The causal closure of the physical world is assumed everywhere in physics but has little empirical support within living organisms. For the spiritual to have effects in nature, and make a difference there, the laws of physical nature would have to be modified or extended. I propose that the renormalized parameters of quantum field theory (masses and charges) are available to be varied locally in order to achieve ends in nature. This is not adding extra forces to nature but rescaling the forces which already exist. We separate metric time in 4 dimensions from process time as the order of actualization of potentialities. This is to allow iterative forward and reverse steps in metric time to influence intermediate variations in the vacuum permittivities to move charged bodies towards achieve specific targets at a later time. Then mental or spiritual influx could have effects in nature, and these should be measurable in biophysics experiments. With this proposal, we see after some centuries how ‘final causes’ could once again be seen active in nature.