Multiple potential mechanisms of graft action is not a new idea

Behavioral and Brain Sciences 18 (1):56-57 (1995)
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Abstract

It is well established that neural grafts can exert functional effects on the host animal by a multiplicity of different mechanisms – by diffuse release of trophic molecules, neurohormones, and deficient neurotransmitters, as well as by growth and reformation of neural circuits. Our challenge is to understand how these different mechanisms complement each other.

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