- New
-
Topics
- All Categories
- Metaphysics and Epistemology
- Value Theory
- Science, Logic, and Mathematics
- Science, Logic, and Mathematics
- Logic and Philosophy of Logic
- Philosophy of Biology
- Philosophy of Cognitive Science
- Philosophy of Computing and Information
- Philosophy of Mathematics
- Philosophy of Physical Science
- Philosophy of Social Science
- Philosophy of Probability
- General Philosophy of Science
- Philosophy of Science, Misc
- History of Western Philosophy
- Philosophical Traditions
- Philosophy, Misc
- Other Academic Areas
- Journals
- Submit material
- More
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
Young David, Jan Lily, Jan Yuh, S. B. Yang, H. Y. Lee, D. M. Young, A. C. Tien, A. Rowson-Baldwin, Y. Y. Shu, Y. N. Jan & L. Y. Jan
Abstract
Rapamycin, a specific inhibitor for mTOR complex 1, is an FDA-approved immunosuppressant for organ transplant. Recent developments have raised the prospect of using rapamycin to treat cancer or diabetes and to delay aging. It is therefore important to asse.Author's Profile
Links
PhilArchive
External links
(no proxy)
Setup an account with your affiliations in order to access resources via your University's proxy server
Through your library
- Only published works are available at libraries.
My notes
Similar books and articles
Resveratrol and rapamycin: are they anti‐aging drugs?Matt Kaeberlein - 2010 - Bioessays 32 (2):96-99.
The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation.Colin W. Ward, John G. Menting & Michael C. Lawrence - 2013 - Bioessays 35 (11):945-954.
Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action.Maher Jacquelyn, Khalili Mandana, Bacchetti Peter, D. Brandman, C. E. Ayala & J. J. Maher - unknown
Improved human islet preparations using glucocorticoid and exendin-4.A. Miki, C. Ricordi, T. Yamamoto, Y. Sakuma, R. Misawa, A. Mita, L. Inverardi, R. Alejandro & H. Ichii - unknown
Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor.Colin W. Ward & Michael C. Lawrence - 2009 - Bioessays 31 (4):422-434.
From Insulin and Insulin-Like Activity to the Insulin Superfamily of Growth-Promoting Peptides: A 20th-Century Odyssey.Stanley Blumenthal - 2010 - Perspectives in Biology and Medicine 53 (4):491-508.
Improvement in health‐related quality of life, independent of fasting glucose concentration, via insulin pen device in diabetic patients.I.-Te Lee, Hsiu-Chen Liu, Yi-Ju Liau, Wen-Jane Lee, Chien-Ning Huang & Wayne Huey-Herng Sheu - 2009 - Journal of Evaluation in Clinical Practice 15 (4):699-703.
Preparation and Characterization of Chitosan-Insulin-Tripolyphosphate Membrane for Controlled Drug Release: Effect of Cross Linking Agent.Holanda Adriana Lima - 2014 - JBNB 5:Holanda Adriana Lima.
Telomerase expression abrogates rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells.G. Suo, A. Sadarangani, W. Tang, B. D. Cowan & J. Y. J. Wang - unknown
An Embedded Automaton to Monitor the Glycolysis Process in Pancreatic β-Cells.G. Poornima Devi, M. Rashith Muhammad & R. Selvakumar - 2014 - Acta Biotheoretica 63 (1):23-31.
Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin cells.E. W. Kraegen, J. A. Sowden, M. B. Halstead, Pw Clark, Kj Rodnick, Dj Chisholm & De James - 1994 - Bioessays 16:753-759.
Temporally regulated expression of insulin and insulin‐like growth factors and their receptors in early mammalian development.Susan Heyner, Robert M. Smith & Gilbert A. Schultz - 1989 - Bioessays 11 (6):171-176.
Endocrine effects on glucose and insulin periodicity.Larry L. Bellinger - 1981 - Behavioral and Brain Sciences 4 (4):576-576.
mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells.Brandon R. Beagle, Duc M. Nguyen, Sharmila Mallya, Sarah S. Tang, Mengrou Lu, Zhihong Zeng, Marina Konopleva, Thanh-Trang Vo & David A. Fruman - unknown
Effect of short‐term intensive insulin therapy on quality of life in type 2 diabetes.Christine Opsteen, Ying Qi, Bernard Zinman & Ravi Retnakaran - 2012 - Journal of Evaluation in Clinical Practice 18 (2):256-261.
Analytics
Added to PP
2017-05-07
Downloads
1 (#1,903,274)
6 months
1 (#1,475,652)
2017-05-07
Downloads
1 (#1,903,274)
6 months
1 (#1,475,652)
Historical graph of downloads
Sorry, there are not enough data points to plot this chart.
Author's Profile
PhilPapers logo by Andrea Andrews and Meghan Driscoll.
This site uses cookies and Google Analytics (see our terms & conditions for details regarding the privacy implications). Use of this site is subject to terms & conditions.
All rights reserved by The PhilPapers Foundation
Server: philpapers-web-5ff6c685cb-rskd8 uwo