Abstract
To discover a unifying theory of biology, it is necessary first to believe in its existence and second to seek its elements. Such a theory would explain the regulation of the cell cycle, differentiation and the origin of life. Some elements of the theory may be obtained by considering both eukaryotic and prokaryotic cell cycles. These elements include cytoskeletal proteins, calcium, cyclins, protein kinase C, phosphorylation, transcriptional sensing, autocatalytic gene expression and the physical properties of lipids. Other more exotic candidate elements include the dynamic enzoskeleton, ATP generation, mechanotransduction, the piezoelectric effect and resonance. Bringing these disparate elements together — and discovering others — will require extensive collaborations between specialists from different sciences. This can only be achieved within the context of an integrated approach to biology.
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Berteaud, A.-J., M. Dardalhon, N. Rebeyrotte and M.D. Averbeck (1975). Action d'un rayonnement electromagnetique a longueur d'onde millimetrique sur la croissance bacterienne. C.R. Acad. Sci. Paris Serie D t. 281: 843–846.
Casaregola, S., V. Norris, M. Goldberg and I.B. Holland (1990). Identification of a 180 kDa protein from E. coli related to a yeast myosin heavy chain. Mol. Microbiol. 4: 505–511.
Castuma, C.E., E. Crooke and A. Kornberg (1993). Fluid membranes with acidic domains activate DnaA, the initiator protein of replication in Escherichia coli. J. Biol. Chem. 268: 24665–24668.
Churchward, G., H. Bremer and R. Young (1982). Transcription in bacteria at different DNA concentrations. J. Bacteriol. 150: 572–581.
Cooper, M.S. (1981). Coherent polarization waves in cell division and cancer. Collective Phenomena 3: 273–288.
Cortay, J.-C., C. Rieul, B. Duclos and A.J. Cozzone (1986). Characterization of the phosphoproteins of Escherichia coli by electrophoretic analysis. Eur. J. Biochem. 159: 227–237.
Davis, R.H., D.R. Morris and P. Coffino (1992). Sequestered end products and enzyme regulation: the case of ornithine decarboxylase. Microbiol. Rev. 56: 280–290.
Devaux, P.F. and A. Zachowski (1994). Maintenance and consequences of membrane phospholipid asymmetry. Chem. Phys. Lipids 73: 107–120.
Frohlich, H. (1978). Coherent electric vibrations in biological systems and the cancer problem. IEEE Transactions on Microwave Theory and Techniques MTT-26: 613–617.
Frohlich, H. (1986). Coherence and the action of enzymes. In: G.R. Welch (Eds.), The Fluctuating Enzyme, pp. 421–449. John Wiley and Sons.
Glaser, M. (1993). Lipid domains in biological membranes. Curr. Opin. Struct. Biol. 3: 475–481.
Grundler, W. (1981). Recent results of experiments on nonthermal effects of millimeter microwaves on yeast growth. Collective Phenomena 3: 181–186.
Hepler, P.K. (1994). The role of calcium in cell division. Cell Calcium 16: 322–330.
Ho, M.-W. (1993). The Rainbow and the Worm: The Physics of Organisms. Singapore, World Scientific Publishing.
Ingber, D.E. (1993). The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell 75: 1249–1252.
Kaidow, A., M. Wachi, J. Nakamura, J. Magae and K. Nagai (1995). Anucleate cell production by Escherichia coli Δhns mutant lacking a histone-like protein, H-NS. J. Bacteriol. 177: 3589–3592.
Killian, J.A., M.C. Koorengevel, J.A. Bouwstra, G. Gooris, W. Dowhan and B. de Kruijff (1994). Effect of divalent cations on lipid organization of cardiolipin isolated from Escherichia coli strain AH930. Biochim. Biophys. Acta 1189: 225–232.
Lauck, L., A.R. Vasconcellos and R. Luzzi (1992). On Frohlich's coherent effects in biological systems: influence of carriers and high order dissipative effects. J. Theoret. Biol. 158: 1–13.
Leuchtag, H.R. (1987). Indications of the existence of ferroelectric units in excitable-membrane channels. J. Theoret. Biol. 127: 321–340.
Lipinski, B. (Ed.) (1982). Electronic Conduction and Mechanoelectrical Transduction in Biological Materials. New York, Marcel Dekker.
Lynch, A.S. and J.C. Wang (1993). Anchoring of DNA to the bacterial cytoplasmic membrane through co-transcriptional synthesis of polypeptides encoding membrane proteins or proteins for export: a mechanism of plasmid hypernegative supercoiling in mutants deficient in DNA topoisomerase I. J. Bacteriol. 175: 1645–1655.
Maddock, J.R. and L. Shapiro (1993). Polar location of the chemoreceptor complex in the Escherichia coli cell. Science 259: 1717–1723.
Matsuhashi, M., A.N. Pankrushina, K. Endoh, H. Watanabe, Y. Mano, M. Hyodo, T. Fujita, K. Kunugita, T. Kaneko and S. Otani (1995). Studies on carbon material requirements for bacterial proliferation and spore germination under stress conditions: a new mechanism involving transmission of physical signals. J. Bacteriol. 177: 688–693.
Monod, J. and F. Jacob (1961). General conclusions: teleonomic mechanisms in cellular metabolism, growth and differentiation. In: Cellular Regulatory Mechanisms, pp. 389–401. Cold Spring Harbor, The Biological Laboratory.
Mozharov, A.D., V.N. Shchipakin, I.L. Fishov and Y.V. Evtodienko (1985). Changes in the composition of membrane phospholipids during the cell cycle of E. coli. FEBS Lett. 186: 103–106.
Niki, H., A. Jaffe, R. Imamura, T. Ogura and S. Hiraga (1991). The new gene mukB codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E. coli. EMBO J. 10: 183–193.
Norris, V. (1989). A calcium flux at the termination of replication triggers cell division in E. coli. Cell Calcium 10: 511–517.
Norris, V. (1989). Phospholipid flip-out controls the cell cycle of E. coli. J. Theoret. Biol. 139: 117–128.
Norris, V. (1992). Phospholipid domains determine the spatial organization of the Escherichia coli cell cycle: the membrane tectonics model. J. Theoret. Biol. 154: 91–107.
Norris, V. (1993). Sequestration of origins of chromosome replication in Escherichia coli by lipid compartments: the pocket hypothesis. J. Theoret Biol. 164: 239–244.
Norris, V. (1995). Hypotheses and the regulation of the bacterial cell cycle. Mol. Microbiol. 15: 785–787.
Norris, V. (1995). Hypothesis: chromosome separation in E. coli involves autocatalytic gene expression, transertion and membrane domain formation. Mol. Microbiol. 16: 1051–1057.
Norris, V. (1995). Hypothesis: transcriptional sensing and membrane domain formation initiate chromosome replication in Escherichia coli. Mol. Microbiol. 15: 985–987.
Norris, V., J.A. Ayala, K. Begg, J.-P. Bouché, P. Bouloc, E. Boye, S. Casaregola, A.J. Cozzone, E. Crooke, R. D'Ari, M.A. de Pedro, W.D. Donachie, R.J. Doyle, G.R. Drapeau, R. Fontana, S. Foster, J.A. Fralick, P. Freestone, R.C. Gayda, M. Goldberg, E. Guzman, J.H. Hageman, C.F. Higgins, M. Hofnung, I.B. Holland, J.-V. Holtje, P. Hughes, M. Inouye, S. Inouye, A. Jaffé, A. Jimenez-Sanchez, D. Joseleau-Petit, W. Keck, F. Kepes, A. Kornberg, P. Kuempel, H. Labischinski, A. Lobner-Olesen, J. Lutkenhaus, P.E. March, M. Matsuhashi, G. McGurk, W. Messer, J. Meury, Y. Milner, K. Modha, K. Nagai, T. Nagata, Y. Nishimura, S. Normark, E. Orr, A. Ottolenghi, L. Paolozzi, P. Poulsen, J.E. Rebollo, E.Z. Ron, J. Rouviere-Yaniv, K. Rudd, G.P.C. Salmond, G. Satta, U. Schwarz, S. Seror, A. Simon, B.G. Spratt, K. Sreekumar, S. Sweeney, R. Utsumi, D. Vinella, M. Wachi, B.M. Wilkins, P.H. Williams and C. Yanofsky (1994). Cell cycle control: prokaryotic solutions to eukaryotic problems? J. Theoret Biol. 168: 227–230.
Norris, V., M. Chen, M. Goldberg, J. Voskuil, M. McGurk and I.B. Holland (1991). Calcium in bacteria: a solution to which problem? Mol. Microbiol. 5: 775–778.
Norris, V. and M.S. Madsen (1995). Autocatalytic gene expression occurs via transertion and membrane domain formation and underlies differentiation in bacteria: a model. J. Mol. Biol. 253: 739–748.
Norris, V., G. Turnock and D. Sigee (1996). The Escherichia coli enzoskeleton. Mol. Microbiol. 19: 197–204.
Rajnicek, A.M., C.D. McCaig and N.A.R. Gow (1994). Electric fields induce curved growth of Enterobacter cloacae, Escherichia coli and Bacillus subtilis cells: implications for mechanisms of galvanotropism and bacterial growth. J. Bacteriol. 176: 702–713.
Reusch, R.N., R. Huang and L.L. Bramble (1995). Poly-3-hydroxybutyrate/polyphosphate complexes form voltage-activated Ca2+ channels in the plasma membranes of Escherichia coli. Biophys. J. 69: 754–766.
Rietveld, A.G., M.C. Koorengevel and B. de Kruijff (1995). Non-bilayer lipids are required for efficient protein transport across the plasma membrane of Escherichia coli. EMBO J. 14: 5506–5513.
Scott, R.H., K.G. Sutton and A.C. Dolphin (1993). Interactions of polyamines with neuronal ion channels. Trends Neurosci. 16: 153–159.
Smith, R.J. (1995). Calcium and bacteria. Adv. Micro. Physiolo. 37: 83–103.
Sweetman, G., M. Trinei, J. Modha, J. Kusel, P. Freestone, I. Fishov, D. Joseleau-Petit, C. Redman, P. Farmer and V. Norris (1996). Electrospray ionization mass spectrometric analysis of phospholipids of Escherichia coli. Mol. Microbiol. in press.
Tocanne, J.-F., L. Cezanne, A. Lopez, B. Piknova, V. Schram, J.-F. Tournier and M. Welby (1994). Lipid domains and lipid/protein interactions in biological membranes. Chem. Phys. Lipids 73: 139–158.
Tyson, J.J. (1991). Modeling the cell division cycle: cdc2 and cyclin interactions. Proc. Nat. Acad. Sci., U.S.A. 88: 7328–7332.
Vos-Scheperkeuter, G.H. and B. Witholt (1982). Co-translational insertion of envelope proteins; theoretical considerations and implications. Ann. Inst. Pasteur 133A: 129–138.
Wang, N., J.P. Butler and D.E. Ingber (1993). Mechanotransduction across the cell surface and through the cytoskeleton. Science 260: 1124–1127.
Welch, G.R. (Ed.) (1986). The Fluctuating Enzyme. New York: John Wiley and Sons.
Xia, W. and W. Dowhan (1995). In vivo evidence of the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli. Proc. Nat. Acad. Sci., U.S.A. 92: 783–787.
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Norris, V., Madsen, M.S. & Freestone, P. Elements of a unifying theory of biology. Acta Biotheor 44, 209–218 (1996). https://doi.org/10.1007/BF00046528
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DOI: https://doi.org/10.1007/BF00046528