Human monoclonal antibodies are extremely difficult to obtain by hybridoma technology. As an alternative, ‘human‐like’ antibodies have been produced by recombinant DNA technology. The first such engineered antibodies consisted of chimaeric proteins, in which murine variable regions were linked to human constant regions. More recently ‘human’ antibodies have been ‘reshaped’ by transplanting the binding site of a murine antibody into a human antibody. Further‐more antibodies have been dissected into groups of domains (Fab's, Fc's) and for example, Fab's have been joined (...) to enzymes resulting in antibody‐enzyme chimaeras. In addition to their potential clinical applications, engineered antibodies will prove invaluable in studies of structure/function relationships of variable and constant regions. (shrink)

In ethics, the use of empirical data has become more and more popular, leading to a distinct form of applied ethics, namely empirical ethics. This ‘empirical turn’ is especially visible in bioethics. There are various ways of combining empirical research and ethical reflection. In this paper we discuss the use of empirical data in a special form of Reflective Equilibrium (RE), namely the Network Model with Third Person Moral Experiences. In this model, the empirical data consist of the moral experiences (...) of people in a practice. Although inclusion of these moral experiences in this specific model of RE can be well defended, their use in the application of the model still raises important questions. What precisely are moral experiences? How to determine relevance of experiences, in other words: should there be a selection of the moral experiences that are eventually used in the RE? How much weight should the empirical data have in the RE? And the key question: can the use of RE by empirical ethicists really produce answers to practical moral questions?In this paper we start to answer the above questions by giving examples taken from our research project on understanding the norm of informed consent in the field of pediatric oncology. We especially emphasize that incorporation of empirical data in a network model can reduce the risk of self‐justification and bias and can increase the credibility of the RE reached. (shrink)

Entretien réalisé à Lyon, le 10 mai 2012, avec Martine Villelongue, directrice de l’université de la Mode. Historienne de l’Art, Martine Villelongue a soutenu une thèse sur l’œuvre de Lucien Bégule (1848-1935), maître-verrier lyonnais, à l’université de Lyon 2 en 1983, publiée en 2005. Elle a ensuite travaillé pendant une quinzaine d’années au musée des Tissus et des Arts Décoratifs de Lyon : montage d’expositions et création du service des publics de ce musée. Après avoir enseigné comme maît...

This article examines Grotius’ lifelong support for Dutch expansion overseas. As noted in other publications of mine, Grotius cooperated closely with the directors of the Dutch East India Company (VOC) in the years 1604–1615. Right up to his arrest for high treason in August 1618, he contributed towards Dutch government discussions about the establishment of a West India Company (WIC). Three years of imprisonment at Loevestein Castle and, following his escape, long years of exile could not weaken his dedication to (...) the cause. His relatives in Holland, in particular his brother Willem de Groot and his brother-in-law Nicolaas van Reigersberch, kept him up-to-date on the fortunes of the VOC and WIC. His expertise on maritime affairs was in high demand. For example, Cardinal Richelieu invited him in November 1626 to become actively involved in the establishment of a French East India Company. As itinerant ideologue of empire, Grotius sought to further his own career and those of his nearest family members, without damaging the interests of the United Provinces. Through Willem de Groot and Nicolaas van Reigersberch, he provided informal advice on Dutch imperial policy to the VOC directors and government officials in The Hague. He was rewarded with the appointment of his brother and his second son, Pieter de Groot, as VOC lawyers (ordinaris advocaten) in 1639 and 1644, respectively. They served as his proxies in diplomatic disputes involving the VOC, the States General and the Portuguese ambassador in autumn 1644, when Pieter and Willem de Groot wrote a defense of VOC claims to the cinnamon-producing areas of Ceylon (modern-day Sri Lanka), liberally citing De Jure Belli ac Pacis. Grotius’ vision of empire hardly changed in the course of 40 years. In his view, the Dutch had gone to the Indies as merchants, not conquerors, and should regulate themselves according to natural law and the law of nations. Thus he contributed to the creation of two political orders, one for Europe and one for the Indies. European diplomatic relations counted for little beyond the Line. VOC and WIC officials could act as judges and executioners in their own cause, without reference to indigenous rulers, other colonial powers, or even the political authorities back home. (shrink)

La 4e de couverture indique :"Alors que le féminisme est plus que jamais nécessaire, il est malmené de toutes parts. D'un côté, des pseudo-radicalités instruisent le procès d'un " féminisme blanc " qui irait d'Olympe de Gouges à aujourd'hui. De l'autre, une mouvance de droite et d'extrême droite instrumentalise le féminisme dans une perspective identitaire, nationaliste et raciste. Face à ces entreprises de brouillage et de régression, il est urgent de réaffirmer la valeur de l'émancipation et de plaider pour un (...) féminisme universel, concret et pluriel. Ni décolonial, ni occidental, le féminisme se construit sans cesse, dans les luttes et la solidarité des combats quotidiens.". (shrink)

Continuing the investigation in his earlier Individuals and individuality, Martine (philosophy, U. of Alabama) demonstrates that indeterminacy in our experience is logically bound to the determinate dimensions of thought and practice.

The present volume contains a selection of papers presented at the conference Mapping Parameters of Meaning, an event organized by the GReG (Groupe de Rèflexion sur les Grammaires) linguistics research group in the Language Department of the University of Paris Ouest Nanterre on November 19-20, 2010. The book addresses the description of meaning construction processes, and the necessity for new linguistic interface-tools to analyze it in its dynamic and multi-dimensional aspect. Syntax, grammar, prosody, discourse organization, subjective and situational filters are (...) not considered as autonomous systems; on the contrary, they are shown to systematically converge in the process of meaning construction and interpretation. The notion of context is discussed throughout the volume, a major concern being to try and define the precise nature of the link between variable contextual parameters and stable linguistic systems. The book will be of value to anyone interested in the interaction between syntax, semantics and pragmatics in the gradual construction and interpretation of meaning in natural languages, including researchers, students and scholars of formal linguistics, cognitive linguistics and discourse analysis. (shrink)

Based on an analysis of 44 cases in Canada, Tunisia, and Cameroon, this research attempts to determine the fundaments of sustainable entrepreneurship (SE) in an international perspective and to shed the light on the potential impact of economic, institutional, and cultural dimensions upon diverse levels of sustainability in smalland medium-size firms (SMEs). Neo-institutional and entrepreneurship theories were combined in an integrative conceptual model to fully embrace the meanings and practices of SE and to question the "culture free" argument of some (...) prescriptions as well as some international programs. The analysis of the rationale behind entrepreneurs committed to sustainability in the three countries compared to less engaged firms shows that entrepreneurs' individual values are crucial in all cases. Socio-cultural specificities and institutional realities can, however, be more or less inductive to the adoption of sustainable practices in SMEs. This study also demonstrates that external stimuli are needed in Tunisia and Cameroon to reach the same environmental involvement as found in Canada. Moreover, support programs to assist SMEs with the adoption of sustainable practices and communication about the issue have to be tailored to the entrepreneur's motives, the firms' levels of openness to sustainability, the socio-cultural practices already embedded, and the countries' priorities. Implications for policy, management, and research are also discussed. (shrink)

Being able to self-regulate one’s learning is essential for academic success but is also very difficult for students. Especially first year students can be overwhelmed with the high study load and autonomy in higher education. To face this challenge, students’ monitoring and self-regulated learning processes are crucial. Yet, often students are not aware of effective SRL strategies or how to use them. In this study, the use of a mobile application with gamification elements to support first-year university students’ SRL processes (...) was investigated. In Study 1a, the Ace your self-study app was implemented in a first-year psychology course, and students’ SRL skills, motivation, self-efficacy, app use and satisfaction, and performance were measured. The results showed a significant increase in autonomous motivation, controlled motivation, and metacognitive self-regulation skills across the 5-week course. Moreover, students who used the mobile application with gamified elements showed higher autonomous motivation. Nevertheless, most students used the app only for a limited number of self-study sessions. In Study 1b, students’ self-study experiences were captured using focus group interviews to shed some more light on why students did or did not use the app. The results show that if students feel they do not need support for their SRL processes during self-study, they are less inclined to use the app. Specifically, regarding using study strategies, it was found that only if students’ strategies do not work well in their perception, they feel the need to change their way of studying and choose another strategy. These results are discussed in the context of theory on SRL and how to support it. (shrink)

The possible Stoic origins of the natural rights and natural law theories of the Dutch jurist Hugo Grotius (1583–1645) has been a subject of scholarly debate in recent years. Yet discussions about Grotian sociability tend to focus exclusively on the meaning of appetitus societatis in De Jure Praedae (written in 1604–1608) and De Jure Belli ac Pacis (1625), with little reference to the historical context. Insufficient consideration has been given to the intended audience(s) of these works, Grotius’ purpose in writing (...) them, and the possible correlation between his overarching argument and his working methods. This article examines Grotius’ use and abuse of Seneca's philosophical works in De Jure Praedae, commissioned by the directors of the Dutch East India Company (or VOC) in autumn 1604. The brutal murder of Sebald de Weert on the island of Ceylon (modern-day Sri Lanka) in June 1603 is analyzed from a Stoic perspective in Chapter 15 of De Jure Praedae. Following his refusal to hand over Portuguese prisoners, De Weert and his crew were butchered on the beach of Batticaloa by Wilama Dharma Suriya, the ruler of the island's interior. Grotius blamed the victim. VOC commanders in monsoon Asia should suppress any residual loyalty which they might feel towards Christendom. It was imperative to conclude alliances with native rulers against the Iberian colonial powers, regardless of the rulers’ (lack of) faith or their horrific treatment of prisoners. As Grotius noted in Chapter 8 of De Jure Praedae, Seneca distinguished between “two kinds of commonwealth, the world state and the city state.” Spanish and Portuguese violations of the natural law – freedom of trade and navigation in particular – deserved condign punishment for the sake of both the fellowship of mankind and, naturally, the VOC and Dutch Republic. In assessing the uses of Stoicism in De Jure Praedae, much can be learned from the physical characteristics of Ms. BPL 917 in Leiden University Library, its sole surviving manuscript copy. Seneca's philosophical works are not cited at all in the original text of Ms. BPL 917, which Grotius copied out in 1604–1605. Instead, quotations from De Ira, De Clementia and De Beneficiis appear in the top and bottom margins of folio-pages or on inserted sheets of paper, which can be dated to 1607–1608. These quotations serve to flesh out an existing argument about the VOC's just war(s) in the East Indies. A case in point is the heavily rewritten Chapter 2. Grotius added quotations from De Clementia at the same time as he reformulated two natural laws on f. 8–9, a folio sheet inserted in or after January 1607. This was no coincidence. Revenging the past misdeeds of the Portuguese, which Grotius had described in great detail in Chapter 11, could no longer be considered the main or only priority of the VOC. Instead, Grotius contended on f. 8–9 that “evil deeds must be corrected” so as to achieve, in Seneca's words, “universal security.” Acting as a kind of global police force, the VOC should punish transgressors of the natural law on account of “that world community” envisioned by the Stoics. The practical consequences were felt during the Twelve Years Truce (1609–1621). Despite a cessation of arms in Europe, the VOC continued to engage in hostilities in the East Indies. The author of De Jure Praedae supported the Company on this. Like Cicero before him, he had successfully harnessed the Stoa to the cause of empire. (shrink)

Kenelm Digby’s Two Treatises, of the Nature of Bodies and of the Nature of Mans Soule defends quite an idiosyncratic approach to mind-body dualism. In his use of the divisibility argument to prove that the human soul cannot be a material substance, Digby takes an uncompromising stand for merely potential material parts. In his Treatise of Bodies the present article focuses on the mode of construction of the definition of quantity as divisibility and on its links to two distinct fundamental (...) arguments against the actual material parts doctrine. The first, positive, argument consists of a semantic reason drawn from Digby’s general doctrine of meaning, whereas the second, negative, argument, addresses the traditional question of the composition of the continuum. The latter, the author contends, does not build on the medieval controversy itself, but on Digby’s opposition to Galileo’s claim of indivisibilism in his Dialogues Concerning Two Sciences. (shrink)

Après la révolution d’Octobre 1917, la transformation des rapports sociaux entre les sexes a été placée au cœur du projet bolchevik de construction du socialisme en Russie. De nouvelles formes d’organisation de la vie domestique, du travail et de la société transformeraient les relations entre les hommes et les femmes. Afin que les femmes puissent participer à égalité avec les hommes aux activités de production et de la sphère publique, il était indispensable de libérer les femmes des tâches domestiques en (...) transférant celles-ci dans la sphère des services collectifs. Qu’en fut-il dans la réalité? Les enquêtes sur les emplois du temps des familles, appelées enquêtes de budget temps, qui ont été réalisées en URSS au début des années 1920 puis à la fin des années 1960 et au début des années 1970, permettent de juger de la réalité de l’évolution des rôles sociaux derrière les discours dans la Russie soviétique. (shrink)

In their article, Luchtenberg and colleagues give voice to the opinions of young people on participation in clinical trials (Luchtenberg et al. 2015). Over time, it has become indisputable that chi...

This book provides an elegant account of the nature of the individual, without reducing it to a cluster of universals or claiming that it is a bare particular that must be acknowledged but never articulated.

Evoquer l'univers de Rousseau est une entreprise ambitieuse qui peut aider à orienter la pensée contemporaine vers la valeur des moyens et des fins à entreprendre pour la formation de l'individu. Dans cet ouvrage les auteurs s'attachent à présenter un écrivain à hauteur d'homme et souhaitent faire partager leurs réflexions sur son oeuvre remarquable. Ils montrent notamment que les idées exprimées dans l'Emile présentent la synthèse des conceptions de Rousseau sur la société, sur l'enfance et sur ses principes d'éducation. Partagée (...) ou controversée, sa pensée constitue une approche moderne des savoirs et des pratiques tournées vers des questions qui importent en ce début de XXIe siècle. En confrontant leur regard à celui du penseur, les auteurs de ce livre invitent le lecteur à découvrir ou redécouvrir l'oeuvre de l'homme des Lumières dans des domaines aussi différents que la musique, le langage, la philosophie politique et l'éducation. Vous êtes donc conviés à un voyage au coeur de la pensée rousseauiste qui a inspiré et irrigué leur réflexion. (shrink)

Journal of Philosophy of Education, EarlyView.

In the last two decades, Ralph Cudworth has been acknowledged as one of the paramount figures in the history of theories of consciousness. This paper discusses the interpretation defended by Udo Thiel and Vili Lähteenmäki. Both contend that, for Cudworth, the reflexivity defining consciousness does not constitute self-consciousness, which, they say, requires self-determination for practical ends. On the contrary, I argue that for Cudworth any degree of consciousness implies a species of self-perception that must be considered a degree of self-consciousness. (...) To do justice to Cudworth’s full position, I claim, we must take into account a kind of consciousness that I call ‘to-oneself ’ consciousness. Furthermore, I argue, the problem of the ethical self-formation of every human soul as one personality should be seen as going beyond the mere consideration of practical rationality. (shrink)

In A History of Florence, Machiavelli recounts revolts, especially of the Ciompi of 1378, which display the repeated surfacings of the desire for freedom navigating ceaselessly between the desire to abolish freedom through the recourse to absolute power and moments when virtue triumphs over fortuna and achieves an order that, while fragile, makes the antagonisms fit in such a way that instead of fights they become debates. For Machiavelli, the speeches made in these situations serve to both analyze the circumstances (...) within which the struggles take on meaning and to display the desire for freedom carving out its path using the energy deployed via the negativity of the desire not to be dominated. Key Words: Ciompi • domination • Florence • guilds • license • Machiavelli • non-domination. (shrink)

In ethics, the use of empirical data has become more and more popular, leading to a distinct form of applied ethics, namely empirical ethics. This 'empirical turn' is especially visible in bioethics. There are various ways of combining empirical research and ethical reflection. In this paper we discuss the use of empirical data in a special form of Reflective Equilibrium (RE), namely the Network Model with Third Person Moral Experiences. In this model, the empirical data consist of the moral experiences (...) of people in a practice. Although inclusion of these moral experiences in this specific model of RE can be well defended, their use in the application of the model still raises important questions. What precisely are moral experiences? How to determine relevance of experiences, in other words: should there be a selection of the moral experiences that are eventually used in the RE? How much weight should the empirical data have in the RE? And the key question: can the use of RE by empirical ethicists really produce answers to practical moral questions? In this paper we start to answer the above questions by giving examples taken from our research project on understanding the norm of informed consent in the field of pediatric oncology. We especially emphasize that incorporation of empirical data in a network model can reduce the risk of self-justification and bias and can increase the credibility of the RE reached. (shrink)

The question of the professionalisation of the actors often makes debate because it could imply that an actor who professionalises is not a good professional even that he is not qualified. This position is all the more reinforced when these actors live moments of professional transition, where the doubts and the uncertainties come to push aside their professional identity. How consequently as well as possible to accompany them at best in these moments which re-questioning? This article aims at showing how (...) by a reflexive plan of training- action an approach of professionalisation can be, a process of construction of the subjects which allows them to become aware of their luggage of experiment, their professionality and, on the other hand which contributes to the construction of their posture of apprenance. It is about a process in movement which joins in the philosophy of the training and the orientation throughout the life, in which the subject has to recognize itself as an actor in the work, as an author of its work and as a subject in work on its constructive activity supporting its development thus. (shrink)

A child of the era of decolonization, Claire Denis grew up in various regions of France’s subSaharan colonial lands, and was brought back to the ‘métropole’ as a teenager in the 1960s.She has thus had a double practice of foreignness, abroad, and in her ‘own’ country, whichshe did not know and where, in similar yet fundamentally different ways than in Africa, shefelt like an outsider again. As the daughter of a colonial administrator – a childhoodbeautifully evoked in her first feature, (...) Chocolat – she had stood as a highly visibleembodiment of the Western presence on colonial soil. On her return to France, she wouldlive through the more banal experience of becoming an invisible intruder, an exile at‘home’– a theme explored in her subsequent works. From the start, Denisthus drew on her personal knowledge of feeling rootless to explore issues that haveremained at the heart of her filmmaking: the deeply perplexing questions of identity andalienation, assimilation and rejection, desire and fear inseparable from the post-colonialmalaise that affects France with particular acuteness. (shrink)

LiDAR (Light Detection and Ranging) is a remote sensing technology. It needs no ambient light, nor the guidance of the human eye to capture and reproduce a likeness of the world around us. Although LiDAR generates a constant stream of technical literature, LiDAR images, once envisaged for their aesthetic and expressive value, seem to call for alternative modes of analysis. How do we approach the fast-expanding archive of scanner images? How do we adequately describe the intriguing, spectral visualizations that its (...) blind process of recording produces? Following a general introduction, I look at Anouk De Clerk’s filmThing(2013), a work entirely comprised of LiDAR images. De Clerk encourages us to envisage LiDAR counterintuitively, not as the product of technological novelty, but as part of an interdisciplinary history of the arts. (shrink)

L’amour conjugal existe au Moyen Âge, la littérature en est un lieu d’expression privilégié. Visible également dans les sources épistolaires ou notariales, il est cependant plus difficile à aborder à travers les archives judiciaires, notamment les procès matrimoniaux ecclésiastiques. L’officialité de Saragosse au xve siècle est par excellence la cour où sont jugés les litiges conjugaux. Les procès consultés offrent un récit récurrent de la relation conflictuelle entre époux et laissent à penser que l’amour n’y a guère sa place. Ce (...) n’est pas totalement vrai. Les affaires d’adultère, les unions clandestines, les demandes de solennisation de mariage ne sont pas toutes déposées ou dénoncées au seul motif de haine et de discorde. Les sentiments sont parfois bien présents, sous-jacents, et attendent seulement d’être lus à travers des actes, des mots précis (amor, affectio, cavalgar, enamorar) ou même des silences. (shrink)

Le thème de la libération (délivrance ou isolement libérateur) constitue un idéal prépondérant dans la littérature philosophique hindoue, qui a su engendrer les métaphysiques associées. Dans un sens très différent de celui que l’Occident accorde à l’idée de liberté ou de libération, les penseurs hindous ont su forger des concepts opératoires en vue d’un affranchissement intérieur extrayant le sujet des vicissitudes de l’existence pour l’immerger dans la Plénitude. Si le Yoga et le Védānta ne proposent pas tout à fait le (...) même concept ni la même expérience de cet idéal, ils n’en visent pas moins une même coïncidence avec un Absolu dont ils affirment la prééminence, à des degrés d’identification analogues, à défaut d’être identiques. (shrink)