Discourse in EuroAmerica in connection with menopause is selectively naturalized, with specific consequences for practice, deflecting attention away from non-biological aspects of ageing. The medicalized discourse of North America is compared with that of contemporary Japan, where emphasis is focused predominantly on social rather than biological change. Following Latour and Haraway, it is argued that culture and nature are not dichotomous. Further, both biology and culture are contingent. `Local biologies', that is, subjective experience constituted from culturally informed knowledge, expectations and (...) practices, are in part shaped by physical sensations and symptoms, that differ quantitatively in Japan and North America. This difference influences - but does not determine - the production of discourse and medical responses to this stage of the life cycle. Situated cultural practices of creating culture/nature boundaries are sites for moral and political disputes, which in turn influence subjective experience, the discourse of medicalization and the politics of ageing. (shrink)