Abstract
This paper focuses on Renaissance and early modern readings of Aristotle’s _Meteorologica_ I 7.344a5-8, showing how the various interpretations of this passage were foundational for the establishment of an epistemology based on hypotheses and conjectures, and how this passage informed major philosophical and scientific elaborations of the time, extending its influence beyond the original field of application. The paper considers authors such as Alexander of Aphrodisias, Philoponus, Nifo, Pomponazzi, Wurstisen, Descartes, Galileo, Charleton and Boyle.