Figure 1

Schematic representation of corticostriatal connections based on [1,2,87,88]. Different cortical areas project to different sub-regions of the striatum, which then project back to respective cortical areas via the internal segment of the globus pallidus (GPi) and the thalamus (direct pathway). Not shown projections include those from different striatal sub-regions to distinct areas in the substantia nigra pars reticulata (SNr) and the external segment of the globus pallidus, as well as those from distinct midbrain nuclei (e.g., substantia nigra compacta and ventral tegmental area) to different striatal sub-regions. Moreover, in the ventral striatum, the Nacc shell, but not the core, projects heavily to the amygdala and lateral hypothalamus, whereas both the shell and core receive inputs from limbic regions (e.g., amygdala and hippocampus). Circle, inhibitory connection; Arrow, excitatory connection; DMS, dorsomedial striatum; DLS, dorsolateral striatum; GPi, internal segment of globus pallidus; VP, ventral pallidum; VA, ventral anterior; DM, dorsomedial; VL, ventrolateral; VM, ventromedial; Nacc C, nucleus accumbens core; Nacc Sh, nucleus accumbens shell.