Abstract
Carrying out research on brains is important for medical advances in various diseases. However, such research ought not be carried out on human brains because the benefits do not outweigh the potential risks. A possible alternative is the use of brain surrogates. Nevertheless, some scholars who uphold a threshold account of moral status suggest the possibility that, with technological advances in the near future, more advanced brain surrogates will have very similar features to humans. This may suffice for these having the same moral status as humans, and as a result, the situation may have implications for brain research, indeed, leading to the implication that this ought also not to be carried out upon brain surrogates. In this article, we present a relational approach to moral status which upholds that brain surrogates do not have the same moral status as human beings. Hence, brain research ought not be rejected on the grounds of equality of moral status between humans and brain surrogates.
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Notes
At least for Henry Greely, Nita Farahany and other scientists who have raised this question, the important thing to consider is not this or that brain surrogate. They all confirm that no brain surrogate currently possesses the relevant characteristic for moral status. The core question for them is what would be the status of a surrogate that attains this characteristic? This is the core question this article also addresses.
References
Farahany, N.A., H.T. Greely, S. Hyman, C. Koch, C. Grady, S.P. Pașca, N. Sestan, P. Arlotta, J.L. Bernat, J. Ting, J.E. Lunshof, E.P.R. Iyer, I. Hyun, B.H. Capestany, G.M. Church, H. Huang, and H. SonG. 2018. The ethics of experimenting with human brain tissue. Nature 556: 429–432.
Farahany, N. 2018. Could Brains in Lab Jars One Day be Entitled to Rights? . In: Ball, K. & Uzielli, J. (eds.) As It Happens. Online: CBC Radio.
Greely, H.T. 2021. Human Brain Surrogates Research: The Onrushing Ethical Dilemma. American Journal of Bioethics 21: 34–45.
Lavazza, A. 2021. Potential ethical problems with human cerebral organoids: Consciousness and moral status of future brains in a dish. Brain Research 1750: 147146.
Lavazza, A., Massimini, M. 2018. Cerebral organoids: Ethical issues and consciousness assessment. Journal of Medical Ethics 44: 606–610.
Munsie, M., I. Hyun, and J. Sugarman. 2017. Ethical issues in human organoid and gastruloid research. Development 144: 942–945.
Jaworska, A. & Tannenbaum, J. 2013. The Grounds of Moral Status. Stanford Encyclopedia of Philosophy Archive.
Emanuel, E.J., D. Wendler, and C. Grady. 2000. What makes clinical research ethical? JAMA 283: 2701–2711.
Greely, H. T. 2018. Organoids, Chimeras, Ex Vivo Brains - Oh My! The Neuroethics Blog [Online]. Available from: http://www.theneuroethicsblog.com/2018/09/organoids-chimeras-ex-vivo-brains-oh-my.html [Accessed September 04, 2018 2020].
Yong, E. 2018. What's Wrong with Growing Blobs of Brain Tissue? The Atlantic, April 25, 2018.
Koplin, J.J., and J. Savulescu. 2019. Moral Limits of Brain Organoid Research. J Law Med Ethics 47: 760–767.
Nas, T.N.A.O.S.E.A.M. 2021. The Emerging Field of Human Neural Organoids, Transplant and Chimeras: Science, Ethics and Governance. Washington, DC: The National Academies.
Buchanan, A. 2009. Moral Status and Human Enhancement. Philosophy & Public Affairs 37: 346–381.
Chen, H.I., J.A. Wolf, R. Blue, M.M. Song, J.D. Moreno, G.L. Ming, and H. Song. 2019. Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras. Cell Stem Cell 25: 462–472.
Lavazza, A., and F.G. Pizzetti. 2020. Human cerebral organoids as a new legal and ethical challenge. Journal Law Bioscience 7 (1): Isaa005.
Leshner, A.I. 2004. Ethical issues in taking neuroscience research from bench to bedside. Cerebrum 6: 66–72.
Kant, I. 1996. The metaphysics of morals. Cambridge; New York: Cambridge University Press.
Lavazza, A. 2020. Human cerebral organoids and consciousness: a double-edged sword. Monash bioethics revs 38 (2): 105–128.
Northoff, G. 2006. Neuroscience of decision making and informed consent: An investigation in neuroethics. Journal of Medical Ethics 32: 70–73.
Sawai, T., H. Sakaguchi, E. Thomas, J. Takahashi, and M. Fujita. 2019. The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness. Stem Cell Reports 13: 440–447.
Mansour, A.A., J.T. Gonçalves, C.W. Bloyd, H. Li, S. Fernandes, D. Quang, S. Johnston, S.L. Parylak, X. Jin, and F.H. Gage. 2018. An in vivo model of functional and vascularized human brain organoids. Nature Biotechnology 36: 432–441.
Han, X., M. Chen, F. Wang, M. Windrem, S. Wang, S. Shanz, Q. Xu, N.A. Oberheim, L. Bekar, S. Betstadt, A.J. Silva, T. Takano, S.A. Goldman, and M. Nedergaard. 2013. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12: 342–353.
Regalado, A. 2019. Chinese scientists have put human brain genes in monkeys—and yes, they may be smarter. MIT Technology Review [Online]. Available from: https://www.technologyreview.com/2019/04/10/136131/chinese-scientists-have-put-human-brain-genes-in-monkeysand-yes-they-may-be-smarter/ [Accessed April 10, 2019 2020].
Shi, L., X. Luo, J. Jiang, Y. Chen, C. Liu, T. Hu, M. Li, Q. Lin, Y. Li, J. Huang, H. Wang, Y. Niu, Y. Shi, M. Styner, J. Wang, Y. Lu, X. Sun, H. Yu, W. Ji, and B. Su. 2019. Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review 6: 480–493.
Muxe-nkondo, G. 2007. Ubuntu as public policy in South Africa: A conceptual framework. International Journal of African Renaissance Studies - Multi-, Inter- and Transdisciplinarity 2: 88–100.
Metz, T. 2007. Toward an African Moral Theory. Journal of Political Philosophy 15: 321–341.
Mbiti, J. 1969. African Religion and Philosophy. Ibadan: Heinemann Educational Books.
Gyekye, K. 1978. The Akan Concept of a Person. International Philosophical Quarterly 18: 277–287.
Menkiti, I. 1984. Person and Community in African Traditional Thought. In: WRIGHT, R. (ed.) African Philosophy, an Introduction. Lanham, MD: University Press of America.
Metz, T. 2012. An African Theory of Moral Status: A Relational Alternative to Individualism and Holism. Ethical Theory and Moral Practice 15: 387–402.
Hobbes, T. 1651. Leviathan Gloucester, UK, Royal Classics.
Metz, T. 2015. An African Theory of Social Justice. In: BIOSEN, C. & MURRAY, M. (eds.) Distributive Justice Debates in Political and Social Thought: Perspectives on Finding a Fair Share. New York: Routledge.
Metz, T. 2017. Ancillary care obligations in light of an African bioethic: From entrustment to communion. Theoretical Medicine and Bioethics 38: 111–126.
Behrens, K. G. 2017. A critique of the principle of ‘respect for autonomy’, grounded in African thought. Developing World Bioethics, 17.
Dolamo, R. 2014. Botho/Ubuntu: The Heart of an African Ethics. Scriptura 112: 1–10.
Metz, T. 2010. Human Dignity, Capital Punishment, and an African Moral Theory: Toward a New Philosophy of Human Rights. Journal of Human Rights 9: 81–99.
Christakis, N.A., and J.H. Fowler. 2014. Friendship and natural selection. Proceedings of the National Academy of Sciences 111: 10796.
Seyfarth, R.M., and D.L. Cheney. 2012. The evolutionary origins of friendship. Annual Review of Psychology 63: 153–177.
Degges-white, S. 2018. Friendology: The Science of Friendship. Psychology Today [Online]. Available from: https://www.psychologytoday.com/us/blog/lifetime-connections/201805/friendology-the-science-friendship [Accessed May 29, 2018 2021].
Roberts, S. G. B., Arrow, H., Gowlett, J. A. J., Lehmann, J. & Dunbar, R. I. M. 2015. Close Social Relationships: An Evolutionary Perspective. In: Dunbar, R. I. M., Gamble, C. & Gowlett, J. A. J. (eds.) Lucy to Language: The Benchmark Papers. Oxford: Oxford Scholarship Online.
Lunshof, J.E. 2021. Brain Surrogates—Empty or Full Makes the Difference. The American Journal of Bioethics 21: 46–48.
Farahany, N.A., H.T. Greely, and C.M. Giattino. 2019. Part-revived pig brains raise slew of ethical quandaries. Nature 568: 299–302.
Lancaster, M.A., M. Renner, C.A. Martin, D. Wenzel, L.S. Bicknell, M.E. Hurles, T. Homfray, J.M. Penninger, A.P. Jackson, and J.A. Knoblich. 2013. Cerebral organoids model human brain development and microcephaly. Nature 501: 373–379.
Donaldson, S., and W. Kymlicka. 2013. Zoopolis: A Political Theory of Animal Rights. New York: Oxford University Press.
Schmitz, K.L. 1981. Ritual Elements in Community. Religious Studies 17: 163–177.
O'connell, C. 2020. The Transformative Power of Engaging in Ritual. Psychology Today [Online]. Available from: https://www.psychologytoday.com/us/blog/wild-rituals/202012/the-transformative-power-engaging-in-ritual [Accessed Dec 16, 2020 2020].
Clayton, K. B. 2012. The Voluntaryist Reader. Moral Laguage [Online]. Available from: https://voluntaryistreader.wordpress.com/2012/12/09/moral-language/#:~:text=These%20questions%20are%20questions%20about,description%20of%20prevailing%20social%20norms. [Accessed September 12, 2012 2021].
Wareham, C.S. 2017. Partiality and distributive justice in African bioethics. Theoretical Medicine and Bioethics 38: 127–144.
Funding
Luís Cordeiro-Rodrigues wishes to thank the funding for his research. His research has been funded by Hunan University’s Fundamental Research Funds for the Central Universities, fund number 531118010426. 本 文受湖南大学“中央高校基本科研业务费”专项资金资助(531118010426).
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Cordeiro-Rodrigues, L., Ewuoso, C. An Afro-Communitarian Relational Approach to Brain Surrogates Research. Neuroethics 14, 561–574 (2021). https://doi.org/10.1007/s12152-021-09475-7
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DOI: https://doi.org/10.1007/s12152-021-09475-7