Genetic Research as Therapy: Implications of “Gene Therapy” for Informed Consent

Journal of Law, Medicine and Ethics 26 (1):38-47 (1998)
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In March 1996, the General Accounting Office issued the report Scientific Research: Continued Vigilance Critical to Protecting Human Subjects. It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always clear to clinicians. Controversy exists regarding whether certain medical procedures should be categorized as research.”This problem currently plagues gene transfer research. A few months prior to the GAO report, an ad hoc committee appointed by National Institutes of Health Director Harold Varmus expressed similar concerns in its assessment of NIH investment in research on gene therapy.



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Defining and Describing Benefit Appropriately in Clinical Trials.Nancy M. P. King - 2000 - Journal of Law, Medicine and Ethics 28 (4):332-343.
RAC Oversight of Gene Transfer Research: A Model Worth Extending?Nancy M. P. King - 2002 - Journal of Law, Medicine and Ethics 30 (3):381-389.
Genetics and bioethics: How our thinking has changed since 1969.LeRoy Walters - 2012 - Theoretical Medicine and Bioethics 33 (1):83-95.
Nanomedicine First-in-Human Research: Challenges for Informed Consent.Nancy M. P. King - 2012 - Journal of Law, Medicine and Ethics 40 (4):823-830.

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References found in this work

The Silent World of Doctor and Patient.Daniel Callahan & Jay Katz - 1984 - Hastings Center Report 14 (6):47.
Experimental Treatment Oxymoron or Aspiration?Nancy M. P. King - 1995 - Hastings Center Report 25 (4):6-15.
Commentary: Examining the ethics of human subjects research.Paul S. Appelbaum - 1996 - Kennedy Institute of Ethics Journal 6 (3):283-287.

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