Abstract
Rats subjected to transient forebrain ischemia (postischemic, or PI, rats) were given extensive postoperative training (136 trials) on a radial eight-arm maze to determine whether working memory was permanently impaired. Animals were pretrained to an asymptote performance. After ischemia, PI rats demonstrated a permanent working memory impairment (p.05). Transient forebrain ischemia appears to preferentially damage hippocampal CA1 neurons. These findings provide further evidence that PI rats demonstrate morphologic and behavioral sequelae similar to those of some human survivors of cardiac arrest.
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This research was supported by USPHS Grant MH40090-02 and American Heart Association Grant 851098.
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Colombo, P.J., Davis, H.P., Simolke, N. et al. Forebrain ischemia produces hippocampal damage and a persistent working memory deficit in rats. Bull. Psychon. Soc. 26, 375–377 (1988). https://doi.org/10.3758/BF03337687
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DOI: https://doi.org/10.3758/BF03337687