Abstract

© 2014 American Association for Cancer Research.Background: Volatile organic compounds from tobacco smoke are associated with cancer, cardiovascular, and respiratory diseases. The objective of this study was to characterize the exposure of nonsmokers to VOCs from secondhand smoke in vehicles using mercapturic acid metabolites.Methods: Fourteen nonsmokers were individually exposed in the backseat to one hour of SHS from a smoker seated in the driver's seat who smoked three cigarettes at 20-minute intervals in a stationary car with windows opened by 10 cm. Baseline and 0-to 8-hour postexposure mercapturic acid metabolites of nine VOCs were measured in urine. Air-to-urine VOC ratios were estimated on the basis of respirable particulate matter or air nicotine concentration, and lifetime excess risk of cancer death from exposure to acrylonitrile, benzene, and 1,3-butadiene was estimated for adults.Results: The greatest increase in 0-to 8-hour postexposure concentrations of mercapturic acids from baseline was MHBMA-3, then CNEMA, PMA, MMA, and HEMA. The LER of cancer death from exposure to acrylonitrile, benzene, and 1,3-butadiene in SHS for 5 hours a week ranged from 15.5 × 10 -6 to 28.1 × 10 -6 for adults, using air nicotine and PM 2.5 to predict air VOC exposure, respectively.Conclusion: Nonsmokers have significant intake of multiple VOCs from breathing SHS in cars, corresponding to health risks that exceed the acceptable level.Impact: Smoking in cars may be associated with increased risks of cancer, respiratory, and cardiovascular diseases among nonsmokers.