Abstract
The Dutch microbiologist/biochemist Albert Jan Kluyver (1888–1956) was an early proponent of the idea of biochemical unity, and how that concept might be demonstrated through the careful study of microbial life. The fundamental relatedness of living systems is an obvious correlate of the theory of evolution, and modern attempts to construct phylogenetic schemes support this relatedness through comparison of genomes. The approach of Kluyver and his scientific descendants predated the tools of modern molecular biology by decades. Kluyver himself is poorly recognized today, yet his influence at the time was profound. Through lens of today however, it has been argued that the focus by Kluyver and others to create taxonomic and phylogenetic schemes using morphology and biochemistry distorted and hindered progress of the discipline of microbiology, because of a perception that the older approaches focused too much on a reductionist worldview. This essay argues that in contrast the careful characterization of fundamental microbial metabolism and physiology by Kluyver made many of the advances of the latter part of the twentieth century possible, by offering a framework which in many respects anticipated our current view of phylogeny, and by directly and indirectly training a generation of scientists who became leaders in the explosive growth of biotechnology.
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References
Abir-Am, Pnina G. 1995. “New Trends in the History of Molecular Biology.” Historical Studies in the Physical and Biological Sciences 26(1): 167–196.
Allen, Garland E. 2005. “Mechanism, Vitalism and Organicism in Late Nineteenth and Twentieth-Century Biology: The Importance of Historical Context.” Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36(2): 261–283.
Allen, S., Kellermeyer, R., Stjernholm, R., and Wood, H. 1964. “Purification and Properties of Enzymes Involved in the Propionic Acid Formation.” Journal of Bacteriology 87: 171–187.
Amsterdamska, Olga. 1995. “Beneficent Microbes: The Delft School of Microbiology and its Industrial Connections.” Pieter Bos and Bert Theunissen (eds.), Beijerinck and the Delft School of Microbiology. Delft: Delft University Press, pp. 193–213.
Barker, H. A. and Hungate, Robert E. 1990. “Cornelius Bernardus Van Niel 1897–1985.” Biographical Memoirs of the National Academy of Sciences 59: 389–423.
Bennett, J. W. and Phaff, Herman J. 1993. “Early Biotechnology: The Delft Connection.” ASM News 59(8): 401–404.
Bartlett, John M. S. and David Stirling. 2003. A Short History of the Polymerase Chain Reaction. In PCR Protocols, eds. John M.S. Bartlett and David Stirling, Methods in Molecular Biology, vol 226: 3–6. Heidelberg: Humana Press.
Benzer, Seymour. 1990. Interview with Seymour Benzer. Interview by Heidi Aspaturian, September 1990. Oral History Project, California Institute of Technology Archives. http://resolver.caltech.edu/CaltechOH:OH_Benzer_S. Retrieved May 22, 2014.
Brock, Thomas D. 1961. Milestones in Microbiology. London:Prentice-Hall International Inc.
Brock, Thomas D. 1983. “Preface to the 1983 edition.” Pieter Bos and Bert Theunissen (eds.), Beijerinck and the Delft School of Microbiology. Delft: Delft University Press, pp. ix–xi.
Brock, T. D. 1988. “The Bacterial Nucleus: A History.” Microbiology Reviews 52(4): 397–411.
Brock, Thomas D. 1995. “The Road to Yellowstone—And Beyond.” Annual Review of Microbiology 49: 1–29.
Brock, Thomas D. 1997. “The Value of Basic Research: Discovery of Thermus aquaticus and Other Extreme Thermophiles.” Genetics 146(4): 1207–1210.
Bronowski, J. 1956. “Science and Human Values: I.” The Creative Mind. Higher Education Quarterly 10(3): 247–259.
Bronowski, Jacob 1985. The Creative Process. Leonardo 18 (4, Special Issue: Jacob Bronowski: A Retrospective): 245–248.
Buchner, Eduard. 1907. ”Cell-free fermentation” Nobel Lecture, December 11, Nobel Lectures, Chemistry 1901–1921, Elsevier Publishing Company, Amsterdam, 1966, pp. 103–120. On line at: “Eduard Buchner—Nobel Lecture: Cell-Free Fermentation”. Nobelprize.org. Nobel Media AB 2013. Web. 20 July 2013. http://www. nobelprize.org/nobel_prizes/chemistry/laureates/1907/buchner-lecture.html.
Bulder, C. J. E. A., LaRivière, J. W. M., and Verhoeven, W. 1989. “Kluyver’s Work in Retrospect: Wisdom of Foresight?’ Antonie van Leeuwenhoek 56(2): 109–126. doi:10.1007/BF00399976.
Burns, Marlene and Piet W. M Van Dijck. 2002. The Development of the Penicillin Production Process in Delft, The Netherlands, During World War II under Nazi Occupation. In Advances in Applied Microbiology, eds. A. Laskin, J. Bennett, and G. Gadd. vol 51:185–200. New York: Academic Press.
Chung, King-Thom, Bryant and Marvin P. 1997. “Robert E. Hungate: Pioneer of Anaerobic Microbial Ecology.” Anaerobe 3(4): 213–217.
“Delft University of Technology: History of the University.” 2013. http://www.tudelft. nl/en/about-tu-delft/history/. September 2, 2013.
Des Chene, Dennis. 2005. “Mechanisms of Life in the Seventeenth Century: Borelli, Perrault, Régis.” Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36(2): 245–260.
Halvorson, H. O. 1955. “To Dr. Henry Tsuchiya Re the `Twenty Top Living Bacteriologists,” January 19, 1955. Series 3: Society of American Bacteriologists/American Society for Microbiology, Folder 13. Presidential Address, “The Hybrid Bacteriologist, etc.” American Society for Microbiology. (Hereafter cited as: Halvorson papers).
Herrington, B. L., White J. C., and Brooks Naylor. Cornell University Faculty Memorial Statement: Otto Rahn, April 9, 1881 — September 26, 1957, pdf file available on line at: http://ecommons.library.cornell.edu/handle/1813/17813.
Holmes, Frederic Lawrence. 2004. Investigative Pathways: Patterns and Stages in the Careers of Experimental Scientists. New Haven: Yale University Press.
Holmes, Frederic L. 2006. Reconceiving the Gene: Seymour Benzer’s Adventures in Phage Genetics, ed. William C. Summers. New Haven: Yale University Press.
Hull, David. 1988. Science as a Process. Chicago: University of Chicago Press.
Hungate, Robert E. 1979. “Evolution of a Microbial Ecologist.” Annual Review of Microbiology 33: 1–21.
Kamp, A. F., La Rivière, J. W. M., and Verhoeven, W. (eds.). 1959. Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers.
Kluyver, A. J. 1922. Inaugural address delivered in the Dutch language on the occasion of his accession to the Chair of Microbiology at the Technological University of Delft on January 18, 1922, under the title ‘Microbiologic en Industrie’. Translated in Albert Jan Kluyver: His Life and Work, ed. A.F. Kamp, J.W.M. La Rivière, and W. Verhoeven, 165–185. New York: Interscience Publishers.
Kluyver, A. J. 1924. “Unity and Diversity in the Metabolism of Micro-organisms” (Translation of: ‘Eenheid en verscheidenlrid in de stofwisseling der microben,’ Chemisch Weekblad 2 1, 266, 1924.), Translated in Albert Jan Kluyver: His Life and Work, ed. A.F. Kamp, J.W.M. La Rivière, and W. Verhoeven. New York: Interscience Publishers, pp. 186–210.
Kluyver, A. J. 1931. The Chemical Activities of Micro-Organisms. London:University of London Press.
Kluyver, A. J. 1947.Three decades progress in microbiology. Antonie van Leeuwenhoek 13(1): 1–20
Kluyver, A. J. 1948. “Address delivered in the Dutch language at the general meeting of the Hollandse Maatschappij der Wetenschappen on May 22, 1948, under the title ‘Homo militans’.” Translated in Albert Jan Kluyver: His Life and Work, ed. A.F. Kamp, J.W.M. La Rivière, and W. Verhoeven. New York: Interscience Publishers.
Kluyver, A. J. 1952. “Microbial Metabolism and Its Industrial Implications.” Chemistry & Industry, no. 7: 136–145.
Kluyver, A. J. 1953a. “Leeuwenhoek Lecture: The Changing Appraisal of the Microbe.” Proceedings of the Royal Society of London. Series B, Biological Sciences 141(903): 147–161. doi:10.1098/rspb.1953.0032.
Kluyver, A. J. 1953b. “An Aspect of the Promotion of Science” Address delivered at the 90th annual meeting of the National Academy of Sciences, in Washington, D.C., April 28, 1953. News Report, National Academy of Sciences-National Research Council, U.S.A., number 3: 33. in Albert Jan Kluyver: His Life and Work, ed. A.F. Kamp, J.W.M. La Rivière, and W. Verhoeven. New York: Interscience Publishers, pp. 473–482.
Kluyver, A. J. 1956. “Microbial Metabolism; Further Evidence for Life’s Unity.” A. J. Kluyver and C. B. van Niel (eds.), The Microbe’s Contribution to Biology. Cambridge, MA: Harvard University Press, pp. 31–72.
Kluyver, Albert Jan and H.J.L Donker. 1925a. The unity in the chemistry of the fermentative sugar dissimilation processes of microbes. Proceedings of the Royal Netherlands Academy of Arts and Sciences, 28 (3): 297–313. on line at: http://www. dwc.knaw.nl/DL/publications/PU00015156.pdf.
Kluyver, Albert Jan and Donker, H. J. L. 1925b. The catalytic transference of hydrogen as the basis of the chemistry of dissimilation processes. Proceedings of the Royal Netherlands Academy of Arts and Sciences, 28 (6): 605–618. on line at: http://www.dwc.knaw.nl/DL/publications/PU00015198.pdf.
Kluyver, Albert J. and Donker, H. J. L. 1926. “Die Einheit in der Biochemie.” Chem. Zelle Gewebe 13: 134–190.
Kluyver, A. J and Perquin, L. H. C. 1932. “On the methodology of research on fungal metabolism.” Biochem. Z. 266: 68–81.
Kluyver, A. J. and van Niel, C. B. 1936. “Prospects for a Natural System of Classification of Bacteria.” Zentralbl Bakteriol Parasitenkd Infektionskr Hyg Abt II 94: 369–403.
Kohler, Robert. 1971. “The Background to Eduard Buchner’s Discovery of Cell-Free Fermentation.” Journal of the History of Biology 4(1): 35–61.
Kohler, Robert E. 1972. “The Reception of Eduard Buchner’s Discovery of Cell-Free Fermentation.” Journal of the History of Biology 5(2): 327–353.
Kohler, Robert E. 1973. “The Enzyme Theory and the Origin of Biochemistry.” Isis 64: 181–196.
La Rivière, J. W. M. 1959. “Kluyver as Professor; Chronicles of the Laboratory.” J. W. M La Rivière and W. Verhoeven (eds.), Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers, pp. 14–48.
Lutsenburg Maas, Miss. H. J. van, and G. van Iterson Jr. 1915. A Microsaccharimeter in: KNAW Proceedings (Amsterdam), 18 (1): 258–269. (available online at: www.dwc.knaw.nl/DL/publications/PU00012501.pdf).
O’Malley, Maureen A. 2007. “The nineteenth century roots of ‘everything is everywhere’.” Nature Reviews Microbiology 5(8): 647–651.
O’Malley, Maureen A. 2008. “Everything Is Everywhere: But the Environment Selects: Ubiquitous Distribution and Ecological Determinism in Microbial Biogeography.” Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 39(3): 314–325.
Pace, Norman R. 1997. “A Molecular View of Microbial Diversity and the Biosphere.” Science 276(5313): 734–740.
Rahn, Otto. 1932. Physiology of Bacteria. Philadelphia: P. Blakiston’s Son & Co. (Available on line at: http://archive.org/details/ost-biology-physiologyofbact00 rahn).
Rheinberger, Hans-Jörg. 1996. “Comparing Experimental Systems: Protein Synthesis in Microbes and in Animal Tissue at Cambridge (Ernest F. Gale) and at the Massachusetts General Hospital (Paul C. Zamecnik), 1945-1960.” Journal of the History of Biology 29(3): 387–416.
Robertson, Muriel. 1949. “Marjory Stephenson.” Obituary Notices of Fellows of the Royal Society 6: 562–577.
van Rossem, A. 1959a. “From Youth to Professor: Student and assistant: 1905–1916.” A. F. Kamp, J. W. M. La Rivière, and W. Verhoeven (eds.), Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers, pp. 5–9.
van Rossem, A. 1959b. “Funeral Oration.” A. F. Kamp, J. W. M. La Rivière, and W. Verhoeven (eds.), Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers, pp. 159–161.
Servos, John W. 1993. “Research Schools and Their Histories.” Osiris 8(Research Schools: Historical Reappraisals): 2–15.
Singleton, Rivers Jr. 1995. “Opinions of Our Readers: Is Modern Biology Molecular Biology?’ Perspectives in Biology and Medicine 38(4): 668–672.
Singleton, Rivers Jr. 1997a. “Heterotrophic CO2-Fixation, Mentors, and Students: The Wood-Werkman ReactionS.” Journal of the History of Biology 30: 91–120.
Singleton, Rivers, Jr. 1997b. Chapter 7 Harland Goff Wood: An American Biochemist. In Comprehensive Biochemistry, eds Rainer Jaenicke and Giorgio Semenza, Volume 40:333–382. New York: Elsevier.
Singleton, Rivers Jr. 2000. “From Bacteriology to Biochemistry: Albert Jan Kluyver and Chester Werkman at Iowa State.” Journal of the History of Biology 33: 141–180.
Singleton, R Jr. 2007. “Wood, Harland Goff.” Noretta Koertge (ed.), New Dictionary of Scientific Biography, 7 vols. Detroit: Charles Scribner’s Sons, pp. 345–349.
Spath, Susan Barbara. 1999. C. B. van Niel and the Culture of Microbiology, 1920–1965. Ph.D. Dissertation, History, Graduate Division, University of California, Berkeley.
Spath, Susan. 2004. “van Niel’s Course in General Microbiology.” ASM News 70(8): 359–363.
Stanier, Roger Y. and Van Niel, C. B. 1941. “The Main Outlines of Bacterial Classification.” Journal of Bacteriology 42(4): 437–466.
Stanier, Roger Y. and van Niel, C. B. 1962. “The Concept of a Bacterium.” Archiv Für Mikrobiologie 42(1): 17–35.
Theunissen, Bert. 1996. “The Beginnings of the ‘Delft Tradition’ Revisited: Martinus. Beijerinck and the Genetics of Microorganisms.” Journal of the History of Biology 29(2): 197–228.
van Niel, Cornelis Bernardus. 1928. The Propionic Acid Bacteria. Haarlem:N. V. Uitgeverszaak J. W. Boissevain and Co.
van Niel, C. B. 1949. “The ‘Delft School’ and the Rise of General Microbiology.” Bacteriological Reviews 13(3): 161–174.
van Niel, C. B. 1957. “Obituary Notice, Albert Jan Kluyver, 1888–1956.” Journal of General Microbiology 16(2): 499–521.
van Niel, C. B. 1959. “Kluyver’s Contributions to Microbiology and Biochemistry.” A. F. Kamp, J. W. M. La Rivière, and W Verhoeven (eds.), Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers, pp. 70–80.
van Niel, C. B. 1967. “The Education of a Microbiologist; Some Reflections.” Annual Review of Microbiology 21: 1–31.
van Wijk, W. E. 1959. “From Youth to Professor the Early Years, 1888-1905.” A. F. Kamp, J. W. M. La Rivière, and W. Verhoeven (eds.), Albert Jan Kluyver: His Life and Work. New York: Interscience Publishers, pp. 3–5.
Watson, J. D. and Crick, F. H. 1953. “Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.” Nature 171(4356): 737–738.
Woese, C. R. and Goldenfeld, N. 2009. “How the Microbial World Saved Evolution from the Scylla of Molecular Biology and the Charybdis of the Modern Synthesis.” Microbiology and Molecular Biology Reviews 73: 14–21.
Woese, C. R., Kandler, O., and Wheelis, M. L. 1990. “Towards a Natural System of Organisms: Proposal for the Domains Archaea, Bacteria, and Eucarya.” Proceedings of the National Academy of Sciences 87(12): 4576–4579.
Wood, W. A. 1961. “Chapter 2: Fermentation of Carbohydrates and Related Compounds.” I. C. Gunsalas and R. Y. La Stanier (eds.), The Bacteria: A Treatise on Structure and Function. Volume II: Metabolism. New York:Academic Press.
Woods, DD. 1957. “Albert Jan Kluyver. 1888–1956.” Biographical Memoirs of Fellows of the Royal Society 3: 109–128.
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Singleton, R., Singleton, D.R. Remembering Our Forebears: Albert Jan Kluyver and the Unity of Life. J Hist Biol 50, 169–218 (2017). https://doi.org/10.1007/s10739-016-9438-7
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DOI: https://doi.org/10.1007/s10739-016-9438-7