Abstract

Recent techniques allow the introduction of in vitro‐manipulated immunoglobulin genes into myeloma cells to produce chimaeric antibodies. These antibodies contain the antigen‐binding variable region (V) of one species linked either to the heavy chain constant region (C) of another species or to a completely unrelated protein, such as that of certain enzymes. Apart from having novel functions and diagnostic and therapeutic applications, these antibody‐related molecules are also valuable in immunochemical studies.