The ethics of two- and one-sided hypothesis tests for clinical trials

Clinical Ethics 2 (2):100-102 (2007)
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Abstract

In medical research, hypothesis tests are used to determine if a novel treatment is efficacious in comparison to a control treatment. Traditionally two-sided tests are recommended and one-sided tests are not. In this review the arguments for two- and one-sided tests are presented. It is argued that in many applications one-sided tests are appropriate and that two-sided tests may expose research subjects to unnecessary risk, and are therefore unethical

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10.1258/147775007781029537

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Arthur David Owen
Harvard University

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