Perspectives in Biology and Medicine 59 (4):471-490 (2016)

Reidar Lie
University of Bergen
The main topic of this article is Otto Frank's forgotten notion of the pressure-volume diagram of the cardiac ventricle as a means to assess the external mechanical work of the heart. Developed by Frank at the end of the 19th century, this idea was reenvisioned as pressure-volume area about 70 to 80 years later by Hiroyuki Suga. This notion now serves as a perspective for defining cardiac contractility and thus enabling the controlled clinical application of cardiac assist devices. We begin our discussion, however, with the work of Ernest H. Starling, whose dominant influence on the thinking of cardio-physiologists led to a neglect of some of the fundamental insights of Frank's...
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Reprint years 2016, 2017
DOI 10.1353/pbm.2016.0042
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