care Med 32(3):179–186. https://doi.org/10.1177/0885066615625628

    Article  PubMed  Google Scholar 

  • Denecke C, Yuan X, Ge X, Kim IK, Bedi D, Boenisch O, Weiland A, Jurisch A, Kotsch K, Pratschke J, Reutzel-Selke A, Tullius SG (2013) Synergistic effects of prolonged warm ischemia and donor age on the immune response following donation after cardiac death kidney transplantation. Surgery 153(2):249–261

    Article  Google Scholar 

  • Dhanani S, Ward R, Hornby L, Barrowman NJ, Hornby K, Shemie SD, Canadian Critical Care Trials Group, Bertram Loeb Research Consortium in Organ and Tissue Donation (2012b) Survey of determination of death after cardiac arrest by intensive care physicians. Crit Care Med 40(5):1449–1455

    Article  Google Scholar 

  • Dhanani S, Hornby L, Ward R, Shemie S (2012a) Variability in the determination of death after cardiac arrest: A review of guidelines and statements. J Intensive Care Med 27(4):238–252

    Article  Google Scholar 

  • Doig CJ, Zygun DA (2008) (Uncontrolled) donation after cardiac determination of death: A note of caution. J Law Med Ethics 36(4):760–765

    Article  Google Scholar 

  • Downie J, Rajotte C, Shea A (2008) Pre-mortem transplantation optimizing interventions: The legal status of consent. Can J Anaesth 55(7):458–469

    Article  Google Scholar 

  • Domínguez-Gil B, Haase-Kromwijk B, Van Leiden H, Neuberger J, Coene L, Morel P, Corinne A, Muehlbacher F, Brezovsky P, Costa AN, Rozental R, Matesanz R, European Committee (Partial Agreement) on Organ Transplantation, Council of Europe (CD-P-TO) (2011) Current situation of donation after circulatory death in European countries. Transpl Int 24(7):676–686. https://doi.org/10.1111/j.1432-2277.2011.01257.x

    Article  Google Scholar 

  • Fabre J (2014) Presumed consent for organ donation: A clinically unnecessary and corrupting influence in medicine and politics. Clin Med 14(6):567–571

    Article  Google Scholar 

  • Farsides B (2012) Respecting wishes and avoiding conflict: Understanding the ethical basis for organ donation and retrieval. Br J Anaesth 108(Suppl 1):i73–i79

    Article  Google Scholar 

  • Fugate JE, Stadtler M, Rabinstein AA, Wijdicks EF (2011) Variability in donation after cardiac death protocols: A national survey. Transplantation 91(4):386–389

    PubMed  Google Scholar 

  • Gardiner D, McGee A (2017) Death, permanence and current practice in donation after circulatory death. QJM 110(4):199–201

    PubMed  CAS  Google Scholar 

  • Gardiner D, Sparrow R (2010) Not dead yet: Controlled non-heart-beating organ donation, consent, and the Dead Donor Rule. Camb Q Healthc Ethics 19(1):17–26

    Article  Google Scholar 

  • De Groot J, Vernooij-Dassen M, Hoedemaekers C, Hoitsma A, Smeets W, van Leeuwen E (2012) Decision making by relatives about brain death organ donation: An integrative review. Transplantation 93(12):1196–1211

    Article  Google Scholar 

  • Haase B, Bos M, Boffa C, Lewis P, Rudge C, Valero R, Wind T, Wright L (2016) Ethical, legal, and societal issues and recommendations for controlled and uncontrolled DCD. Transpl Int 29(7):771–779

    Article  Google Scholar 

  • Hamer CL, Rivlin MM (2003) A stronger policy of organ retrieval from cadaveric donors: Some ethical considerations. J Med Ethics 29(3):196–200

    Article  CAS  Google Scholar 

  • Harrington MM (2009) The thin flat line: Redefining who is legally dead in organ donation after cardiac death. Issues Law Med 25(2):95–143

    PubMed  Google Scholar 

  • Hoogland ER, Snoeijs MG, van Heurn LW (2010) DCD kidney transplantation: Results and measures to improve outcome. Curr Opin Organ Transplant 15(2):177–182

    Article  Google Scholar 

  • Hornby K, Hornby L, Shemie SD (2010) A systematic review of autoresuscitation after cardiac arrest. Crit Care Med 38:1246–1253

    Article  CAS  Google Scholar 

  • Hulme W, Allen J, Manara A, Murphy P, Gardiner D, Poppit E (2016) Factors influencing the family consent rate for organ donation in the UK. Anaesthesia 71(9):1053–1063. https://doi.org/10.1111/anae.13535

    Article  PubMed  CAS  Google Scholar 

  • Joffe AR (2007) The ethics of donation and transplantation: Are definitions of death being distorted for organ transplantation? Philos Ethics Humanit Med 2:28

    Article  Google Scholar 

  • Joffe AR, Carcillo J, Anton N, deCaen A, Han YY, Bell MJ, Maffei FA, Sullivan J, Thomas J, Garcia-Guerra G (2011) Donation after cardiocirculatory death: A call for a moratorium pending full public disclosure and fully informed consent. Philos Ethics Humanit Med 6:17

    Article  Google Scholar 

  • Kalkbrenner KJ, Hardart GE (2012) Consent for donation after cardiac death: A survey of organ procurement organizations. J Intensive Care Med 27(4):253–263

    Article  Google Scholar 

  • Kayler LK, Srinivas TR, Schold JD (2011) Influence of CIT-induced DGF on kidney transplant outcomes. Am J Transplant 11(12):2657–2664

    Article  CAS  Google Scholar 

  • Khushf G (2010) A matter of respect: A defense of the dead donor rule and of a “whole-brain” criterion for determination of death. J Med Philos 35(3):330–364

    Article  Google Scholar 

  • Kirkpatrick JN, Beasley KD, Caplan A (2010) Death is just not what it used to be. Camb Q Healthc Ethics 19(1):7–16

    Article  Google Scholar 

  • Machado C, Korein J (2009) Irreversibility: Cardiac death versus brain death. Rev Neurosci 20(3–4):199–202

    PubMed  Google Scholar 

  • Magliocca JF, Magee JC, Rowe SA, Gravel MT, Chenault RH 2nd, Merion RM, Punch JD, Bartlett RH, Hemmila MR (2005) Extracorporeal support for organ donation after cardiac death effectively expands the donor pool. J Trauma 58(6):1095–1101

    Article  Google Scholar 

  • Manara AR, Murphy PG, O’Callaghan G (2012) Donation after circulatory death. Br J Anaesth 108(Suppl 1):108–121

    Article  Google Scholar 

  • Marquis D (2010) Are DCD donors dead? Hastings Cent Rep 40(3):24–31

    Article  Google Scholar 

  • Mateos-Rodríguez A, Pardillos-Ferrer L, Navalpotro-Pascual JM, Barba-Alonso C, Martin-Maldonado ME, Andrés-Belmonte A (2010) Kidney transplant function using organs from non-heart-beating donors maintained by mechanical chest compressions. Resuscitation 81(7):904–907

    Article  Google Scholar 

  • Morrissey PE, Monaco AP (2014) Donation after circulatory death: Current practices, ongoing challenges, and potential improvements. Transplantation 97(3):258–264

    Article  Google Scholar 

  • Müller S (2010) Revival der Hirntod-Debatte: Funktionelle Bildgebung für die Hirntod-Diagnostik. Ethik Med 22(1):5–17

    Article  Google Scholar 

  • Ortega-Deballon I, Vailhen DR, de la Plaza Horche E (2012) When health care priorities are unclear: do we obtain organs or try to save lives? Am J Emerg Med 30(6):1001–1003

    Article  Google Scholar 

  • Ortega-Deballon I, Hornby L, Shemie SD (2015) Protocols for uncontrolled donation after circulatory death: A systematic review of international guidelines, practices and transplant outcomes. Crit Care 19:268

    Article  Google Scholar 

  • Overby KJ, Weinstein MS, Fiester A (2015) Addressing consent issues in donation after circulatory determination of death. Am J Bioeth 15(8):3–9

    Article  Google Scholar 

  • Plum F, Posner JB (2007) The diagnosis of stupor and coma, 4. Aufl. Oxford University Press, New York

    Google Scholar 

  • President’s Commission (1981) Defining death: A report on the medical, legal and ethical issues in the determination of death. US Government Printing Office, Washington (DC)

    Google Scholar 

  • Rady MY, Verheijde JL (2012) Prediction of time to death after terminal withdrawal of life-support in non-heartbeating organ donation: Unaccounted variables and window of opportunity. Crit Care Med 40(3):986–988

    Article  Google Scholar 

  • Richards B, Rogers WA (2007) Organ donation after cardiac death: Legal and ethical justifications for antemortem interventions. Med J Aust 187(3):168–170

    PubMed  Google Scholar 

  • SAMW (2017) Feststellung des Todes im Hinblick auf Organtransplantationen und Vorbereitung der Organentnahme. https://www.samw.ch/dam/jcr:9f60a9e3-b52a-4584-aa10-3dbd39c6d9e5/richtlinien_samw_tod_organtransplantation.pdf. Zugegriffen: 1. Aug. 2018 (Richtlinien der Schweizerischen Akademie für medizinische Wissenschaften SAMW)

    Google Scholar 

  • Schneider A, Böttiger BW, Popp E (2009) Cerebral resuscitation after cardiocirculatory arrest. Anesth Analg 108(3):971–979

    Article  Google Scholar 

  • Sheth KN, Nutter T, Stein DM, Scalea TM, Bernat JL (2012) Autoresuscitation after asystole in patients being considered for organ donation. Crit Care Med 40(1):158–161

    Article  Google Scholar 

  • Shemie SD, Simpson C, Blackmer J, MacDonald S, Dhanani S, Torrance S, Byrne P, Donation Physician Ethics Guide Meeting Participants (2017) Ethics guide recommendations for organ-donation-focused physicians: Endorsed by the Canadian Medical Association. Transplantation 101(5S Suppl 1):S41–S47

    Article  Google Scholar 

  • Sitter-Liver B (2003) Gerechte Organallokation: Zur Verteilung knapper Güter in der Transplantationsmedizin. Academic Press, Fribourg

    Google Scholar 

  • Sorondo MS (2007) The signs of death. The proceedings of the working group 11–12 September 2006. Pontificia Academia Scientiarum, Vatikan City

    Google Scholar 

  • Sparrow R (2012) The dead donor rule and means-end reasoning. A reply to Napier. Camb Q Healthc Ethics 21(1):141–146

    Article  Google Scholar 

  • Truog RD, Miller FG (2010) Counterpoint: Are donors after circulatory death really dead, and does it matter? No and not really. Chest 138(1):16–18

    Article  Google Scholar 

  • Verheijde JL, Rady MY (2010) Conversion of catastrophic neurological injuries to heart-beating organ donation. Intensive Care Med 36(12):2158–2159

    Article  Google Scholar 

  • Vernez SL, Magnus D (2011) Can the dead donor rule be resuscitated? Am J Bioeth 11(8):1

    Article  Google Scholar 

  • Webster PA (2010) Reply to: A call for full public disclosure and moratorium on donation after cardiac death in children. Pediatr Crit Care Med 11(5):643–644

    Article  Google Scholar 

  • Weiss J, Shaw D, Schober R, Abati V, Immer FF, Comité National du Don d’Organes (CNDO) (2017) Attitudes towards organ donation and relation to wish to donate posthumously. Swiss Med Wkly 147:w14401

    PubMed  Google Scholar 

  • Wind J, Snoeijs MG, van der Vliet JA, Winkens B, Christiaans MH, Hoitsma AJ, van Heurn LW (2011) Preservation of kidneys from controlled donors after cardiac death. Br J Surg 98(9):1260–1266

    Article  CAS  Google Scholar 

Download references

Danksagung

Wir danken Tanja Krones, Leitende Ärztin Klinische Ethik und Geschäftsführerin Klinisches Ethikkomitee des Universitätsspitals Zürich, für ihre Ratschläge bei der Gestaltung der Umfrage.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Markus Christen.

Ethics declarations

Interessenkonflikt

M. Christen und M. Gloor geben an, dass kein Interessenkonflikt besteht.

Ethische Standards

Das Projekt inkl. der Befragungen wurde im Einklang mit nationalem Recht durchgeführt. Das Einverständnis aller Teilnehmer wurde eingeholt.

Caption Electronic Supplementary Material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Christen, M., Gloor, M. Ethische Relevanz und faktische Mängel in der Kommunikation von Spezifika der Organspende nach Kreislaufstillstand. Ethik Med 30, 343–361 (2018). https://doi.org/10.1007/s00481-018-0501-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00481-018-0501-0

Schlüsselwörter

Keywords

Navigation