Skip to main content
Log in

The human genome project: Towards an analysis of the empirical, ethical, and conceptual issues involved

  • Published:
Biology and Philosophy Aims and scope Submit manuscript

Abstract

In this paper I claim that the goal of mapping and sequencing the human genome is not wholly new, but rather is an extension of an older project to map genes, a central aim of genetics since its birth. Thus, the discussion about the value of the HGP should not be posed in global terms of acceptance or rejection, but in terms of how it should be developed. The first section of this paper presents a brief history of the project. The second section distinguishes among four kinds of issues relevant to an evaluation of the HGP: those economic and organizational issues related to the feasibility of the project; the ethical questions arising in the development of the project and the application of the data gathered; the empirical issues relevant to the scientific value of the project; and conceptual issues like reductionism and determinism relevant to understand the nature and scope of the project. In a third section, I analyze in detail whether the HGP and, more generally, molecular biology is reductionistic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ayala, F.J.: 1974, ‘Introduction’, in F.J. Ayala and Th. Dobzhansky (eds.), Studies in the Philosophy of Biology, Macmillan, London, pp. vii-xiv.

    Google Scholar 

  • Ayala, F.J.: 1987, ‘Two Frontiers of Human Biology: What the Sequence Won't Tell Us’, Issues in Science and Technology 3, 51–56.

    Google Scholar 

  • Baltimore, D.: 1987, ‘Genome Sequencing: A Small-Science Approach’, Issues in Science and Technology 3, 48–50.

    Google Scholar 

  • Beatty, J.: 1980, ‘The Insights and Oversights of Molecular Genetics: The Place of the Evolutionary Perspective’, PSA 1980 1, 341–355.

    Google Scholar 

  • Cantor, Ch.R.: 1990, ‘Orchestrating the Human Genome Project’, Science 248, 49–51.

    Google Scholar 

  • Conseel Valenciá de Cultura: 1990, El Proyecto del Genoma Humano, Valencia: Monografies del Consell Valencià de Cultura.

    Google Scholar 

  • Council for Responsible Genetics: 1990a, ‘Position Paper on Human Genome Initiative’, Committe for Responsible Genetics, Boston, MA.

    Google Scholar 

  • Council for Responsible Genetics: 1990b, ‘Position Paper on Genetic Discrimination’, Committee for Responsible Genetics, Boston, MA.

    Google Scholar 

  • Crow, J.F.: 1991, ‘Alternative Theories of Molecular Evolution’, manuscript.

  • Culliton, B.J.: 1990, ‘Mapping Terra Incognita (Humani Corporis)’, Science 250, 210–212.

    Google Scholar 

  • Dulbecco, R.: 1986, ‘A Turning Point in Cancer Research: Sequencing the Human Genome’, Science 231, 1055–6.

    Google Scholar 

  • Dulbecco, R. and R. Chiaberge: 1988, Ingegneri della Vita. Medicine e morale nell'era del DNA. Sperling & Kupfer Editori S.p.A. I have used the Spanish translation: 1989, Ingenieros de la Vida. Medicina y ética en la era del ADN, Piramide, Madrid.

    Google Scholar 

  • Fodor, J.A.: 1974, ‘Special Sciences (Or: The Disunity of Science as a Working Hypothesis)’, Synthesis 28, 97–115.

    Google Scholar 

  • Gilbert, Walter: 1987, ‘Genome Sequencing: Creating a New Biology for the Twenty-First Century’, Issues in Science and Technology 3, 26–35.

    Google Scholar 

  • Goosens, W.K.: 1978, ‘Reduction by Molecular Genetics’, Philosophy of Science 45, 73–95.

    Google Scholar 

  • Grene, M.: 1974, ‘Reducibility: Another Side Issue?’, in The Understanding of Nature. Essays in the Philosophy of Biology, D. Reidel, Dordrecht, pp. 53–73.

    Google Scholar 

  • Grisolia, S.: 1989, ‘Mapping the Human Genome’, The Hastings Center Report 19, 18–19.

    Google Scholar 

  • Grisolía, S.: 1990, ‘Presente y Futuro del Genoma Humano’, Política Científica 24, 52–58.

    Google Scholar 

  • Grisolía, S.: 1991, ‘UNESCO Program for the Human Genome Project’, Genomics 9, 404–405.

    Google Scholar 

  • Hood, L. and Ll. Smith: 1987, ‘Genome Sequencing: How to Proceed’, Issues in Science and Technology 3, 36–46.

    Google Scholar 

  • Hull, D.: 1973, Philosophy of Biological Science. Prentice Hall, Englewood Cliffs, NJ.

    Google Scholar 

  • Jacob, F.: 1970, La logique du vivant: Une histoire de l'héridité, Paris, Gallimard. I have used the Spanish translation: 1986, La Lógica de lo Viviente, Salvat, Barcelona.

    Google Scholar 

  • Jordan, E.: 1990, ‘Impact of the HGP on Biological Science: Sharing of and Access to Data’, paper presented at the II Workshops on International Cooperation for the Human Genome Project: Ethics. 12–14 November 1990, Valencia, Spain.

  • Keller, E.F.: 1990, ‘Physics and the Emergence of Molecular Biology: A History of Cognitive and Political Synergy’, Journal of the History of Biology 23, 389–409.

    Google Scholar 

  • Kitcher, P.: 1984, ‘1953 And All That: A Tale of Two Sciences’, Philosophical Review 93, 335–373.

    Google Scholar 

  • Lappé, M.: 1987, ‘The limits of Genetic Inquiry’, Hastings Center Report 17, 5–10.

    Google Scholar 

  • Lewin, R.: 1987, ‘National Academy Looks at Human Genome Project, Sees Progress’, Science 235, 747–48.

    Google Scholar 

  • Lewontin, R.C., S. Rose and L.J. Kamin: 1984, Not in Our Genes: Biology, Ideology, and Human Nature, Pantheon, New York.

    Google Scholar 

  • Marshall, E.: 1990, ‘Data Sharing: A Declining Ethic?’, Science 248, 952–957.

    Google Scholar 

  • Marshall, E.: 1990, ‘Agencies, Journals Set Some Rules’, Science 248, 954.

    Google Scholar 

  • McKusick, V.A.: 1989, ‘Mapping and Sequencing the Human Genome’, The New England Journal of Medicine 320, 910–915.

    Google Scholar 

  • Medawar, P.: 1974, ‘A Geometric Model of Reduction and Emergence’, in F.J. Ayala and Th. Dobzhsansky (eds.), Studies in the Philosophy of Biology, Macmillan, London, pp. 57–63.

    Google Scholar 

  • Miller, R.: 1987, Fact and Method: Explanation, Confirmation and Reality in the Natural and the Social Science, Princeton University Press, Princeton, NJ.

    Google Scholar 

  • Mohr, H.: 1989, ‘Is the Program of Molecular Biology Reductionistic?’, in P. Hoyningen-Huene and F.M. Wuketits (eds.), Reductionism and Systems Theory in the Life Sciences, Kluwer, pp. 137–159.

  • Moya, A.: 1991, ‘Dos Aproximaciones al Proyecto Genoma’, Arbor 544, 175–180.

    Google Scholar 

  • Nelkin, D. and L. Tancredi: 1989, Dangerous Diagnostics: The Social Power of Biological Information, Basic Books, New York.

    Google Scholar 

  • Olby, R.: 1990, ‘The Molecular Revolution in Biology’, in R.C. Olby (et al.) (eds.), Companion to the History of Modern Science, Routledge, New York, pp. 503–520.

    Google Scholar 

  • Olson, M., L. Hood, Ch. Cantor and D. Bolstein: 1989, ‘A Common Language for Physical Mapping of the Human Genome’, Science 245, 1434.

    Google Scholar 

  • Oppenheim, P. and H. Putnam: 1958, ‘Unity of Science as a Working Hypothesis’, in H. Feigl, M. Scriven and G. Maxwell (eds.), Minnesota Studies in the Philosophy of S Science II, pp. 3–36.

  • Palca, J.: 1987, ‘Human Genome Sequencing Plan Wins Unanimous Approval in U.S.’, Nature 326, 429.

    Google Scholar 

  • Palca, J.: 1989, ‘Conflict over Conflict of Interest’, Science 245, 1440.

    Google Scholar 

  • Popper, K.R.: 1974, ‘Scientific Reduction and the Essential Incompleteness of All Science’, in F.J. Ayala and Th. Dobzhansky (eds.), Studies in the Philosophy of B Biology, pp. 259–284.

  • Quintanilla, M.A.: 1989, ‘La Biotecnologia reclama normas deontológicas de validez universal’, Tendencias Científicas y Sociales 14, 7.

    Google Scholar 

  • Roberts, L.: 1989, ‘New Game Plan for Genome Mapping’, Science 245, 1438–1440.

    Google Scholar 

  • Roberts, L.: 1990a, ‘Genome Project: An Experiment in Sharing’, Science 248, 953.

    Google Scholar 

  • Roberts, L.: 1990b, ‘The Great Clone Giveaway’, Science 248, 956.

    Google Scholar 

  • Ruse, M.: 1976, ‘Reduction in Genetics’, in R.S. Cohen et al. (eds.), PSA 1974, Reidel, Dordrecht, pp. 653–670.

    Google Scholar 

  • Ruse, M.: 1989, ‘Sociobiology and Reductionism’, in P. Hoyningen-Huene and F.M. Wuketits (eds.), Reductionism and Systems Theory in the Life Sciences, pp. 45–83

  • Sarkar, S. and A.I. Tauber: 1991, ‘Fallacious Claims for the Human Genome Project’, Nature 353, 691.

    Google Scholar 

  • Schaffner, K.F.: 1967, ‘Approaches to Reduction’, Philosophy of Science 34, 137–147.

    Google Scholar 

  • Schaffner, K.F.: 1977, ‘Reduction, Reductionism, Values, and Progress in the Biomedical Sciences’, in R.G. Colodny (ed.), Logic, Laws, & Life. Some Philosophical Complications. Pittsburg University Press, Pittsburgh, pp. 143–171.

    Google Scholar 

  • Schlessinger, D.: 1990, ‘Current State and Prospects of Physical Mapping of Complex Genomes’, presented at the II Workshop on International Cooperation for the Human Genome Project: Ethics. 12–14 November 1990, Valencia, Spain.

  • Smith, Ll. and L. Hood: 1987, ‘Mapping and Sequencing the Human Genome: How To Proceed’, Bio/Technology 5, 933–939.

    Google Scholar 

  • Sober, L.: 1984, The Nature of Selection, MIT Press, Cambridge, Mass.

    Google Scholar 

  • Sober, E.: 1988, Reconstructing the Past, Parsimony, Evolution, and Inference, MIT Press, Cambridge, Mass.

    Google Scholar 

  • Stephens, J.C., M.L. Cavanaugh, M.I. Gradie, M.L. Mador, K.K. Kidd: 1990, ‘Mapping the Human Genome: Current Status’, Science 250, 237–244.

    Google Scholar 

  • Stith, S.P.: 1978, ‘The Recombinant DNA Debate’, Philosophy and Public Affairs 7, 187–205.

    Google Scholar 

  • Suzuki, D. and P. Knudtson: 1989, ‘Genetics. The Clash Between the New Genetics and Human Values. Cambridge, Mass.: Harvard University Press.

    Google Scholar 

  • Tauber, A.I. and S. Sarkar: (forthcoming), ‘The Human Genome Project: Has Blind Reductionism Gone Too Far?’, Perspectives in Biology and Medicine.

  • Teitelman, R.: 1989, Gene Dreams. Wall Street, Academia, and the Rise of Biotechnology. New York: Basic Books.

    Google Scholar 

  • Thorpe, W.H.: 1974, ‘Reductionism in Biology’, in F.J. Ayala and Th. Dobzhsansky (s.), Studies in the Philosophy of Biology, Macmilla, London, pp. 109–138.

    Google Scholar 

  • U.S. Department of Health and Human Services & U.S. Department of Energy: 1990, Understanding Our Genetic Inheritance. The U.S. Human Genome Project: The First F Five Years. FY 1991–1995.

  • Vicedo, M.: 1991, ‘Review of D. Nelkin and L. Tancredi, Dangerous Diagnostics: The Social Power of Biological Information, S.H. Snyder, Brainstorming: The Science and Politics of Opiate Research, and R. Teitelman, Gene Dreams: Wall Street, Academia, and the Rise of Biotechnology, Isis 82, 161–173.

    Google Scholar 

  • Vicedo, M.: ‘The Human Genome Project: Predictive Medicine and Preventive Ethics’, Arbor 544, 181–207.

  • Vicedo, M.: ‘Reductionism with Open Eyes. Reply to A. Tauber and S. Sarkar’, manuscript.

  • Viceers, T.: 1990, ‘A View From Britain’, presented at the ‘II Workshop on International Cooperation for the Human Genome Project: Ethics’, Valencia, 12–14 November 1990.

  • Watson, J.D.: 1990, ‘The Human Genome Project, Past, Present, and Future’, Science 248, 44–49.

    Google Scholar 

  • Wimsatt, W.C.: 1976, ‘Reductive Explanation: A Functional Account’, Boston Studies in the Philosophy of Science 32, 671–710.

    Google Scholar 

  • Workshop on International Cooperation for the Human Genome Project: 1988, ‘Valencia Declaration on the Human Genome Project’, in Consell Valenciá de Cultura (1990), p. 147.

  • Workshop on International Cooperation for the Human Genome Projects: Ethics: 1990, ‘Valencia Declaration on Ethics and the Human Genome Project’.

  • Zinder, N.D.: 1990, ‘The Genome Initiative: How To Spell Human’, Scientific American 263, 96.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vicedo, M. The human genome project: Towards an analysis of the empirical, ethical, and conceptual issues involved. Biol Philos 7, 255–278 (1992). https://doi.org/10.1007/BF00129970

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00129970

Key words

Navigation