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Diets and Circadian Rhythms: Challenges from Biology for Medicine

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Abstract

Autoimmune diseases such as rheumatoid arthritis and gastrointestinal disorders such as stomach ulcers are often treated with drugs. NSAIDs, a common treatment in rheumatoid arthritis, may cause stomach ulcers which call for additional medications, notably antacids in the sense of drugs that suppress acid secretion by the stomach. Infection with Helicobacter pylori also plays a role in the ulcers. The infection is typically treated with antibiotics added to antacids. Considering NSAIDs and antacids, we suspect that overmedication is common to the extent that particular diets are a better option. Current research and current treatments with these drugs are also problematic since circadian rhythms are mostly disregarded. All the processes involved in the disorders treated show marked variations in the course of the day. Hence experiments conforming to the guidelines of evidence-based medicine, and treatments in line with them, have outcomes strongly depending on the time factor. This calls for reforms in medicine with fresh inputs from biology.

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Authors and Affiliations

  1. Department of Registration and Research, Comprehensive Cancer Centre Middle Netherlands (IKMN), PO Box 19079,, 3501 DB, Utrecht, The Netherlands

    Wim J. van der Steen

  2. Maluslaan, 3, 1185 KZ, Amstelveen, The Netherlands

    Vincent K. Y. Ho

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  1. Wim J. van der Steen
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  2. Vincent K. Y. Ho
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Correspondence to Vincent K. Y. Ho.

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van der Steen, W.J., Ho, V.K.Y. Diets and Circadian Rhythms: Challenges from Biology for Medicine. Acta Biotheor 54, 267–275 (2006). https://doi.org/10.1007/s10441-007-9002-0

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  • DOI: https://doi.org/10.1007/s10441-007-9002-0

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