The paper uses the Neo-Kantian distinction between Natural and Human sciences and its methodological implications to navigate W. E. B. Du Bois’s and Alain L. Locke’s theories of race. In tracing a continuity between these two figures, the paper also shows how their respective reliance on Neo-Kantian categories leads them to different results. The goal is to show how, while Du Bois’s Neo-Kantianism is best understood as a Diltheyan Neo-Kantianism of the psycho-physical unity of human nature influenced by an anti-metaphysical (...) orientation, Locke’s Neo-Kantianism can be seen as a Neo-Kantianism whose focus is the rejection of causality and of the causal nexus between biological and non-biological traits. (shrink)