Mathematical methods for inferring regulatory networks interactions: Application to genetic regulation

Acta Biotheoretica 52 (4):391-400 (2004)
This paper deals with the problem of reconstruction of the intergenic interaction graph from the raw data of genetic co-expression coming with new technologies of bio-arrays (DMA-arrays, protein-arrays, etc.). These new imaging devices in general only give information about the asymptotical part (fixed configurations of co-expression or limit cycles of such configurations) of the dynamical evolution of the regulatory networks (genetic and/or proteic) underlying the functioning of living systems. Extracting the casual structure and interaction coefficients of a gene interaction network from the observed configurations is a complex problem. But if all the fixed configurations are supposedly observed and if they are factorizable into two or more subsets of values, then the interaction graph possesses as many connected components as the number of factors and the solution is obtained in polynomial time. This new result allows us for example to partly solve the topology of the genetic regulatory network ruling the flowering in Arabidopsis thaliana
Keywords Philosophy   Philosophy of Biology   Evolutionary Biology
Categories (categorize this paper)
DOI 10.1023/B:ACBI.0000046605.48037.7d
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history
Request removal from index
Download options
Our Archive

Upload a copy of this paper     Check publisher's policy on self-archival     Papers currently archived: 25,015
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles
Genetic Justice Must Track Genetic Complexity.Colin Farrelly - 2007 - Cambridge Quarterly of Healthcare Ethics 17 (1):45-53.
Are Self-Organizing Biochemical Networks Emergent?Christophe Malaterre - 2009 - In Maryvonne Gérin & Marie-Christine Maurel (eds.), Origins of Life: Self-Organization and/or Biological Evolution? EDP Sciences. pp. 117--123.
Conceptual and Methodological Biases in Network Models.Ehud Lamm - 2009 - Annals of the New York Academy of Sciences 1178:291-304.

Monthly downloads

Added to index


Total downloads

18 ( #258,343 of 2,082,116 )

Recent downloads (6 months)

1 ( #396,083 of 2,082,116 )

How can I increase my downloads?

My notes
Sign in to use this feature

There  are no threads in this forum
Nothing in this forum yet.

Other forums