Abstract

© 2014, Springer International Publishing Switzerland.Purpose: The Patient-Reported Outcomes Measurement Information System initiative was developed to advance the methodology of PROs applicable to chronic diseases. Chronic obstructive pulmonary disease is a progressive chronic disease associated with poor health. This study was designed to examine the correlation of PROMIS health-related quality of life scales and clinical measures among COPD patients. Methods: A cross-sectional analysis was conducted comparing patients who were stable with those currently experiencing a COPD exacerbation. All PROMIS measures for adults available at the time of the study, disease-targeted and other HRQOL instruments, health literacy, percent predicted FEV1, and a 6-min walk distance were assessed when patients were considered clinically stable. Results: Stable COPD patients reported significantly better health-related quality of life on PROMIS domains than patients experiencing an exacerbation. PROMIS domain scores were significantly correlated with each of legacy measures. Six-min walk scores were most highly correlated with the PROMIS physical function domain scores followed by the fatigue, social and to a lesser extent depression, and anxiety domain scores. Percent predicted FEV1 score was significantly associated with PROMIS physical function scores. Conclusion: This study provides support for the validity of the PROMIS measures in COPD patients.