Abstract
The article investigates the validity of two different versions of the slippery slope argument construed in relation to human gene therapy: the empirical and the conceptual argument. The empirical version holds that our accepting somatic cell therapy will eventually cause our accepting eugenic medical goals. The conceptual version holds that we are logically committed to accepting such goals once we have accepted somatic cell therapy. It is argued that neither the empirical nor the conceptual version of the argument can provide a conclusive moral reason for banning somatic cell therapy. According to a third interpretation, referred to as the arbitrary result argument, the many apparent similarities between somatic cell therapy and eugenic-based human genetic engineering drive us to make principled choices concerning what differences and similarities between the two practices should be regarded as morally (ir)relevant. Decisions of this kind are likely to have unpredictable moral consequences. Thus formulated, the slippery slope argument has much plausibility. One objects to somatic cell therapy not so much because of what is at the bottom of the slope on which it lies, but because it is on a slope of which one does not know what is at the bottom. While the arbitrary result argument does not provide a conclusive reason for prohibiting human gene therapy, it reminds of a very important thing: when making bioethical decisions, we should be as specific and as consistent as possible about our basic moral and medical concepts.
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Aula, P., M. Hietala, P. Niemelä, A.R. Aro, A. Hakonen and L. Peltonen: 1996, 'Miten suomalaiset suhtautuvat geenitesteihin', Duodecim 112, 95–102.
Beauchamp, T.L. and J.F. Childress: 1989, Principles of Biomedical Ethics, 3rd edn. Oxford and New York: Oxford University Press.
Berger, E.M.: 1996, 'Ethics of Gene Therapy', in: B. Gert, E.M. Berger, G.F. Cahill, Jr., K.D. Clouser, C.M. Culver, J.B. Moeschler and G.H.S. Singer (eds.), Morality and the New Genetics. Sudbury, MA: Jones and Barlett Publishers, pp. 209–223.
Berger, E.M. and B.M. Gert: 1991, 'Genetic Disorders and the Ethical Status of Germ-Line Gene Therapy', The Journal of Medicine and Philosophy 16, 667–683.
Boone, C.K.: 1988, 'Bad Axioms in Genetic Engineering', Hastings Center Report (August-September) 18, 9–13.
Buchanan, A., D.W. Brock, N. Daniels and D. Wikler: 2000, From Chance to Choice: Genetics and Justice. New York: Cambridge University Press.
Caplan, A.L.: 1992, 'If Gene Therapy is the Cure, What is the Disease?', in: G.J. Annas and S. Elias (eds.), Gene Mapping: Using Law and Ethics as Guides. Oxford: Oxford University Press, pp. 128–141.
Chadwick, R.: 1998, 'Gene Therapy', in: H. Kuhse and P. Singer (eds.), A Companion to Bioethics. Oxford: Blackwell Publishers, pp. 189–197.
Clarke, A.: 1999, 'The Genetic Dissection of Complex Traits', in: V. Launis, J. Pietarinen and J. Räikkä (eds.), Genes and Morality: New Essays. Amsterdam and Atlanta, GA: Rodopi, pp. 103–119.
Den Hartogh, G.: 1998, 'The Slippery Slope Argument', in: H. Kuhse and P. Singer (eds.), A Companion to Bioethics. Oxford: Blackwell Publishers, pp. 280–290.
Elias, S. and G.J. Annas: 1992, 'Somatic and Germ-Line Gene Therapy', in: G.J. Annas and S. Elias (eds.), Gene Mapping: Using Law and Ethics as Guides. New York and Oxford: Oxford University Press, pp. 142–154.
Gelehrter, T.D and F.S. Collins: 1990, Principles of Medical Genetics. Baltimore: Williams & Wilkins.
Govier, T.: 1982, 'What's Wrong with Slippery Slope Arguments?', Canadian Journal of Philosophy 12, 303–316.
Hansen, B.S.: 1996, 'Something Rotten in the State of Denmark: Eugenics and the Ascent of the Welfare State', in: G. Broberg and N. Roll-Hansen (eds.), Eugenics and the Welfare State: Sterilization Policy in Denmark, Sweden, Norway, and Finland. East Lansing: Michigan State University Press, pp. 9–76.
Harris, J.: 1993, 'Is Gene Therapy a Form of Eugenics?', Bioethics 7, 178–187.
Heise, D.R.: 1975, Causal Analysis. New York: John Wiley & Sons.
Hietala, M., A. Hakonen, A.R. Aro, P. Niemelä, L. Peltonen and P. Aula: 1995, 'Attitudes Toward Genetic Testing among the General Population and Relatives of Patients with a Severe Genetic Disease: A Survey from Finland', American Journal of Human Genetics 56, 1493–1500.
Hietala, M.: 1996, 'From Race Hygiene to Sterilization: The Eugenics Movement in Finland', in: G. Broberg and N. Roll-Hansen (eds.), Eugenics and the Welfare State: Sterilization Policy in Denmark, Sweden, Norway, and Finland. East Lansing: Michigan State University Press, pp. 195–258.
Hoedemaekers, R. and H. ten Have: 1999, 'Genetic Health and Genetic Disease', in: V. Launis, J. Pietarinen and J. Räikkä (eds.), Genes and Morality: New Essays. Amsterdam and Atlanta, GA: Rodopi, pp. 121–143.
Holtug, N.: 1993, 'Human Gene Therapy: Down the Slippery Slope?', Bioethics 7, 402–419.
Holtug, N.: 1998, 'Creating and Patenting New Life Forms', in: H. Kuhse and P. Singer (eds.), A Companion to Bioethics. Oxford: Blackwell Publishers, pp. 206–214.
Häyry, H.: 1994, 'How to Assess the Consequences of Genetic Engineering?', in: A. Dyson and J. Harris (eds.), Ethics and Biotechnology. London and New York: Routledge, pp. 144–156.
Juengst, E.T.: 1997, 'Can Enhancement Be Distinguished from Prevention in Genetic Medicine?', The Journal of Medicine and Philosophy 22, 125–142.
Lamb, D.: 1988, Down the Slippery Slope: Arguing in Applied Ethics. London: Croom Helm.
Lippman, A.: 1992, 'Led (Astray) by Genetic Maps: The Cartography of the Human Genome and Health Care', Social Science and Medicine 35, 1469–1476.
Mackie, J.L.: 1975, 'Causes and Conditions', in: E. Sosa (ed.), Causation and Conditionals. Oxford: Oxford University Press, pp. 15–38.
Marteau, T., S. Michie, H. Drake and M. Bobrow: 1995, 'Public Attitudes Towards the Selection of Desirable Characteristics in Children', Journal of Medical Genetics 32, 796–798.
McGleenan, T.: 1995, 'Human Gene Therapy and Slippery Slope Arguments', Journal of Medical Ethics 21, 350–355.
Moseley, R.: 1991, 'Commentary: Maintaining the Somatic/ Germ-Line Distinction: Some Ethical Drawbacks', The Journal of Medicine and Philosophy 16, 641–647.
Neri, D.: 1998, 'Eugenics', in: R. Chadwick (ed.), Encyclopedia of Applied Ethics, vol. 2. San Diego, CA: Academic Press, pp. 161–173.
Paul, S.: 1997, 'Genetic Testing: Sliding Down the Slippery Slope?', Biomedical Ethics 2, 69–73.
Pitt, J.C.: 1987, 'The Autonomy of Technology', in: P.T. Durbin (ed.), Technology and Responsibility. Dordrecht: D. Reidel Publishing Company, pp. 99–114.
Proctor, R.N.: 1992, 'Genomics and Eugenics: How Fair is the Comparison?', in: G.J. Annas and S. Elias (eds.), Gene Mapping: Using Law and Ethics as Guides. Oxford: Oxford University Press, pp. 57–93.
Rachels, J.: 1986, The End of Life: Euthanasia and Morality. Oxford: Oxford University Press.
Reiss, M.J. and R. Straughan: 1996, Improving Nature? The Science and Ethics of Genetic Engineering. Cambridge: Cambridge University Press.
Resnik, D.: 1994, 'Debunking the Slippery Slope Argument Against Human Germ-Line Gene Therapy', The Journal of Medicine and Philosophy 19, 23–40.
Stich, S.P.: 1978, 'The Recombinant DNA Debate', Philosophy and Public Affairs 7, 187–205.
Trianosky, G.W.: 1978, 'Rule-Utilitarianism and the Slippery Slope', The Journal of Philosophy 75, 414–424.
Van der Burg, W.: 1991, 'The Slippery Slope Argument', Ethics 102, 42–65.
Van der Burg, W.: 1998, 'Slippery Slope Arguments', in: R. Chadwick (ed.), Encyclopedia of Applied Ethics, vol. 4. San Diego, CA: Academic Press, pp. 129–142.
Walters, L. and J.G. Palmer: 1997, The Ethics of Human Gene Therapy. New York and Oxford: Oxford University Press.
Walton, D.N.: 1992, Slippery Slope Arguments. Oxford: Clarendon Press.
Weatherall, D.J.: 1988, 'The Slow Road to Gene Therapy', Nature 331, 13–14.
Williams, B.: 1985, 'Which Slopes are Slippery?', in: M. Lockwood (ed.), Moral Dilemmas in Modern Medicine. Oxford and New York: Oxford University Press, pp. 126–137.
Wood-Harper, J.: 1994, 'Manipulation of the Germ-Line: Towards Elimination of Major Infectious Diseases?', in: A. Dyson and J. Harris (eds.), Ethics and Biotechnology. London and New York: Routledge, pp. 121–143.
Zimmerman, B.K.: 1991, 'Human Germ-Line Therapy: The Case for Its Development and Use', The Journal of Medicine and Philosophy 16, 593–612.
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Launis, V. Human gene therapy and the slippery slope argument. Med Health Care Philos 5, 169–179 (2002). https://doi.org/10.1023/A:1016052122403
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DOI: https://doi.org/10.1023/A:1016052122403