Abstract
The gastrointestinal tract is normally investigated using reductionism methods in human studies, where the focus is on each segment of the gastrointestinal system and the specific links between various parts of it. This helps researchers and clinicians to produce a simple relationship between the elements of the gastrointestinal tract based on clinical diagnosis and treatment. However, there is evidence indicating that the gastrointestinal tract has properties that are beyond function of the simple systems, such as, multiplicity of elements, network communication, emergence, self-organization, sudden transition, nonlinearity, and adaptation, all of which are attributes of complex systems. It seems that the gastrointestinal tract is an appropriate candidate for complexity research. If the gastrointestinal tract is assumed as a complex system, then it would be more fitting to study the tract using holistic methods through interdisciplinary perspective. In the present paper, the features of the gastrointestinal that correlate to complex systems have been explained using physiological examples from studies done on human subjects.
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References
Adelson, D. W., & Million, M. (2004). Tracking the moveable feast: Sonomicrometry and gastrointestinal motility. Physiology, 19(1), 27–32. https://doi.org/10.1152/nips.01439.2003.
Aliev, R. R., Richards, W., & Wikswo, J. P. (2000). A simple nonlinear model of electrical activity in the intestine. Journal of Theoretical Biology, 204(1), 21–28. https://doi.org/10.1006/jtbi.2000.1069.
Amaral, L. A. N., & Ottino, J. M. (2004). Complex networks: Augmenting the framework for the study of complex systems. European Physical Journal B, 38(2), 147–162. https://doi.org/10.1140/epjb/e2004-00110-5.
Barrett, K. E., Barman, S. M., Boitano, S., Brooks, H. L. (2019). Ganong’ s Review of Medical Physiology. In: M.-H. Education, (Ed.), 26th edn. New York: McGraw-Hill Education. www.mhprofessional.com.
Bar-Yam, Y. (1992). Dynamics of complex systems. In: R. L. Devaney, (Ed.). Addison-Wesley.
Bassingthwaighte, J. B. (2000). Strategies for the physiome project. Annals of Biomedical Engineering, 28(8), 1043–1058. https://doi.org/10.1114/1.1313771.
Brookes, S. J. H., Spencer, N. J., Costa, M., & Zagorodnyuk, V. P. (2013). Extrinsic primary afferent signalling in the gut. Nature Reviews Gastroenterology and Hepatology, 10(5), 286–296. https://doi.org/10.1038/nrgastro.2013.29.
Browning, K. N., & Travagli, R. A. (2014). Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions. Comprehensive Physiology, 4(4), 1339–1368. https://doi.org/10.1002/cphy.c130055.
Côté, C. D., Zadeh-Tahmasebi, M., Rasmussen, B. A., Duca, F. A., & Lam, T. K. T. (2014). Hormonal signaling in the gut. Journal of Biological Chemistry, 289(17), 11642–11649. https://doi.org/10.1074/jbc.O114.556068.
Cryan, J. F., O’riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., et al. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018.
Davies, P. (2004). Cosmic blueprint: New discoveries in natures ability to order universe, 2nd edn. Templeton Foundation Press. http://books.google.com/books?hl=en&lr=&id=NEXcZEbru08C&oi=fnd&pg=PR7&dq=Cosmic+blueprint+:+new+discoveries+in+nature’s+creative+ability+to+order+the+universe&ots=1s5z2OTw7Q&sig=4N7OfvS0owN5CUyaTG8nMsMUoQQ
Dekkers, R. (2015). Applied systems theory (2nd ed.). New York: Springer. https://doi.org/10.1007/978-3-319-10846-9.
Deloose, E., Janssen, P., Depoortere, I., & Tack, J. (2012). The migrating motor complex: Control mechanisms and its role in health and disease. Nature Reviews Gastroenterology and Hepatology, 9(5), 271–285. https://doi.org/10.1038/nrgastro.2012.57.
Dimaline, R., & Varro, A. (2014). Novel roles of gastrin. Journal of Physiology, 592(14), 2951–2958. https://doi.org/10.1113/jphysiol.2014.272435.
Dixon, J. B. (2010). Mechanisms of chylomicron uptake into lacteals. Annals of the New York Academy of Sciences, 1207(1), 1–8. https://doi.org/10.1111/j.1749-6632.2010.05716.x.
Dockray, G. J. (2013). Enteroendocrine cell signalling via the vagus nerve. Current Opinion in Pharmacology, 13(6), 954–958. https://doi.org/10.1016/j.coph.2013.09.007.
Dockray, G. J. (2014). Gastrointestinal hormones and the dialogue between gut and brain. Journal of Physiology, 592(14), 2927–2941. https://doi.org/10.1113/jphysiol.2014.270850.
Du, P., O’Grady, G., Gibbons, S. J., Yassi, R., Lees-Green, R., Farrugia, G., et al. (2010). Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT2B knockout mice with altered interstitial cells of Cajal networks. Biophysical Journal, 98(9), 1772–1781. https://doi.org/10.1016/j.bpj.2010.01.009.
Fan, D. (2017). Holistic integrative medicine: Toward a new era of medical advancement. Frontiers of Medicine, 11(1), 152–159. https://doi.org/10.1007/s11684-017-0499-6.
Fardet, A., & Rock, E. (2014). Toward a new philosophy of preventive nutrition: From a reductionist to a holistic paradigm to improve nutritional recommendations. Adv Nutr., 5(4), 430–446. https://doi.org/10.3945/an.114.006122.430.
Fuchs, C. (2003). Structuration theory and self-organization. Systemic Practice and Action Research, 16(2), 133. http://proquest.umi.com/pqdweb?did=323181991&Fmt=7&clientId=29974&RQT=309&VName=PQD
Furness, J. B. (2012). The enteric nervous system and neurogastroenterology. Nature Reviews Gastroenterology and Hepatology, 9(5), 286–294. https://doi.org/10.1038/nrgastro.2012.32.
Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H. (2014). The enteric nervous system and gastrointestinal innervation: Integrated local and central control. In: M. Lyte & J. F. Cryan, (Eds.), Vol. 817. New York: Springer. https://doi.org/10.1007/978-1-4939-0897-4
Gannotta, R., Malik, S., Chan, A. Y., Urgun, K., Hsu, F., & Vadera, S. (2018). Integrative Medicine as a Vital Component of Patient Care. Cureus, 10(8), 8–12. https://doi.org/10.7759/cureus.3098.
Hainsworth, R. (2004). Pathophysiology of syncope. Clinical Autonomic Research, 14(SUPPL. 1), 18–24. https://doi.org/10.1007/s10286-004-1004-2.
Hall, J. E. (2016). Guyton and hall textbook of medical physiology (13e) (13th ed.). Philadelphia: Elsevier Inc. https://doi.org/10.1007/s13398-014-0173-7.2.
Halley, J. D., & Winkler, D. A. (2008). Consistent concepts of self-organization and self-assembly. Complexity, 14(2), 10–17. https://doi.org/10.1002/cplx.
Holst, J. J. (2007). The physiology of glucagon-like peptide 1. Physiological Reviews, 87(4), 1409–1439. https://doi.org/10.1152/physrev.00034.2006.
Huggett, R. J. (1985). Earth surface systems. Earth surface systems (pp. 17–30). Berlin: Springer.
Huizinga, J. D., & Lammers, W. J. E. P. (2009). Gut peristalsis is governed by a multitude of cooperating mechanisms. American Journal of Physiology. Gastrointestinal and Liver Physiology, 296(1), 1–8. https://doi.org/10.1152/ajpgi.90380.2008.
Hunter, P. J., & Smith, N. P. (2016). The cardiac physiome project. Journal of Physiology, 594(23), 6815–6816. https://doi.org/10.1113/JP273415.
IUPS. (n.d.). Physiome Project Research. http://physiomeproject.org/research/digestive
Kaye, W. (2008). Neurobiology of anorexia and bulimia nervosa. Physiology & Behavior, 94(1), 121–135. https://doi.org/10.1016/j.physbeh.2007.11.037.
Képès, F. (2007). BIOLOGICAL NETWORKS complex systems and interdisciplinary science—Vol. 3. (F. Képès, Ed.). World Scientific Publishing Co. Pte. Ltd.
Kwapień, J., & Drozdz, S. (2012). Physical approach to complex systems. Physics Reports, 515(3–4), 115–226. https://doi.org/10.1016/j.physrep.2012.01.007.
Laine, L., Takeuchi, K., & Tarnawski, A. (2008). Gastric mucosal defense and cytoprotection: Bench to bedside. Gastroenterology, 135(1), 41–60. https://doi.org/10.1053/j.gastro.2008.05.030.
Laviano, A., Inui, A., Marks, D. L., Meguid, M. M., Pichard, C., Rossi Fanelli, F., et al. (2008). Neural control of the anorexia-cachexia syndrome. American Journal of Physiology-Endocrinology and Metabolism, 295(5), E1000–E1008. https://doi.org/10.1152/ajpendo.90252.2008.
Lee, M. G., Ohana, E., Park, H. W., Yang, D., & Muallem, S. (2012). Molecular mechanism of pancreatic and salivary gland fluid and HCO 3—secretion. Physiological Reviews, 92(1), 39–74. https://doi.org/10.1152/physrev.00011.2011.
Leng, G., Adan, R. A. H., Belot, M., Brunstrom, J. M., De Graaf, K., Dickson, S. L., et al. (2017). The determinants of food choice. Proceedings of the Nutrition Society, 76(3), 316–327. https://doi.org/10.1017/S002966511600286X.
Mackie, A. (2019). The digestive tract: A complex system. In A. Mackie, O. Gouseti, G. Bornhorst, & S. Bakalis (Eds.), Interdisciplinary approaches to food digestion (pp. 11–27). Cham: Springer. https://doi.org/10.1007/978-3-030-03901-1_2.
Marshall, A. (2002). The Unity of Nature. London: Imperial College Press.
Masroori, C. (2010). An islamic language of toleration: Rumi’s criticism of religious persecution. Political Research Quarterly, 63(2), 243–256. https://doi.org/10.1177/1065912908330348.
Mawdsley, J. E., & Rampton, D. S. (2005). Psychological stress in IBD: New insights into pathogenic and therapeutic implications. Gut, 54(10), 1481–1491. https://doi.org/10.1136/gut.2005.064261.
Mayer, E. A. (2011). Gut feelings: The emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453–466. https://doi.org/10.1038/nrn3071.
Mazloom, R. (2019). A new approach for digestive disease diagnosis: Dynamics of gastrointestinal electrical activity. Medical Hypotheses, 128, 64–68. https://doi.org/10.1016/j.mehy.2019.05.009.
Meadows, D. H. (2009). Thinking in systems. In D. Wright (Ed.), Sustainable investing: Revolutions in theory and practice. London: Earthscan. https://doi.org/10.4324/9781315558837.
Mescher, Anthony L. (2016). Junqueira’s basic histology (14th ed.). New York: McGraw-Hill Education.
Miller, L., Clavé, P., Farré, R., Lecea, B., Ruggieri, M. R., Ouyang, A., et al. (2013). Physiology of the upper segment, body, and lower segment of the esophagus. Annals of the New York Academy of Sciences, 1300(1), 261–277. https://doi.org/10.1111/nyas.12250.
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014). Neurobiology of food intake in health and disease. Nature Reviews Neuroscience, 15(6), 367–378. https://doi.org/10.1038/nrn3745.
Neunlist, M., & Schemann, M. (2014). Nutrient-induced changes in the phenotype and function of the enteric nervous system. Journal of Physiology, 592(14), 2959–2965. https://doi.org/10.1113/jphysiol.2014.272948.
Northrop, R. B. (2011). Introduction to complexity and complex systems. Introduction to complexity and complex systems. Boca Raton: CRC Press. https://doi.org/10.1201/9781439894989.
Podolsky, D. K., Camilleri, M., Fitz, J. G., Kalloo, A. N., Shanahan, F., & Wang, T. C. (Eds.). (2016). Yamada’s textbook of gastroenterology (6th ed.). New York: Wiley.
Powley, T. L., & Phillips, R. J. (2002). Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? I. Morphology and topography of vagal afferents innervating the GI tract. American Journal of Physiology: Gastrointestinal and Liver Physiology, 283(6), 1217–1225. https://doi.org/10.1152/ajpgi.00249.2002.
Pustovit, R. V., Callaghan, B., Ringuet, M. T., Kerr, N. F., Hunne, B., Smyth, I. M., et al. (2017). Evidence that central pathways that mediate defecation utilize ghrelin receptors but do not require endogenous ghrelin. Physiological Reports, 5(15), 1–11. https://doi.org/10.14814/phy2.13385.
Rao, M., & Gershon, M. D. (2016). The bowel and beyond: the enteric nervous system in neurological disorders. Nat Rev Gastroenterol Hepatol., 13(9), 517–528. https://doi.org/10.1016/j.physbeh.2017.03.040.
Raybould, H. E. (2018). In: Bruce M. Koeppen & B. A. Stanton, (Eds.), Berne & levy physiology, 7th edn. Amsterdam: Elsevier Inc.
Reimann, F., Tolhurst, G., & Gribble, F. M. (2012). G-protein-coupled receptors in intestinal chemosensation. Cell Metabolism, 15(4), 421–431. https://doi.org/10.1016/j.cmet.2011.12.019.
Sanders, K. M., Kito, Y., Hwang, S. J., & Ward, S. M. (2016). Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells. Physiology, 31(5), 316–326. https://doi.org/10.1152/physiol.00006.2016.
Sanders, K. M., Koh, S. D., Ro, S., & Ward, S. M. (2012). Regulation of gastrointestinal motility—insights from smooth muscle biology. Nat Rev Gastroenterol Hepatol, 9(11), 635–645. https://doi.org/10.1201/b11479-5.
Sarna, S. K. (2006). Molecular, functional, and pharmacological targets for the development of gut promotility drugs. American Journal of Physiology. Gastrointestinal and Liver Physiology, 291(4), G545–G555. https://doi.org/10.1152/ajpgi.00122.2006.
Seidler, U. E. (2013). Gastrointestinal HCO3- transport and epithelial protection in the gut: New techniques, transport pathways and regulatory pathways. Current Opinion in Pharmacology, 13(6), 900–908. https://doi.org/10.1016/j.coph.2013.10.001.
system| Definition of system in English by Lexico Dictionaries. (n.d.). https://www.lexico.com/en/definition/system. Accessed 13 July 2019
Vanden Berghe, P., Tack, J., & Boesmans, W. (2008). Highlighting Synaptic Communication in the Enteric Nervous System. Gastroenterology, 135(1), 20–23. https://doi.org/10.1053/j.gastro.2008.06.001.
von Bertalanffy, L. (1968). General systems theory: Foundations. Developments, Applications: IEEE Transactions on Systems, Man, and Cybernetics. https://doi.org/10.1109/tsmc.1974.4309376.
Wallace, J. L. (2008). Prostaglandins, NSAIDs, and gastric mucosal protection: Why doesn’t the stomach digest itself? Physiological Reviews, 88(4), 1547–1565. https://doi.org/10.1152/physrev.00004.2008.
Williams, J. A., Chen, X., & Sabbatini, M. E. (2009). Small G proteins as key regulators of pancreatic digestive enzyme secretion. American Journal of Physiology-Endocrinology and Metabolism, 296(3), E405–E414. https://doi.org/10.1152/ajpendo.90874.2008.
Wu, T., Rayner, C. K., Young, R. L., & Horowitz, M. (2013). Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology, 13(6), 928–934. https://doi.org/10.1016/j.coph.2013.09.002.
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Mazloom, R. Evidence of the Physiologic Functions of the Gastrointestinal Tract as a Complex System. Found Sci 26, 257–274 (2021). https://doi.org/10.1007/s10699-020-09656-2
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DOI: https://doi.org/10.1007/s10699-020-09656-2