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Hybrid Model of Erythropoiesis

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Abstract

A hybrid model of cell dynamics is presented. It is illustrated by model examples and applied to study erythropoiesis (red blood cell production). In this approach, cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models. Spatial organization of erythropoiesis occurring in specific structures of the bone marrow, called erythroblastic island, is investigated.

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Acknowledgments

Authors thank Prof. Mark Koury and all members of the INRIA Team DRACULA for fruitful discussions.

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Authors and Affiliations

  1. Faculté de Médecine Laennec, UMR 5558, Lyon, France

    P. Kurbatova

  2. Institut Camille Jordan, University Lyon 1, UMR 5208 CNRS, 69622, Villeurbanne, France

    N. Eymard & V. Volpert

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  1. P. Kurbatova
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  2. N. Eymard
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  3. V. Volpert
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Correspondence to P. Kurbatova.

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Kurbatova, P., Eymard, N. & Volpert, V. Hybrid Model of Erythropoiesis. Acta Biotheor 61, 305–315 (2013). https://doi.org/10.1007/s10441-013-9188-2

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  • DOI: https://doi.org/10.1007/s10441-013-9188-2

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