Abstract
To study the possible role of catecholaminergic processes underlying the exaggerated expression of behavioral arousal during early development in the mouse, the locomotor activity of 10-to 12-day-old mice following d-amphetamine injection was recorded over a 5-h period in a shuttle-cage apparatus. Reliable effects of a 1-mg/kg dose of d- amphetamine were observed only in the oldest age group. The relative influences of d- and l-amphetamine were then assessed at this age. The stereoisomers were approximately equipotent in elevating activity above saline control levels and demonstrated comparable latency and duration of effects. The results support the notion that heightened arousal at this age is mediated by a noradrenergic system.
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Alleva, E., & Bignami, G. (1985). Development of mouse activity, stimulus reactivity, habituation, and response to amphetamine and scopolamine. Physiology & Behavior, 34, 519–523.
Aulakh, C. S., Bhattacharyya, A. K., & Pradhan, S. N. (1982). Correlation of behavioral and neurochemical effects of d- and 1-amphetamines. Drug Development Research, 2, 65–72.
Bunney, B. S., Walters, J. R., Kuhar, M. J., Roth, R. H., & Agha-janian, G. K. (1975). D & l amphetamine stereoisomers: Comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications, 1, 177–190.
Campbell, B. A., Lytle, L. D., & Fibiger, H. C. (1969). Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science, 166, 637–638.
Campbell, B. A., & Mabry, P. D. (1972). Ontogeny of behavioral arousal: A comparative study. Journal of Comparative & Physiological Psychology, 81, 371–379.
Campbell, B. A., & Mabry, P. D. (1973). The role of catecholamines in behavioral arousal during ontogenesis. Psychopharmacologia, 31, 253–264.
Carlton, P. L. (1969). Brain-acetylcholine and inhibition. In J. Tapp (Ed.), Progress in brain research: Reinforcement and behavior (pp. 286–327). New York: Academic Press.
Forster, M. J., & Nagy, Z. M. (1983). Potentiation of locomotor activity by d-amphetamine in infant Swiss-Webster mice. Physiological Psychology, 11, 278–282.
Kirk, R. E. (1968). Experimental design: Procedures for the behavioral sciences. Monterey, CA: Brooks/Cole.
Lucot, J. B., & Seiden, L. S. (1986). Effects of serotonergic agonists and antagonists on the locomotor activity of neonatal rats. Pharmacology, Biochemistry & Behavior, 24, 537–541.
Mabry, P. D., & Campbell, B. A. (1974). Ontogeny of serotonergic inhibition of behavioral arousal in the rat. Journal of Comparative & Physiological Psychology, 86, 193–201.
Moorcroft, W. H. (1975). Ontogeny of forebrain inhibition of behavioral arousal in the rat. Brain Research, 35, 513–522.
Murphy, J. M., Meeker, R. B., Porada, K. J., & Nagy, Z. M. (1979). GABA-mediated behavioral inhibition during ontogeny in the mouse. Psychopharmacology, 64, 237–242.
Murphy, J. M., & Nagy, Z. M. (1976). Neonatal thyroxine stimulation accelerates the maturation of both locomotor and memory processes in mice. Journal of Comparative & Physiological Psychology, 90, 1082–1091.
Nagy, Z. M., & Forster, M. J. (1982). Development of serotonin-mediated behavioral inhibition in the hyperthyroid mouse. Pharmacology, Biochemistry & Behavior, 16, 203–206.
Nagy, Z. M., Murphy, J. M., & Ray, D. (1975). Development of behavioral arousal and inhibition in the Swiss-Webster mouse. Bulletin of the Psychonomic Society, 6, 146–148.
North, R. B., Harik, S. I., & Snyder, S. H. (1974). Amphetamine isomers: Influences on locomotor and stereotyped behavior of cats. Pharmacology, Biochemistry & Behavior, 2, 115–118.
Ray, D., & Nagy, Z. M. (1978). Emerging cholinergic mechanisms and ontogeny of response inhibition in the mouse. Journal of Comparative & Physiological Psychology, 92, 335–349.
Schneirla, T. C. (1965). Aspects of stimulation and organization in approach/withdrawal processes underlying vertebrate behavior. In D. S. Lehrman, R. A. Hinde, & E. Shaw (Ed.), Advances in the study of behavior (Vol. 1, pp. 1–74). New York: Academic Press.
Segal, D. S. (1975). Behavioral characterization of d- and l- amphetamine: Neurochemical implications. Science, 190, 475–477.
Sobrian, S. K., Weltman, M., & Pappas, B. A. (1975). Neonatal locomotor and long-term behavioral effects of d-amphetamine in the rat. Developmental Psychobiology, 8, 241–250.
Zabik, J. E., Levine, R. M., & Maickel, R. P. (1978). Drug interactions with brain biogenic amines and the effects of amphetamine isomers on locomotor activity. Pharmacology, Biochemistry & Behavior, 8, 429–435.
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Ray, D., Nagy, Z.M. The development of locomotor response to d- and l-amphetamine in the infant mouse. Bull. Psychon. Soc. 30, 359–362 (1992). https://doi.org/10.3758/BF03334088
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DOI: https://doi.org/10.3758/BF03334088